Faculty Guide

Title

Associate Professor of Molecular Biology and of the Rosenstiel Basic Medical Sciences Research Center

Biology
Health: Science, Society, and Policy

Expertise

Molecular immunology. Antibody transport.

Profile

Director, Professional Science Master's Program in Biotechnology

Awards and Honors

National Institute of Child Health and Human Development RO1 Grant (2000 - 2005)

National Institute of Child Health and Human Development K02 Research Career Development Award (1996 - 2001)

National Institute of Child Health and Human Development RO1 Grant (1995 - 2000)

Michael L. Walzer '56 Award for Teaching (1994 - 1995)

March of Dimes Birth Defects Foundation Basil O'Connor Starter Scholar Award (1992 - 1995)

National Institute of Child Health and Human Development RO1 Grant (1991 - 1995)

Cancer Research Institute Fellowship (1987 - 1990)

European Molecular Biology Organisation Fellowship (1980)

Medical Council Research Studentship (1980)

Courses Taught

BIOL	15b	Biology: Human Implications
BIOL	15b	Cells and Organisms
BIOL	350d	Graduate Student Research Seminar
BIOT	200a	Biotechnology Proseminar
BIOT	201b	Business of Biotechnology
BIOT	203b	Fundamentals of Management for Biotechnology
CONT	300b	Ethical Practice in Health-Related Sciences

Scholarship

Liu, X., L. Ye, Y. Bai, H. Mojidi, N.E. Simister, X. Zhu, 2008. "Activation of the JAK/STAT-1 signaling pathway by IFN-gamma can down-regulate functional expression of the MHC class I-related neonatal Fc receptor for IgG." J. Immunol. 181. (2008): 449-463.

Ye, L., W. Tuo, X. Liu, N.E. Simister, and X. Zhu. "Identification and characterization of an alternatively spliced variant of the MHC class I-related porcine neonatal Fc receptor for IgG." Dev. Comp. Immunol. 32. (2008): 966-979.

Newton, E.E., Z Wu and N.E. Simister. "Characterization of basolateral targeting signals in the neonatal Fc receptor." J. Cell Sci. 118. (2005): 2461-2469.

Wernick, N.L.B. , Haucke, V. and Simister, N.E.. "Recognition of the tryptophan-based endocytosis signal in the neonatal Fc receptor by the mu subunit of AP-2." J. Biol. Chem 280. (2005): 7309-7316.

Bitonti, A.J., J.A Dumont, S.C. Low, R.T. Peters, K. Kropp, V.J. Palombella, J.M. Stattel, Y. Lu, C.A. Tan, J.J. Song, A.M. Garcia, N.E. Simister, G.M. Spiekermann, W.I. Lencer and R.S. Blumberg. "Pulmonary delivery of a novel erythropoietin." (2004).

Shah, U., B.L Dickinson, R.S. Blumberg, N.E. Simister, W.I. Lencer andW.A. Walker. "Distribution of the IgG Fc Receptor, FcRn, in the Human Fetal Intestine." Pediatr. Res. 53. (2003): 295-301.

Simister, Neil. Blumberg, R.S., N.E. Simister and W.I. Lencer, 2003. Receptor specific transepithelial transport of immunogens. European Patent 0805628.

Simister,Neil. "Placental transport of immunoglobulin G." Vaccine 21. (2003): 3354-3369.

Simister,Neil. Blumberg, R.S. W.I. Lencer and N.E. Simister, 2002. Receptor specific transepithelial transport of therapeutics. U.S. Patent 6,485,726..

McCarthy, K.M., M. Lam, L. Subramanian, R. Shakya, Z. Wu, E.E. Newton and N.E. Simister. "Effects of mutations in potential phosphorylation sites on transcytosis of FcRn." Journal of Cell Science 114. (2001): 1591-1598.

Wu, Z. and N.E. Simister. "Tryptophan- and dileucine-based endocytosis signals in the neonatal Fc receptor." J. Biol. Chem 276 (2001): 5240-5247.

Kacskovics, I, Z. Wu, N.E. Simister, L.V. Frenyó and L. Hammarström. "Cloning and characterization of the bovine MHC class-I like Fc receptor." Journal of Immunololgy 164. (2000): 1889-1987.

McCarthy, K.M., Y.L. Yoong and N.E. Simister. "Bidirectional transcytosis of IgG by the rat neonatal Fc receptor expressed in a rat kidney cell line: a system to study protein transport across epithelia." Journal of Cell Science 113. (2000): 1277-1285.

Mikulska, J.E. and N.E. Simister. "Analysis of the promoter region of the human FcRn gene." Biochim. Biophys. Acta 1492 (2000): 180-184.

Mikulska, J.E., L. Pablo, J. Canel and N.E. Simister. "Cloning and analysis of the gene encoding the human neonatal Fc receptor." 27. (2000): 231-240.

Simister,Neil. Blumberg, R.S. W.I. Lencer and N.E. Simister, 2000. Receptor specific transepithelial transport of therapeutics. U.S. Patent 6,030,613..

Simister,Neil. Blumberg, R.S., W.I. Lencer and N.E. Simister, 2000. Receptor specific transepithelial transport of immunogens. U.S. Patent 6,086,875..