(file last updated: [8/10/1998 - 15:22:13])
Undergraduate Concentration
The chemistry concentrationoffers a broad training in modern chemistry, covering the majorsubfields--biochemistry, inorganic, organic, and physical--andat the same time allowing students to pursue their special interest(s).Chemistry is the central science and chemistry concentration providesa solid preparation for professional work in chemistry and alliedfields; for study at the graduate level, in chemistry and in otherrelated fields (biochemistry, environmental science, pharmacology,polymer science, etc.); for professional schools (e.g., medicine,dentistry); and for developing an understanding of the technologicaland scientific issues challenging our society today--useful professionallyin law and business, as well as in everyday life. Chemistry concentratorsare given the opportunity to develop extensive, practical experience,through laboratory courses using both macro- and microscale techniques.Chemistry concentrators are encouraged to participate in independentresearch, which is an important part of a scientific education.
Graduate Program in Chemistry
The graduate program in chemistry,leading to the M.S. and Ph.D. degrees, includes course work, seminarparticipation, and research, and is designed to lead to a broadunderstanding of the subject. Entering students may be admittedto either the master's or the doctoral program. The Ph.D. is offeredwith specializations in inorganic, organic, and physical chemistry,and chemical physics. All students will be required to demonstrateknowledge in advanced areas of inorganic, organic, and physicalchemistry. The doctoral program is designed to be flexible sothat individual programs of study may be devised to satisfy theparticular interests and needs of each student. In each case thisprogram will be decided by joint consultation between the student,the Graduate Studies Committee, and the thesis supervisor, whenselected. The doctoral program will normally include a basic setof courses in the student's own area of interest, to be supplementedby advanced courses in chemistry and, where appropriate, biochemistry,biology, mathematics, and physics.
Ph.D. in Chemistry withSpecialization in Chemical Physics
The graduate program in chemicalphysics is an interdisciplinary specialization designed to meetthe needs of students who wish to prepare themselves for the studyof scientific problems using the methods and theories of modernphysics and physical chemistry. This objective is attained by(1) formal course work in chemistry, physics, and, possibly, mathematics;(2) participation in relevant graduate seminars; (3) a programof supervised research involving chemical physics; and (4) independentstudy. The program is designed to be flexible in providing individualprograms of study to satisfy the particular interests and needsof each student. Final programs of study and research will bearrived at by the student, the student's research supervisor,and the Chemical Physics Committee. Only candidates for the Ph.D.degree will be accepted. A master's degree is not offered, butstudents who satisfy the appropriate requirements will be eligiblefor the M.S. degree in chemistry.
The most important qualificationfor becoming a chemistry concentrator is interest in and enjoymentof chemistry. In chemistry, as in other sciences, courses buildon each other: therefore, it is important to begin early. Moststudents (but not all) take general chemistry and calculus intheir first year. Students are required to take PHYS 11a,b (BasicPhysics I, II) to provide a strong foundation for physical chemistry.Every October, interested students meet with chemistry facultyand concentrators at a "meet the majors" gathering calledto discuss concentration in chemistry. Students should consultwith their faculty advisors to develop a program of courses toshape their needs and interests. To apply for the Honors Program,a student must select a research advisor and submit a proposedplan to the department by September 10 of his or her senior year.
The general requirements foradmission to the Graduate School, given in an earlier sectionof this Bulletin, apply to candidates for admission tothe graduate program in chemistry. In addition, the undergraduatecurriculum of applicants should include courses in physics andmathematics (differential and integral calculus) and courses ingeneral, inorganic, organic, and physical chemistry.
Iu-Yam Chan, Chair
Magnetic resonance and opticalspectroscopy under pressure. Dynamics of quantum tunneling reactions.
Li Deng
Asymmetric catalysis and asymmetric synthesis.Solid phase synthesis and combinatorial chemistry. Chiral recognition.Chemical approaches towards understanding protein functions.
Emily Dudek, UndergraduateAdvising Head
Coordination compounds of transitionmetals. Synthesis of polynuclear chelates. Characterization ofcompounds through magnetic and spectroscopic properties.
Irving Epstein
Oscillating chemical reactionsand dynamic instabilities. Mathematical modeling of biochemicalkinetics and neural systems.
Bruce Foxman
X-ray structure determination.Coordination polymers. Chemical, physical, and crystallographicstudies of solid-state reactions. Automatic solution of crystalstructures using novel computer techniques.
Michael Henchman
Thermodynamics and kinetics.Chemistry of ions in the gas phase and applications to interstellarmolecules and solution chemistry. Application of science to theexamination of works of art. Image analysis.
James Hendrickson
Synthesis of natural products.Computerization of synthesis design and development of new syntheticreactions.
Judith Herzfeld
Statistical thermodynamicsof spontaneous order in crowded solutions of self-assembling proteinsand surfactants. Solid state NMR studies of structure and functionin biological membranes.
Peter Jordan
Statistical mechanics of membranetransport. Electrostatic modeling of ion pores. Molecular dynamics.Theories of ionic solvation.
Philip Keehn
Synthetic methods, organicsynthesis of strained rings, and theoretically interesting molecules.Host-guest complexes. Plant medicinals. Applications of NMR spectroscopyto organic systems. Photooxidation. Laser chemistry.
Wenbin Lin
Organometallic and inorganicsynthesis. Photonic and electroactive coordination complexes.Homogeneous and heterogeneous catalysis. Molecular self-assemblyand surface chemistry.
Gregory Petsko (Director,Rosenstiel Center)
Protein crystallography, especiallydirect observation of transient species by low-temperature andLaue methods. Signal transduction in allergy and chemotaxis. Proteindynamics. Protein engineering. Structure/function of p-glycoproteins.Yeast genetics.
Thomas Pochapsky
Self-assembly of chemical andbiological systems. Transient interactions in solution by NMR.NMR of soluble proteins. Protein stability and folding by NMRand mutagenesis.
Arthur Reis
Forensic science.
Dagmar Ringe (RosenstielCenter)
Protein crystallography andprotein engineering. Rational drug design. Mechanisms for enzymaticcatalysis by diffraction and mutagenesis. Structure and functionof PLP containing enzymes, GTP binding proteins, and DNA bindingproteins. Modular protein design.
Barry Snider
Development of new syntheticmethods. Mechanisms of synthetically important reactions. Totalsynthesis of natural products.
Colin Steel
Chemistry of excited moleculesand radicals. The kinetics and mechanisms of photochemical andthermal reactions. Photophysics and photochemistry of infraredlaser-induced reactions.
Thomas Tuttle
Chemistry of liquid solutions.Composition and structures of species in metal solutions in polarsolvents. Application of spectroscopy, e.g., magnetic resonance,optical and spectropolarimetry, to elucidation of the compositionand structure of solutions. Theory of chemical species in solution.
Anatol Zhabotinsky
Chemical and biological kinetics.Oscillating chemical reactions. Chemical waves and pattern formation.Metabolic regulation. Dynamics of cell populations.
Degree of Bachelor of Arts
A.Two semesters of general chemistry lectures (CHEM 10a,b; 11a,bor 15a,b) with laboratory (CHEM 18a,b; 19a,b).
B.Five semester lecture courses, at least four of them in CHEM,chosen from among CHEM 25a,b and courses in CHEM or BCHM numbered40 or higher (including BIBC 105b and NBCH 148b). Courses shouldinclude at least one in each of the following subfields: inorganicchemistry (CHEM 121a, 122b), organic chemistry (CHEM 25a,b), physicalchemistry (CHEM 41a,b).
C.CHEM 29a plus three laboratory courses chosen from CHEM 29b, 39b,59a, or 59b.
D.MATH 10a,b or 11a,b; and PHYS 11a,b.
E.Additional requirements for degree with departmental honors: Twosemesters of CHEM 99d (Senior Research); grade point average of3.00 or higher in all courses offered for concentration, includinglaboratories. Students must petition the department by September10 of their senior year to enter the Senior Honors Program. Studentsinterested in taking a program of study approved by the AmericanChemical Society should consult their faculty advisors.
F.Students planning to pursue graduate study in chemistry shouldbe sure that their program of study includes at least two semesterseach of organic chemistry lectures (CHEM 25a,b) and laboratory(CHEM 29a,b) and physical chemistry lectures (CHEM 41a,b) andlaboratory (CHEM 59a,b). Physics laboratory (PHYS 19a,b), a readingknowledge of a foreign language (preferably German) and a workingknowledge of a computer language are also advisable.
G.All transfer students must pass satisfactorily a minimum of threechemistry or biochemistry courses at Brandeis at a level of CHEM25 or higher with one of the three being CHEM 39b, 59a, or 59b.
H.A student may graduate with a double concentration in biologyand chemistry if the concentration requirements in each departmentare fully met.
I.A student may graduate with a double concentration in chemistryand biochemistry if the concentration requirements in each departmentare fully met.
Degree of Bachelor of Science
A.Two semesters of general chemistry lectures (CHEM 10a,b; 11a,b;or 15a,b) with laboratory (18a,b; 19a,b).
B.Two semesters of organic chemistry lectures (CHEM 25a,b) withlaboratory (29a,b).
C.Two semesters of physical chemistry lectures (CHEM 41a,b).
D.One semester of inorganic chemistry lectures (CHEM 121a or 122b).
E.Three four-credit laboratory courses (CHEM 39b; 59a,b; or onearranged with a laboratory instructor).
F.Two additional 100-level CHEM courses. (A 100-level BCHM coursemay be substituted for one of the two courses.)
G.MATH 10a,b and PHYS 11a,b.
H.Additional requirements for degree with departmental honors: Twosemesters of CHEM 99d (Senior Research) and a grade point averageof 3.00 or higher in all courses offered for concentration includinglaboratories. Students must petition the department by September10 of their senior year to enter the senior honor program.
I.For students planning to pursue graduate study in chemistry, physicslaboratory PHYS 19a,b (Physics Laboratory I, II) a reading knowledgeof a foreign language (preferably German), and a working knowledgeof a computer language are advisable.
J.All transfer students must pass satisfactorily a minimum of threechemistry or biochemistry courses at Brandeis at a level of CHEM25 or higher with one of the three being CHEM 39b, 59a, or 59b.
Combined B.A./M.S. Program
Candidates for departmentalhonors may be admitted to a special four-year B.A./M.S. programupon recommendation of the department and the Graduate School.Application must be made by May 1 preceding the senior year. Studentsmust complete requirements A-E as described in the requirementsfor degree of Bachelor of Arts. Additionally, a 130-level organiccourse, a 140-level physical course, and two other 100-level coursesfrom the School of Science must be taken. At least four of thesecourses may not be counted towards the concentration requirement.Grades of B- or better are required in the 100-level science courses.
The minor in chemistry consistsof the equivalent of six full-credit (four-semester-hour) coursesand three half-credit (two-semester-hour) courses:
A.CHEM 11a and 11b (or CHEM 10a and 10b, or 15a and 15b).
B.CHEM 18a and 18b (or 19a and 19b).
C.CHEM 25a.
D.CHEM 29a.
E.Three additional full-credit (four-semester-hour) chemistry coursesthat meet the concentration requirements. BCHM 101a, 101b, or104b may count as one of the three courses.
EitherCHEM 10a,b lecture and CHEM 18a,b laboratory, or CHEM 11a,blecture and CHEM 18a,b laboratory or CHEM 15a,b lectureand CHEM 19a,b laboratory will satisfy the general chemistry requirementsof most medical schools. The organic chemistry requirements ofmost medical schools will be satisfied by CHEM 25a,b lecture andCHEM 29a,b laboratory.
Program of Study
Each candidate is requiredto successfully complete one year of study at the graduate levelin chemistry, or, with prior permission of the Graduate StudiesCommittee, in related fields. The program will include laboratorywork and, normally, six term courses at the graduate level. Thedetailed program of study will be chosen jointly by the candidateand the Graduate Studies Committee to reflect the candidate'sarea of interest as well as a perspective of other areas.
Library Training Requirement
All graduate students are requiredto complete a designated library training program in their firstyear.
Placement and Evaluationof Progress
Recommendations for the courseof study in the first year will be based upon the performanceon the qualifying examinations.
Qualifying Examination
Each student is expected todemonstrate a satisfactory knowledge of undergraduate chemistryin qualifying examinations in physical, organic, and inorganicchemistry. These examinations are set twice a year, before thestart of each term. The results of these examinations will determinethe student's initial program of course work and will be consideredby the Graduate Studies Committee in evaluating the student'sprogress.
Residence Requirement
The minimum residence requirementfor the M.S. degree is one year.
Teaching
It is expected that all graduatestudents participate in undergraduate teaching during the courseof their studies.
Program of Study
A balanced program of studywill be prepared by the students and the Graduate Studies Committee.In general, students will be required to take a minimum of sevengraduate-level courses, of which two must be outside the student'sfield of research. If a student fails to pass a qualifying examinationafter two attempts, a graduate course must be taken in that areaof chemistry before the end of the second year. A list of coursesappropriate for this purpose is available upon request. For studentsentering with a master's degree or the equivalent, two to fivecourses may be transferred for credit. It is expected that doctoralstudents will choose a research advisor during the first year,normally in the second term.
Qualifying Examination
Each student is expected todemonstrate a satisfactory knowledge of undergraduate chemistryin qualifying examinations in physical, organic, and inorganicchemistry. These examinations are set twice a year, before thestart of each term. The results of these examinations will determinethe student's initial program of course work and will be consideredby the Graduate Studies Committee in evaluating the student'sprogress.
Placement and Evaluationof Progress
Recommendations for the courseof study in the first year will be based upon the performanceon the qualifying examinations. Admission to the Ph.D. degreeprogram will be based on the student's record in course work duringthe first year and his or her performance on the qualifying examinations.Further progress will be evaluated on a yearly basis by the GraduateStudies Committee.
Residence Requirement
The minimum residence requirementis three years.
Seminar
Each student in residence isrequired to attend and participate in the seminar in their chosenarea of concentration throughout the period of graduate study.Each student is expected to present two seminars during theirresidence.
Teaching
It is expected that all graduatestudents participate in undergraduate teaching during the courseof their studies.
Library Training Requirement
All graduate students are requiredto complete a designated library training program in their firstyear.
Language and Computer ProgrammingRequirements
Each student in the organicand inorganic Ph.D. programs must demonstrate a useful readingknowledge of scientific French, German, or Russian within thefirst two years of residence. Each student in the physical chemistryPh.D. program must demonstrate a working knowledge of Fortran,BASIC, or C.
Final Examinations
The graduate student must demonstrateproficiency by taking final examinations in his or her major field:organic, physical, or inorganic chemistry. In the organic chemistryprogram, a cumulative examination procedure is used. Each year,six one-hour examinations (on unannounced topics) and one three-hourexamination (on an announced reading) are given. Each one-hourexamination passed is worth one unit and each reading examinationis worth up to three units depending upon the pass level. Thefinal examination requirement is satisfied by the student havingaccumulated nine units of which no more than six are from readingexaminations. In physical chemistry and inorganic chemistry, thestudent is assigned a set of propositions generally during thethird term of graduate work. In physical chemistry the set consistsof three propositions; the student takes a written examinationon one proposition and is examined orally on all three. In inorganicchemistry the student is assigned two propositions. The studenttakes a written examination on one proposition and is examinedorally on a research proposal (supplied either by the studentor faculty) and the remaining proposition. Students in all fieldsmust maintain satisfactory progress by passing these examinations.
Dissertation and Defense
A dissertation is requiredthat describes the results of an original investigation and demonstratesthe competence of the candidate in independent investigation,critical ability, and effectiveness of expression. The studentmust successfully defend the dissertation in a Final Oral Examination.
Requirements for the Degreeof Doctor of Philosophy in Chemistry with Specialization in ChemicalPhysics
Program of Study
It is expected that some candidatesfor the Ph.D. degree in chemistry with specialization in chemicalphysics may require a longer period of time in course work thanwill students in either of the fields of physics or chemistry.In general, the program for the Ph.D. in chemistry with specializationin chemical physics will include eight term graduate courses: four in physical chemistry, one in either organic or inorganicchemistry, and three in physics. No specific course work in mathematicsis required, but students are expected to be familiar with thetechniques necessary for the proper pursuit of their research.
Students may satisfy theirprogram's course requirements in part or in its entirety by passing(or giving evidence of ability to pass) the final examinationin the appropriate number of such courses. Courses in areas relatedto chemistry and physics may also be considered by the ChemicalPhysics Committee in partial fulfillment of the requirements.
Qualifying Examinations
Each student is expected todemonstrate a satisfactory knowledge of undergraduate chemistry,physics, and mathematics by the performance in three qualifyingexaminations: organic or inorganic chemistry and one each in physicalchemistry and physics/mathematics. These examinations are settwice a year, in August and January. The results of these examinationswill determine the student's initial program of course work andalso be considered by the Chemical Physics Committee in evaluatingthe student's progress.
Library Training Requirement
All graduate students are requiredto complete a designated library training program in their firstyear.
Language and Computer ProgrammingRequirements
There is no foreign languagerequirement for the Ph.D. degree in chemical physics. Each studentmust demonstrate a working knowledge of Fortran, BASIC, or C.
Seminar
Each student in residence isrequired to attend and to participate in the Chemical PhysicsSeminar. Participation in other seminars in physics and chemistryis also recommended.
Teaching
It is expected that all graduatestudents participate in undergraduate teaching during the courseof their studies.
Final Examinations
Final examinations in chemicalphysics are generally taken during the third term of graduatework. The student is assigned a set of three propositions; thestudent takes a written examination on one proposition and isexamined orally on the remaining two.
Residence Requirement
The minimum residence requirementfor the Ph.D. degree is three years.
Dissertation and Defense
A dissertation is requiredthat describes the results of an original investigation and demonstratesthe competence of the candidate in independent investigation,critical ability, and effectiveness of expression. The studentmust successfully defend the dissertation in a Final Oral Examination.
CHSC 3a The Planet as anOrganism: Gaia Theory and the Human Prospect
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Does NOT meet the concentrationrequirement in chemistry. Prerequisite: High school biology, chemistry,and algebra.
In the Gaian view, all lifeon Earth is part of a giant living organism that encompasses theentire planet with a global anatomy, metabolism, and physiology.This course explores the scientific basis for this view, the controversysurrounding it, and its implications for the human enterprise.Usually offered in odd years.
Ms. Herzfeld
CHSC 4a Chemicals and Toxicity
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Does NOT meet the concentrationrequirement in chemistry. Prerequisite: High school chemistryand biology.
The harmful actions of somenaturally occurring chemicals have clinical, environmental, economic,and forensic consequences. Chemical, biological, and genetic factorsthat influence toxicity of selected substances, e.g., pesticides,chemical carcinogens as well as tobacco, will be considered. Therationale for antidotal therapy as well as procedures to assesstoxicological activities and to estimate risk-benefit ratios willbe reviewed. Usually offered in odd years.
Ms. Van Vunakis
CHSC 5a The Magnitude ofThings and How on Earth They Matter
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Does NOT meet the concentrationrequirement in chemistry. Enrollment limited to 25.
Four statements concerningthe age, condition, and destiny of earth as affected by humansare used to implement examinations of relevant issues. These examinationsrequire knowledge in several scientific disciplines that willbe provided as the substance of the course. Usually offered ineven years.
Mr. Tuttle
CHSC 6a Forensic Science:Col. Mustard, Candlestick, Billiard Room
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Prerequisite: High schoolchemistry and biology. DOES NOT meet the concentration requirementsin chemistry.
Examines the use of chemicalanalytical instrumentation, pathology, toxicology, DNA analysis,and anthropology. Actual criminal cases are discussed. Error analysis,reliability and predictability of results are considered. Usuallyoffered every year.
Mr. Reis
CHSC 7a Chaos
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Prerequisite: High schoolalgebra. Does NOT meet the concentration requirements in chemistry.This course may not be taken for credit by students who have receivedcredit for MATH 2a.
This course is devoted to thestudy, from theoretical and experimental perspectives, of thedeterministic, nonrepetitive behavior of physical and biologicalsystems that has come to be known as chaos. Students will examinenot only the scientific, but also the philosophical, historical,and social contexts of the field. Usually offered every thirdyear.
Mr. Epstein
CHSC 8b Chemistry and Art
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Does NOT meet the concentrationrequirements in chemistry. Lab fee: $25. Signature of the instructorrequired.
Topics include a scientificdescription of the materials and methods used in making worksof art; light and the chemistry of color; pigments and dyes; restorationand conservation; scientific examination of artworks: the identificationof fakes; and scientific probes of influence and style. Usuallyoffered in even years.
Mr. Henchman
CHEM 10a Basic Chemistry
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Signature of the instructorrequired. This course satisfies the quantitative reasoning requirementonly when taken with the corresponding lab. This course may notbe taken for credit by students who have taken CHEM 11a or 15ain previous years.
Designed for students whosehigh school records indicate they are not prepared for CHEM 11.CHEM 10a,b will prepare students for organic chemistry, coveringthe general topics of CHEM 11 but with less sophistication. Threeclass hours plus one, one-hour recitation per week. The correspondinglab is CHEM 18a. Usually offered every year.
Ms. Dudek
CHEM 10b Basic Chemistry
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Prerequisite: A satisfactorygrade (C- or better) in CHEM 10a or the equivalent. Signatureof the instructor required. This course satisfies the quantitativereasoning requirement only when taken with the corresponding lab.This course may not be taken for credit by students who have takenCHEM 11b or 15b in previous years.
A continuation of CHEM 10a,covering the general topics of CHEM 11b, but with less sophistication.Three class hours plus one, one-hour recitation per week. Thecorresponding lab is CHEM 18b. Usually offered every year.
Ms. Dudek
CHEM 11a General Chemistry:Principles of Material Evolution
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This course satisfies thequantitative reasoning requirement only when taken with the correspondinglab. This course may not be taken for credit by students who havetaken CHEM 10a or 15a in previous years.
Introduces chemical principlesgoverning the evolution of our material world through the condensationand aqueous stages, including nuclear properties, chemical periodicity,molecular shape, stoichiometry, phase changes, properties of aqueoussolutions, dynamic equilibrium, acid-based reactions, and solubility.Three class hours and one, one-hour recitation per week. The correspondinglab is CHEM 18a. Usually offered every year.
Ms. Herzfeld
CHEM 11b General Chemistry:Principles of Material Evolution
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Prerequisite: A satisfactorygrade (C- or better) in CHEM 11a or the equivalent. This coursesatisfies the quantitative reasoning requirement only when takenwith the corresponding lab. This course may not be taken for creditby students who have taken CHEM 10b or 15b in previous years.
Introduces chemical principlesgoverning the evolution of our material world through the prebiotic,biotic, and anthropic stages including quantum chemistry, coordinationchemistry, the first and second laws of thermodynamics, kinetics,redox and electrochemistry. Three class hours and one, one-hourrecitation per week. The corresponding lab is CHEM 18b. Usuallyoffered every year.
Ms. Herzfeld
CHEM 15a Honors GeneralChemistry, Lectures
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Signature of the instructoror departmental invitation letter required. This course satisfiesthe quantitative reasoning requirement only when taken with thecorresponding lab. This course may not be taken for credit bystudents who have taken CHEM 10a or 11a in previous years.
An advanced version of CHEM11a for students with good preparation. Three class hours andone, one-hour recitation per week. The corresponding laboratoryis CHEM 19a. Usually offered every year.
Mr.Foxman
CHEM 15b Honors GeneralChemistry, Lectures
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A satisfactory grade (C-or better) in CHEM 15a or the equivalent. A continuation of CHEM15a. This course satisfies the quantitative reasoning requirementonly when taken with the corresponding lab. This course may notbe taken for credit by students who have taken CHEM 10b or 11bin previous years.
An advanced version of CHEM11b for students with good preparation. Three class hours andone, one-hour recitation per week. The corresponding laboratoryis CHEM 19b. Usually offered every year.
Mr. Pochapsky
CHEM 18a General ChemistryLaboratory I
Corequisite: CHEM 11a. DroppingCHEM 11a (lecture) necessitates written permission from the labinstructor to continue with the lab. May yield half-course credittoward rate of work and graduation. Two semester hour credits.Laboratory fee: $45 per semester. Enrollment limited to 40 persection. This course may not be taken for credit by students whohave taken CHEM 19a in previous years.
Develops modern laboratorytechniques and demonstrates in practice the concepts of stoichiometry,ideal gas law, titrimetric and gravimetric analysis, and thermochemistry.Spectroscopy is introduced. One afternoon of laboratory per week.One, one-hour laboratory lecture per week. One, one-hour optionalrecitation per week. Usually offered every year.
Ms. Dudek
CHEM 18b General ChemistryLaboratory II
Prerequisites: A satisfactorygrade (C- or better) in CHEM 18a and corequisite 11a. Corequisite:CHEM 11b. Dropping CHEM 11b (lecture) necessitates written permissionfrom the lab instructor to continue with the lab. May yield half-coursecredit toward rate of work and graduation. Two semester hour credits.Laboratory fee: $45 per semester. Enrollment limited to 44 persection. This course may not be taken for credit by students whohave taken CHEM 19b in previous years.
The second semester of thegeneral chemistry laboratory program. Introduction to qualitativeanalysis, quantitative analysis via titration, cell potentials,and spectrophotometry. Experiments involve kinetics, acid-baseequilibria, electrochemistry, thermodynamics, and coordinationchemistry. Usually offered every year.
Ms. Dudek
CHEM 19a Honors GeneralChemistry Laboratory I
Corequisite: CHEM 15a. DroppingCHEM 15a (lecture) necessitates written permission from the labinstructor to continue with the lab. May yield half-course credittoward rate of work and graduation. Two semester hour credits.Laboratory fee: $45 per semester. Enrollment limited to 12 persection. This course may not be taken for credit by students whohave taken CHEM 18a in previous years.
Develops modern laboratorytechniques at a higher level than CHEM 18a, using advanced equipment.One afternoon of laboratory per week. One, one-hour laboratorylecture per week. Usually offered every year.
Mr. Henchman
CHEM 19b Honors GeneralChemistry Laboratory II
Prerequisite: A satisfactorygrade (C- or better) in CHEM 19a; Corequisite: CHEM 15b. DroppingCHEM 15b (lecture) necessitates written permission from the labinstructor to continue with the lab. May yield half-course credittoward rate of work and graduation. Two semester hour credits.Laboratory fee: $45 per semester. Enrollment limited to 12 persection. This course may not be taken for credit by students whohave taken CHEM 18b in previous years.
Continuation of CHEM 19a andincludes one long project. Usually offered every year.
Mr. Tuttle
CHEM 25a Organic Chemistry,Lectures
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Prerequisite: A satisfactorygrade (C- or better) in CHEM 10b, 11b, 15b, or the equivalent.
Structure, reactions, preparations,and uses of the compounds of carbon. Three class hours and one,one-hour recitation per week. Usually offered every year.
Mr. Keehn
CHEM 25b Organic Chemistry,Lectures
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Prerequisite: A satisfactorygrade (C- or better) in CHEM 25a or its equivalent.
A continuation of CHEM 25a.Three class hours and one, one-hour recitation per week. Usuallyoffered every year.
Mr. Snider
CHEM 29a Organic ChemistryLaboratory I
Prerequisites: A satisfactorygrade (C- or better) in CHEM 18b or 19b or the equivalent. Corequisite:CHEM 25a. Dropping CHEM 25a necessitates written permission fromlab instructor to continue with the lab. May yield half-coursecredit toward rate of work and graduation. Two semester hour credits.Laboratory fee: $45. Enrollment limited to 35 per section.
Gives experience in the importanttechniques of organic chemical practice. Includes synthesis oftypical organic compounds and characterization using analyticaland instrumental procedures. One afternoon of laboratory per week.One, one-hour laboratory lecture per week. Usually offered everyyear.
Mr. Hendrickson
CHEM 29b Organic ChemistryLaboratory II
Prerequisites: A satisfactorygrade (C- or better) in CHEM 29a or the equivalent. Corequisite:CHEM 25b. Dropping CHEM 25b necessitates written permission fromlab instructor to continue with the lab. May yield half-coursecredit toward rate of work and graduation. Two semester hour credits.Laboratory fee: $45. Enrollment limited to 35 per section.
A continuation of CHEM 29a.One afternoon of laboratory per week. One, one-hour laboratorylecture per week. Usually offered every year.
Mr. Keehn
CHEM 33a Environmental Chemistry
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Prerequisite: One year ofgeneral chemistry, CHEM 10a,b; 11a,b; or 15a,b; or the equivalent.
Surveys our understanding ofthe undisturbed environment and how it developed, and addressesenvironmental problems arising from human activities. Relevantchemistry of the atmosphere and hydrosphere will be emphasized,with brief discussions of related science of the geosphere andbiosphere. Usually offered in even years.
Mr. Lin
CHEM 39b Intermediate ChemistryLaboratory
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Prerequisites: Satisfactorygrades (C- or better) in: CHEM 10a,b, 11a,b, 15a,b or equivalent;CHEM 18a,b, 19a,b or equivalent; CHEM 25a,b or equivalent; CHEM29a,b or equivalent. Four semester-hour credits. Laboratory fee:$45 per semester. Enrollment limited to 10.
In this lab compounds are synthesizedand a wide range of modern analytical methods--spectroscopic,electrical, and magnetic--are used to characterize the products.The lectures cover the instrumentation and its theoretical bases.One, four-and-a-half hour lab per week. Two, one-hour lab lecturesper week. Usually offered in odd years.
Staff
CHEM 41a Physical Chemistry,Lectures I
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Prerequisites: Satisfactorygrades (C- or better) in CHEM 10b, 11b, 15b or equivalent; MATH10a,b or equivalent; PHYS 11a,b. Organic chemistry is also recommended.
Kinetic theory of gases, topicsin chemical thermodynamics; introductory aspects of statisticalmechanics. Three lecture hours per week. Usually offered everyyear.
Mr. Miller
CHEM 41b Physical Chemistry,Lectures II
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Prerequisites: Satisfactorygrades (C- or better) in CHEM 10b, 11b, 15b or equivalent; MATH10a,b or equivalent; PHYS 11a,b. Organic chemistry is also recommended.
Topics include quantum mechanics,spectroscopy, and statistical thermodynamics. Three lecture hoursper week. Usually offered every year.
Mr. Tuttle
CHEM 59a Advanced ExperimentalChemistry
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Prerequisites: A satisfactorygrade (C- or better) in CHEM 18b or equivalent; CHEM 41a or 41b(may be taken concurrently) or equivalent. Laboratory fee: $45per semester.
An advanced course in methodsand techniques of experimental chemistry. CHEM 59a and b forma two-semester sequence, either half of which may be taken independently.The program includes methodology of quantitative measurement,statistical data analysis, and report writing; and spectroscopicand other instrumental methods in a modern chemical research environment.Physicochemical phenomena are used as a vehicle in the study.One, one-hour lecture and one afternoon of laboratory per week.Usually offered every year.
Mr. Steel
CHEM 59b Advanced ExperimentalChemistry
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Prerequisites: A satisfactorygrade (C- or better) in CHEM 18b or equivalent; CHEM 41a or b(may be taken concurrently) or equivalent. Laboratory fee: $45per semester.
See CHEM 59a for course description.Usually offered every year.
Mr. Tuttle
CHEM 95a Directed Studiesin Chemistry
Prerequisites: CHEM 25a,and 29a, or equivalent. Does not meet the concentration requirementsin chemistry. Laboratory fee: $45 per semester. Signature of theinstructor required. May not be repeated for credit. A designatedlibrary training component must be completed as soon as it isoffered.
Readings and/or independentlaboratory work. Periodic conferences with advisor and a finalwritten report. CHEM 95a and 95b may be taken individually asone-semester courses or together as a year-long sequence. Usuallyoffered every year.
Staff
CHEM 95b Directed Studiesin Chemistry
See CHEM 95a for special notesand course description. Usually offered every year.
Staff
CHEM 99d Senior Research
Prerequisites: CHEM 41a,59a or 59b, or equivalent, which may be taken concurrently. Openonly to senior honors candidates. Does not meet the concentrationrequirements in chemistry. Laboratory fee: $45 per semester. Permissionof department and signature of the instructor required. A designatedlibrary training component must be completed as soon as it isoffered. At the end of the first semester, the introduction tothe research thesis with extensive bibliography is due.
A year-long course focusedon a research project with a member of the department. Successfulcompletion of the course will involve the writing of a detailedreport on the project. Usually offered every year.
Staff
CHEM 110b Instrumental AnalyticalChemistry
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Prerequisites: Satisfactorygrade(s) in CHEM 41a and b, CHEM 59a and b, or equivalent. Laboratoryfee: $45. Signature of the instructor required.
Techniques of instrumentalchemical analysis. Application of instrumental methods to theseparation and analysis of complex mixtures. Students rotate throughongoing research laboratories. Data treatment includes computersin the analytical chemistry laboratory. Two afternoons per week;approximately two hours of laboratory lecture and six hours oflaboratory per week. Offered on request.
Staff
CHEM 111a ComputationalChemistry
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Prerequisites: Satisfactorygrades in CHEM 41a, b, or equivalent. Does not meet the concentrationrequirements in chemistry. Signature of the instructor required.
Selected topics in computationalchemistry, including two or three of the following: small moleculemodeling; biomolecular modeling; numerical integration methods;quantum mechanical modeling; least squares analyses; design ofsynthesis; data analysis. Practice in use of common software withconsideration of their capabilities. Usually offered in even years.
Staff
CHEM 121a Inorganic ChemistryI, Lectures
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Prerequisite: A satisfactorygrade in CHEM 25a and b. Signature of the instructor required.
Symmetry, structure, and bondingin inorganic compounds. Solid-state chemistry. Ionic and electronicconductors, including superconductors. Applications of group theoryand bonding theory to main group compounds and transition metalcomplexes. Coordination chemistry. Usually offered every year.
Mr. Foxman
CHEM 122b Inorganic ChemistryII, Lectures
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Prerequisite: A satisfactorygrade in CHEM 25a and b. Signature of the instructor required.
Transition metal chemistry:physical and chemical properties of classical coordination compoundsand organometallics, including spectra, magnetism, isomerism,reaction mechanisms, and catalysis. Inorganic rings, chains, andclusters. Introduction to bioinorganic chemistry. Usually offeredevery year.
Staff
CHEM 130a Advanced OrganicChemistry: Structure
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Prerequisite: A satisfactorygrade in an undergraduate organic chemistry course. Signatureof the instructor required.
Introduction to physical organicchemistry and its application to organic and biochemical applications.
Ms. Ringe
CHEM 131a Advanced OrganicChemistry: Topics in Structure and Reactivity
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Prerequisite: A satisfactorygrade in an undergraduate organic chemistry course. Signatureof the instructor required.
Broad coverage of a varietyof transformations involving additions, eliminations, substitutions,oxidations, reductions, and rearrangements. Usually offered everyyear.
Mr. Keehn
CHEM 132b Advanced OrganicChemistry: Spectroscopy
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Prerequisite: A satisfactorygrade in an undergraduate organic chemistry course. Signatureof the instructor required.
Application of spectroscopyto the elucidation of structure and stereochemistry of organiccompounds, with special emphasis on modern NMR methods. Usuallyoffered every year.
Staff
CHEM 134b Advanced OrganicChemistry: Synthesis
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Prerequisite: A satisfactorygrade in an undergraduate organic chemistry course. Signatureof the instructor required.
Modern synthetic methods arecovered, with an emphasis on mechanism and stereochemical controland organometallic methods. Formation of carbon-carbon singleand double bonds and carbocycles and procedures for oxidation,reduction, and functional group interchange are discussed. Selectedtotal syntheses are examined. Usually offered every year.
Mr. Deng
CHEM 137b The Chemistryof Organic Natural Products
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Prerequisites: A satisfactorygrade in CHEM 25a and b, or the equivalent. Signature of the instructorrequired.
Natural products chemistrywill be surveyed within a biogenetic framework. Occurrence, isolation,structure elucidation, biogenesis, and synthesis will be coveredwith an emphasis on modern methods of establishing biogenesisand biogenetic type synthesis. Usually offered every year.
Mr. Snider
CHEM 141a Chemical Thermodynamics
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Prerequisites: Satisfactorygrade in undergraduate physical chemistry. Familiarity with multivariablecalculus. Signature of the instructor required.
Statistical, classical, andirreversible thermodynamics; principles, tools, and applications.Usually offered every year.
Messrs. Steel and Zhabotinsky
CHEM 141b Kinetics
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Prerequisite: A satisfactorygrade in undergraduate physical chemistry. Signature of the instructorrequired.
Macroscopic kinetics: elementaryreactions and rate laws. Kinetic study of reaction mechanisms:techniques for kinetic measurements; fast reactions; treatmentof kinetic data. Microscopic kinetics: molecular dynamics, transitionstate theory. Reactions in the gas phase and in solution. Catalyticand chain reactions. Enzyme kinetics. Nonlinear dynamics: chemicaloscillations and waves. Usually offered every year.
Mr. Zhabotinsky
CHEM 142a Quantum Chemistry
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Prerequisites: Passing gradesin CHEM 41a and b, or equivalent. Signature of the instructorrequired.
This class will discuss solutionsof the Schroedinger equation for simple systems; operator techniquesand approximation methods; atoms; the Born-Oppenheimer approximation;diatomic molecules; polyatomic molecules; and introduction toquantum chemical calculation. Usually offered every year.
Mr. Chan
CHEM 145b Special Topicsin Chemistry
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Prerequisites: Undergraduatephysical chemistry and some familiarity with simple differentialequations.
Topics vary from year to year.Usually offered every third year. Last offered in the spring of1994.
Staff
CHEM 150b Special Topicsin Chemistry
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Signature of the instructorrequired.
Topics vary from year to year.Usually offered every third year. Last offered in the fall of1996.
Mr. Petsko
CHEM 200d Advanced ChemistryLaboratory
Usually offered every year.
Staff
CHEM 220c Inorganic ChemistrySeminar
Required of graduate studentsin inorganic chemistry, who must audit this course each year.Usually offered every year.
Staff
CHEM 229b Special Topicsin Inorganic Chemistry: Introduction to X-ray Structure Determination
Topics include basic diffractionand space group theory, practical manipulations of crystals andX-ray diffraction equipment, solving crystal structures, and interpretationof structural chemistry. Course will feature self-paced tutorialson the VAX 8650. Usually offered every third year. Last offeredin the spring of 1995.
Staff
CHEM 231c Organic ChemistrySeminar
Required of graduate studentsin organic chemistry, who must audit this course each year. Usuallyoffered every year.
Staff
CHEM 232b Heterocyclic Chemistry
The nature of aromatic heterocycleswill be surveyed, followed by detailed discussion of their characteristicreactions and modes of synthesis. The course is organized to showa general predictive framework behind the details. Emphasis isplaced on the mechanisms of heterocycle reactions. Usually offeredin odd years.
Staff
CHEM 234b Chemistry of OrganometallicCompounds
The chemistry of organo-transitionmetal complexes, including their structures, chemical reactions,and use as reagents in organic synthesis. Usually offered everythird year. Last offered in the spring of 1995.
Staff
CHEM 235b Advanced NMR Spectroscopy
A detailed discussion of modernNMR methods will be presented. The course is designed so as tobe accessible to nonspecialists, but still provide a strong backgroundin the theory and practice of modern NMR techniques. Topics includethe theory of pulse and multidimensional NMR experiments, chemicalshift, scalar and dipolar coupling, NOE, spin-operator formalism,heteronuclear and inverse-detection methods, Hartmann-Hahn andspin-locking experiments. Experimental considerations such aspulse sequence design, phase cycling, and gradient methods willbe discussed. Guest lecturers will provide insight into particulartopics such as solid-state NMR and NMR instrumental design. Usuallyoffered in even years.
Mr. Pochapsky
CHEM 241c Physical ChemistrySeminar
Required of graduate studentsin physical chemistry, who must audit this course each year. Usuallyoffered every year.
Staff
CHEM 243b Statistical Thermodynamics
Elementary statistical mechanicsof ensembles of molecules and applications to thermodynamic systems.Usually offered every third year. Last offered in the spring of1996.
Staff
CHEM 250c Chemical PhysicsSeminar
Required of graduate studentsin chemical physics, who must audit this course each year. Usuallyoffered every year.
Staff
Research Courses
CHEM 404d Organic Chemistry
Synthesis of natural products;development of new synthetic reactions; computerization of synthesisdesign systematics.
Mr. Hendrickson
CHEM 405d Biochemistry
Structure and function proteinsby X-ray crystallography, site-directed mutagenesis and moleculardynamics simulations; time-resolved studies of enzyme catalysisby Laue diffraction; and multi-drug resistance and the cysticfibrosis of gene product.
Mr. Petsko
CHEM 407d Biochemistry
Structure and function of proteinsby kinetic and structural methods, coupled with low temperatureand time-resolved diffraction methods; structures of native andmutant proteins, complexed and uncomplexed, aimed at modelingof active sites and specific inhibitors.
Ms. Ringe
CHEM 408d Physical Chemistry
Experimental and theoreticalstudy of chemical species in solution; and spectroscopic investigationsof metal solutions in polar solvents.
Mr. Tuttle
CHEM 410d Biophysical Chemistry
Statistical thermodynamic modelingof long-range order in crowded self-assembling systems and NMRstudies of functional molecular mechanisms in biological membranes.
Ms. Herzfeld
CHEM 411d Physical Chemistry
Chemistry of excited moleculesand radicals and the kinetics and mechanisms of photochemicaland thermal reactions; and photophysics and photochemistry ofinfrared laser-induced reactions.
Mr. Steel
CHEM 413d Physical Chemistry
Membrane transport; electrostaticmodeling of ion pores; molecular dynamics of ionic motion in biologicalmolecules; and theories of ionic solvation.
Mr. Jordan
CHEM 414d Physical Chemistry
Kinetic studies of the reactionsand properties of ions in the gas phase. Scientific analysis ofartworks.
Mr. Henchman
CHEM 415d Physical Chemistry
Experimental and theoreticalstudies of oscillating chemical reactions and dynamic instabilities;theoretical approaches to neurobiology and neural networks; mathematicalmodeling of biochemical kinetics.
Mr. Epstein
CHEM 416d Physical Chemistry
High-pressure effects on Jahn-Telleractive molecules; dynamical processes in molecular crystals andone-dimensional aggregates; dynamics of quantum tunneling reactions.
Mr. Chan
CHEM 417d Organic Chemistry
Organic synthesis of strainedrings and theoretically interesting molecules; synthetic methods;enclathration and host-guest complexation in tri-o-thymotide andcalixarenes; plant medicinals; application of nuclear magneticresonance spectroscopy to organic systems; photooxidation; thermalchemistry; laser chemistry.
Mr. Keehn
CHEM 418d Inorganic Chemistry
Synthesis of organic and metal-organiccompounds for photonic and electronic applications. Spectroscopicinvestigations of novel photonic materials. Organometallic complexesin homogeneous catalysis. Molecular self-assembly.
Mr. Lin
CHEM 419d Inorganic Chemistry
X-ray structure determination;coordination polymers; chemical, physical, and crystallographicstudies of solid-state reactions; and automatic solution of crystalstructures using novel computer techniques.
Mr. Foxman
CHEM 421d Organic Chemistry
Synthetic methodology and naturalproduct synthesis, carbon-carbon bond forming reactions of alkenesand their application to natural product synthesis, intramolecularreactions, oxidative free-radical cyclizations, ketene cycloadditions,ene and Prins reactions, and synthesis of biologically activenatural products.
Mr. Snider
CHEM 422d Organic Chemistry
Total synthesis of therapeuticagents and molecular biological studies of their mode(s) of action;development of new synthetic methodology; and design of systemsthat self-assemble.
Mr. Gordon
CHEM 423d Organic Chemistry
Multimolecular complexes; aminoacid residue side-chain interactions in peptides and proteins;and globular protein stability and protein structure by multidimensionaland multinuclear NMR methods.
Mr. Pochapsky
CHEM 424d Organic Chemistry
Catalytic enantioselective reactions andtheir applications in asymmetric synthesis. New strategies forthe design and discovery of selective catalysts. Chiral recognition.Synthetic probes for the elucidation of protein functions in biologicalprocesses involving enzymatic DNA modifications and protein-DNAinteraction.
Mr. Deng
Chemistry Colloquium
Lectures by faculty and invitedspeakers. Required of all graduate students. Noncredit.
Computational Neuroscience