Faculty Guide

Title

Instructor in the Rabb School of Continuing Studies, Division of Graduate Professional Studies.

Rabb School of Continuing Studies, Division of Graduate Professional Studies

Expertise

Genetics, Statistical Genetics, Biomarkers, Clinical Trials, Phamacogenetics

Profile

Cliona Molony, PhD, has close to 10 years of experience in Statistical Genetics, Genetic Epidemology and Bioinformatics in academia and industry, and she currently leads a research group at a major pharma. Research interests cover topics in statistical genetics such as association analysis, gene environment interactions as well as experience in systems biology and personalized medicine efforts.

Courses Taught

RBIF

115

Statistical Genetics

Scholarship

Hao K, Lamb J, Zhang C, Xie T, Wang K, Zhang B, Chudin E, Lee NP, Mao M, Zhong H, Greenawalt D, Ferguson MD, Ng IO, Sham PC, Poon RT, Molony C, Schadt EE, Dai H, Luk JM. "Clinicopathologic and gene expression parameters predicts liver cancer prognosis.." BMC Cancer 11. 1 (2012): 481.

Dobrin, R., Zhu, J., Molony, C., Argman, C., Parrish, M. L., Carlson, S., Allan, M. F., Pomp, D., Schadt, E. E.. "Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease." Genome Biol 10. 5 (2009): R55.

Kelly, H., Barton, D., Molony, C., Puri, P.. "Linkage analysis of candidate genes in families with vesicoureteral reflux." J Urol 182. 4 Suppl (2009): 1669-72.

Degnan, J. H., Lasky-Su, J., Raby, B. A., Xu, M., Molony, C., Schadt, E. E., Lange, C.. "Genomics and genome-wide association studies: an integrative approach to expression QTL mapping." Genomics 92. 3 (2008): 129-33.

Lasky-Su, J., Lyon, H. N., Emilsson, V., Heid, I. M., Molony, C., Raby, B. A., Lazarus, R., Klanderman, B., Soto-Quiros, M. E., Avila, L., Silverman, E. K., Thorleifsson, G., Thorsteinsdottir, U., Kronenberg, F., Vollmert, C., Illig, T., Fox, C. S., Le. "On the replication of genetic associations: timing can be everything!." Am J Hum Genet 82. 4 (2008): 849-58.

Schadt, E. E., Molony, C., Chudin, E., Hao, K., Yang, X., Lum, P. Y., Kasarskis, A., Zhang, B., Wang, S., Suver, C., Zhu, J., Millstein, J., Sieberts, S., Lamb, J., GuhaThakurta, D., Derry, J., Storey, J. D., Avila-Campillo, I., Kruger, M. J., Johnson,. "Mapping the genetic architecture of gene expression in human liver." PLoS Biol 6. 5 (2008): e107.

Kelly, H., Molony, C. M., Darlow, J. M., Pirker, M. E., Yoneda, A., Green, A. J., Puri, P., Barton, D. E.. "A genome-wide scan for genes involved in primary vesicoureteric reflux." J Med Genet 44. 11 (2007): 710-7.

Kelly, H., Ennis, S., Yoneda, A., Bermingham, C., Shields, D. C., Molony, C., Green, A. J., Puri, P., Barton, D. E.. "Uroplakin III is not a major candidate gene for primary vesicoureteral reflux." Eur J Hum Genet 13. 4 (2005): 500-2.

Molony, C. M., Fitzgerald, A. P., Shields, D. C.. "Overdispersion of allele frequency differences between populations: implications for meta-analyses of genotypic disease associations." Eur J Hum Genet 13. 1 (2005): 79-85.

Morley, M., Molony, C. M., Weber, T. M., Devlin, J. L., Ewens, K. G., Spielman, R. S., Cheung, V. G.. "Genetic analysis of genome-wide variation in human gene expression." Nature 430. 7001 (2004): 743-7.

Aronne, L. J., Tonstad, S., Moreno, M., Gantz, I., Erondu, N., Suryawanshi, S., Molony, C., Sieberts, S., Nayee, J., Meehan, A. G., Shapiro, D., Heymsfield, S. B., Kaufman, K. D., Amatruda, J. M.. "A clinical trial assessing the safety and efficacy of taranabant, a CB1R inverse agonist, in obese and overweight patients: a high-dose study." Int J Obes (Lond) 34. 5 (0): 919-35.

Derry, J. M., Zhong, H., Molony, C., MacNeil, D., Guhathakurta, D., Zhang, B., Mudgett, J., Small, K., El Fertak, L., Guimond, A., Selloum, M., Zhao, W., Champy, M. F., Monassier, L., Vogt, T., Cully, D., Kasarskis, A., Schadt, E. E.. "Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross." PLoS One 5. 12 (0): e14319.

Greenawalt, D. M., Dobrin, R., Chudin, E., Hatoum, I. J., Suver, C., Beaulaurier, J., Zhang, B., Castro, V., Zhu, J., Sieberts, S. K., Wang, S., Molony, C., Heymsfield, S. B., Kemp, D. M., Reitman, M. L., Lum, P. Y., Schadt, E. E., Kaplan, L. M.. "A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort." Genome Res 21. 7 (0): 1008-16.

Hao, K., Lamb, J., Zhang, C., Xie, T., Wang, K., Zhang, B., Chudin, E., Lee, N. P., Mao, M., Zhong, H., Greenawalt, D., Ferguson, M. D., Ng, I. O., Sham, P. C., Poon, R. T., Molony, C., Schadt, E. E., Dai, H., Luk, J. M.. "Clinicopathologic and gene expression parameters predict liver cancer prognosis." BMC Cancer 11. (0): 481.

Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M. C., Speliotes, E. K., Magi, R., Workalemahu, T., White, C. C., Bouatia-Naji, N., Harris, T. B., Berndt, S. I., Ingelsson, E., Wil. "Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution." Nat Genet 42. 11 (0): 949-60.

Kreimer, A., Litvin, O., Hao, K., Molony, C., Pe'er, D., Pe'er, I.. "Inference of modules associated to eQTLs." Nucleic Acids Res 40. 13 (0): e98.

Lamb, J. R., Zhang, C., Xie, T., Wang, K., Zhang, B., Hao, K., Chudin, E., Fraser, H. B., Millstein, J., Ferguson, M., Suver, C., Ivanovska, I., Scott, M., Philippar, U., Bansal, D., Zhang, Z., Burchard, J., Smith, R., Greenawalt, D., Cleary, M., Derry. "Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting." PLoS One 6. 7 (0): e20090.

Poordad, F., Bronowicki, J. P., Gordon, S. C., Zeuzem, S., Jacobson, I. M., Sulkowski, M. S., Poynard, T., Morgan, T. R., Molony, C., Pedicone, L. D., Sings, H. L., Burroughs, M. H., Sniukiene, V., Boparai, N., Goteti, V. S., Brass, C. A., Albrecht, J.. "Factors that predict response of patients with hepatitis C virus infection to boceprevir." Gastroenterology 143. 3 (0): 608-18 e1-5.

Saxena, R., Elbers, C. C., Guo, Y., Peter, I., Gaunt, T. R., Mega, J. L., Lanktree, M. B., Tare, A., Castillo, B. A., Li, Y. R., Johnson, T., Bruinenberg, M., Gilbert-Diamond, D., Rajagopalan, R., Voight, B. F., Balasubramanyam, A., Barnard, J., Bauer,. "Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci." Am J Hum Genet 90. 3 (0): 410-25.

Stone, D. J., Molony, C., Suver, C., Schadt, E. E., Potter, W. Z.. "ApoE genotyping as a progression-rate biomarker in phase II disease-modification trials for Alzheimer's disease." Pharmacogenomics J 10. 3 (0): 161-4.

Su, W. L., Sieberts, S. K., Kleinhanz, R. R., Lux, K., Millstein, J., Molony, C., Schadt, E. E.. "Assessing the prospects of genome-wide association studies performed in inbred mice." Mamm Genome 21. 3-4 (0): 143-52.

Xie, T., Zhang, C., Zhang, B., Molony, C., Oudes, A., Roberts, C., Dai, H., Schadt, E., Lamb, J.. "A survey of cancer cell lines reveals highly structured and hierarchical relationships within and between DNA and mRNA that may be the result of selection." Omics 14. 1 (0): 91-7.

Yang, X., Zhang, B., Molony, C., Chudin, E., Hao, K., Zhu, J., Gaedigk, A., Suver, C., Zhong, H., Leeder, J. S., Guengerich, F. P., Strom, S. C., Schuetz, E., Rushmore, T. H., Ulrich, R. G., Slatter, J. G., Schadt, E. E., Kasarskis, A., Lum, P. Y.. "Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver." Genome Res 20. 8 (0): 1020-36.

Zhong, H., Beaulaurier, J., Lum, P. Y., Molony, C., Yang, X., Macneil, D. J., Weingarth, D. T., Zhang, B., Greenawalt, D., Dobrin, R., Hao, K., Woo, S., Fabre-Suver, C., Qian, S., Tota, M. R., Keller, M. P., Kendziorski, C. M., Yandell, B. S., Castro, . "Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes." PLoS Genet 6. 5 (0): e1000932.

Zhong, H., Yang, X., Kaplan, L. M., Molony, C., Schadt, E. E.. "Integrating pathway analysis and genetics of gene expression for genome-wide association studies." Am J Hum Genet 86. 4 (0): 581-91.