The design of the Center, with its open floor plan, shared resources and assembled faculty of diverse expertise and perspectives, creates an interactive atmosphere that encourages collaborative and innovative research.
The Rosenstiel Basic Medical Sciences Research Center was founded in 1970, seeded by a generous endowment from Lewis S. Rosenstiel.
In particular, the Center has a rich history in developing cutting-edge imaging technologies to study molecular structure and dynamics both in vitro and in vivo at resolutions ranging from the micron to the sub-nanometer level.
Areas of expertise include single-particle cryo-electron microscopy, cryo-electron tomography (ET), correlative light and electron microscopy (CLEM), super-resolution fluorescent cryo-microscopy, total internal reflection fluorescence (TIRF) microscopy, multi-wavelength live-cell imaging, X-ray crystallography and NMR spectroscopy.
Other advanced technologies employed include subcellular proteome mapping, using mass-spectrometry microscopy to locate and compare the identity of components in normal and diseased cells, and deep genome sequencing and bioinformatics to identify master regulatory gene networks that govern disease.
Through the development and integration of these approaches, researchers in the Center are defining the subcellular components, structures and mechanisms that underlie disease onset and progression.