Faculty Guide

Title

Assistant Professor of Biochemistry

Biochemistry

Expertise

I have a long-standing interest in RNA processing mechanisms and RNA-protein interactions. I am particularly interested in the maturation of human pre-mRNA transcripts.

Profile

Investigator Scientist, Medical Research Council Laboratory of Molecular Biology, Cambridge, U.K. (2008); Post-doctoral Fellow, Medical Research Council Laboratory of Molecular Biology, Cambridge, U.K. (2000 – 2008); Human Frontier Science Program, Long-term Fellowship (2000 - 2003); Ph.D., Yale University (2000)

Awards and Honors

Life Member, Clare Hall College, University of Cambridge, U.K. (2006)

Research Fellow, Clare Hall College, University of Cambridge, U.K. (2002)

Human Frontier Science Program, Long-term Fellowship (2000)

Courses Taught

BCBP	200b	Reading in Macromolecular Structure-Function Analysis
BCHM	103b	Advanced Biochemistry: Cellular Information Transfer Mechanisms
BCHM	224b	The RNA World: Chemistry, Structure, and Mechanism

Scholarship

T. Pugh, D. Weeraratne, T.C. Archer, D.A. Pomeranz Krummel, D. Auclair, et al.. "Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations within a broad landscape of genetic heterogeneity." Nature 488. (2012): 106-11

van der Feltz C, Anthony K, Brilot A, Pomeranz Krummel D. "Architecture of the spliceosome." Biochemistry 51. (2012): 3321-3333.

Pomeranz Krummel, D.A., Nagai, K., Oubridge, C. "Spliceosome RNP structure.." Faculty 1000 2. (2010): 39.

Hernández H, Makarova OV, Makarov E, Morgner N, Muto Y, Pomeranz Krummel D, Robinson CV. "Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP." PLoS One 4. (2009): e7202.

Oubridge C, Pomeranz Krummel DA, Leung A, Li J, Nagai K. "Interpreting a low resolution map of human U1 snRNP using anomalous scatterers." Structure 17. (2009): 930-938.

Pomeranz Krummel DA, Oubridge C, Leung A, Li J, Nagai K. "Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution." Nature 458. 7237 (2009): 475-480.

Obayashi E, Oubridge C, Pomeranz Krummel D, Nagai K. "Crystallisation of RNA-protein Complexes." Methods in Molecular Biology, Macromolecular Crystallography Protocols: Volume 1 363. (2006): 257-274..

Thompson C, Pomeranz Krummel D, Jacobsen H, Nagai K, Cooke A. "Identification of nuclear spliceosomal antigens targeted by NOD mouse antibodies following sodium iodide intake." Autoimmunity 39. (2006): 99-106.

Pomeranz Krummel D, Muto Y, Oubridge C, Hernandez H, Robinson C, Neuhaus D, Nagai K.. "The structure and biochemical properties of the human spliceosomal protein U1C." Journal of Molecular Biology 341. (2004): 185-198.

Thompson C, Jacobsen H, Pomeranz Krummel D, Nagai K, Cooke A. "Non-depleting anti-CD4 antibody not only prevents onset but resolves sialadenitis in NOD mice." Autoimmunity 37. (2004): 549-554.