Bruce Goode

Cell biology, Biochemistry, and Genetics of the Cytoskeleton.

University of California, Santa Barbara, Ph.D.

University of California, Santa Barbara, B.A.

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Email:	goode@brandeis.edu
Phone:	781-736-2464
Office:	Rosenstiel Basic Medical Science Research Center, 532

Awards and Honors

Editorial Board Member of eLife (new journal sponsored by HHMI, Welcome Trust, and Max Planc) (2012)

Chair of Gordon Research Conference (Plant and Microbial Cytoskeleton) (2010)

Editor-in-Chief of 'Cytoskeleton' (formerly Cell Motility & Cytoskeleton) (2009)

NIH R01 Grant - Yeast Formins and Cell Polarity (2008)

NIH R21 Grant - Developing a genetically encoded light-activated WASp molecule (2008)

American Heart Association Grant - Elucidating Formin Function in Cardiac Muscle (2007)

Co-chair Plant and Fungal Cytoskeleton Gordon Research Conference (2008) (2007)

Faculty of 1000 (2007)

March of Dimes Grant (2007)

NIH R01 Grant - Mechanisms of Actin Assembly (2007)

Chair "Actin Dynamics" mini-symposium at ASCB Conference (2005)

Editorial board, Molecular Biology of the Cell (2005)

Program Committee: Yeast Genetics and Molecular Biology Conference (2005)

Strage Award for Aspiring Young Science Faculty (2005)

American Cancer Society Research Grant (2004 - 2008)

March of Dimes Research Grant (2004 - 2007)

NIH Research Career Development Award (K02) (2004 - 2009)

Basil O'Connor Starter Scholar Award from the March of Dimes Foundation (2002 - 2004)

NIH R01 grant - Mechanisms of Actin Assembly (2002)

Pew Biomedical Scholar Award (2001)

NIH Postdoctoral Training Fellowship (1996 - 1999)

Courses Taught

BIOL	103b	Mechanisms of Cell Functions
BIOL	200a	Proseminar

Faculty Guide

Bruce Goode

Graziano, B.R., Jonasson, E.M., Pullen, J., Gould, C., and Goode, B.L.. "A ligand-induced mechanism for activation of an NPF-formin pair in actin assembly." Journal of Cell Biology in press. in press (2013): in press. (forthcoming)

Ydenberg, C., Padrick, S., Sweeney, M., Gandhi, M., Sokolova, O., and Goode, B.L.. "GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism." Current Biology in press. in press (2013): in press. (forthcoming)

Breitsprecher D, Goode BL. "Formins at a glance." Journal of Cell Science 126. 1 (2013): 1-7.

Chaudhry F, Breitsprecher D, Little K, Sharov G, Sokolova O, Goode BL. "Srv2/cyclase-associated protein forms hexameric shurikens that directly catalyze actin filament severing by cofilin." Molecular Biology of the Cell 24. 1 (2013): 31-41.

Smith BA, Daugherty-Clarke K, Goode BL, Gelles J. "Pathway of actin filament branch formation by Arp2/3 complex revealed by single-molecule imaging." PNAS 110. 4 (2013): 1285-90.

Tu D, Graziano BR, Park E, Zheng W, Li Y, Goode BL, Eck MJ. "Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6." PNAS 109. 50 (2013): E3424-33.

Breitsprecher D, Jaiswal R, Bombardier JP, Gould CJ, Gelles J, Goode BL. "Rocket launcher mechanism of collaborative actin assembly defined by single-molecule imaging." Science 336. 6085 (2012): 1164-8.

Maiti S, Michelot A, Gould C, Blanchoin L, Sokolova O, Goode BL. "Structure and activity of full-length formin mDia1." Cytoskeleton 69. 6 (2012): 393-405.

Breitsprecher D, Koestler SA, Chizhov I, Nemethova M, Mueller J, Goode BL, Small JV, Rottner K, Faix J. "Cofilin cooperates with fascin to disassemble filopodial actin filaments." Journal of Cell Science 124. 19 (2011): 3305-3318.

Chesarone-Cataldo M, Guérin C, Yu JH, Wedlich-Soldner R, Blanchoin L, Goode BL. "The myosin passenger protein Smy1 controls actin cable structure and dynamics by acting as a formin damper." Developmental Cell 21. 2 (2011): 217-230.

Gould, C.J., S. Maiti, A. Michelot, B. Graziano, L. Blanchoin, and B.L. Goode. "The formin DAD domain plays dual roles in autoinhibition and actin nucleation." Current Biology 21. (2011): 384-90.

Graziano BR, DuPage AG, Michelot A, Breitsprecher D, Moseley JB, Sagot I, Blanchoin L, Goode BL. "Mechanism and cellular function of Bud6 as an actin nucleation-promoting factor." Molecular Biology of the Cell 22. 21 (2011): 4016-28.

Huang, W., S. Ghisletti, K. Saijo, M. Gandhi, M. Aouadi, G.J. Tesz, D.X. Zhang, J. Yao, M.P. Czech, B.L. Goode, M.G. Rosenfeld, and C.K. Glass. "Coronin 2A mediates actin-dependent derepression of inflammatory response genes." Nature 470. (2011): 414-8.

Tu, D., Y. Li, H,K. Song, A.V. Toms, C.J. Gould, S.B. Ficarro, J.A. Marto, B.L. Goode and M.J. Eck. "Crystal structure of a coiled-coil domain from human ROCK1." PLOS One 6. 3 (2011): e18080.

Ydenberg CA, Smith BA, Breitsprecher D, Gelles J, Goode BL. "Cease-fire at the leading edge: new perspectives on actin filament branching, debranching, and cross-linking." Cytoskeleton 68. 11 (2011): 596-602.

Balcer, H.I., K. Daugherty-Clarke, and B.L. Goode. "Mapping surfaces on the p40/ARPC1 subunit of Arp2/3 complex required for actin nucleation and in vivo function." Journal of Biological Chemistry 285. (2010): 8481-8491.

Chaudhry, F., L. Talarico, K. Little, O. Quintero-Monzon, and B.L. Goode. "A central role for the WH2 domain of Srv2/CAP in recharging actin monomers to drive actin turnover in vitro and in vivo." Cytoskeleton 67. (2010): 120-133.

Chesarone, M., DuPage, A.G., and B.L. Goode. "Unleashing formins to remodel the actin and microtubule cytoskeletons." Nature Reviews Molecular and Cell Biology 11. (2010): 62-74.

Gandhi, M., M. Jangi, and B.L. Goode. "Identification of conserved surfaces of coronin required for actin binding and in vivo functions." J. Biol. Chem 285. (2010): 34899-908.

Okada, K., F. Bartoloni, A. Deaconescu, J.B. Moseley, Z. Dogic, N. Grigorieff, G.G. Gundersen, and B.L. Goode. "Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1." Journal of Cell Biology 189. (2010): 1087-1096.

Boettner, D., J.L. D’Agostino, T. Torres, K. Daugherty-Clarke, A. Uyger, A. Reider, B. Wendland, S. Lemmon, and B.L. Goode. "The F-BAR domain protein Syp1 negatively regulates WASp-Arp2/3 complex activity during endocytic patch formation." Current Biology 19. (2009): 1979-1987.

Chesarone, M., C.J. Gould, J.B. Moseley, and B.L. Goode. "Displacement of formins from growing barbed ends by Bud14 is critical for proper actin network architecture and function." Developmental Cell 16. (2009): 292-302.

Chesarone, M., and B.L. Goode. "Actin nucleation and elongation factors: mechanisms and interplay." Current Opinion in Cell Biology 21. (2009): 28-37.

Gandhi, M., V. Achard, L. Blanchoin, and B.L. Goode. "Coronin switches roles in actin disassembly depending on the nucleotide state of actin." Molecular Cell 34. (2009): 364-374.

Stroupe, M.E., C. Xu, B.L. Goode, and N. Grigorieff. "Actin filament labels for localizing protein components in large complexes viewed by electron microscopy." RNA 15. (2009): 244-248.

Bartoloni, F., J.B. Moseley, J. Schmoranzer, L. Cassimeris, B.L. Goode, and G. Gundersen. "The formin mDia2 stabilizes microtubules independently of its actin nucleating activity." J. Cell BIol. in press (2008).

Bartoloni, F., J.B. Moseley, J. Schmoranzer, L. Cassimeris, B.L. Goode, and G. Gundersen. "The formin mDia2 stabilizes microtubules independently of its actin nucleating activity." Journal of Cell Biology 181. (2008): 523-536.

Daugherty, K., and B.L. Goode. "Identification of surfaces on the p35/ARPC2 subunit of Arp2/3 complex required for cell growth, actin nucleation, and endocytosis." J. Biol. Chem. in press (2008).

Daugherty-Clarke, K., and B.L. Goode. "WASp identity theft by a bacterial effector." Developmental Cell 15. (2008): 333-334.

Gandhi, M., and B.L. Goode. "Coronin: the double-edged sword of actin dynamics." The Coronin family of actin binding proteins. vol. in press Ed. C. Clemens. Landes Bioscience., 2008

Yonetani, A.¿ R.J. Lustig, J.B. Moseley, T. Takeda, B.L. Goode, and F. Chang. "Regulation and targeting of the fission yeast formin Cdc12p in cytokinesis." Mol. Biol. Cell Epub ahead of print. (2008).

B.L. Goode and M.J. Eck. "Mechanism and function of formins in control of actin assembly." Ann Rev Biochem 76. (2007): 593-627.

Bertling E., O. Quintero-Monzon, P.K. Mattila, B.L. Goode, and P. Lappalainen. "Mechanism and biological role of profilin-Srv2/CAP interaction." J Cell Science 120. (2007): 1225-1234.

Lu, J., W. Meng, F. Poy, S. Maiti, B.L. Goode, and M. Eck. "Structure of the FH2 domain of Daam1; implications for formin regulation of actin assembly." J Mol Biol 369. (2007): 1258-1269.

Moseley, J.B., F. Bartoloni, K. Okada, Y. Wen, G. Gundersen, and B.L. Goode. "Regulated binding of Adenomatous polyposis coli (APC) protein to actin." J Biol Chem 282. 17 (2007): 12661-12668.

Gandhi, M., B.L. Goode, and C.S. Chan. "Four novel suppressors of gic1 gic2 and their roles in cytokinesis and polarized cell growth in S. cerevisiae." Genetics 174. (2006): 665-678.

Goode, BL. "Srv2/cyclase-associated protein: a recycling center for actin monomers and cofilin." Actin monomer binding proteins. Ed. P. Lappalainen. Landes Bioscience, 2006. 45-52.

Moseley, J.B., K. Okada, H.I. Balcer, D. Kovar, T. Pollard, and B.L. Goode. "Twinfilin is an actin filament-severing protein and promotes rapid turnover of actin in vivo." J Cell Science 119. (2006): 1547-1557.

Moseley, J.B., S. Maiti, and B.L. Goode. "Formin proteins: purification and measurement of effects on actin assembly.." Meth Enz 406. (2006): 215-234.

Moseley, J.B., and B.L. Goode. "The yeast actin cytoskeleton: from cellular function to biochemical mechanism." Microbiol Mol Biol Rev 70. (2006): 605-645.

Okada, K., H. Ravi, E.M. Smith, and B.L. Goode. "Aip1 and cofilin promote rapid turnover of yeast actin patches and cables: a coordinated mechanism for severing and capping filaments." Mol Biol Cell 17. (2006): 2855-2868.