Volen National Center for Complex Systems, 342A
DegreesMassachusetts Institute of Technology, Ph.D.
Brandeis University, B.A.
ExpertiseMolecular mechanisms of memory storage; the role of brain oscillations; the molecular and network basis of schizophrenia
ProfileWork in the Lisman laboratory deals with the mechanisms of memory and with schizophrenia. A major goal is to understand the molecular mechanism by which memory is stored at synapses. We are testing the hypothesis that a complex between the enzyme, CaMKII, and the NMDA channel is the basis of memory storage. Other work on memory deals with the roles of brain oscillations in working memory. These oscillations appear to provide a code by which multiple memories can be organized and communicated between brain regions. A second major goal of the laboratory is to understand the brain processes that are abnormal in Schizophrenia. One manifestation of the disease is an abnormality in brain oscillations. We have identified the thalamus as a site where this abnormality originates and are working to understand the molecular and cellular mechanisms involved.
|BCBP||297b||Master's Lab Research II|
|BIOL||350a||Graduate Student Research Seminar|
|BIOL||350b||Graduate Student Research Seminar|
|NBIO||45a||The Cognitive and Neurobiological Basis of Memory|
|NBIO||161a||Cellular and Network Mechanisms of Memory|
Awards and Honors
Election to the rank of American Association for the Advancement of Science (AAAS) Fellow. (2013)
Zalman Abraham Kekst Chair in Neuroscience (2006)
The National Alliance for Research on Schizophrenia and Depression Investigator Award (2003)
Javits Neuroscience Investigator Award (1989 - 1996)
MERIT (Method to Extend Research in Time) Award, National Eye Institute (1987 - 1992)
Grass Foundation Fellow (1972)
Marine Biological Laboratory Award (1971)
Lisman, John. "Causal Role of Abnormal Thalamic Low Frequency Oscillations in Schizophrenia." Gordon's Research Conference: Thalamo-cortical interactions. Ventura, CA. February 17.2016.
Lisman, John. "Low-Frequency Brain Oscillations in Schizophreni." JAMA Psychiatry 73. 3 (2016): 298-299.
Duan AR, Varela C, Zhang Y, Shen Y, Xiong L, Wilson MA, Lisman J.. "elta frequency optogenetic stimulation of the thalamic nucleus reuniens is sufficient to produce working memory deficits: relevance to schizophrenia.." Biol Psychiatry 77. (2015): 1098-1107.
Kabakov AY, Lisman JE.. "Catalytically Dead alphaCaMKII K42M Mutant Acts as a Dominant Negative in the Control of Synaptic Strength.." PLoS One 10. e0123718 (2015)
Lisman J,Raghavachari S.. "Biochemical principles underlying the stable maintenance of LTP by the CaMKII/NMDAR complex.." Brain Res. 1621. (2015): 51-61.
Lisman, John. "The challenge of understanding the brain: where we stand in 2015." Neuron 86. (2015): 864-882.
Otmakhov N, Gorbacheva EV, Regmi S, Yasuda R, Hudmon A, Lisman J.. "Excitotoxic Insult Results in a Long-Lasting Activation of CaMKIIα and Mitochondrial Damage in Living Hippocampal Neurons.." PLoS One 10. 3 (2015): eCollection.
Otmakhov N, Regmi S, Lisman JE. "Fast Decay of CaMKII FRET Sensor Signal in Spines after LTP Induction Is Not Due to Its Dephosphorylation." PLoS One 10. e0130457 (2015)
Sanders H, Renno-Costa C, Idiart M, Lisman J.. "Grid Cells and Place Cells: An Integrated View of their Navigational and Memory Function." Trends Neurosci 38. (2015): 763-775.
Jonas P, Lisman J.. "Structure, function, and plasticity of hippocampal dentate gyrus microcircuits.." Front Neural Circuits. 8. 107 (2014): eCollection 2014..
Lisman, John. "Gamma frequency feedback inhibition accounts for key aspects of orientation selectivity in V1.." Network 25. 1-2 (2014): 63-71.
Lisman, John. "Refreshing memories.." Elife Epub. (2014).
Lisman, John. "Two-phase model of the basal ganglia: implications for discontinuous control of the motor system.." Philos Trans R Soc Lond B Biol Sci. 369. 1655 (2014): 1-6.
Rennó-Costa C, Lisman JE, Verschure PF.. "A signature of attractor dynamics in the CA3 region of the hippocampus.." PLoS Comput Biol. 10. 5 (2014): eCollection 2014 May.
Sanders H, Kolterman BE, Shusterman R, Rinberg D, Koulakov A, Lisman J.. "A network that performs brute-force conversion of a temporal sequence to a spatial pattern: relevance to odor recognition.." Front Comput Neurosci. 8. 108 (2014): eCollection 2014.
John E. Lisman, Ole Jensen. "The Theta-Gamma Neural Code." Neuron 77. 6 (2013): 1002-1006.
Lisman J, Sternberg EJ,. "Habit and Non-Habit Systems for Unconscious and Conscious Behavior: Implications for Multi-Tasking." J Cogn Neurosci. 25. 2 (2013): 273-283.
Sanders H, Berends M, Major G, Goldman MS, Lisman J,. "NMDA and GABAB (KIR) Conductances: The "Perfect Couple" for Bistability.." Journal of Neuroscience 33. 2 (2013): 424-9.
Sanhueza M, Lisman J. "The CaMKII/NMDAR complex as a molecular memory." Molecular Brain 6. 10 (2013): 1-8.
Wittmann BC, Tan GC, Lisman JE, Dolan RJ, Düzel E. "DAT genotype modulates striatal processing and long-term memory for items associated with reward and punishment.." Neuropsychologia. 51. 12 (2013): 2469-77.
De Almeida L, Idiart M, Villavicencio A, Lisman J.. "Alternating predictive and short-term memory modes of entorhinal grid cells.." Hippocampus 22. 8 (2012): 1647-51.
Zhang Y, Buonanno A, Vertes RP, Hoover WB, Lisman JE. "NR2C in the thalamic reticular nucleus; effects of the NR2C knockout.." PLoS One. 7. 7 (2012): e41908.
Faas GC, Raghavachari S, Lisman JE, Mody I.. "Calmodulin as a direct detector of Ca(2+) signals.." Nature Neuroscience 14. 3 (2010): 301-304.
Lisman J, Spruston N. "Questions About STDP as a General Model of Synaptic Plasticity." Frontiers in Synaptic Neuroscience 2. 140 (2010): 1-5.
Lisman JE, Pi H-J, Zhang Y, Otmakhova NA,. "A thalamo-hippocampal-VTA loop may produce the positive feedback that underlies the psychotic break in schizophrenia." Biological Psychiatry 68. (2010): 17-24.
Lisman, John. "Formation of the nonfunctional and functional pools of granule cells in the dentate gyrus: role of neurogenesis, LTP and LTD.." Journal of Physiology Nov 22. [Epub ahead of print].. (2010).
Lisman, John. "Working memory: the importance of theta and gamma oscillations.." Current Biology 20. (2010): R490-492.
M. A. Erickson, L. Maramara, J. Lisman. "A Single 2-spike Burst Induces GluR1-dependent Associative Short-Term Potentiation: A Potential Mechanism for Short Term Memory." Journal of Cognitive Neuroscience 22. (2010): 2530-2540.
Pi H-J, Otmakhov N, Lemelin D, De Koninck P, Lisman J. "Autonomous CaMKII can promote either LTP or LTD, depending on the state of T305/T306 phosphorylation." Journal of Neuroscience 30. (2010): 8704-8709.
Pi H-J, Otmakhov N, Lemelin D, De Koninck P, Lisman J. "CaMKII control of spine size and synaptic strength: role of phosphorylation states and nonenzymatic action.." Proc Natl Acad Sci U.S.A. 107. (2010): 14437-14442.
Rennó-Costa C, Lisman JE, Verschure PF.. "The mechanism of rate remapping in the dentate gyrus.." Neuron 68. (2010): 1051-1058.
de Almeida L, Idiart M, Lisman J. "Single place fields in hippocampal CA3 cells: a two-stage transformation from grid cells." Hippocampus Oct 6. [Epub ahead of print]. (2010).
Lisman, John, Redish, A. David. "Prediction, sequences and the hippocampus." Phil. Trans. R. Soc. B 364. Special theme issue on Predictions (2009): 1193-1201.
Zhang, Yuchun, Llinas, Rodolfo R, Lisman, John E.. "Inhibition of NMDARs in the nucleus reticularis of the thalamus produces delta frequency bursting.." Frontiers in Neuroscience 3. (2009): Article 20:1-9.
de Almeida, Licurgo, Idiart, Marco, Lisman, John E.. "A second function of gamma-frequency oscillations: a E%-max winner-take-all mechanism selects which cells fire." Journal of Neuroscience 29. 23 (2009): 7497-7503.
de Almeida, Licurgo, Idiart, Marco, Lisman, John E.. "The input-output transformation of the hippocampal granule cells: from grid cells to place fields." Journal of Neuroscience 29. 23 (2009): 7504-12.
Lisman, J.E., Coyle, J.T., Green, R.W., Javitt, D.C., Benes, F.M., Heckers, S., Grace, A.A.. "Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia." Trends in Neuroscience 31. 5 (2008): 234-242.
Pi, Hyun, Lisman, John. "Coupled phosphatase and kinase switches produce the tristability required for long-term potentiation and long-term depression." Journal of Neuroscience 28. 49 (2008): 13132-13138.
Zhang, Yuchun, Behrens, Margarita, Lisman, John. "Prolonged exposure to NMDAR antagonist suppresses inhibitory synaptic transmission in prefrontal cortex." Journal of Neurophysiology 100. 2 (2008): 959-965.