Faculty Guide

Title

Professor of Biochemistry and Howard Hughes Medical Institute Investigator

Biochemistry
Volen National Center for Complex Systems

Expertise

Structure and function of ion channel proteins. Membrane transport and mechanisms of electrical excitation.

Awards and Honors

Member, National Academy of Sciences (2007)

National Institutes of Health grant renewed, "Ion Channel Mechanisms" (2006 - 2010)

President, Biophysical Society (2000 - 2001)

Pew Scholars Program National Advisory Committee (1999)

"Decade of the Brain" lecture, Society for Neuroscience (1998)

MERIT (Method to Extend Research in Time) Award, National Institutes of Health (1996 - 2001)

Alden W. Spencer Neurobiology Award, Columbia University College of Physicians and Surgeons (1994 - 1995)

Howard Hughes Medical Institute Investigator (1989)

K.S. Cole Award in Membrane Physics (1985 - 1986)

Muscular Dystrophy Association Postdoctoral Fellowship (1974 - 1976)

National Institutes of Health Molecular Biology Training Grant (1972 - 1974)

National Institutes of Health University Fellowship (1970 - 1972)

National Science Foundation Traineeship (1969 - 1970)

Courses Taught

BCHM	102a	Quantitative Approaches to Biochemical Systems
BCHM	103b	Advanced Biochemistry: Information Transfer Mechanisms
BCHM	104a	Physical Chemistry of Macromolecules I
BCHM	251b	Structure and Function of Membrane Proteins
CHEM	141a	Thermodynamics and Statistical Thermodynamics

Scholarship

Lim, H.H., Shane, T., and Miller, C. "Intracellular proton access in a Cl-/H+ antiporter." PLoS Biol 10. * (2012): 1-8.

Lim, HH and Miller, C. "News & Views: It takes two to transport - or is it one?." Nature Struct. Mol. Biol. 19. (2012): 129-130.

Miller, C. and Piasta, K.. "Feel the force: Bio-electricity and the sensing of electric fields." The Biochemist 33. (2012): 26-29.

Piasta, K., Theobald, D.L., Miller, C.. "Potassium-selective block of barium permeation through single KcsA channels.." J. Gen Physiol. 138. (2012): 421-426.

Stockbridge, R., Lim, H.H, Otten, R., Williams, C., Shane, T., Weinberg, Z., and Miller, C. "Fluoride resistance and transport by riboswitch-controlled CLC antiporters.." PNAS 109. * (2012): 15289-15294.

Tsai, M-F., Fang, Y., and Miller, CMiller. "Sided functions of an arginine-agmatine exchange-transporter oriented in liposomes." Biochemistry 51. ** (2012): 1577-1585.

Clapham, D., and Miller, C.. "A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels." PNAS 108. (2011): 19492-19497.

Jayaram, H, Robertson, J.L. Wu, F., Williams, C., and Miller, C.. "Structure of a slow CLC Cl-/H+ antiporter from a cyanobacterium. Biochemistry 50:788-794.." Biochemistry 50. 0000 (2011): 788-794.

Miller, C. "Model-free free energy for voltage-gated channels.." J. Gen Physiol 139. (2011): 1-2.

Fang, Y, Jayaram, H, Shane, T., Kolmakova-Partensky, L., Wu, F., Williams, C., Xiong, Y., Miller, C. "Structure of a prokaryotic virtual proton pump at 3.2 Å resolution." Nature 460. (2010): 1040-1043.

Miller, Christopher. "A provisional mechanism for Cl-/H+ exchange in CLC transport proteins." Phil Trans Roy Soc B 364. (2009): 175-180.

Miller, Christopher. "Intracellular proton-transfer mutants in a bacterial CLC Cl-/H+ exchanger." J Gen Physiol 133. (2009): 131-138.

Miller, Christopher. "Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger." PNAS 105. (2009): 11194-99.

Miller, Christopher. "News and Views: Coughing up flu¿s proton channels." Nature 451. (2008): 532-533.

Miller, Christopher. "A bacterial arginine-agmatine exchange transporter involved in extreme acid resistance.." J. Biol. Chem. 282. (2007): 176-182.

Miller, Christopher. "Uncoupling and turnover in a CLC Cl-/H+ exchanger." J. Gen. Physiol. 129. (2007): 317-329.

Nguitragool, W. and Miller, C.. "CLC Cl-/H+ exchangers constrained by covalent cross-linking." Proc. Nat. Acad. Sci. USA 104. (2007): 20659-20665.

Miller,Christopher with Accardi, A., Kolmakova-Partensky, L., Williams, C., and Miller. "Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels." J. Gen. Physiol. 123. (2004): 109-119.

Miller,Christopher with Accardi, A., Kolmakova-Partensky, L., Williams, C., and Miller. "Secondary active transport mediated by prokaryotic homologue of CLC CI channels.." Nature 427. (2004): 803-807.

Miller,Christopher with Blaustein, R.O. and Miller C.. "News and Views: Ion channels: Shake, rattle or roll?." Nature (2004): 499-500.

Miller,Christopher with Nimigean, CM., Shane, T., and Miller, C.. "A cyclic nuceleotide modulated prokaryotic K+ channel." J. Gen Physiol. 124. (2004): 203-210.

Miller,Christopher, ed.. Ion Channel Reconstitution. New York: Plenum Press, 1986.