Leslie Claire Griffith

Title

Professor of Biology, and Director of the Volen National Center for Complex Systems

Biology
Volen National Center for Complex Systems

Expertise

Biochemistry of synaptic plasticity and neuronal basis of behavior.

Profile

See my webpage at: http://www.bio.brandeis.edu/faculty/griffith.html

Degrees

Stanford University, M.D.

Stanford University, Ph.D.

Massachusetts Institute of Technology, B.S.

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Contact

Email:	griffith@brandeis.edu
Phone:	781-736-3125
Office:	Carl J. Shapiro Science Center, 2-06B

Webpage

Awards and Honors

Keynote Speaker, Southeast Nerve Net Conference, St. Augustine, FL (2011)

Invited Speaker, 10th Anniversary Symposium for the Kyoto Drosophila Genetics Resource Center (2010)

Plenary Speaker, Neurofly Meeting, Manchester, England (2010)

Elected member of the Drosophila Board (2008)

Meyerof Lecturer, Max-Planck Institute, Heidelberg (2008)

Society for Neuroscience Presidential Lecture (2008)

Scholar in residence, Neural Systems and Behavior, Marine Biological Labs, Woods Hole (2007 - 2006)

McKnight Technological Innovation Award (1999 - 2000)

National Institutes of Health Career Development Award (1996 - 2001)

Whitehall Foundation Grant (1995 - 1997)

Alfred P. Sloan Research Fellowship (1994 - 1996)

Klingenstein Research Fellowship (1994 - 1997)

Courses Taught

BIOL	42a	Physiology
BIOL	149b	Molecular Pharmacology
BIOL	350a	Graduate Student Research Seminar
BIOL	350b	Graduate Student Research Seminar
NBIO	142b	Sleep
NBIO	148b	Cellular Neuroscience
NBIO	250d	Neuroscience Proseminar

Scholarship

Griffith, L.C.. "Neuromodulatory control of sleep in Drosophila melanogaster: Integration of competing and complementary behaviors." Curr. Op. Neurobiol. In Press. (2013). (forthcoming)

Pirez, N., Christmann, B. and Griffith, L.C.. "Circadian regulation of locomotor circuits in Drosophila involves pigment-dispersing factor (PDF)." J. Neurophysiol. In Revision. (2013). (forthcoming)

Shang, Y., Donelson, N.C., Vecsey, C.G., Guo, F., Rosbash, M. and Griffith, L.C.. "Modulation of the Drosophila arousal system by short neuropeptide F differentially regulates sleep and feeding." Cell In Revision. (2013). (forthcoming)

Griffith, L.C.. "Courtship Learning." Handbook of behavioral genetics of Drosophila melanogaster. 1st ed. vol. 1 Ed. Dubnau, J.. Cambridge, England: Cambridge University Press, 2012 (forthcoming)

Griffith, L.C.. "Identifying behavioral circuits in Drosophila melanogaster: Moving targets in a flying insect." Curr. Op. Neurobiol. (2012). (forthcoming)

Parisky, K.M., Agosto Rivera, J.L. and Griffith, L.C.. "Alterations in sleep architecture by ambient temperature require light and a functional circadian clock in Drosophila." Submitted (2012). (forthcoming)

Vecsey, C.G., Pirez, N. and Griffith, L.C.. "The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on target cells." J. Neurosci. Submitted. (2013).

Berni, J., Pulver, S.R., Griffith, L.C. and Bate, M.. "Autonomous circuitry for substrate exploration in freely moving Drosophila larvae." Curr. Biol. 22. (2012): 1861-1870.

Donelson, N., Kim, E.Z., Slawson, J.B., Vecsey, C.G., Huber, R. and Griffith, L.C.. "High-resolution long-term tracking for analysis of Drosophila sleep and locomotion." PLoS ONE 7. 5 (2012): e46025.

Maiya, R., Lee, S. Berger, K.H., Kong, E.C., Slawson, J.B., Griffith, L.C., Huganir, R.L., Margolis, B. and Heberlein, U.. "DlgS97/SAP97, a neuronal isoform of Discs Large, regulates ethanol tolerance." PLoSONE 7. 11 (2012): e48967.

Trott, A., Donelson, N.C., Griffith, L.C. and Ejima, A.. "Song choice is modulated by female movement in Drosophila males." PLoSONE 7. 9 (2012): e46025.

Ejima, A. and Griffith, L.C.. "Assay for courtship suppression." CSH Protoc. doi: 10.1101/pdb.prot5575. (2011).

Griffith, L.C.. "Circadian biology: The supporting cast takes on a starring role." Curr. Biol. 21. (2011): R313-314.

Li, Y., Liu, X., Wu, Y., Xu, Z., Li, H., Griffith, L. C., Zhou, Y.. "Intracellular regions of the Eag potassium channel play a critical role in generation of voltage-dependent currents." J Biol Chem 286. 2 (2011): 1389-99.

Shang, Y., Haynes, P., Pirez, N., Harrington, K.I., Pollack, J., Hong, P. Griffith, L.C., and Rosbash, M.. "Imaging analysis of clock neurons reveals light buffers the wake-promoting effect of dopamine." Nat. Neurosci. 14. (2011): 889-895.

Slawson, J. B., Kuklin, E. A., Ejima, A., Mukherjee, K., Ostrovsky, L., Griffith, L. C.. "Central regulation of locomotor behavior of Drosophila melanogaster depends on a CASK isoform containing CaMK-like and L27 domains." Genetics 187. 1 (2011): 171-84.

Kang, K., Pulver, S. R., Panzano, V. C., Chang, E. C., Griffith, L. C., Theobald, D. L., Garrity, P. A.. "Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception." Nature 464. 7288 (2010): 597-600.

Pulver, S. R., Griffith, L. C.. "Spike integration and cellular memory in a rhythmic network from Na+/K+ pump current dynamics." Nat Neurosci 13. 1 (2010): 53-9.

Bostrom, S. L., Dore, J., Griffith, L. C.. "CaMKII uses GTP as a phosphate donor for both substrate and autophosphorylation." Biochem Biophys Res Commun 390. 4 (2009): 1154-9.

Griffith, L. C., Ejima, A.. "Courtship learning in Drosophila melanogaster: diverse plasticity of a reproductive behavior." Learn Mem 16. 12 (2009): 743-50.

Griffith, L. C., Ejima, A.. "Multimodal sensory integration of courtship stimulating cues in Drosophila melanogaster." Ann N Y Acad Sci 1170. (2009): 394-8.

Griffith, L. C.. "Attention K-Mart shoppers: blowout on Aisle 7!." Neuron 64. 4 (2009): 443-5.

Hornstein, N. J., Pulver, S. R., Griffith, L. C.. "Channelrhodopsin2 mediated stimulation of synaptic potentials at Drosophila neuromuscular junctions." J Vis Exp 25 (2009).

Pulver, S. R., Pashkovski, S. L., Hornstein, N. J., Garrity, P. A., Griffith, L. C.. "Temporal dynamics of neuronal activation by Channelrhodopsin-2 and TRPA1 determine behavioral output in Drosophila larvae." J Neurophysiol (2009).

Pulver, S. R., Pashkovski, S. L., Hornstein, N. J., Garrity, P. A., Griffith, L. C.. "Temporal dynamics of neuronal activation by Channelrhodopsin-2 and TRPA1 determine behavioral output in Drosophila larvae." J Neurophysiol 101. 6 (2009): 3075-88.

Slawson, J. B., Kim, E. Z., Griffith, L. C.. "High-resolution video tracking of locomotion in adult Drosophila melanogaster." J Vis Exp 24 (2009).

Sun, X. X., Bostrom, S. L., Griffith, L. C.. "Alternative splicing of the eag potassium channel gene in Drosophila generates a novel signal transduction scaffolding protein." Mol Cell Neurosci 40. 3 (2009): 338-43.

Agosto, J., Choi, J. C., Parisky, K. M., Stilwell, G., Rosbash, M., Griffith, L. C.. "Modulation of GABA(A) receptor desensitization uncouples sleep onset and maintenance in Drosophila." Nat Neurosci (2008).

Ejima, A., Griffith, L. C.. "Courtship initiation is stimulated by acoustic signals in Drosophila melanogaster." PLoS ONE 3. 9 (2008): e3246.

Griffith, L. C., Rosbash, M.. "Sleep: hitting the reset button." Nat Neurosci 11. 2 (2008): 123-4.

Griffith, L. C.. "CaMKII: new tricks for an old dog." Cell 133. 3 (2008): 397-9.

Griffith, L. C.. "Neuroscience: love hangover." Nature 451. 7174 (2008): 24-5.

Parisky, K. M., Agosto, J., Pulver, S. R., Shang, Y., Kuklin, E., Hodge, J. J., Kang, K., Liu, X., Garrity, P. A., Rosbash, M., Griffith, L. C.. "PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit." Neuron 60. 4 (2008): 672-82.

Shang, Y., Griffith, L. C., Rosbash, M.. "Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain." Proc Natl Acad Sci U S A 105. 50 (2008): 19587-94.

Ejima, A., Griffith, L. C.. "Measurement of courtship behavior in Drosophila." CSH Protocols (2007).

Ejima, A., Smith, B. P., Lucas, C., van der Goes van Naters, W., Miller, C. J., Carlson, J. R., Levine, J. D., Griffith, L. C.. "Generalization of courtship learning in Drosophila is mediated by cis-vaccenyl acetate." Curr Biol 17. 7 (2007): 599-605.

Mattaliano, M. D., Montana, E. S., Parisky, K. M., Littleton, J. T., Griffith, L. C.. "The Drosophila ARC homolog regulates behavioral responses to starvation." Mol Cell Neurosci 36. 2 (2007): 211-21.

Mullasseril, P., Dosemeci, A., Lisman, J. E., Griffith, L. C.. "A structural mechanism for maintaining the 'on-state' of the CaMKII memory switch in the post-synaptic density." J Neurochem 103. 1 (2007): 357-64.

Pulver, S.R., Griffith, L. C.. "Dr. Strangslug, or how I learned to stop worrying and love the brain." Nat Neurosci 10. (2007): 933.

Griffith,Leslie Claire. "Sequential learning of pheromonal cues modulates memory consolidation in trainer-specific associative courtship conditioning." Curr. Biol. 15. (2005): 194-206.

Griffith,Leslie Claire wiith Hodge, J.J.L., Choi, J.C., O'Kane, C.J. "Shaw potassium channel genes in Drosophila." J. Neurobiol. (2004).

Griffith,Leslie Claire with Mehren, J.E., Eljima, A. and Griffith. "Unconventional sex: Fresh approaches to courtship learning." (2004): 745-750.

Griffith,Leslie Claire. "Associative learning of courtship behavior with scents of females." 45th Annual Drosophila Research Conference, 2004.

Griffith,Leslie Claire. "Calcium-independent CaMKII in the adult Drosophila CNS enhances the training of pheromonal cues." J. Neurosci (2004): 10584-10593.

Griffith,Leslie Claire. "Regulation of calcium/calmodulin-dependent protein kinase II activation by intramolecular and intermolecular interactions." (2004): 8394-8398.

Griffith,Leslie Claire. Regulation of the Ca2=- stimulable pool of CaMKII by scaffold-dependent autophosphorylation'. Proc. of Cold Spring Harbor Receptor and Channel Meeting. 2004.

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