Instructor in the Rabb School of Continuing Studies, Division of Graduate Professional Studies.


Ph.D., Boston University

Field of Specialty

Dmitriy Leyfer, PhD, specializes in gene expression and omics data analysis.

Contact Information

Rabb School

Dmitriy Leyfer

Dmitriy Leyfer, PhD, is a Bioinformatics Scientist at Broad Institute of MIT and Harvard. His research interests include expression analysis, regulatory modules, biological networks, epigenetics, and evolution.


Mcfarland K. … Leyfer D, et al.. "Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease." PLoS ONE (2012). (forthcoming)

Mcfarland K. … Leyfer D, et al.. "Genome-wide increase in histone H2A ubiquitylation in a mouse model of Huntington’s disease." PLoS ONE (2012). (forthcoming)

Funari VA, Voevodski K, Leyfer D, et al.. "Quantitative gene expression profiles in real time from expressed sequence tag databases." Gene Expression 14. 6 (2010): 321-36.

Guner, Ugur and Leyfer, Dmitriy. TINC: Target Identification by Network Connectivity.. Proc. of Moscow Conference in Computational Molecular Biology. Moscow, Russia: mccmb.belozersky.msu.ru, 2009.

Aksenov S., Leyfer D., Miller R. and Church B.. Network Inference of Prokaryote Biology.. Proc. of Conference on Metabolic Engineering. Bethesda, Maryland: genomicscience.energy.gov, 2006.

Leyfer D. and Weng Z. "Genome-wide decoding of hierarchical modular structure of transcriptional regulation by cis-element and expression clustering." Bioinformatics 21. Suppl 2 (2005): ii197-ii203.

Levitin L. and Leyfer D.. Zipf Law and Distribution of Paralog Families.. Proc. of IBSB 2004. Kyoto, Japan: www.jsbi.org, 2004.

Leyfer D, Bond A, Tworog E, Perron D, Maska S, Brito A, Kamens J, Weng Z, Voss J.. "cis-Element clustering correlates with dose-dependent pro- and antisignaling effects of IL18." Genes Immun 5. 5 (2004): 354-62.

Halees A., Leyfer D., Weng Z.. "PromoSer: A large-scale mammalian promoter and transcription start site identification service." Nucleic Acids Res 31. 13 (2003): 3554-9.

Leyfer D., Funari V., Berwick R., Haverty P., Frith M., Tolan D.. A Novel Algorithm for In-silico EST Expression Profiling. Proc. of BGRS 2002. Novosibirsk, Russia: www.bionet.nsc.ru/meeting/bgrs_proceedings/papers/2002/, 2002.

Courses Taught

RBIF 114 Whole-genome Gene Expression Analysis