2000-01 Bulletin Entry for:


Chemistry


Objectives


Undergraduate Concentration

The chemistry concentration offers a broad training in modern chemistry, covering the major subfields--biochemistry, inorganic, organic, and physical--and at the same time allowing students to pursue their special interest(s). Chemistry is the central science and chemistry concentration provides a solid preparation for professional work in chemistry and allied fields; for study at the graduate level, in chemistry and in other related fields (biochemistry, environmental science, pharmacology, polymer science, etc.); for professional schools (e.g., medicine, dentistry); and for developing an understanding of the technological and scientific issues challenging our society today--useful professionally in law and business, as well as in everyday life. Chemistry concentrators are given the opportunity to develop extensive, practical experience, through laboratory courses using macro- and microscale techniques. Chemistry concentrators are encouraged to participate in independent research, which is an important part of a scientific education.

Graduate Program in Chemistry

The graduate program in chemistry, leading to the M.S. and Ph.D. degrees, includes course work, seminar participation, and research, and is designed to lead to a broad understanding of the subject. Entering students may be admitted to either the master's or the doctoral program. The Ph.D. is offered with specializations in inorganic, organic, and physical chemistry, and chemical physics. All students will be required to demonstrate knowledge in advanced areas of inorganic, organic, and physical chemistry. The doctoral program is designed to be flexible so that individual programs of study may be devised to satisfy the particular interests and needs of each student. In each case this program will be decided by joint consultation between the student, the Graduate Studies Committee, and the thesis supervisor, when selected. The doctoral program will normally include a basic set of courses in the student's own area of interest, to be supplemented by advanced courses in chemistry and, where appropriate, biochemistry, biology, mathematics, and physics.

Ph.D. in Chemistry with Specialization in Chemical Physics

The graduate program in chemical physics is an interdisciplinary specialization designed to meet the needs of students who wish to prepare themselves for the study of scientific problems using the methods and theories of modern physics and physical chemistry. This objective is attained by (1) formal course work in chemistry, physics, and, possibly, mathematics; (2) participation in relevant graduate seminars; (3) a program of supervised research involving chemical physics; and (4) independent study. The program is designed to be flexible in providing individual programs of study to satisfy the particular interests and needs of each student. Final programs of study and research will be arrived at by the student, the student's research supervisor, and the Chemical Physics Committee. Only candidates for the Ph.D. degree will be accepted. A master's degree is not offered, but students who satisfy the appropriate requirements will be eligible for the M.S. degree in chemistry.


How to Become an Undergraduate Concentrator


The most important qualification for becoming a chemistry concentrator is interest in and enjoyment of chemistry. In chemistry, as in other sciences, courses build on each other; therefore, it is important to begin early. Most students (but not all) take general chemistry and calculus in their first year. Students are required to take PHYS 11a,b (Basic Physics I, II) to provide a strong foundation for physical chemistry. Every October, interested students meet with chemistry faculty and concentrators at a "meet the majors" gathering called to discuss concentration in chemistry. Students should consult with their faculty advisors to develop a program of courses to shape their needs and interests. To apply for the Honors Program, a student must select a research advisor and submit a proposed plan to the department by September 10 of his or her senior year.


How to Be Admitted to the Graduate Program


The general requirements for admission to the Graduate School, given in an earlier section of this Bulletin, apply to candidates for admission to the graduate program in chemistry. In addition, the undergraduate curriculum of applicants should include courses in physics and mathematics (differential and integral calculus) and courses in general, inorganic, organic, and physical chemistry.


Faculty


Iu-Yam Chan, Chair

Magnetic resonance and optical spectroscopy under pressure. Dynamics of quantum tunneling reactions.

Li Deng

Asymmetric catalysis and asymmetric synthesis. Solid phase synthesis and combinatorial chemistry. Chiral recognition. Chemical approaches towards understanding protein functions.

Emily Dudek, Undergraduate Advising Head

Coordination compounds of transition metals. Synthesis of polynuclear chelates. Characterization of compounds through magnetic and spectroscopic properties.

Irving Epstein

Oscillating chemical reactions and pattern formation in reaction diffusion systems. Mathematical modeling of biochemical kinetics and neural systems.

Bruce Foxman

X-ray structure determination. Coordination polymers. Chemical, physical, and crystallographic studies of solid-state reactions. Automatic solution of crystal structures using novel computer techniques.

Michael Henchman

Thermodynamics, kinetics and chemistry of ions in the gas phase. Scientific analysis of works of art and its dissemination via the Web.

James Hendrickson

Synthesis of natural products. Computerization of synthesis design and development of new synthetic reactions.

Judith Herzfeld

Statistical thermodynamics of spontaneous order in crowded solutions of self-assembling proteins and surfactants. Solid state NMR studies of structure and function in biological membranes.

Peter Jordan

Statistical mechanics of membranes and of membrane transport. Electrostatic modeling of ion pores. Molecular dynamics. Theories of ionic solvation.

Philip Keehn

Synthetic methods, organic synthesis of strained rings, and theoretically interesting molecules. Host-guest complexes. Plant medicinals. Applications of NMR spectroscopy to organic systems. Photooxidation. Laser chemistry.

Wenbin Lin

Organometallic and inorganic synthesis. Photonic and electroactive coordination complexes. Homogeneous and heterogeneous catalysis. Molecular self-assembly and surface chemistry.

Gregory Petsko (Director, Rosenstiel Center)

Protein crystallography, especially direct observation of transient species by low-temperature and Laue methods. Signal transduction in allergy and chemotaxis. Protein dynamics. Protein engineering. Structure/function of p-glycoproteins. Yeast genetics.

Thomas Pochapsky

Self-assembly of chemical and biological systems. Transient interactions in solution by NMR. NMR of soluble proteins. Protein stability and folding by NMR and mutagenesis.

Arthur Reis

Forensic science.

Dagmar Ringe (Rosenstiel Center)

Protein crystallography and structural enzymology. Rational drug design. Structure and function of PLP dependent enzymes, DNA binding proteins, and enzymes that utilize bimetallic centers for catalysis.

Barry Snider

Development of new synthetic methods. Mechanisms of synthetically important reactions. Total synthesis of natural products.

Colin Steel

Chemistry of excited molecules and radicals. The kinetics and mechanisms of photochemical and thermal reactions. Photophysics and photochemistry of infrared laser-induced reactions.

Thomas Tuttle

Chemistry of liquid solutions. Composition and structures of species in metal solutions in polar solvents. Application of spectroscopy, e.g., magnetic resonance, optical and spectropolarimetry, to elucidation of the composition and structure of solutions. Theory of chemical species in solution.

Anatol Zhabotinsky

Chemical and biological kinetics. Oscillating chemical reactions. Chemical waves and pattern formation. Metabolic regulation. Dynamics of cell populations.


Requirements for the Undergraduate Concentration


Degree of Bachelor of Arts

A. Two semesters of general chemistry lectures (CHEM 10a,b; 11a,b; or 15a,b) with laboratory (CHEM 18a,b; 19a,b).

B. Five semester lecture courses, at least four of them in CHEM, chosen from among CHEM 25a,b and courses in CHEM or BCHM numbered 40 or higher (including BIBC 105b and NBIO 148b). Courses should include at least one in each of the following subfields: inorganic chemistry (CHEM 121a, 122b), organic chemistry (CHEM 25a,b), physical chemistry (CHEM 41a,b).

C. CHEM 29a plus three laboratory courses chosen from CHEM 29b, 39b, 59a, or 59b.

D. MATH 10a,b or 11a,b; and PHYS 11a,b.

E. Additional requirements for degree with departmental honors: Two semesters of CHEM 99d (Senior Research); grade point average of 3.00 or higher in all courses offered for concentration, including laboratories. Students must petition the department by September 10 of their senior year to enter the Senior Honors Program. Students interested in taking a program of study approved by the American Chemical Society should consult their faculty advisors.

F. Students planning to pursue graduate study in chemistry should be sure that their program of study includes at least two semesters each of organic chemistry lectures (CHEM 25a,b) and laboratory (CHEM 29a,b), physical chemistry lectures (CHEM 41a,b) and laboratory (CHEM 59a,b), and BCHM 100a. Physics laboratory (PHYS 19a,b), a reading knowledge of a foreign language (preferably German) and a working knowledge of a computer language are also advisable.

G. All transfer students must pass satisfactorily a minimum of three chemistry or biochemistry courses at Brandeis at a level of CHEM 25 or higher with one of the three being CHEM 39b, 59a, or 59b.

H. A student may graduate with a double concentration in biology and chemistry if the concentration requirements in each department are fully met.

I. A student may graduate with a double concentration in chemistry and biochemistry if the concentration requirements in each department are fully met.

Degree of Bachelor of Science

A. Two semesters of general chemistry lectures (CHEM 10a,b; 11a,b; or 15a,b) with laboratory (18a,b; 19a,b).

B. Two semesters of organic chemistry lectures (CHEM 25a,b) with laboratory (29a,b).

C. Two semesters of physical chemistry lectures (CHEM 41a,b).

D. One semester of inorganic chemistry lectures (CHEM 121a or 122b).

E. Three, four-credit laboratory courses (CHEM 39b; 59a,b; or one arranged with a laboratory instructor).

F. Two additional 100-level CHEM courses. (A 100-level BCHM course may be substituted for one of the two courses.)

G. MATH 10a,b and PHYS 11a,b.

H. Additional requirements for degree with departmental honors: Two semesters of CHEM 99d (Senior Research) and a grade point average of 3.00 or higher in all courses offered for concentration including laboratories. Students must petition the department by September 10 of their senior year to enter the senior honor program.

I. For students planning to pursue graduate study in chemistry, BCHM 100a, physics laboratory PHYS 19a,b (Physics Laboratory I, II) a reading knowledge of a foreign language (preferably German), and a working knowledge of a computer language are advisable.

J. All transfer students must pass satisfactorily a minimum of three chemistry or biochemistry courses at Brandeis at a level of CHEM 25 or higher with one of the three being CHEM 39b, 59a, or 59b.

Combined B.A./M.S. Program

Candidates for departmental honors may be admitted to a special four-year B.A./M.S. program upon recommendation of the department and the Graduate School. Application must be made by May 1 preceding the senior year. Students must complete requirements A-E as described in the requirements for degree of Bachelor of Arts. Additionally, a 130-level organic course, a 140-level physical course, and two other 100-level courses from the School of Science must be taken. At least four of these courses may not be counted towards the concentration requirement. Grades of B- or better are required in the 100-level science courses.


Requirements for the Undergraduate Minor


The minor in chemistry consists of the equivalent of six full-credit (four-semester-hour) courses and three half-credit (two-semester-hour) courses:

A. CHEM 11a and 11b (or CHEM 10a and 10b, or 15a and 15b).

B. CHEM 18a and 18b (or 19a and 19b).

C. CHEM 25a.

D. CHEM 29a.

E. Three additional full-credit (four-semester-hour) chemistry courses that meet the concentration requirements. BCHM 101a, 101b, or 104b may count as one of the three courses.


Special Notes Relating to Undergraduates


Either CHEM 10a,b lecture and CHEM 18a,b laboratory, or CHEM 11a,b lecture and CHEM 18a,b laboratory or CHEM 15a,b lecture and CHEM 19a,b laboratory will satisfy the general chemistry requirements of most medical schools. The organic chemistry requirements of most medical schools will be satisfied by CHEM 25a,b lecture and CHEM 29a,b laboratory.


Requirements for the Degree of Master of Science


Program of Study

Each candidate is required to successfully complete one year of study at the graduate level in chemistry, or, with prior permission of the Graduate Studies Committee, in related fields. The program will include laboratory work and, normally, six term courses at the graduate level. The detailed program of study will be chosen jointly by the candidate and the Graduate Studies Committee to reflect the candidate's area of interest as well as a perspective of other areas.

Library Training Requirement

All graduate students are required to complete a designated library training program in their first year.

Placement and Evaluation of Progress

Recommendations for the course of study in the first year will be based upon the performance on the qualifying examinations.

Qualifying Examination

Each student is expected to demonstrate a satisfactory knowledge of undergraduate chemistry in qualifying examinations in physical, organic, and inorganic chemistry. These examinations are set twice a year, before the start of each term. The results of these examinations will determine the student's initial program of course work and will be considered by the Graduate Studies Committee in evaluating the student's progress.

Residence Requirement

The minimum residence requirement for the M.S. degree is one year.

Teaching

It is expected that all graduate students participate in undergraduate teaching during the course of their studies.


Requirements for the Degree of Doctor of Philosophy


Program of Study

A balanced program of study will be prepared by the student and the Graduate Studies Committee. In general, students will be required to take a minimum of seven graduate-level courses, of which two must be outside the student's field of research. If a student fails to pass a qualifying examination after two attempts, a graduate course must be taken in that area of chemistry before the end of the second year. A list of courses appropriate for this purpose is available upon request. For students entering with a master's degree or the equivalent, two to four courses may be transferred for credit. It is expected that doctoral students will choose a research advisor during the first year, normally in the second term.

Qualifying Examination

Each student is expected to demonstrate a satisfactory knowledge of undergraduate chemistry in qualifying examinations in physical, organic, and inorganic chemistry. These examinations are set twice a year, before the start of each term. The results of these examinations will determine the student's initial program of course work and will be considered by the Graduate Studies Committee in evaluating the student's progress.

Placement and Evaluation of Progress

Recommendations for the course of study in the first year will be based upon the performance on the qualifying examinations. Admission to the Ph.D. degree program will be based on the student's record in course work during the first year and his or her performance on the qualifying examinations. Further progress will be evaluated on a yearly basis by the Graduate Studies Committee.

Residence Requirement

The minimum residence requirement is three years.

Seminar

Each student in residence is required to attend and participate in the seminar in their chosen area of concentration throughout the period of graduate study. Each student is expected to present two seminars during their residence.

Teaching

It is expected that all graduate students participate in undergraduate teaching during the course of their studies.

Library Training Requirement

All graduate students are required to complete a designated library training program in their first year.

Language and Computer Programming Requirements

Each student in the organic and inorganic Ph.D. programs must demonstrate a useful reading knowledge of scientific French, German, or Russian within the first two years of residence. Each student in the physical chemistry Ph.D. program must demonstrate a working knowledge of Fortran, BASIC, or C.

Final Examinations

The graduate student must demonstrate proficiency by taking final examinations in his or her major field: organic, physical, or inorganic chemistry. In the organic chemistry program, a cumulative examination procedure is used. Each year, six one-hour examinations (on unannounced topics) are given. The final examination requirement is satisfied by passing six cumulative exams. In physical chemistry and inorganic chemistry, the student is assigned a set of propositions generally during the third term of graduate work. In physical chemistry the set consists of three propositions; the student takes a written examination on one proposition and is examined orally on all three. In inorganic chemistry the student is assigned two propositions. The student takes a written examination on one proposition and is examined orally on a research proposal (supplied either by the student or faculty) and the remaining proposition. Students in all fields must maintain satisfactory progress by passing these examinations.

Dissertation and Defense

A dissertation is required that describes the results of an original investigation and demonstrates the competence of the candidate in independent investigation, critical ability, and effectiveness of expression. The student must successfully defend the dissertation in a Final Oral Examination.


Requirements for the Degree of Doctor of Philosophy in Chemistry with Specialization in Chemical Physics

Program of Study

It is expected that some candidates for the Ph.D. degree in chemistry with specialization in chemical physics may require a longer period of time in course work than will students in either of the fields of physics or chemistry. In general, the program for the Ph.D. in chemistry with specialization in chemical physics will include eight term graduate courses: four in physical chemistry, one in either organic or inorganic chemistry, and three in physics. No specific course work in mathematics is required, but students are expected to be familiar with the techniques necessary for the proper pursuit of their research.

Students may satisfy their program's course requirements in part or in its entirety by passing (or giving evidence of ability to pass) the final examination in the appropriate number of such courses. Courses in areas related to chemistry and physics may also be considered by the Chemical Physics Committee in partial fulfillment of the requirements.

Qualifying Examinations

Each student is expected to demonstrate a satisfactory knowledge of undergraduate chemistry, physics, and mathematics by the performance in three qualifying examinations: organic or inorganic chemistry and one each in physical chemistry and physics/mathematics. These examinations are set twice a year, in August and January. The results of these examinations will determine the student's initial program of course work and also be considered by the Chemical Physics Committee in evaluating the student's progress.

Library Training Requirement

All graduate students are required to complete a designated library training program in their first year.

Language and Computer Programming Requirements

There is no foreign language requirement for the Ph.D. degree in chemical physics. Each student must demonstrate a working knowledge of Fortran, BASIC, or C.

Seminar

Each student in residence is required to attend and to participate in the Chemical Physics Seminar. Participation in other seminars in physics and chemistry is also recommended.

Teaching

It is expected that all graduate students participate in undergraduate teaching during the course of their studies.

Final Examinations

Final examinations in chemical physics are generally taken during the third term of graduate work. The student is assigned a set of three propositions; the student takes a written examination on one proposition and is examined orally on the remaining two.

Residence Requirement

The minimum residence requirement for the Ph.D. degree is three years.

Dissertation and Defense

A dissertation is required that describes the results of an original investigation and demonstrates the competence of the candidate in independent investigation, critical ability, and effectiveness of expression. The student must successfully defend the dissertation in a Final Oral Examination.


Courses of Instruction



(1-99) Primarily for Undergraduate Students


CHSC 3a The Planet as an Organism: Gaia Theory and the Human Prospect

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Does NOT meet the concentration requirement in chemistry. Prerequisites: High school biology, chemistry, and algebra.

In the Gaian view, all life on Earth is part of a giant living organism that encompasses the entire planet with a global anatomy, metabolism, and physiology. This course explores the scientific basis for this view, the controversy surrounding it, and its implications for the human enterprise. Usually offered in odd years.

Ms. Herzfeld

CHSC 4a Chemicals and Toxicity

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Does NOT meet the concentration requirement in chemistry. Prerequisites: High school chemistry and biology.

The harmful actions of some naturally occurring chemicals have clinical, environmental, economic, and forensic consequences. Chemical, biological, and genetic factors that influence toxicity of selected substances, e.g., pesticides, chemical carcinogens as well as tobacco, will be considered. The rationale for antidotal therapy as well as procedures to assess toxicological activities and to estimate risk-benefit ratios will be reviewed. Usually offered in odd years.

Ms. Van Vunakis

CHSC 5a The Magnitude of Things and How on Earth They Matter

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Does NOT meet the concentration requirement in chemistry. Enrollment limited to 25.

Four statements concerning the age, condition, and destiny of earth as affected by humans are used to implement examinations of relevant issues. These examinations require knowledge in several scientific disciplines that will be provided as the substance of the course. Usually offered in even years.

Mr. Tuttle

CHSC 6a Forensic Science: Col. Mustard, Candlestick, Billiard Room

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Prerequisites: High school chemistry and biology. Does NOT meet the concentration requirements in chemistry. A library intensive course.

Examines the use of chemical analytical instrumentation, pathology, toxicology, DNA analysis, and other forensic tools. Actual and literary cases are discussed. Error analysis, reliability, and predictability of results are considered. Usually offered every year.

Mr. Reis

CHSC 7a Chaos

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Prerequisite: High school algebra. Does NOT meet the concentration requirements in chemistry. This course may not be taken for credit by students who have received credit for MATH 2a.

This course is devoted to the study, from theoretical and experimental perspectives, of the deterministic, nonrepetitive behavior of physical and biological systems that has come to be known as chaos. Students will examine not only the scientific, but also the philosophical, historical, and social contexts of the field. Usually offered every third year.

Mr. Epstein

CHSC 8b Chemistry and Art

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Does NOT meet the concentration requirements in chemistry. Lab fee: $25. Signature of the instructor required.

Topics include a scientific description of the materials and methods used in making works of art; light and the chemistry of color; pigments and dyes; restoration and conservation; scientific examination of artworks: the identification of fakes; and scientific probes of influence and style. Usually offered in even years.

Mr. Henchman

CHEM 10a Basic Chemistry

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Signature of the instructor required. This course may not be taken for credit by students who have taken CHEM 11a or 15a in previous years.

Designed for students whose high school records indicate they are not prepared for CHEM 11. CHEM 10a,b will prepare students for organic chemistry. A basic course in chemical principles; emphasis on stoichiometry, thermochemistry, atomic structure and periodicity, molecular structure and bonding, states of matter, and properties of solutions. Three class hours plus one, one-hour recitation per week. The corresponding lab is CHEM 18a. Usually offered every year.

Ms. Dudek

CHEM 10b Basic Chemistry

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Prerequisite: A satisfactory grade (C- or better) in CHEM 10a or the equivalent. Signature of the instructor required. This course may not be taken for credit by students who have taken CHEM 11b or 15b in previous years.

A continuation of CHEM 10a. A basic course in chemical principles; emphasis on kinetics, chemical equilibra, thermodynamics, electrochemistry, coordination, compounds, nuclear chemistry, and descriptive chemistry. Three class hours plus one, one-hour recitation per week. The corresponding lab is CHEM 18b. Usually offered every year.

Ms. Dudek

CHEM 11a General Chemistry: Principles of Material Evolution

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This course may not be taken for credit by students who have taken CHEM 10a or 15a in previous years.

Introduces chemical principles governing the evolution of our material world through the condensation and aqueous stages, including nuclear properties, chemical periodicity, molecular shape, stoichiometry, phase changes, properties of aqueous solutions, dynamic equilibrium, acid-based reactions, and solubility. Three class-hours and one, one-hour recitation per week. The corresponding lab is CHEM 18a. Usually offered every year.

Ms. Herzfeld

CHEM 11b General Chemistry: Principles of Material Evolution

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Prerequisite: A satisfactory grade (C- or better) in CHEM 11a or the equivalent. This course may not be taken for credit by students who have taken CHEM 10b or 15b in previous years.

Introduces chemical principles governing the evolution of our material world through the prebiotic, biotic, and anthropic stages including quantum chemistry, coordination chemistry, the first and second laws of thermodynamics, kinetics, redox and electrochemistry. Three class hours and one, one-hour recitation per week. The corresponding lab is CHEM 18b. Usually offered every year.

Ms. Herzfeld

CHEM 15a Honors General Chemistry, Lectures

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By invitation or the signature of the instructor required. This course may not be taken for credit by students who have taken CHEM 10a or 11a in previous years.

An introduction to the principles of modern chemistry for students with demonstrated interest and aptitude. Topics normally include chemical bonding, gasses and states of matter, chemical equilibrium and thermodynamics, chemical kinetics and nuclear chemistry. Three class hours and one, one-hour recitation per week. The corresponding laboratory is CHEM 19a. Usually offered every year.

Mr.Henchman

CHEM 15b Honors General Chemistry, Lectures

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A satisfactory grade (C- or better) in CHEM 15a or the equivalent. A continuation of CHEM 15a. This course may not be taken for credit by students who have taken CHEM 10b or 11b in previous years.

An advanced version of CHEM 11b for students with good preparation. Three class hours and one, one-hour recitation per week. The corresponding laboratory is CHEM 19b. Usually offered every year.

Staff

CHEM 18a General Chemistry Laboratory I

Corequisite: CHEM 11a. Dropping CHEM 11a (lecture) necessitates written permission from the lab instructor to continue with the lab. May yield half-course credit toward rate of work and graduation. Two semester hour credits. Laboratory fee: $45 per semester. Enrollment limited to 40 per section. This course may not be taken for credit by students who have taken CHEM 19a in previous years.

Develops modern laboratory techniques and demonstrates in practice the concepts of stoichiometry, ideal gas law, titrimetric and gravimetric analysis, and thermochemistry. Spectroscopy is introduced. One afternoon of laboratory per week. One, one-hour laboratory lecture per week. One, one-hour optional recitation per week. Usually offered every year.

Ms. Dudek

CHEM 18b General Chemistry Laboratory II

Prerequisites: A satisfactory grade (C- or better) in CHEM 18a and CHEM 11a. Corequisite: CHEM 11b. Dropping CHEM 11b (lecture) necessitates written permission from the lab instructor to continue with the lab. May yield half-course credit toward rate of work and graduation. Two semester hour credits. Laboratory fee: $45 per semester. Enrollment limited to 44 per section. This course may not be taken for credit by students who have taken CHEM 19b in previous years.

The second semester of the general chemistry laboratory program. Introduction to qualitative analysis, quantitative analysis via titration, cell potentials, and spectrophotometry. Experiments involve kinetics, acid-base equilibria, electrochemistry, thermodynamics, and coordination chemistry. Usually offered every year.

Ms. Dudek

CHEM 19a Honors General Chemistry Laboratory I

Corequisite: CHEM 15a. Dropping CHEM 15a (lecture) necessitates written permission from the lab instructor to continue with the lab. May yield half-course credit toward rate of work and graduation. Two semester hour credits. Laboratory fee: $45 per semester. Signature of the instructor required. This course may not be taken for credit by students who have taken CHEM 18a in previous years.

Develops modern laboratory techniques at a higher level than CHEM 18a, using more advanced topics and equipment. One afternoon of laboratory per week. One, one-hour laboratory lecture per week. Usually offered every year.

Mr. Henchman

CHEM 19b Honors General Chemistry Laboratory II

Prerequisite: A satisfactory grade (C- or better) in CHEM 19a; Corequisite: CHEM 15b. Dropping CHEM 15b (lecture) necessitates written permission from the lab instructor to continue with the lab. May yield half-course credit toward rate of work and graduation. Two semester hour credits. Laboratory fee: $45 per semester. Signature of departmental representative required. This course may not be taken for credit by students who have taken CHEM 18b in previous years.

Continuation of CHEM 19a and includes one long project. Usually offered every year.

Mr. Tuttle

CHEM 25a Organic Chemistry, Lectures

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Prerequisite: A satisfactory grade (C- or better) in CHEM 10b, 11b, 15b, or the equivalent.

Structure, reactions, preparations, and uses of the compounds of carbon. Three class hours and one, one-hour recitation per week. Usually offered every year.

Mr. Snider

CHEM 25b Organic Chemistry, Lectures

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Prerequisite: A satisfactory grade (C- or better) in CHEM 25a or its equivalent.

A continuation of CHEM 25a. Three class hours and one, one-hour recitation per week. Usually offered every year.

Mr. Hendrickson

CHEM 29a Organic Chemistry Laboratory I

Prerequisite: A satisfactory grade (C- or better) in CHEM 18b or 19b or the equivalent. Corequisite: CHEM 25a. Dropping CHEM 25a necessitates written permission from lab instructor to continue with the lab. May yield half-course credit toward rate of work and graduation. Two semester hour credits. Laboratory fee: $45. Enrollment limited to 35 per section.

Gives experience in the important techniques of organic chemical laboratory practice of isolation and purification of organic compounds by crystallization, distillation, and chromatography, and their characterization using analytical and instrumental methods. One afternoon of laboratory per week. One, 50-90 minute laboratory lecture per week. Usually offered every year.

Mr. Keehn

CHEM 29b Organic Chemistry Laboratory II

Prerequisite: A satisfactory grade (C- or better) in CHEM 29a or the equivalent. Corequisite: CHEM 25b. Dropping CHEM 25b necessitates written permission from lab instructor to continue with the lab. May yield half-course credit toward rate of work and graduation. Two semester hour credits. Laboratory fee: $45. Enrollment limited to 35 per section.

A continuation of CHEM 29a with an emphasis on the synthesis of typical organic compounds. One afternoon of laboratory per week. One, 50-90 minute laboratory lecture per week. Usually offered every year.

Mr. Keehn

CHEM 33a Environmental Chemistry

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Prerequisite: One year of general chemistry, CHEM 10a,b; 11a,b; or 15a,b; or the equivalent.

Surveys our understanding of the undisturbed environment and how it developed, and addresses environmental problems arising from human activities. Relevant chemistry of the atmosphere and hydrosphere will be emphasized, with brief discussions of related science of the geosphere and biosphere. Usually offered in even years.

Mr. Lin

CHEM 39b Intermediate Chemistry Laboratory

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Prerequisites: Satisfactory grades (C- or better) in: CHEM 10a,b, 11a,b, 15a,b or equivalent; CHEM 18a,b, 19a,b or equivalent; CHEM 25a,b or equivalent; CHEM 29a,b or equivalent. Four semester-hour credits. Laboratory fee: $45 per semester. Enrollment limited to 10.

In this lab compounds are synthesized and a wide range of modern analytical methods--spectroscopic, electrical, and magnetic--are used to characterize the products. The lectures cover the instrumentation and its theoretical bases. One, four-and-a-half hour lab per week and two, one-hour lab lectures per week. Usually offered in odd years.

Staff

CHEM 41a Physical Chemistry, Lectures I

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Prerequisites: Satisfactory grades (C- or better) in CHEM 10b, 11b, 15b or equivalent; MATH 10a,b or equivalent; PHYS 11a,b. Organic chemistry is also recommended.

Kinetic theory of gases, topics in chemical thermodynamics; introductory aspects of statistical mechanics. Three lecture hours per week. Usually offered every year.

Mr. Jordan

CHEM 41b Physical Chemistry, Lectures II

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Prerequisites: Satisfactory grades (C- or better) in CHEM 10b, 11b, 15b or equivalent; MATH 10a,b or equivalent; PHYS 11a,b. Organic chemistry is also recommended.

Topics include quantum mechanics, spectroscopy, and statistical thermodynamics. Three lecture hours per week. Usually offered every year.

Mr. Tuttle

CHEM 59a Advanced Experimental Chemistry

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Prerequisites: A satisfactory grade (C- or better) in CHEM 18b or equivalent; CHEM 41a or 41b (may be taken concurrently) or equivalent. Laboratory fee: $45 per semester.

An advanced course in methods and techniques of experimental chemistry. CHEM 59a and b form a two-semester sequence, either half of which may be taken independently. The program includes methodology of quantitative measurement, statistical data analysis, and report writing; and spectroscopic and other instrumental methods in a modern chemical research environment. Physicochemical phenomena are used as a vehicle in the study. One, one-hour lecture and one afternoon of laboratory per week. Usually offered every year.

Mr. Steel

CHEM 59b Advanced Experimental Chemistry

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Prerequisites: A satisfactory grade (C- or better) in CHEM 18b or equivalent; CHEM 41a or b (may be taken concurrently) or equivalent. Laboratory fee: $45 per semester.

See CHEM 59a for course description. Usually offered in even years.

Mr. Tuttle

CHEM 95a Directed Studies in Chemistry

Prerequisites: CHEM 25a, and 29a, or equivalent. Does not meet the concentration requirements in chemistry. Laboratory fee: $45 per semester. Signature of the instructor required. May not be repeated for credit. A designated library training component must be completed as soon as it is offered. A library intensive course.

Readings and/or independent laboratory work. Periodic conferences with advisor and a final written report. CHEM 95a and 95b may be taken individually as one-semester courses or together as a year-long sequence. Usually offered every year.

Staff

CHEM 95b Directed Studies in Chemistry

See CHEM 95a for special notes and course description. Usually offered every year.

Staff

CHEM 99d Senior Research

Prerequisites: CHEM 41a, 59a or 59b, or equivalent, which may be taken concurrently. Open only to senior honors candidates. Does not meet the concentration requirements in chemistry. Laboratory fee: $45 per semester. Permission of department and signature of the instructor required. A designated library training component must be completed as soon as it is offered. At the end of the first semester, the introduction to the research thesis with extensive bibliography is due. A library intensive course.

A year-long course focused on a research project with a member of the department. Successful completion of the course will involve the writing of a detailed report on the project. Usually offered every year.

Staff


(100-199) For Both Undergraduate and Graduate Students


CHEM 110b Instrumental Analytical Chemistry

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Prerequisite: Satisfactory grade(s) in CHEM 41a and b, CHEM 59a and b, or equivalent. Laboratory fee: $45. Signature of the instructor required.

Techniques of instrumental chemical analysis. Application of instrumental methods to the separation and analysis of complex mixtures. Students rotate through ongoing research laboratories. Data treatment includes computers in the analytical chemistry laboratory. Two afternoons per week; approximately two hours of laboratory lecture and six hours of laboratory per week. Offered on request.

Staff

CHEM 111a Computational Chemistry

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Prerequisite: Satisfactory grades in CHEM 41a and b, or equivalent. Does not meet the concentration requirements in chemistry. Signature of the instructor required.

Selected topics in computational chemistry, including two or three of the following: small molecule modeling; biomolecular modeling; numerical integration methods; quantum mechanical modeling; least squares analyses; design of synthesis; data analysis. Practice in use of common software with consideration of their capabilities. Usually offered in even years.

Staff

CHEM 121a Inorganic Chemistry I, Lectures

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Prerequisite: A satisfactory grade in CHEM 25a and b. Signature of the instructor required.

Symmetry, structure, and bonding in inorganic compounds. Solid-state chemistry. Ionic and electronic conductors, including superconductors. Applications of group theory and bonding theory to main group compounds and transition metal complexes. Coordination chemistry: structure and reactions. Usually offered every year.

Mr. Foxman

CHEM 122b Inorganic Chemistry II, Lectures

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Prerequisite: A satisfactory grade in CHEM 25a and b. Signature of the instructor required.

Theory and experiments; synthesis, characterization and properties of organometallic compounds and their applications in homogeneous catalysis and organic synthesis. Usually offered every year.

Mr. Lin

CHEM 130a Advanced Organic Chemistry: Structure

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Prerequisite: A satisfactory grade in an undergraduate organic chemistry course. Signature of the instructor required.

Chemical bonding and structure, stereochemical principles and conformational analysis, organic reaction mechanisms, structures and activities of reactive intermediates, and pericyclic reactions.

Mr. Deng

CHEM 131a Advanced Organic Chemistry: Topics in Structure and Reactivity

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Prerequisite: A satisfactory grade in an undergraduate organic chemistry course. Signature of the instructor required.

Broad coverage of a variety of transformations involving additions, eliminations, substitutions, oxidations, reductions, and rearrangements. Usually offered every year.

Staff

CHEM 132b Advanced Organic Chemistry: Spectroscopy

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Prerequisite: A satisfactory grade in an undergraduate organic chemistry course. Signature of the instructor required.

Application of spectroscopy to the elucidation of structure and stereochemistry of organic compounds, with emphasis on modern NMR and MS methods. Usually offered every year.

Mr. Snider

CHEM 134b Advanced Organic Chemistry: Synthesis

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Prerequisite: A satisfactory grade in an undergraduate organic chemistry course. Signature of the instructor required.

Modern synthetic methods are covered, with an emphasis on mechanism and stereochemical control and organometallic methods. Formation of carbon-carbon single and double bonds and carbocycles and procedures for oxidation, reduction, and functional group interchange are discussed. Selected total syntheses are examined. Usually offered every year.

Mr. Deng

CHEM 137b The Chemistry of Organic Natural Products

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Prerequisite: A satisfactory grade in CHEM 25a and b, or the equivalent. Signature of the instructor required.

Natural products chemistry will be surveyed within a biogenetic framework. Occurrence, isolation, structure elucidation, biogenesis, and synthesis will be covered with an emphasis on modern methods of establishing biogenesis and biogenetic type synthesis. Usually offered every year.

Staff

CHEM 141a Chemical Thermodynamics

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Prerequisite: Satisfactory grade in undergraduate physical chemistry. Familiarity with multivariable calculus. Signature of the instructor required.

Statistical, classical, and irreversible thermodynamics; principles, tools, and applications. Usually offered every year.

Mr. Jordan

CHEM 141b Kinetics

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Prerequisite: A satisfactory grade in undergraduate physical chemistry. Signature of the instructor required.

Macroscopic kinetics: elementary reactions and rate laws. Kinetic study of reaction mechanisms: techniques for kinetic measurements; fast reactions; treatment of kinetic data. Microscopic kinetics: molecular dynamics, transition state theory. Reactions in the gas phase and in solution. Catalytic and chain reactions. Enzyme kinetics. Nonlinear dynamics: chemical oscillations and waves. Usually offered every year.

Mr. Zhabotinsky

CHEM 142a Quantum Chemistry

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Prerequisite: Passing grades in CHEM 41a and b, or equivalent. Signature of the instructor required.

This class will discuss solutions of the Schroedinger equation for simple systems; operator techniques and approximation methods; atoms; the Born-Oppenheimer approximation; diatomic molecules; polyatomic molecules; and introduction to quantum chemical calculation. Usually offered every year.

Mr. Chan

CHEM 145b Special Topics in Chemistry

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Prerequisites: Undergraduate physical chemistry and some familiarity with simple differential equations.

Topics vary from year to year. Usually offered every third year. Last offered in the spring of 1994.

Staff

CHEM 150b Special Topics in Chemistry

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Signature of the instructor required.

Topics vary from year to year. The topic for 2000-01 is drug discovery research. Usually offered every third year. Last offered in the spring of 2000.

Mr. Petsko


(200 and above) Primarily for Graduate Students


CHEM 200d Advanced Chemistry Laboratory

Usually offered every year.

Staff

CHEM 220c Inorganic Chemistry Seminar

Required of graduate students in inorganic chemistry, who must audit this course each year. Usually offered every year.

Staff

CHEM 229b Special Topics in Inorganic Chemistry: Introduction to X-ray Structure Determination

Topics include basic diffraction and space group theory, practical manipulations of crystals and X-ray diffraction equipment, solving crystal structures, and interpretation of structural chemistry. Course will feature self-paced exercises on PCs. Usually offered every third year. Last offered in the spring of 2000.

Staff

CHEM 231c Organic Chemistry Seminar

Required of graduate students in organic chemistry, who must audit this course each year. Usually offered every year.

Staff

CHEM 232b Heterocyclic Chemistry

The nature of aromatic heterocycles will be surveyed, followed by detailed discussion of their characteristic reactions and modes of synthesis. The course is organized to show a general predictive framework behind the details. Emphasis is placed on the mechanisms of heterocycle reactions. Usually offered in odd years.

Staff

CHEM 234b Chemistry of Organometallic Compounds

The chemistry of organo-transition metal complexes, including their structures, chemical reactions, and use as reagents in organic synthesis. Usually offered every third year. Last offered in the fall of 1999.

Staff

CHEM 235b Advanced NMR Spectroscopy

A detailed discussion of modern NMR methods will be presented. The course is designed so as to be accessible to nonspecialists, but still provide a strong background in the theory and practice of modern NMR techniques. Topics include the theory of pulse and multidimensional NMR experiments, chemical shift, scalar and dipolar coupling, NOE, spin-operator formalism, heteronuclear and inverse-detection methods, Hartmann-Hahn and spin-locking experiments. Experimental considerations such as pulse sequence design, phase cycling, and gradient methods will be discussed. Guest lecturers will provide insight into particular topics such as solid-state NMR and NMR instrumental design. Usually offered in even years.

Mr. Pochapsky

CHEM 241c Physical Chemistry Seminar

Required of graduate students in physical chemistry, who must audit this course each year. Usually offered every year.

Staff

CHEM 243b Statistical Thermodynamics

Elementary statistical mechanics of ensembles of molecules and applications to thermodynamic systems. Usually offered every third year. Last offered in the spring of 1996.

Staff

CHEM 250c Chemical Physics Seminar

Required of graduate students in chemical physics, who must audit this course each year. Usually offered every year.

Staff


Research Courses

CHEM 404d Organic Chemistry

Synthesis of natural products; development of new synthetic reactions; computerization of synthesis design systematics.

Mr. Hendrickson

CHEM 405d Biochemistry

Structure and function proteins by X-ray crystallography, site-directed mutagenesis and molecular dynamics simulations; time-resolved studies of enzyme catalysis by Laue diffraction; and multi-drug resistance and the cystic fibrosis of gene product.

Mr. Petsko

CHEM 407d Biochemistry

Structural enzymology using a combination of kinetic, mutagenesis, and structural techniques, including low temperature and time-resolved diffraction methods.

Ms. Ringe

CHEM 408d Physical Chemistry

Experimental and theoretical study of chemical species in solution; and spectroscopic investigations of metal solutions in polar solvents.

Mr. Tuttle

CHEM 410d Biophysical Chemistry

Statistical thermodynamic modeling of long-range order in crowded self-assembling systems and NMR studies of functional molecular mechanisms in biological membranes.

Ms. Herzfeld

CHEM 413d Physical Chemistry

Membrane transport; electrostatic modeling of ion pores; molecular dynamics of ionic motion in biological molecules; theories of ionic solvation; and statistical mechanics of membranes.

Mr. Jordan

CHEM 414d Physical Chemistry

Kinetic studies of the reactions and properties of ions in the gas phase. Scientific analysis of works of art and its dissemination via the Web.

Mr. Henchman

CHEM 415d Physical Chemistry

Experimental and theoretical studies of oscillating chemical reactions and pattern formation in reaction diffusion systems; theoretical approaches to neurobiology and neural networks; mathematical modeling of biochemical kinetics.

Mr. Epstein

CHEM 416d Physical Chemistry

High-pressure effects on Jahn-Teller active molecules; dynamical processes in molecular crystals and one-dimensional aggregates; dynamics of quantum tunneling reactions.

Mr. Chan

CHEM 417d Organic Chemistry

Organic synthesis of strained rings and theoretically interesting molecules; synthetic methods; enclathration and host-guest complexation in tri-o-thymotide and calixarenes; plant medicinals; application of nuclear magnetic resonance spectroscopy to organic systems; photooxidation; thermal chemistry; laser chemistry.

Mr. Keehn

CHEM 418d Inorganic Chemistry

Synthesis of organic and metal-organic compounds for photonic and electronic applications. Spectroscopic investigations of novel photonic materials. Organometallic complexes in homogeneous catalysis. Molecular self-assembly.

Mr. Lin

CHEM 419d Inorganic Chemistry

X-ray structure determination; coordination polymers; chemical, physical, and crystallographic studies of solid-state reactions; automatic solution of crystal structures using novel computer techniques.

Mr. Foxman

CHEM 421d Organic Chemistry

Synthetic methodology and natural product synthesis, carbon-carbon bond forming reactions of alkenes and their application to natural product synthesis, intramolecular reactions, oxidative free-radical cyclizations, ketene cycloadditions, ene and Prins reactions, and synthesis of biologically active natural products.

Mr. Snider

CHEM 423d Organic Chemistry

Multimolecular complexes; amino acid residue side-chain interactions in peptides and proteins; and globular protein stability and protein structure by multidimensional and multinuclear NMR methods.

Mr. Pochapsky

CHEM 424d Organic Chemistry

Catalytic enantioselective reactions and their applications in asymmetric synthesis. New strategies for the design and discovery of selective catalysts. Chiral recognition. Synthetic probes for the elucidation of protein functions in biological processes involving enzymatic DNA modifications and protein-DNA interaction.

Mr. Deng

Chemistry Colloquium

Lectures by faculty and invited speakers. Required of all graduate students. Noncredit.


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