Bassine Science Building, 326
DegreesBrandeis University, Ph.D.
California Institute of Technology, B.S.
ExpertiseSingle and multichannel extracellular recording (neurophysiology)
In vivo whole cell recording
In vivo 2-photon imaging
In vivo optical stimulation with optogenetic channels
Data analysis and statistics
ProfileA fundamental mystery of brain science is to understand how networks of neurons assemble during development and function in circuits to enable perception and behavior. Unraveling this mystery requires an understanding of the relationships between the cellular-level properties of circuits – the anatomical “wiring diagram” of connectivity on the one hand, and the functional properties of single neurons and synapses on the other – and the systems-level properties such as sensory responses or motor outputs.
In the Neural Circuits Lab, we are applying a new generation of optical and optogenetic tools to observe both fine-scale circuit features and systems-level responses at the same time, in the living brain. We combine these optical approaches with advanced physiological and anatomical techniques to address previously inaccessible questions about neural circuitry and its development in mammalian visual cortex. Webpage
|BIOL||107a||Data Analysis and Statistics Workshop|
|NBIO||306a||Topics in Neurobiology|
|NBIO||306b||Topics in Neurobiology|
|NBIO||306d||Topics in Neurobiology|
Van Hooser SD, Escobar GM, Maffei A, Miller P.. "Emerging feed-forward inhibition allows the robust formation of direction selectivity in the developing ferret visual cortex." J Neurophysiol (2014). (forthcoming)
Ghiretti AE, Moore AR, Brenner RG, Chen LF, West AE, Lau NC, Van Hooser SD, Paradis S. "Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo." J Neurosci 34. 2 (2014): 392-407.
Hengen KB, Lambo ME, Van Hooser SD, Katz DB, Turrigiano GG. "Firing rate homeostasis in visual cortex of freely behaving rodents.." Neuron 80. 2 (2013): 335-42.
Van Hooser SD, Roy A, Rhodes HJ, Culp JH, Fitzpatrick D. "Transformation of receptive field properties from lateral geniculate nucleus to superficial V1 in the tree shrew." J Neurosci 33. 28 (2013): 11494-505.
Clemens JM, Ritter NJ, Roy A, Miller JM, Van Hooser SD. "The laminar development of direction selectivity in ferret visual cortex." Journal of Neuroscience 32. 50 (2012): 18177-85.
Felch DL, Van Hooser SD. "Molecular compartmentalization of lateral geniculate nucleus in the gray squirrel (Sciurus carolinensis).." Frontiers in Neuroanatomy 6. (2012): 12.
Van Hooser SD, Li Y, Christensson M, Smith GB, White LE, Fitzpatrick D. "Initial neighborhood biases and the quality of motion stimulation jointly influence the rapid emergence of direction preference in visual cortex." Journal of Neuroscience 32. 21 (2012): 7258-66.
Johnson, Elizabeth N., Van Hooser, Stephen D., Fitzpatrick, David. "The representation of S-cone signals in primary visual cortex.." Journal of Neuroscience 30. 31 (2010): 10337-50.