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RBIF 102

Molecular Biology, Genetics, and Disease

This course covers concepts of classic genetics, from Mendelian inheritance to quantitative and complex traits, associations and population genetics. It addresses the anatomy and function of genomes from humans and model organisms, and how individual components form signaling pathways. Using the Human Genome Projects as an example, sequencing and mapping technologies are covered. Basic sequence analysis methods are introduced, along with techniques to navigate genome browsers and other relevant databases. Cloning and methods for genetic manipulation, including CRISPR, are introduced.

At the end of the course, students will be able to:

Navigate genome browsers and databases relevant to genetics and genomics

Analyze pedigrees and apply genetics to identify disease associations.

Use techniques of physical and genetic mapping and sequencing.

Use comparative genomics to detect homologous sequences within and between organisms and to define evolutionary relationships.

Predict possible consequences of mutations and genetic variation within and outside of genes.

Use examples from developmental biology, human disease and immunology to illustrate genetic control mechanisms and mutations.

Give examples of the biological implications of signaling pathways and cascades.

Compare and contrast CRISPR and other methods for genetic manipulation

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