Nelson C. Lau

Title

Assistant Professor of Biology

Biology
Rosenstiel Basic Medical Sciences Research Center

Expertise

Gene expression, RNA interference, Molecular Biology

Degrees

Massachusetts Institute of Technology, Ph.D.

State University of New York, Albany, B.S.

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Contact

Email:	nlau@brandeis.edu
Phone:	781-736-2445
Office:	Rosenstiel Basic Medical Science Research Center, 332

Awards and Honors

Searle Scholar Award (2010)

NIH NICHD K99/R00 Career Transition Award (2008)

Helen Hay Whitney Foundation Postdoctoral Fellowship (2005)

AAAS Newcomb Cleveland Award (2003)

Courses Taught

BIOL	105b	Molecular Biology
BIOL	124b	Epigenetics
BIOL	176b	RiboNucleicAcids (RNA)
BIOL	305a	Topics in Molecular Genetics and Development
BIOL	305b	Topics in Molecular Genetics and Development
BIOL	305d	Topics in Molecular Genetics and Development
BISC	8a	Stem Cells and Regenerative Medicine

Scholarship

Matts, J.A., Sytnikova, Y., Chirn, G., Igloi, G.L., and Lau, N.C.. "Small RNA library construction from minute biological samples.." Methods in Molecular Biology. In press. ed. vol. In press. Ed. Mikiko Siomi. New York City: Humana Press, 2013. In press.. (forthcoming)

Hall, S.E. †, Chirn, G., Lau, N.C†. and Sengupta, P.. "RNAi pathways contribute to develop-mental history-dependent phenotypic plasticity in C. elegans.." RNA 19. 3 (2013): 306-19.

Sytnikova, Y, and Lau, N.C.. "Does the APC/C mark MIWI and piRNAs for a final farewell?." Developmental Cell 24. 2 (2013): 119-20.

Lau, Nelson C.. "Small RNAs in the animal gonad: Guarding genomes and guiding development.." Int J Biochem Cell Biol. 42. 8 (2010): 1134-47.

Wu Q, Luo Y, Lu R, Lau N, Lai EC, Li WX, Ding SW.. "Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs.." Proc Natl Acad Sci U S A 107. 4 (2010): 1606-11.

Lau, Nelson C. Ohsumi, T., Borowsky, M., Kingston, R.E., & M.D. Blower. "Systematic and Single Cell Analysis of Xiwi and Xenopus Piwi-interacting RNAs." EMBO Journal 28. 19 (2009): 2945-58.

Lau, Nelson C., Robine, N. Martin, R. Chung, W. J. Niki, Y. Berezikov, E. Lai, E. C.. "Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line." Genome Res 19. 10 (2009): 1776-85.

Robine, N., Lau, Nelson C., Balla S, Jin Z, Okamura K, Kuramochi-Miyagawa S, Blower MD, Lai EC.. "A broadly conserved pathway generates 3' UTR-directed primary piRNAs." Current Biology 19. 24 (2009): 2066-76.

Lau, Nelson C.. "Analysis of small endogenous RNAs." Curr Protoc Mol Biol Chapter 26. (2008): Unit 26.7.

Miska, E. A. Alvarez-Saavedra, E. Abbott, A. L. Lau, Nelson C. Hellman, A. B. McGonagle, S. M. Bartel, D. P. Ambros, V. R. Horvitz, H. R.. "Most Caenorhabditis elegans microRNAs are individually not essential for development or viability." PLoS Genet 3. 12 (2007): e215.

Seto, A. G. Kingston, R. E. Lau, Nelson C.. "The coming of age for Piwi proteins." Mol Cell 26. 5 (2007): 603-9.

Lau, Nelson C., Seto, A. G. Kim, J. Kuramochi-Miyagawa, S. Nakano, T. Bartel, D. P. Kingston, R. E.. "Characterization of the piRNA complex from rat testes." Science 313. 5785 (2006): 363-7.

Abbott, A. L., Alvarez-Saavedra, E., Miska, E. A., Lau, Nelson C., Bartel, D. P., Horvitz, H. R., & Ambros, V.. "The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans." Dev Cell 9. 3 (2005): 403-14.

Lau, Nelson C., & Lai, E.C.. "Diverse roles for RNA in gene regulation." Genome Biol 6. 4 (2005): 315.

Li, M., Jones-Rhoades, M. W., Lau, Nelson C., Bartel, D. P., & Rougvie, A. E.. "Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects." Dev Cell 9. 3 (2005): 415-22.

Lim, L. P. Lau, Nelson C. Garrett-Engele, P. Grimson, A. Schelter, J. M. Castle, J. Bartel, D. P. Linsley, P. S. Johnson, J. M.. "Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs." Nature 433. 7027 (2005): 769-73.

Bergman, N. H., Lau, Nelson C., Lehnert, V., Westhof, E., & Bartel, D. P.. "The three-dimensional architecture of the class I ligase ribozyme." RNA 10. 2 (2004): 176-84.

Landthaler, M., Lau, Nelson C., & D.A. Shub. "Group I intron homing in Bacillus phages SPO1 and SP82: a gene conversion event initiated by a nicking homing endonuclease." J Bacteriol 186. 13 (2004): 4307-14.

Lau, Nelson C., Bartel D.P.. "Censors of the genome." Sci Am 289. 2 (2003): 34-41.

Lim, L.P., Lau, Nelson C., Weinstein, E. G., Abdelhakim, A., Yekta, S., Rhoades, M. W., Burge, C. B., & Bartel, D. P.. "The microRNAs of Caenorhabditis elegans." Genes Dev 17. 8 (2003): 991-1008.

Landthaler, M., Begley, U., Lau, Nelson C., & D.A. Shub. "Two self-splicing group I introns in the ribonucleotide reductase large subunit gene of Staphylococcus aureus phage Twort." Nucleic Acids Res 30. 9 (2002): 1935-43.

Lau, Nelson C., Lim, L.P., Weinstein, E.G., and Bartel, D.P.. "An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans." Science 294. 5543 (2001): 858-62.