Bing Xu

Title

Professor of Chemistry

Chemistry

Expertise

Materials Chemistry; biofunctional materials; polymer chemistry and surface chemistry; functional molecular and nanomaterials for biomedicine.

Degrees

University of Pennsylvania, Ph.D.

Nanjing University, M.S.

Nanjing University, B.A.

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Contact

Email:	bxu@brandeis.edu
Phone:	781-736-5201
Office:	Edison-Lecks Science Building, EL320

Awards and Honors

DuPont Asian & European Young Investigator Award (2001)

NIH Postdoctoral Fellowship (1997)

Glenn Brown Award of International Liquid Crystal Society (1996)

Courses Taught

CHEM	59a	Advanced Experimental Chemistry I
CHEM	69a	Advanced Experimental Chemistry II
CHEM	132b	Advanced Organic Chemistry: Spectroscopy
CHEM	160a	Materials Chemistry: Molecular Foundation for Nanobiotechnology
CHEM	240c	Physical Chemistry Seminar
CHEM	250c	Biophysical Chemistry Seminar
CHEM	260c	Materials Chemistry Seminar

Scholarship

Li, J. Y.; Kuang, Y.; Gao, Y.; Du, X. W.; Shi, J. F.; Xu, B.. "D-Amino Acids Boost the Selectivity and Confer Supramolecular Hydrogels of a Non-steroidal Anti-inflammatory Drug (NSAID)." J. Am. Chem. Soc. 135. 2 (2013): 542-545.

Gao, Y.; Shi, J. F.; Yuan, D.; Xu, B.. "Imaging enzyme-triggered self-assembly of small molecules inside live cells." Nat. Commun. 3. (2012): 1033.

Pan, Y.; Long, M. J. C.; Lin,H.-C.; Hedstrom, L.; Xu, B.. "Magnetic Nanoparticles for Direct Protein Sorting inside Live Cells." Chem. Sci. 3. 12 (2012): 3495-3499.

Kuang, Y.; Gao, Y.; Xu, B.. "Supramolecular hydrogelators of N-terminated dipeptides selectively inhibit cancer cells." Chem. Commun. 47. (2011): 12625-12627.

Li, X. M.; Kuang, Y.; Lin, H.-C.; Gao, Y.; Shi, J. F.; Xu, B.. "Supramolecular Nanofibers and Hydrogels of Nucleopeptides." Angew. Chem. Intl. Ed. 50. (2011): 9365-9369..

Li, X. M.; Kuang, Y.; Shi, J. F.; Gao, Y.; Lin, H.C.; Xu, B.. "Multifunctional, Biocompatible Supramolecular Hydrogelators Consist Only of Nucleobase, Amino Acid, and Glycoside." J. Am. Chem. Soc., 133. (2011): 17513-17518.

Long, M. J. C.; Pan, Y.; Lin, H.-C.; Hedstrom, L.; Xu, B.. "Cell Compatible Trimethoprim (TMP)-Decorated Iron Oxide Nanoparticles Bind Dihydrofolate Reductase (DHFR) for Magnetically Modulating Focal Adhesion of Mammalian Cells." J. Am. Chem. Soc. 133. (2011): 10006-10009.

Pan, Y.; Long, M. J. C.; Li, X. M.; Shi, J. F.; Hedstrom, L.; Xu, B.. "Glutathione (GSH)-Decorated Magnetic Nanoparticles for Binding Glutathione-S-transferase (GST) Fusion Protein and Manipulating Live Cells." Chem. Sci. 2. (2011): 945-948..

Zhang, Y.; Kuang, Y.; Gao, Y.; Xu, B.. "Versatile Small Molecule Motifs for Self-assembly in Water and Formation of Biofunctional Supramolecular Hydrogels." Langmuir 27. (2011): 529-537.

uang, Y; Gao, Y.; Shi, J. F.; Lin, H.-C.; Xu, B.. "Supramolecular Hydrogels Based on the Epitope of Potassium Ion Channels." Chem. Commun. 47. (2011): 8772-8774.

Gao, Y., Zhao, F., Wang, Q. G., Zhang, Y., Xu, B.. "Small peptide nanofibers as the matrices of molecular hydrogels for mimicking enzymes and enhancing the activity of enzymes." Chemical Society Reviews 39. 9 (2010): 3425-3433.

Gao, Y.; Yang, Z. M.; Kuang, Y.; Ma, M. L.; Li, J. Y.; Zhao, F.; Xu, B.*. "“Enzyme-instructed Self-assembly of Peptide Derivatives to Form Nanofibers and Hydrogels”." Biopolymers: Peptide Sci 94. (2010): 19-31.

Li, X. M., Li, J. Y., Gao, Y. A., Kuang, Y., Shi, J. F., Xu, B.. "Molecular Nanofibers of Olsalazine Form Supramolecular Hydrogels for Reductive Release of an Anti-inflammatory Agent." Journal of the American Chemical Society 132. 50 (2010): 17707-17709.

Ma, M. L., Kuang, Y., Gao, Y., Zhang, Y., Gao, P., Xu, B.. "Aromatic-Aromatic Interactions Induce the Self-Assembly of Pentapeptidic Derivatives in Water To Form Nanofibers and Supramolecular Hydrogels." Journal of the American Chemical Society 132. 8 (2010): 2719-2728.

Pan, Y., Gao, J. H., Zhang, B., Zhang, X. X., Xu, B.. "Colloidosome-based Synthesis of a Multifunctional Nanostructure of Silver and Hollow Iron Oxide Nanoparticles." Langmuir 26. 6 (2010): 4184-4187.

Gao JH, Gu HW, Xu B. "Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications." ACCOUNTS OF CHEMICAL RESEARCH 42. 8 (2009): 1097-1107.

Gao Y, Kuang Y, Guo ZF, Guo ZH, Krauss IJ,Xu, Bing. "Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131. 38 (2009): 13576-13577.

Gao, J. H.; Xu, B.. "Applications of Nanomaterials inside Cells." Nano Today, 4. (2009): 37-51.

Liang, G.; Yang, Z. M., Zhang, R. J.; Li, L. H.; Fan, Y. J.; Kuang, Y.; Gao, Y.; Wang, T.; Lu, W. W.; Xu, B.. "A Supramolecular Hydrogel of A D-Aminoacid Dipeptide for Controlled Drug Release in vivo." Langmuir 25. 15 (2009): 8419-8422..

Wang, Q. G.; Li, L. H.; Xu, B.. "Bioinspired Supramolecular Confinement of Luminol and Heme Proteins to Enhance Chemiluminescent Quantum Yield." Chem. Eur. J., 15. (2009): 3168-3172.

Xu, Bing. "Gels as Functional Nanomaterials for Biology and Medicine." LANGMUIR 25. 15 (2009): 8375-8377.

Yang, C.; Yang, Z. M.; Gu, H. W.; Chang, C. K.; Gao, P.; Xu, B.. "Facet-Selective 2-D Self-Assembly of TiO2 Nanoleaves via Supramolecular Interactions." Chem. Mater 20. (2009): 7514-7520.

Yang, Z. M.; Ma M. L.; Xu, B.*. "Using Matrix Metalloprotease-9 (MMP-9) to Trigger Supramolecular Hydrogelation." Soft Matter 5. (2009): 2546-2548.

Zhao, F.; Ma, M. L.; Xu, B.. "Molecular Hydrogels of Therapeutic Agents." Chem. Soc. Rev. 38. (2009): 883-891.

Gao, J. H.; Liang, G. L.; Cheung, J.; Pan, Y.; Kuang, Y.; Zhao, F.; Zhang, B.; Zhang, X. X.; Wu, E. X.; Xu, B.. "Multifunctional Yolk-shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent." J. Am. Chem. Soc. 130. (2008): 11828-11833.

Jinhao Gao, Wei Zhang, Pingbo Huang, Bei Zhang, Xixiang Zhang, Bing Xu. "Intracellular Spatial Control of Fluorescent Magnetic Nanoparticles." Journal of the American Chemical Society 130. (2008): 3710-3711.

Li, L. H.; Xu, B.. "Synthesis and Characterization of 5-substituted 8-hydroxyquinoline Derivatives and Their Metal Complexes.." Tetrahedron, 64. (2008): 10986-10995.

Wang, Q. G., Yang, Z. M., Gao, Y., Ge, W. W., Wang, L., Xu, B.. "Enzymatic hydrogelation to immobilize an enzyme for high activity and stability." Soft Matter 4. (2008): 550-553.

Wang, Q. G., Yang, Z. M., Ma, M. L., Chang, C. K., Xu, B.. "High Catalytic Activities of Artificial Peroxidase Based on Supramolecular Hydrogel Containing Heme Model." Chemistry-a European Journal 14. (2008): 5073-5078.

Xu, Keming, Ge, Weiwei, Liang, Gaolin, Wang, Ling, Yang, Zhimou, Wang, Qigang, Hsing, I. ming, Xu, Bing. "Bisphosphonate-containing supramolecular hydrogels for topical decorporation of uranium-contaminated wounds in mice." International Journal of Radiation Biology 84. 5 (2008): 353 - 362.

Zhimou Yang, Gaolin Liang, Bing Xu. "Enzymatic Hydrogelation of Small Molecules." Accounts of Chemical Research 41. 2 (2008): 315-326.

Gao, J. H., Liang, G. L., Zhang, B., Kuang, Y., Zhang, X. X., Xu, B.. "FePt@CoS2 yolk-shell nanocrystals as a potent agent to kill HeLa cells." Journal of the American Chemical Society 129. 5 (2007): 1428-1433.

Gao, J. H., Zhang, B., Gao, Y., Pan, Y., Zhang, X. X., Xu, B.. "Fluorescent Magnetic Nanocrystals by Sequential Addition of Reagents in a One-Pot Reaction: A Simple Preparation for Multifunctional Nanostructures." Journal of the American Chemical Society 129. (2007): 11928-11935.

Gilbert, Y., Deghorain, M., Wang, L., Xu, B., Pollheimer, P. D., Gruber, H. J., Errington, J., Hallet, B., Haulot, X., Verbelen, C., Hols, P., Dufrene, Y. F.. "Single-molecule force spectroscopy and imaging of the vancomycin/D-Ala-D-Ala interaction." Nano Letters 7. 3 (2007): 796-801.

Li, Z. Y., Lam, W. M., Yang, C., Xu, B., Ni, G. X., Abbah, S. A., Cheung, K. M. C., Luk, K. D. K., Lu, W. W.. "Chemical composition, crystal size and lattice structural changes after incorporation of strontium into biomimetic apatite." Biomaterials 28. 7 (2007): 1452-1460.

Liang, G. L., Xu, K. M., Li, L. H., Wang, L., Kuang, Y., Yang, Z. M., Xu, B.. "Using Congo red to report intracellular hydrogelation resulted from self-assembly of small molecules." Chemical Communications (2007): 4096-4098 .

Wang, Q. G., Yang, Z. M., Wang, L., Ma, M. L., Xu, B.. "Molecular hydrogel-immobilized enzymes exhibit superactivity and high stability in organic solvents." Chemical Communications 10 (2007): 1032-1034.

Wang, Q.G., Yang, Z. M., Zhang, X. Q., Xiao, X. D., Chang, C. K., Xu, B.. "A Supramolecular Hydrogel-Encapsulated Hemin as an Artificial Enzyme to Mimic Peroxidase." Angewandte Chemie-International Edition in English 46. (2007): 4285-4289.

Yang, Z. M., Gu, H. W., Du, J., Gao, J. H., Zhang, B., Zhang, X. X., Xu, B.. "Self-assembled hybrid nanofibers confer a magnetorheological supramolecular hydrogel." Tetrahedron 63. (2007): 7349-7357.

Yang, Z. M., Ho, P. L., Liang, G. L., Chow, K. H., Wang, Q. G., Cao, Y., Guo, Z. H., Xu, B.. "Using beta-lactamase to trigger supramolecular hydrogelation." Journal of the American Chemical Society 129. 2 (2007): 266-267.

Yang, Z. M., Liang, G. L., Guo, Z. F., Guo, Z. H., Xu, B.. "Intracellular Hydrogelation of Small Molecules Inhibits Bacterial Growth." Angewandte Chemie-International Edition in English 46. (2007): 8216-8219.

Yang, Z. M., Liang, G. L., Ma, M. L., Abbah, A. S., Lu, W. W., Xu, B.. "D-glucosamine-based supramolecular hydrogels to improve wound healing." Chemical Communications 8 (2007): 843-845.

Yang, Z. M., Liang, G. L., Ma, M. L., Gao, Y., Xu, B.. "Conjugates of naphthalene and dipeptides produce molecular hydrogelators with high efficiency of hydrogelation and superhelical nanofibers." Journal of Materials Chemistry 17. 9 (2007): 850-854.

Yang, Z. M., Liang, G. L., Ma, M. L., Gao, Y., Xu, B.. "In vitro and in vivo enzymatic formation of supramolecular hydrogels based on self-assembled nanofibers of a beta-amino acid derivative." Small 3. 4 (2007): 558-562.

Yang, Z. M., Liang, G. L., Xu, B.. "Enzymatic Control of the Self-Assembly of Small Molecules: A New Way to Generate Supramolecular Hydrogels." Soft Matter 2. (2007): 515-520.

Yang, Z. M., Xu, B.. "Supramolecular hydrogels based on biofunctional nanofibers of self-assembled small molecules." Journal of Materials Chemistry 17. (2007): 2385-2393.

Yang, Z. M., Xu, K. M., Guo, Z. F., Guo, Z. H., Xu, B.. "Intracellular Enzymatic Formation of Nanofibers Results in Hydrogelation and Regulated Cell Death." Advanced Materials 17. (2007): 3152-3156..

Gao, J. H., Li, L. H., Ho, P. L., Mak, G. C., Gu, H. W., Xu, B.. "Combining fluorescent probes and biofunctional magnetic nanoparticles for rapid detection of bacteria in human blood." Advanced Materials 18. 23 (2006): 3145-+.

Gao, J. H., Zhang, B., Zhang, X. X., Xu, B.. "Magnetic-dipolar-interaction-induced self-assembly affords wires of hollow nanocrystals of cobalt selenide." Angewandte Chemie-International Edition 45. 8 (2006): 1220-1223.

Gu, H. W., Xu, K. M., Xu, C. J., Xu, B.. "Biofunctional magnetic nanoparticles for protein separation and pathogen detection." Chemical Communications 9 (2006): 941-949.

Liang, G. L., Wang, L., Yang, Z. M., Koon, H., Mak, N., Chang, C. K., Xu, B.. "Using enzymatic reactions to enhance the photodynamic therapy effect of porphyrin dityrosine phosphates." Chemical Communications 48 (2006): 5021-5023.

Ni, G. X., Lu, W. W., Xu, B., Chiu, K. Y., Yang, C., Li, Z. Y., Lam, W. M., Luk, K. D. K.. "Interfacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone." Biomaterials 27. 29 (2006): 5127-5133.

Wang, L., Yang, Z. M., Gao, J. H., Xu, K. M., Gu, H. W., Zhang, B., Zhang, X. X., Xu, B.. "A biocompatible method of decorporation: Bisphosphonate-modified magnetite nanoparticles to remove uranyl ions from blood." Journal of the American Chemical Society 128. 41 (2006): 13358-13359.

Wang, L., Zhang, M., Yang, Z. M., Xu, B.. "The first pamidronate containing polymer and copolymer." Chemical Communications 26 (2006): 2795-2797.

Wong, C. K. Y., Gu, H. W., Xu, B., Yuen, M. M. F.. "A new approach in measuring Cu-EMC adhesion strength by AFM." Ieee Transactions on Components and Packaging Technologies 29. 3 (2006): 543-550.

Yang, Z. M., Liang, G. L., Wang, L., Xu, B.. "Using a Kinase/Phosphatase Switch to Regulate a Supramolecular Hydrogel and Forming the Supramolecular Hydrogel in vivo." Journal of the American Chemical Society 128. (2006): 3038-3043.

Yang, Z. M., Liang, G. L., Xu, B.. "Supramolecular hydrogels based on beta-amino acid derivatives." Chemical Communications 7 (2006): 738-740.

Yang, Z. M., Xu, B.. "Using enzymes to control molecular hydrogelation." Advanced Materials 18. 22 (2006): 3043-3046.

Zheng, R. K., Gu, H. W., Xu, B., Fung, K. K., Zhang, X. X., Ringer, S. P.. "Self-assembly and self-orientation of truncated octahedral magnetite nanocrystals." Advanced Materials 18. 18 (2006): 2418-+.

Zheng, R. K., Gu, H. W., Xu, B., Zhang, X. X.. "The origin of the non-monotonic field dependence of the blocking temperature in magnetic nanoparticles." Journal of Physics-Condensed Matter 18. 26 (2006): 5905-5910.

Gu, H. W., Xu, K. M., Yang, Z. M., Chang, C. K., Xu, B.. "Synthesis and cellular uptake of porphyrin decorated iron oxide nanoparticles - a potential candidate for bimodal anticancer therapy." Chemical Communications 34 (2005): 4270-4272.

Gu, H. W., Yang, Z. M., Gao, J. H., Chang, C. K., Xu, B.. "Heterodimers of nanoparticles: Formation at a liquid-liquid interface and particle-specific surface modification by functional molecules." Journal of the American Chemical Society 127. 1 (2005): 34-35.

Gu, H. W., Zheng, R. K., Liu, H., Zhang, X. X., Xu, B.. "Direct synthesis of a bimodal nanosponge based on FePt and ZnS." Small 1. 4 (2005): 402-406.

Li, L. H., Xu, B.. "Multivalent vancomycins and related antibiotics against infectious diseases." Current Pharmaceutical Design 11. 24 (2005): 3111-3124.

Yang, Z. M., Xu, K. M., Wang, L., Gu, H. W., Wei, H., Zhang, M. J., Xu, B.. "Self-assembly of small molecules affords multifunctional supramolecular hydrogels for topically treating simulated uranium wounds." Chemical Communications 35 (2005): 4414-4416.

Zheng, R. K., Gu, H. W., Xu, B., Zhang, X. X.. "Memory effects in a nanoparticle system: Low-field magnetization and ac susceptibility measurements." Physical Review B 72. 1 (2005): 7.

Gu, H. W., Fu, D., Weng, L. T., Xie, J., Xu, B.. "Solventless polymerization to grow thin films on solid substrates." Advanced Functional Materials 14. 5 (2004): 492-500.

Gu, H. W., Zheng, R. K., Zhang, X. X., Xu, B.. "Facile one-pot synthesis of bifunctional heterodimers of nanoparticles: A conjugate of quantum dot and magnetic nanoparticles." Journal of the American Chemical Society 126. 18 (2004): 5664-5665.

Gu, H. W., Zheng, R. K., Zhang, X. X., Xu, B.. "Using soft lithography to pattern highly oriented polyacetylene (HOPA) films via solventless polymerization." Advanced Materials 16. 15 (2004): 1356-+.

Xu, C. J., Xu, K. M., Gu, H. W., Zheng, R. K., Liu, H., Zhang, X. X., Guo, Z. H., Xu, B.. "Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles." Journal of the American Chemical Society 126. 32 (2004): 9938-9939.

Xu, C. J., Xu, K. M., Gu, H. W., Zhong, X. F., Guo, Z. H., Zheng, R. K., Zhang, X. X., Xu, B.. "Nitrilotriacetic acid-modified magnetic nanoparticles as a general agent to bind histidine-tagged proteins." Journal of the American Chemical Society 126. 11 (2004): 3392-3393.

Yang, Z. M., Gu, H. W., Fu, D. G., Gao, P., Lam, J. K., Xu, B.. "Enzymatic formation of supramolecular hydrogels." Advanced Materials 16. 16 (2004): 1440-+.

Yang, Z. M., Gu, H. W., Zhang, Y., Wang, L., Xu, B.. "Small molecule hydrogels based on a class of antiinflammatory agents." Chemical Communications 2 (2004): 208-209.

Yang, Z. M., Xu, B.. "A simple visual assay based on small molecule hydrogels for detecting inhibitors of enzymes." Chemical Communications 21 (2004): 2424-2425.

Zhang, Y., Yang, Z. M., Yuan, F., Gu, H. W., Gao, P., Xu, B.. "Molecular recognition remolds the self-assembly of hydrogelators and increases the elasticity of the hydrogel by 10(6)-fold." Journal of the American Chemical Society 126. 46 (2004): 15028-15029.

Gu, H. W., Ho, P. L., Tong, E., Wang, L., Xu, B.. "Presenting vancomycin on nanoparticles to enhance antimicrobial activities." Nano Letters 3. 9 (2003): 1261-1263.

Gu, H. W., Ho, P. L., Tsang, K. W. T., Wang, L., Xu, B.. "Using biofunctional magnetic nanoparticles to capture vancomycin-resistant enterococci and other gram-positive bacteria at ultralow concentration." Journal of the American Chemical Society 125. 51 (2003): 15702-15703.

Gu, H. W., Ho, P. L., Tsang, K. W. T., Yu, C. W., Xu, B.. "Using biofunctional magnetic nanoparticles to capture Gram-negative bacteria at an ultra-low concentration." Chemical Communications 15 (2003): 1966-1967.

Gu, H. W., Xu, B., Rao, J. C., Zheng, R. K., Zhang, X. X., Fung, K. K., Wong, C. Y. C.. "Chemical synthesis of narrowly dispersed SmCo5 nanoparticles." Journal of Applied Physics 93. 10 (2003): 7589-7591.

Gu, H. W., Xu, C. J., Weng, L. T., Xu, B.. "Solventless polymerization: Spatial migration of a catalyst to form polymeric thin films in microchannels." Journal of the American Chemical Society 125. 31 (2003): 9256-9257.

Xing, B. G., Ho, P. L., Yu, C. W., Chow, K. H., Gu, H. W., Xu, B.. "Self-assembled multivalent vancomycin on cell surfaces against vancomycin-resistant enterococci (VRE)." Chemical Communications 17 (2003): 2224-2225.

Xing, B. G., Yu, C. W., Ho, P. L., Chow, K. H., Cheung, T., Gu, H. W., Cai, Z. W., Xu, B.. "Multivalent antibiotics via metal complexes: Potent divalent vancomycins against vancomycin-resistant enterococci." Journal of Medicinal Chemistry 46. 23 (2003): 4904-4909.

Yu, H. H., Xu, B., Swager, T. M.. "A proton-doped calix[4]arene-based conducting polymer." Journal of the American Chemical Society 125. 5 (2003): 1142-1143.

Zhang, Y., Gu, H. W., Yang, Z. M., Xu, B.. "Supramolecular hydrogels respond to ligand-receptor interaction." Journal of the American Chemical Society 125. 45 (2003): 13680-13681.

Fu, D. G., Weng, L. T., Du, B. Y., Tsui, O. K. C., Xu, B.. "Solventless polymerization at the gas-solid interface to form polymeric thin films." Advanced Materials 14. 5 (2002): 339-343.

Xing, B. A., Choi, M. F., Zhou, Z. Y., Xu, B.. "Spontaneous enrichment of organic molecules from aqueous and gas phases into stable metallogel." Langmuir 18. 25 (2002): 9654-9658.

Xing, B. G., Choi, M. F., Xu, B.. "A stable metal coordination polymer gel based on a calix[4]arene and its 'uptake' of non-ionic organic molecules from the aqueous phase." Chemical Communications 4 (2002): 362-363.

Xing, B. G., Choi, M. F., Xu, B.. "Design of coordination polymer gels as stable catalytic systems." Chemistry-a European Journal 8. 21 (2002): 5028-5032.

Xing, B. G., Yu, C. W., Chow, K. H., Ho, P. L., Fu, D. G., Xu, B.. "Hydrophobic interaction and hydrogen bonding cooperatively confer a vancomycin hydrogel: A potential candidate for biomaterials." Journal of the American Chemical Society 124. 50 (2002): 14846-14847.

Faculty Guide