Michael Thomas Marr

Title

Assistant Professor of Biology

Biology
Rosenstiel Basic Medical Sciences Research Center

Expertise

Mechanisms of gene expression

Degrees

Cornell University, Ph.D.

Bucknell University, B.S.

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Contact

Email:	mmarr@brandeis.edu
Phone:	781-736-2481
Office:	Rosenstiel Basic Medical Science Research Center, 519

Awards and Honors

Ellison Medical Foundation New Scholar in Aging Award (2009)

March of Dimes Basil O'Connor Award (2009)

Courses Taught

BIOL	22a	Genetics and Molecular Biology
BIOL	105b	Molecular Biology
BIOL	156a	Project Laboratory in Biotechnology
BIOL	200a	Proseminar
BIOL	305d	Topics in Molecular Genetics and Development
BIOL	320a	Current Topics in Chromatin Structure
BIOL	320b	Current Topics in Chromatin Structure

Scholarship

Ghiretti A, Kenny K, Marr M. 2nd, and Paradis S.. "CaMKII-dependent phosphorylation of the GTPase Rem2 is required to restrict dendritic complexity." J Neurosci. In Press. (2013). (forthcoming)

Calla Olson, Michael Spellberg, Marissa Donovan, Michael T. Marr II.. "Multi-level control of gene expression by Foxo transcription factors." Translational Control. Cold Spring Harbor Laboratory, Cold Spring Harbor NY. September 2012.

Calla Olson, Michael T. Marr II. "Insulin receptor 5' UTR provides resistance against eIF4A inhibition." Translational Control. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. September 2012.

Marr, S. Pennington, K. and Marr, M.T., 2nd. "Efficient metal-specific transcription activation by Drosophila MTF-1 requires conserved cysteine residues in the carboxy-terminal domain.." Biochim Biophys Acta. 1819. 8 (2012): 902-12.

Pennington, KL and Marr, M.T.. "TAF1 knockdown increases RNA pol II occupancy and activity at Drosophila melanogaster metallothionein A gene.." Mechanisms of Eukaryotic Transcription. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. August 2011.

Sims, HI, Chirn, GW, Marr, Michael Thomas. "Single nucleotide in the MTF-1 binding site can determine metal-specific transcription activation.." Proc Natl Acad Sci U S A. 109. (2012): 16516-21.

Marr, SK, Sims, H., Chirn, G., Marr, M.T.. "Two Regions of the Drosophila Transcription activator MTF-1 and a differential use of cis elements contribute to metal specific transcription activation.." Mechanisms of Eukaryotic Transcription. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. August 2011.

Kadener, S., Rodriguez, J., Abruzzi, K. C., Khodor, Y. L., Sugino, K., Marr, M. T., 2nd, Nelson, S., Rosbash, M.. "Genome-wide identification of targets of the drosha-pasha/DGCR8 complex." RNA 15. 4 (2009): 537-45.

Kadener, S., Rodriguez, J., Abruzzi, K. C., Khodor, Y. L., Sugino, K., Marr, M. T., 2nd, Nelson, S., Rosbash, M.. "Genome-wide identification of targets of the drosha-pasha/DGCR8 complex." RNA 15. 4 (2009): 537-45.

Marr, M. T., 2nd. "TAF4 takes flight." Proc Natl Acad Sci U S A 106. 5 (2009): 1295-6.

Deato, M. D., Marr, M. T., Sottero, T., Inouye, C., Hu, P., Tjian, R.. "MyoD targets TAF3/TRF3 to activate myogenin transcription." Mol Cell 32. 1 (2008): 96-105.

Hsu, J. Y., Juven-Gershon, T., Marr, M. T., 2nd, Wright, K. J., Tjian, R., Kadonaga, J. T.. "TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription." Genes Dev 22. 17 (2008): 2353-8.

King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., Marr, M., Pincus, D., Putnam, N., Rokas, A., Wright, K. J., Zuzow, R., Dirks, W., Good, M., Goodstein, D., Lemons, D., Li. "The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans." Nature 451. 7180 (2008): 783-8.

Casas-Tinto, S., Marr, M. T., 2nd, Andreu, P., Puig, O.. "Characterization of the Drosophila insulin receptor promoter." Biochim Biophys Acta 1769. 4 (2007): 236-43.

Marr, M. T., 2nd, D'Alessio, J. A., Puig, O., Tjian, R.. "IRES-mediated functional coupling of transcription and translation amplifies insulin receptor feedback." Genes Dev 21. 2 (2007): 175-83.

Marr, M. T., 2nd, Isogai, Y., Wright, K. J., Tjian, R.. "Coactivator cross-talk specifies transcriptional output." Genes Dev 20. 11 (2006): 1458-69.

Wright, K. J., Marr, M. T., 2nd, Tjian, R.. "TAF4 nucleates a core subcomplex of TFIID and mediates activated transcription from a TATA-less promoter." Proc Natl Acad Sci U S A 103. 33 (2006): 12347-52.

Adelman, K., Marr, M. T., Werner, J., Saunders, A., Ni, Z., Andrulis, E. D., Lis, J. T.. "Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS." Mol Cell 17. 1 (2005): 103-12.

Marr, M. T., Roberts, J. W., Brown, S. E., Klee, M., Gussin, G. N.. "Interactions among CII protein, RNA polymerase and the lambda PRE promoter: contacts between RNA polymerase and the -35 region of PRE are identical in the presence and absence of CII protein." Nucleic Acids Res 32. 3 (2004): 1083-90.

Taatjes, D. J., Marr, M. T., Tjian, R.. "Regulatory diversity among metazoan co-activator complexes." Nat Rev Mol Cell Biol 5. 5 (2004): 403-10.

Puig, O., Marr, M. T., Ruhf, M. L., Tjian, R.. "Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway." Genes Dev 17. 16 (2003): 2006-20.

Park, J. S., Marr, M. T., Roberts, J. W.. "E. coli Transcription repair coupling factor (Mfd protein) rescues arrested complexes by promoting forward translocation." Cell 109. 6 (2002): 757-67.

Marr, M. T., Datwyler, S. A., Meares, C. F., Roberts, J. W.. "Restructuring of an RNA polymerase holoenzyme elongation complex by lambdoid phage Q proteins." Proc Natl Acad Sci U S A 98. 16 (2001): 8972-8.

Marr, M. T., Roberts, J. W.. "Function of transcription cleavage factors GreA and GreB at a regulatory pause site." Mol Cell 6. 6 (2000): 1275-85.

Sharp, M. M., Chan, C. L., Lu, C. Z., Marr, M. T., Nechaev, S., Merritt, E. W., Severinov, K., Roberts, J. W., Gross, C. A.. "The interface of sigma with core RNA polymerase is extensive, conserved, and functionally specialized." Genes Dev 13. 22 (1999): 3015-26.

Ko, D. C., Marr, M. T., Guo, J., Roberts, J. W.. "A surface of Escherichia coli sigma 70 required for promoter function and antitermination by phage lambda Q protein." Genes Dev 12. 20 (1998): 3276-85.

Roberts, J. W., Yarnell, W., Bartlett, E., Guo, J., Marr, M., Ko, D. C., Sun, H., Roberts, C. W.. "Antitermination by bacteriophage lambda Q protein." Cold Spring Harb Symp Quant Biol 63. (1998): 319-25.

Darst S.A., Roberts, J.W., Malhotra, A. Marr, M., Severinov, K. & Severinova, E.. "Pribnow Box Recognition and Melting by Escherichia coli RNA Polymerase.." Nucleic Acids and Molecular Biology. vol. 11 London: Springer Verlag, 1997. 27-40.

Marr, M. T., Roberts, J. W.. "Promoter recognition as measured by binding of polymerase to nontemplate strand oligonucleotide." Science 276. 5316 (1997): 1258-60.

Severinova, E., Severinov, K., Fenyo, D., Marr, M., Brody, E. N., Roberts, J. W., Chait, B. T., Darst, S. A.. "Domain organization of the Escherichia coli RNA polymerase sigma 70 subunit." J Mol Biol 263. 5 (1996): 637-47.