Faculty Guide

Title

Professor Emeritus

Biochemistry
Chemistry
Neuroscience
Rosenstiel Basic Medical Sciences Research Center

Expertise

Protein crystallography, especially direct observation of transient species by low-temperature and Laue methods. Protein dynamics. Protein engineering. Yeast genetics. The biology of the quiescent state (G0) of the eukaryotic cell. Enzyme evolution. Neurodegenerative diseases, especially Parkinson's and Alzheimer's Diseases.

Awards and Honors

Honorary Degree, Dalhousie University (2011)

President-Elect, International Union of Biochemistry and Molecular Biology (2010)

Wlected to American Philosophical Society (2010)

President, American Society for Biochemistry and Molecular Biology (2008)

Associate Member, Tufts-New England Medical Center Cancer Research Center (2007)

Sachar Award (Shared with Prof. Dagmar Ringe) (2006)

Adjunct Professor of Neurology, Brigham & Women's Hospital, Harvard Medical School (2005 - 2006)

Co-Chair, Gordon Conference on Enzymes (2005)

Fellow, American Academy of Arts and Sciences (2005)

McKnight Endowment Fund for Neuroscience Award (2005)

Fellow, American Academy of Arts and Sciences (2002)

Member, Institute of Medicine, National Academy of Sciences (2001 - 2002)

Roche Diagnostics: Funding for Postdoctoral Training (2001 - 2002)

Ellison Medical Foundation Fellowship (1999)

Member, Japanese Biochemical Society (1997 - 1998)

Guggenheim Fellowship (1996)

Gyula and Katica Tauber Chair in Biochemistry and Molecular Pharmacodynamics (1996)

Member, National Academy of Sciences (1994 - 1995)

Markey (1990)

Alexander von Humboldt Senior Scientist Award (1989)

Prizer Awardin Enzyme Chemistry, American Chemical Society (1986)

SIDHU Award for outstanding contributions to x-ray diffraction (1980)

Sloan Foundation Fellowship (1978 - 1982)

U.S. Public Health Service Research Career Development Award (1978 - 1983)

European Molecular Biology Organization Fellowship (1973)

American Institute of Chemists Student Award (1970)

Chemical and Engineering News Nationa Merit Award (1970)

Danforth Foundation Fellowship (1970 - 1973)

Rhodes Scholarship (1970 - 1973)

Sigma Xi Student Award (1970)

Courses Taught

BCHM	100a	Introductory Biochemistry
BCHM	101a	Advanced Biochemistry: Enzyme Mechanisms
BCHM	103b	Advanced Biochemistry: Information Transfer Mechanisms
BCHM	171b	Protein X-ray Crystallography
BIOP	200b	Reading in Macromolecular Structure-Function Analysis
CHEM	11a	General Chemistry I

Scholarship

Petsko, G. A.. "Preserving some sanity." Genome Biol 12. 1 (2011): 102.

Petsko, G. A.. "There is a sanity clause." Genome Biol 12. 2 (2011): 105.

Auclair, J. R., Boggio, K. J., Petsko, G. A., Ringe, D., Agar, J. N.. "Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis." Proc Natl Acad Sci U S A 107. 50 (2010): 21394-9.

Gleick, P. H., Adams, R. M., Amasino, R. M., Anders, E., Anderson, D. J., Anderson, W. W., Anselin, L. E., Arroyo, M. K., Asfaw, B., Ayala, F. J., Bax, A., Bebbington, A. J., Bell, G., Bennett, M. V., Bennetzen, J. L., Berenbaum, M. R., Berlin, O. B., . "Climate change and the integrity of science." Science 328. 5979 (2010): 689-90.

Lewandowski, N. M., Ju, S., Verbitsky, M., Ross, B., Geddie, M. L., Rockenstein, E., Adame, A., Muhammad, A., Vonsattel, J. P., Ringe, D., Cote, L., Lindquist, S., Masliah, E., Petsko, G. A., Marder, K., Clark, L. N., Small, S. A.. "Polyamine pathway contributes to the pathogenesis of Parkinson disease." Proc Natl Acad Sci U S A 107. 39 (2010): 16970-5.

Petsko, G. A.. "A Faustian bargain." Genome Biol 11. 10 (2010): 138.

Petsko, G. A.. "And they said it wouldn't last." Genome Biol 11. 5 (2010): 121.

Petsko, G. A.. "Every dog has his day in court." Genome Biol 11. 11 (2010): 139.

Petsko, G. A.. "Hand-made biology." Genome Biol 11. 6 (2010): 124.

Petsko, G. A.. "Shadows on the wall." Genome Biol 11. 9 (2010): 136.

Petsko, G. A.. "The devil's in the details." Genome Biol 11. 4 (2010): 117.

Petsko, G. A.. "The long and the short of it." Genome Biol 11. 12 (2010): 145.

Petsko, G. A.. "The past is a foreign country." Genome Biol 11. 8 (2010): 131.

Petsko, G. A.. "When failure should be the option." BMC Biol 8. (2010): 61.

Petsko, G. A.. "When the pie is too small." Genome Biol 11. 7 (2010): 127.

Petsko, G.. "Save university arts from the bean counters." Nature 468. 7327 (2010): 1003.

Lieberman, R. L., Wustman, B. A., Huertas, P., Powe, A. C., Jr., Pine, C. W., Khanna, R., Schlossmacher, M. G., Ringe, D., Petsko, G. A.. "Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease." Nat Chem Biol 3. 2 (2007): 101-7.

Petsko, G. A.. "Jumping the shark." Genome Biol 8. 1 (2007): 101.

Desmarais, W., Bienvenue, D. L., Bzymek, K. P., Petsko, G. A., Ringe, D., Holz, R. C.. "The high-resolution structures of the neutral and the low pH crystals of aminopeptidase from Aeromonas proteolytica." J Biol Inorg Chem 11. 4 (2006): 398-408.

Ding, X., Rasmussen, B. F., Petsko, G. A., Ringe, D.. "Direct crystallographic observation of an acyl-enzyme intermediate in the elastase-catalyzed hydrolysis of a peptidyl ester substrate: Exploiting the "glass transition" in protein dynamics." Bioorg Chem 34. 6 (2006): 410-23.

Petsko, G. A.. "A model worth considering?." Genome Biol 7. 12 (2006): 121.

Petsko, G. A.. "Do the math." Genome Biol 7. 11 (2006): 119.

Petsko, G. A.. "Facts and figures." Genome Biol 7. 7 (2006): 111.

Petsko, G. A.. "Instructions for repair." Genome Biol 7. 4 (2006): 106.

Petsko, G. A.. "Senior moments." Genome Biol 7. 8 (2006): 113.

Petsko, G. A.. "The next epidemic." Genome Biol 7. 5 (2006): 108.

Petsko, G. A.. "The ninth wave." Genome Biol 7. 6 (2006): 109.

Petsko,Gregory. "Transamination Based Cycloserine Inactivation of Alanine Racemase." Biochemistry (2005).

Petsko,Gregory. "'Sleeping Beauty' quiescence in Saccharomyces cerrvisiae." Microbiol Mol Biology Rev. (2004).

Petsko,Gregory. "Anchoring a cationic ligand: the structure of the Fab fragment of the anti -morphine antibody 9b1 and its complex with morphine." J. Mol. Bol. (2004).

Petsko,Gregory. "Crystal structure at 1.8 a resolution of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis." Biochemistry (2004).

Petsko,Gregory. "Crystal structure of 3-carboxy-cis, cis-muconate lactonizing enzyme from Pseudomonas putida, a fumarase class II type cycloismoerase: enzyme evolution in parallel pathways." Biochemistry (2004).

Petsko,Gregory. "Diversity in Hapten recognition: Structural Study of an Anti-cocaine Antibody M82G2." J. Mol. Biol. (2004).

Petsko,Gregory. "Spectroscopic and X-ray crystallographic characterization of bestain bound to the aminopeptidase from Aeromonas (Vibrio) proteolytica:." Biochemistry (2004).

Petsko,Gregory. "Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases." Biochemistry (2004).

Petsko,Gregory. "The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: member of the DJ1/Thij/Pfpl superfamily." Proc. National Acad. Sci. (2004).

Petsko,Gregory. "The Parkinson's disease protein DJ-1 is neuroprotetive due to cysteine-sulfinic acid-driven mitochondrial localization." Proc. Natl. Acad. Sci. (2004).

Petsko,Gregory. "Xylose isomerase in substrate and inhibitor michaelis states: atomic resolution studies of a metal-mediated hydride shift." Biochemistry (2004).