Faculty Guide

Title

Instructor in the Rabb School of Continuing Studies, Division of Graduate Professional Studies.

Rabb School of Continuing Studies, Division of Graduate Professional Studies

Expertise

Molecular Biology, Cell Biology, Protein Expression, Human Genetic Diseases, Oncology

Profile

Paolo G.V. Martini, PhD, is an Associate Director in the Protein Expression and Purification Research Department at Shire Human Genetic Therapies in Cambridge, MA. His research focus is largely on identification, cloning, expression, and testing of proteins mainly involved in small-population human genetic diseases. He is also consulting on several international scientific projects, collaborations, and organizations.

Awards and Honors

Breast Cancer Research Foundation Fellowship (2000)

Susan G. Komen Breast Cancer Foundation Postdoctoral Fellowship (1998)

Schering Foundation Postdoctoral Fellowship (1996)

Courses Taught

RBIO	101	Molecular Biology Lab: from DNA to Protein
RBIO	102	Molecular, Cell and Developmental Biology

Scholarship

Martini, P. G., Taylor, D. M., Bienkowska, J., Jackson, J., McAllister, G., Keilhack, H., Campbell, R. K.. "Comparative expression analysis of four breast cancer subtypes versus matched normal tissue from the same patients." J Steroid Biochem Mol Biol 109. 3-5 (2008): 207-11.

O'Lone, R., Knorr, K., Jaffe, I. Z., Schaffer, M. E., Martini, P. G., Karas, R. H., Bienkowska, J., Mendelsohn, M. E., Hansen, U.. "Estrogen receptors alpha and beta mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen species." Mol Endocrinol 21. 6 (2007): 1281-96.

Pravettoni, A., Mornati, O., Martini, P. G., Marino, M., Colciago, A., Celotti, F., Motta, M., Negri-Cesi, P.. "Estrogen receptor beta (ERbeta) and inhibition of prostate cancer cell proliferation: studies on the possible mechanism of action in DU145 cells." Mol Cell Endocrinol 263. 1-2 (2007): 46-54.

Guerini, V., Sau, D., Scaccianoce, E., Rusmini, P., Ciana, P., Maggi, A., Martini, P. G., Katzenellenbogen, B. S., Martini, L., Motta, M., Poletti, A.. "The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype." Cancer Res 65. 12 (2005): 5445-53.

Muda, M., He, C., Martini, P. G., Ferraro, T., Layfield, S., Taylor, D., Chevrier, C., Schweickhardt, R., Kelton, C., Ryan, P. L., Bathgate, R. A.. "Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity." Mol Hum Reprod 11. 8 (2005): 591-600.

Martini, P. G., Katzenellenbogen, B. S.. "Modulation of estrogen receptor activity by selective coregulators." J Steroid Biochem Mol Biol 85. 2-5 (2003): 117-22.

Rajendran, R. R., Nye, A. C., Frasor, J., Balsara, R. D., Martini, P. G., Katzenellenbogen, B. S.. "Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97)." J Biol Chem 278. 7 (2003): 4628-38.

Martini, P. G., Katzenellenbogen, B. S.. "Regulation of prothymosin alpha gene expression by estrogen in estrogen receptor-containing breast cancer cells via upstream half-palindromic estrogen response element motifs." Endocrinology 142. 8 (2001): 3493-501.

Delage-Mourroux, R., Martini, P. G., Choi, I., Kraichely, D. M., Hoeksema, J., Katzenellenbogen, B. S.. "Analysis of estrogen receptor interaction with a repressor of estrogen receptor activity (REA) and the regulation of estrogen receptor transcriptional activity by REA." J Biol Chem 275. 46 (2000): 35848-56.

Katzenellenbogen, B. S., Choi, I., Delage-Mourroux, R., Ediger, T. R., Martini, P. G., Montano, M., Sun, J., Weis, K., Katzenellenbogen, J. A.. "Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology." J Steroid Biochem Mol Biol 74. 5 (2000): 279-85.

Katzenellenbogen, B. S., Montano, M. M., Ediger, T. R., Sun, J., Ekena, K., Lazennec, G., Martini, P. G., McInerney, E. M., Delage-Mourroux, R., Weis, K., Katzenellenbogen, J. A.. "Estrogen receptors: selective ligands, partners, and distinctive pharmacology." Recent Prog Horm Res 55. (2000): 163-93; discussion 194-5.

Martini, P. G., Delage-Mourroux, R., Kraichely, D. M., Katzenellenbogen, B. S.. "Prothymosin alpha selectively enhances estrogen receptor transcriptional activity by interacting with a repressor of estrogen receptor activity." Mol Cell Biol 20. 17 (2000): 6224-32.

Gee, A. C., Carlson, K. E., Martini, P. G., Katzenellenbogen, B. S., Katzenellenbogen, J. A.. "Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor." Mol Endocrinol 13. 11 (1999): 1912-23.

Montano, M. M., Ekena, K., Delage-Mourroux, R., Chang, W., Martini, P., Katzenellenbogen, B. S.. "An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens." Proc Natl Acad Sci U S A 96. 12 (1999): 6947-52.

Negri-Cesi, P., Poletti, A., Colciago, A., Magni, P., Martini, P., Motta, M.. "Presence of 5alpha-reductase isozymes and aromatase in human prostate cancer cells and in benign prostate hyperplastic tissue." Prostate 34. 4 (1998): 283-91.