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Chemistry Research and Facilities

 

Research Labs

You can learn more about current research and lab groups in the Chemistry Department by checking individual faculty members' pages. Additionally, certain lab groups are below (note that this is not a comprehensive list):

Nonlinear Dynamics Group: (Irving Epstein) Covers oscillatory chemical reactions, spatial pattern formation, dynamical systems and neurobiology.

Solid State Reactions and Polymorphism of Molecular Crystals: contact Prof. Bruce Foxman for more information. 

Hedstrom Laboratory: (Lizbeth Hedstrom) Uses approaches derived from both chemistry and biology to investigate molecular mechanisms of cellular biochemistry and physiology. Projects are organized around the themes of purine/pyrimidine metabolism and protease action and include problems in inhibitor design, protein engineering and cellular metabolism. 

Herzfeld Group: (Judith Herzfeld) Primarily interested in force fields for efficiently simulating chemical reactions in complex media, control of water by gas vesicle proteins for buoyance in unicellular organisms, and active ion transport by membrane proteins for energy storage and homeostasis.

Krauss Research Group: (Isaac Krauss) Problems in organic synthesis and chemical biology. Our chemical biology program is directed at the design and synthesis of carbohydrate clusters which mimic important binding surfaces in biology.

Pochapsky Lab: (Thomas Pochapsky) Directed towards an understanding of non-covalent interactions in chemical and biochemical systems.

Petsko and Ringe Labs: (Dagmar Ringe and Greg Petsko) Interests are generally in the relationship of protein three-dimensional structure to chemical function. Research is focused on the modification of the catalytic properties of a number of pharmaceutically or industrially important enzymes. 

Thomas Research Group: (Christine Thomas) Interests include Heterobimetallic complexes supported by phosphinoamide ligands, and Tridentate pincer-type ligands featuring a central cationic phosphenium donor. 

Wade Lab: (Casey Wade) Seeks to interface molecular inorganic/organometallic chemistry and materials science with the goals of developing more effective catalysts for energy-relevant chemical transformations and materials for small molecule and ion separation.

Xu Group: (Bing Xu) Interdisciplinary integration of organic chemistry, materials science, surface chemistry, biochemistry, and nanotechnology to design new biofunctional materials, including nanomaterials, for the exploration in biomedicine (e.g., molecular drug delivery, cancer therapy, biomedical diagnostics, and biomimetics), and other fundamental problems in nanoscience and biological science.

Facilities

X-Ray Structure Determination Facility

The X-Ray Structure Determination Facility is well-equipped to study "small molecules," and consists of a Nonius CAD-4 linear diffractometer  and a Bruker-Nonius Kappa Apex II CCD instrument, equipped with Mo and Cu radiation sources. 

The Kappa Apex II CCD machine, acquired recently with NSF funding, is a workhorse, ultimate state-of-the-art instrument that serves faculty and students at Brandeis and nearby institutions. The instrument can collect data at temperatures between 90 and 500K, and is capable of establishing stereochemistry, absolute configuration, composition, phase transitions as well as fine details of crystal and molecular structure for organic, inorganic and organometallic compounds.

All inquiries should be directed to Prof. Bruce M. Foxman. Upon request, details of crystal mounting requirements or service and other issues will be sent to you by email. For additional information, visit the x-ray web site.

BrUNMR: Nuclear Magnetic Resonance Facility

The Brandeis University Nuclear Magnetic Resonance Facility (BrUNMR) is open to all members of the Brandeis research community who require solution state NMR for their work. It is comprised of four well-equipped spectrometers ranging in magnetic fields from 400 to 800 MHz.
  • Varian Inova 400 is primarily used by the chemistry department as a walk-up instrument for small molecule analysis.
  • Varian Inova 500 and 600 are heavily used by the chemistry and biochemistry departments for multidimensional structural and dynamic studies of biomolecules.
  • Bruker Avance 800 (located in the Landsman Research Facility) is a state-of-the-art regional facility instrument available to all NIH-funded researchers. 

Instrumentation

Other instrumentation available, in the department facility and in individual faculty members' laboratories, includes ESR, UPLC-MS, MALDI-TOF-MS, solid-state NMR, CD, Fluorescence Spectrometer, mass and GC/mass spectrometers, and computerized UV-visible and a Fourier-Transform IR spectrometers. Controlled atmosphere dry boxes, continuous flow stirred tank reactors, gas and liquid chromatography equipment, and a variety of laser sources are available to students. 

Machine Shop

The Machine Shop is available for custom fabrication work. The shop is located in Kalman Room 3 and is operated by Frank Mello. All projects should be discussed with Frank to decide their feasibility. If it is a project that Frank can accomplish, a Lab Supply requisition needs to be filled out, assigned a chargeline, signed by the PI and turned into the chemistry office for processing.