Shantanu Jadhav
Degrees
University of California, San Diego, Ph.D.Indian Institute of Technology, Bombay, B.Sc.
Expertise
Neural basis of learning, memory and decision making in the mammalian brain.Profile
Our research aims to understand the neural basis of cognition and behavior by studying processing at the cellular and network level in the neuronal circuits of the brain. We investigate how activity in population of neurons across different brain structures supports the ability to learn, remember and make decisions. We utilize multiple techniques, including behavior, chronic in vivo electrophysiology during behavior, optogenetics and computational methods.http://www.bio.brandeis.edu/jadhavlab/index.html
Courses Taught
| NBIO | 145b | Systems Neuroscience |
| NBIO | 207a | Advanced Topics in Data Analysis |
| NPSY | 139a | Memory and the Brain |
Awards and Honors
RO1 grant, National Institute of Mental Health (2017 - 2022)
Whitehall Foundation Award (2016 - 2019)
2015 Alfred P. Sloan Research Fellowship in Neuroscience (2015 - 2017)
2015 NARSAD Young Investigator Award, Brain and Behavior Foundation (2015 - 2018)
K99/R00 Career Transition Grant, National Institute of Mental Health, NIH (2013 - 2017)
Peter and Patricia Gruber International Research Award (2013)
Scholarship
Tang W, Jadhav SP. "Sharp-wave ripples as a signature of hippocampal-prefrontal reactivation for memory during sleep and waking states." Neurobiology of Learning and Memory doi: https://doi.org/10.1016/j.nlm.2018.01.002. 1 (2018): 1:10.
Tang W, Shin JD, Frank LM, Jadhav SP. "Hippocampal-prefrontal reactivation during learning is stronger in awake compared with sleep states." Journal of Neuroscience 37. 49 (2017): 11789-11805.
Zielinski MC, Tang W, Jadhav SP. "The role of replay and theta sequences in mediating hippocampal-prefrontal interactions for memory and cognition." Hippocampus doi: 10.1002/hipo.22821. 1 (2017): 1:13.
Jadhav, Shantanu, Rothschild G, Roumis DK, Frank LM. "Coordinated Excitation and Inhibition of Prefrontal Ensembles during Awake Hippocampal Sharp-Wave Ripple Events." Neuron 90. (2016): 1-15.
Papale AE, Zielinski MC, Frank, LM, Jadhav SP, Redish AD. "Interplay between hippocampal sharp-wave ripple events and vicarious trial and error behaviors in decision making." Neuron 92. 5 (2016): 975-982.
Shin JD and Jadhav SP. "Multiple modes of hippocampal-prefrontal interactions in memory-guided behavior." Current Opinion in Neurobiology 40. 1 (2016): 161-169.
Jadhav SP, Frank LM. "Memory replay in the hippocampus." Time, Space and Memory in the Hippocamal Formation. Ed. D. Derdikman; J. Knierim. Springer, 2014
Felix SH, Shah KG, Tolosa VM, Sheth HJ, Tooker AC, Delima TL, Jadhav SP, Frank LM, Pannu SS. "Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive." Journal of Visualized Experiments 79. 1 (2013): e50609.
Jadhav SP; Kemere C; German PW, Frank LM. "Awake hippocampal sharp-wave ripples support spatial memory." Science 336. 6087 (2012): 1454-1458.
Carr MF*, Jadhav SP*, Frank LM. "Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval." Nature Neuroscience 14. 2 (2011): 147-153.
Morita T, Kang H, Wolfe J, Jadhav SP, Feldman DE. "Psychometric curve and behavioral strategies for whisker-based texture discrimination in rats." PLoS One 6. 6 (2011): e20437.
Jadhav SP, Feldman DE. "Texture coding in the whisker system." Current Opinion in Neurobiology 20. 1 (2010): 1-6.
Jadhav SP, Wolfe J, Feldman DE. "Sparse temporal coding of elementary tactile features during active whisker sensation." Nature Neuroscience 12. 6 (2009): 792-800.
Li L, Bender KJ, Drew PJ, Jadhav SP, Sylwestrak E, Feldman DE. "Endocannabinoid signaling is required for development and critical period plasticity of the whisker map in somatosensory cortex." Neuron 64. 4 (2009): 537-549.
Vyas A*, Jadhav S*, Chattarji S. "Prolonged chronic stress induces amygdaloid neuronal hypertrophy and enhanced anxiety-like behavior." Neuroscience 143. 2 (2006): 387-393.
Gabernet L, Jadhav SP, Feldman DE, Carandini M, Scanziani M. "Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition." Neuron 48. 2 (2005): 315-327.
Mitra R, Jadhav S, McEwen BS, Vyas A, Chattarji S. "Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala." PNAS 102. 26 (2005): 9371-9376.