find out more
For more information about soft lithography, download the review paper by Y. Xia and G. Whitesides, (AICE vol 37, 5, pages 550-575).
Microfluidic devices
Making a linear gradient
Custom-designed microfluidic devices are increasingly improving the way modern scientific research is performed. They are widely used in variety of scientific fields such as cell biology, tissue engineering, drug delivery, DNA array technology and proteomics. Soft lithography is a simple and extremely flexible procedure that allows fabrication of simple devices and geometries. Because of their small size and transparency, microchannels are optimally suited for microscopy. We take advantage of the flexibility offered by such versatile technique to mimic complex biological systems.
We have designed and built variety of microfluidic devices in order to create spatio-temporal chemical gradient to investigate the mechanism of chemotaxis in dictyostelium. Also in collaboration with the group of Dr. Mark Poznansky and Daniel Irimia at MGH, we developed a microfluidic device, which allows for rapid gradients changes. In collaboration with Roman Stocker at MIT, we have also designed a microfluidic device to mimic a falling alga that leaks nutrients.
Making waves
