Susan Sondej Pochapsky

Title

Associate Research Professor of Chemistry

Chemistry
Rosenstiel Basic Medical Sciences Research Center

Expertise

Associate Research Professor in the Department of Chemistry

Degrees

University of Illinois, Urbana-Champaign, Ph.D.

University of Illinois, Urbana-Champaign, M.S.

Wayne State University, B.A.

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Contact

Email:	ssp@brandeis.edu
Phone:	781-736-2543
Office:	Rosenstiel Basic Medical Sciences Research Center, 601

Scholarship

E. K. Asciutto, M. J. Young, J. Madura, S. S. Pochapsky and T. C. Pochapsky. "Solution Structural Ensembles of Substrate-Free Cytochrome P450cam." Biochemistry 51. (2012): 3383-3393. (forthcoming)

E. K. Asciutto, M. Dang, S. S. Pochapsky, J. Madura, and T. C. Pochapsky. "Experimentally restrained molecular dynamics simulations for characterizing the open states of cytochrome P450cam." Biochemistry 50. (2011): 1664-1671.

H. Lin, S. S. Pochapsky and I. J. Krauss. "A Short Asymmetric Route to the Bromophycolide A and D Skeleton." Org. Lett. 13. (2011): 1222-1225.

M. Dang, S. S. Pochapsky and T. C. Pochapsky. "Spring-loading the active site of cytochrome P450cam." Metallomics 3. (2011): 339-343.

R. Herbst, I. Perovic, V. Martin-Diaconescu, K. O'Brien, P. Chivers, S. Pochapsky, T. Pochapsky, and M. Maroney. "The communication between the zinc and nickel sites in dimeric HypA: Metal recognition and pH sensing." J. Am. Chem. Soc 132. (2010): 10338-10351.

Yu, M., Pochapsky, S. S. and Snider, B. B.. "Synthesis of (+/-)-Bistellettadine A." Organic Letters 12. (2010): 828-831.

Ascuitto, E. K. , J. D. Madura, S. S. Pochapsky, B. OuYang and T. C. Pochapsky. "Structural and dynamic implications of an effector-induced backbone amide cis-trans isomerization in cytochrome P450cam." Journal of Molecular Biology 388. (2009): 801-814.

Pochapsky, S. S., M. Dang, B. OuYang, A. K. Simorellis and T. C. Pochapsky. "Redox-dependent dynamics in cytochrome P450cam." Biochemistry 48. (2009): 4254-4261.

OuYang, B., S. S. Pochapsky, M. Dang and T. C. Pochapsky. "Evidence for a functional proline switch in cytochrome P450cam." Structure 16. (2008): 916-923.

Pochapsky, S. S., J. C. Sunshine and T. C. Pochapsky. "Completing the circuit: Direct-observe C-13,N-15 double-quantum spectroscopy permits sequential resonance assignments near a paramagnetic center in acireductone dioxygenase." Journal of the American Chemical Society 130. 7 (2008): 2156-2157.

Yu, M., S. S. Pochapsky and B. B. Snider. "Synthesis of 7-Epineoptilocaulin, Mirabilin B, and Isoptilocaulin. A Unified Biosynthetic Porposal for the Ptilocaulin and Batzelladine Alkaloids. Synthesis and Structure Revision of Netamines E and G." Journal of Organic Chemistry 73. (2008): 9065-9074.

Zhang, W. , S. S. Pochapsky, T. C. Pochapsky and N. U. Jain. "Solution NMR Structure of Putidaredoxin-Cytochrome P450cam Complex via a Combined Residual Dipolar Coupling-Spin Labeling Approach Suggests a Role for Trp106 of Putidaredoxin in Complex Formation." Journal of Molecular Biology 384. (2008): 349-363.

Pochapsky, Susan Sondej and Pochapsky, Thomas C.. NMR for Physical and Biological Scientists. 1 ed. New York: Garland Publishing, 2007.

Ju, T. T., R. B. Goldsmith, S. C. Chai, M. J. Maroney, S. S. Pochapsky and T. C. Pochapsky. "One protein, two enzymes revisited: A structural entropy switch interconverts the two isoforms of acireductone dioxygenase." Journal of Molecular Biology 363. 4 (2006): 523-534.

OuYang, B., S. S. Pochapsky, G. M. Pagani and T. C. Pochapsky. "Specific effects of potassium ion binding on wild-type and L358P cytochrome P450(cam)." Biochemistry 45. 48 (2006): 14379-14388.

Pochapsky, T. C., S. S. Pochapsky, T. T. Ju, C. Hoefler and J. Liang. "A refined model for the structure of acireductone dioxygenase from Klebsiella ATCC 8724 incorporating residual dipolar couplings." Journal of Biomolecular NMR 34. 2 (2006): 117-127.

Rui, L. Y., S. S. Pochapsky and T. C. Pochapsky. "Comparison of the complexes formed by cytochrome P450(cam) with cytochrome b(5) and putidaredoxin, two effectors of camphor hydroxylase activity." Biochemistry 45. 12 (2006): 3887-3897.

Wei, J. Y., T. C. Pochapsky and S. S. Pochapsky. "Detection of a high-barrier conformational change in the active site of cytochrome P450(cam) upon binding of putidaredoxin." Journal of the American Chemical Society 127. 19 (2005): 6974-6976.

Pochapsky, S. S., T. C. Pochapsky and J. W. Wei. "A model for effector activity in a highly specific biological electron transfer complex: The cytochrome P450(cam)-putidaredoxin couple." Biochemistry 42. 19 (2003): 5649-5656.

Bosco, D. A., E. Z. Eisenmesser, S. Pochapsky, W. I. Sundquist and D. Kern. "Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A." Proceedings of the National Academy of Sciences of the United States of America 99. 8 (2002): 5247-5252.

Kostic, M., S. S. Pochapsky and T. C. Pochapsky. "Rapid recycle C-13',N-15 and C-13,C-13' heteronuclear and homonuclear multiple quantum coherence detection for resonance assignments in paramagnetic proteins: Example of Ni2+-containing acireductone dioxygenase." Journal of the American Chemical Society 124. 31 (2002): 9054-9055.

Kostic, M., S. S. Pochapsky, J. Obenauer, H. P. Mo, G. M. Pagani, R. Pejchal and T. C. Pochapsky. "Comparison of functional domains in vertebrate-type Ferredoxins." Biochemistry 41. 19 (2002): 5978-5989.

Pochapsky, T. C., S. S. Pochapsky, T. T. Ju, H. P. Mo, F. Al-Mjeni and M. J. Maroney. "Modeling and experiment yields the structure of acireductone dioxygenase from Klebsiella pneumoniae." Nature Structural Biology 9. 12 (2002): 966-972.

Haase, W.-C., P. H. Seeberger and S. S. Pochapsky. "Tools for ¿On-Bead¿ Monitoring and Analysis in Solid-Phase Oligosaccharide Synthesis." Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries. Ed. P. H. Seeberger. New York: John Wiley & Sons, Inc., 2001. 165-174.

Pochapsky, S. S. and T. C. Pochapsky. "Nuclear Magnetic Resonance as a Tool in Drug Discovery, Metabolism and Disposition." Current Topics in Medicinal Chemistry 1. (2001): 427-441.

Mo, H. P., S. S. Pochapsky and T. C. Pochapsky. "A model for the solution structure of oxidized terpredoxin, a Fe2S2 ferredoxin from Pseudomonas." Biochemistry 38. 17 (1999): 5666-5675.

Mo, H. P., Y. Dai, S. S. Pochapsky and T. C. Pochapsky. "H-1, C-13 and N-15 NMR assignments for a carbon monoxide generating metalloenzyme from Klebsiella pneumoniae." Journal of Biomolecular NMR 14. 3 (1999): 287-288.

Chin, J., B. Fell, S. Pochapsky, M. J. Shapiro and J. R. Wareing. "2D SECSY NMR for combinatorial chemistry. High-resolution MAS spectra for resin-bound molecules." Journal of Organic Chemistry 63. 4 (1998): 1309-1311.

Seeberger, P. H., X. Beebe, G. D. Sukenick, S. Pochapsky and S. J. Danishefsky. "Monitoring the progress of solid-phase oligosaccharide synthesis by high-resolution magic angle spinning NMR: Observations of enhanced selectivity for beta-glycoside formation from alpha-1,2-anhydrosugar donors in solid-phase couplings." Angewandte Chemie-International Edition in English 36. 5 (1997): 491-493.

Haghjoo, K., P. W. Cash, R. S. Farid, B. R. Komisaruk, F. Jordan and S. S. Pochapsky. "Solution structure of vasoactive intestinal polypeptide (11-28)-NH2, a fragment with analgesic properties." Peptide Research 9. 6 (1996): 327-331.

Pochapsky, S. S., H. P. Mo and T. C. Pochapsky. "Closed-shell ion pair aggregation in non-polar solvents characterized by NMR diffusion measurements." Journal of the Chemical Society-Chemical Communications 24. (1995): 2513-2514.

Bax, A. and S. S. Pochapsky. "Optimized Recording of Heteronuclear Multidimensional Nmr-Spectra Using Pulsed Field Gradients." Journal of Magnetic Resonance 99. 3 (1992): 638-643.

Ye, X. M., T. C. Pochapsky and S. S. Pochapsky. "H-1-Nmr Sequential Assignments and Identification of Secondary Structural Elements in Oxidized Putidaredoxin, an Electron-Transfer Protein from Pseudomonas." Biochemistry 31. 7 (1992): 1961-1968.

Pochapsky, T. C., P. M. Stone and S. S. Pochapsky. "Interionic Contacts in Complex Ion-Pairs Detected by Rotating-Frame Nuclear Overhauser Effects." Journal of the American Chemical Society 113. 4 (1991): 1460-1462.

Pochapsky, S. S., H. F. VanBrocklin, M. J. Welch and J. A. Katzenellenbogen. "Synthesis and Tissue Distribution of Fluorine-18 Labeled Trifluorohexadecanoic Acids. Considerations in the Development of Metabolically Blocked Myocardial Imaging Agents." Bioconjugate Chemistry 2. (1990): 231-244.

(Pochapsky) Sondej, S. C. and J. A. Katzenellenbogen. "Gem-Difluoro Compounds - a Convenient Preparation from Ketones and Aldehydes by Halogen Fluoride Treatment of 1,3-Dithiolanes." Journal of Organic Chemistry 51. 18 (1986): 3508-3513.