Rosenstiel Basic Medical Sciences Research Center, 447
DegreesUniversity of Chicago, Ph.D.
University of Chicago, B.S.
Cryo super-resolution fluorescence microscopy
ProfileI am developing a cryo-stage for super-resolution fluorescence microscopy. The purpose of working under cryo conditions is three fold: cryofixation better preserves a biological sample than chemical fixation, fluorophores emit more photons before bleaching under cryo conditions and hence provide better resolution, and the same area of a cryo specimens can be imaged using both light and electron microscopy. The stage permits the use of a water immersion lens operating at ambient temperature whole the sample is held at near liquid nitrogen temperatures. Webpage
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Awards and Honors
Distinguished Scientist (Biological) Microscopical Society of America (2013)
Fellow Microscopical Society of America (2013)
Member, National Academy of Sciences (2003)
Fellow, Biophysical Society (2002)
Alexander Hollaender Award from the National Academy of Sciences (2001)
Fellow, American Academy of Arts and Sciences (2001)
Burnham Institute Distinguished Lecture Series (2000)
Miller Visiting Professor, University of California at Berkeley (2000)
Annual Schmidt Lecture, Weizman Institute (1998)
Blakeslee Lecture, Smith College (1996)
Abraham S. & Gertrude Burg Chair in Life Sciences (1993)
Fellow, American Society of Microbiology (1993)
Tom Garrad Lectureship, Oklahoma Medical Research Foundation (1993)
Elisabeth Roberts Cole Award, American Biophysical Society (1992 - 1993)
Fellow, American Association for the Advancement of Science (1992 - 1993)
Bacaner Research Awards Lecture, University of Minnesota (1990)
MERIT (Method to Extend Research in Time) Award "to investigators of proven research competence and productivity" (1990 - 1995)
Guggenheim Fellowship (1987 - 1988)
National Institutes of Health Career Development Award (1969 - 1972)
LaboratoryGrant, NSF-USDP Center of Excellence Award (1968 - 1971)
National Science Foundation Postdoctoral Fellowship (1968)
American Cancer Society Postdoctoral Fellowship (1967)
Air Force Office of Scientific Research Postgraduate Fellowship (1966)
National Science Foundation Cooperative (Predoctoral) Fellowship (1963 - 1965)
U.S. Public Health Service Predoctoral Fellowship (1961 - 1963)
DeRosier, David. "A Partial Atomic Structure for the Flagellar Hook of Salmonella Typhimurium.." Proc Natl Acad Sci U S A (2005): 1023-8.
DeRosier, David. "Structure of the Bacterial Flagellar Hook and Implication for the Molecular Universal Joint Mechanism." Nature (2004): 1062-8.
DeRosier, David. "The Role Actin Filaments Play in Providing the Characteristic Curved form of Drosophila Bristles." Mol. Biol. Cell. (2004): 5481-91.
DeRosier, David. "Three-Dimensional Structure and Organization of a Receptor/Signaling Complex.." Proc Natl Acad Sci U S A. (2004): 17480-5.