DegreesUniversity of Leeds, Ph.D.
University of Liverpool, B.S.
ExpertiseIon channel function and regulation in neurons, myocytes and model systems
Electrophysiology and live cell TIRF microscopy
SUMO and ubiquitin modification pathways
ProfileIon channels are protein machines that control how electrical signals are generated and propagated in the body. The activity of ion channels is fundamental to many aspects of physiology and behavior including learning, memory, our perception of pain and taste, how the body moves and how the heart beats. Using electrophysiology, microscopy and spectroscopy I study the regulation of ion channels in living cells to understand how channels function under normal conditions and what goes wrong to cause disease.
|BCBP||297b||Master's Lab Research II|
|BCHM||251b||Structure and Function of Membrane Proteins|
|NBIO||146a||The Neurobiology of Human Disease|
Awards and Honors
Guest Editor, Frontiers in Molecular Neuroscience (2013)
Cranefield Award for physiology (2012)
Best Science Research; University of Chicago -Pediatrics (2011)
CTSA Grant 'SUMO regulation in cerebral ischemia' (2010)
IUPHAR committee on K2P ion channels (2005)
Medical Research Council Scholar (1999)
Wellcome Trust Research Scholar (1998)
LD Plant & SA Goldstein. "Two-pore potassium channels." Handbook of Ion Channels. vol. In press Ed. Jie Zheng, Matthew Trudeau. Taylor & Francis publishers, 2015 (forthcoming)
Burgos P, Zúñiga R, Domínguez P, Delgado-López F, Plant LD, Zúñiga L. "Differential expression of two-pore domain potassium channels in rat cerebellar granule neurons." Biochem Biophys Res Commun 453. 4 (2014): 754-60.
KMJ McMurray, MG Distler, P Sidhu, JM Cook, LA Arnold, AA Palmer and LD Plant. "Glo1 inhibitors for neuropsychiatric and anti-epileptic drug development." Biochem Soc Transactions 42. 2 (2014): 461-
Plant, Leigh; Xiong, D; Dai, H; Goldstein SA. "Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits." Proc Natl Acad Sci U S A (2014).
Plant, Leigh. "Multilevel regulation: Controlling BK channels in clock neurons." Journal of General Physiology 142. 6 (2013): 579-83 <doi: 10.1085/jgp.201311128>.
Shelat PB, Plant LD, Wang JC, Lee E, Marks JD. "The membrane-active tri-block copolymer pluronic F-68 profoundly rescues rat hippocampal neurons from oxygen-glucose deprivation-induced death through early inhibition of apoptosis.." Journal of Neuroscience 33. 30 (2013): 12287-9
LD Plant, L Zuniga, D Araki, JD Marks, SA Goldstein. "SUMOylation Silences Heterodimeric TASK Potassium Channels Containing K2P1 Subunits in Cerebellar Granule Neurons." Science Signalling 5. 251 (2012): doi: 10.1126/scisignal.2003431.
MG Distler, LD Plant, G Sokoloff, AJ Hawk, I Aneas, S Meredith, M Nobrega, AA Palmer. "Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal." Journal of Clinical Investigation 22. 6 (2012): 2306-15.
Plant, Leigh. "A role for K2P channels in the operation of somatosensory nociceptors." Frontiers in Molecular Neuroscience 5. 21 (2012): 1-5.
Plant, L. D. Dowdell, E. J. Dementieva, I. S. Marks, J. D. Goldstein, S. A.. "SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons." J Gen Physiol 137. 5 (2011): 441-54.
Plant, L. D. Dementieva, I. S. Kollewe, A. Olikara, S. Marks, J. D. Goldstein, S. A.. "One SUMO is sufficient to silence the dimeric potassium channel K2P1." Proc Natl Acad Sci U S A 107. 23 (2010): 10743-8.
Thomas, D. Plant, L. D. Wilkens, C. M. McCrossan, Z. A. Goldstein, S. A.. "Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium." Neuron 58. 6 (2008): 859-70.
Plant, L. D. Bowers, P. N. Liu, Q. Morgan, T. Zhang, T. State, M. W. Chen, W. Kittles, R. A. Goldstein, S. A.. "A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y." J Clin Invest 116. 2 (2006): 430-5.
Plant, L. D. Webster, N. J. Boyle, J. P. Ramsden, M. Freir, D. B. Peers, C. Pearson, H. A.. "Amyloid beta peptide as a physiological modulator of neuronal 'A'-type K+ current." Neurobiol Aging 27. 11 (2006): 1673-83.
Goldstein, S. A. Bayliss, D. A. Kim, D. Lesage, F. Plant, L. D.. "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels." Pharmacol Rev 57. 4 (2005): 527-40.
McGarry, H. F. Plant, L. D. Taylor, M. J.. "Diethylcarbamazine activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway." Filaria J 4. (2005): 4.
Plant, L. D. Rajan, S. Goldstein, S. A.. "K2P channels and their protein partners." Curr Opin Neurobiol 15. 3 (2005): 326-33.
Rajan, S. Plant, L. D. Rabin, M. L. Butler, M. H. Goldstein, S. A.. "Sumoylation silences the plasma membrane leak K+ channel K2P1." Cell 121. 1 (2005): 37-47.
Plant, L. D. Boyle, J. P. Smith, I. F. Peers, C. Pearson, H. A.. "The production of amyloid beta peptide is a critical requirement for the viability of central neurons." J Neurosci 23. 13 (2003): 5531-5.
Smith, I. F. Plant, L. D. Boyle, J. P. Skinner, R. A. Pearson, H. A. Peers, C.. "Chronic hypoxia potentiates capacitative Ca2+ entry in type-I cortical astrocytes." J Neurochem 85. 5 (2003): 1109-16.
Plant, L. D. Boyle, J. P. Thomas, N. M. Hipkins, N. J. Benedikz, E. Hooper, N. M. Henderson, Z. Vaughan, P. F. Peers, C. Cowburn, R. F. Pearson, H. A.. "Presenilin-1 mutations alter K+ currents in the human neuroblastoma cell line, SH-SY5Y." Neuroreport 13. 12 (2002): 1553-6.
Plant, L. D. Kemp, P. J. Peers, C. Henderson, Z. Pearson, H. A.. "Hypoxic depolarization of cerebellar granule neurons by specific inhibition of TASK-1." Stroke 33. 9 (2002): 2324-8.
Smith, I. F. Boyle, J. P. Plant, L. D. Pearson, H. A. Peers, C.. "Hypoxic remodeling of Ca2+ stores in type I cortical astrocytes." J Biol Chem 278. 7 (2002): 4875-81.
Ramsden, M. Plant, L. D. Webster, N. J. Vaughan, P. F. Henderson, Z. Pearson, H. A.. "Differential effects of unaggregated and aggregated amyloid beta protein (1-40) on K(+) channel currents in primary cultures of rat cerebellar granule and cortical neurones." J Neurochem 79. 3 (2001): 699-712.