Isaac Krauss

Professor of Chemistry

Departments/Programs

Chemistry

Degrees

Columbia University, Ph.D.
Columbia University, M.Phil.
Columbia University, M.A.
Stanford University, B.A.

Expertise

Organic Synthesis, Chemical Biology, Glycobiology, Vaccines, Transition-metal-catalyzed reactions

Profile

B.A., Stanford University, 1998
Ph. D. Columbia University, 2003
Post-Doc, Memorial Sloan-Kettering Cancer 2003-2008
NIH NRSA Postdoctoral Fellow, 2005-2007

Assistant Professor, Brandeis University, 2008
Associate Professor, Brandeis University, 2015
Professor, Brandeis University, 2020

Courses Taught

CBIO	102a	Chemical Innovation Feeding Biological Discovery
CHEM	91g	Introduction to Research Practice
CHEM	135a	Advanced Organic Chemistry: Modern Catalytic Reactions in Organic Synthesis
CHEM	230b	Organic Chemistry and Chemical Biology Seminar

Awards and Honors

Welcome-Sigma Xi Distinguished Lectureship (2017-2019) (2016)

Strage Award (2015)

Walzer Award for Teaching (2015)

NSF CAREER AWARD (2013)

Thieme Chemistry Journal Award (2013)

Scholarship

Neralkar, Mahesh; Tian, Leiming; Krauss, Isaac. "Synthesis of mannosidase-stable Man3 and Man4 glycans containing S-linked Mana1→2Man termini." Organic Letters (accepted). (2021). (forthcoming)

Polyak, D.; Xu, B; Krauss, I. J.. "Homoallylation of aldehydes with α- and γ-susbtituted cyclopropylcarbinylboronates." (2021). (forthcoming)

Redman, Richard; Krauss, Isaac. "Directed evolution of 2’-fluoro-modified, RNA-supported carbohydrate clusters that bind tightly to HIV antibody 2G12." Journal of the American Chemical Society (submitted). (2021). (forthcoming)

Matos, J. O.; Kumar, R. P.; Ma, A. C.; Patterson, M.; Krauss, I. J.; Oprian, D. D.. "The Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase." Biochemistry 59. 35 (2020): 3271–3283.

Nguyen, D. N.; Redman, R. L.; Horiya, S.; Bailey, J. K.; Xu, B.; Stanfield, R. L.; Temme, S. J.; LaBranche, C. C.; Wang, S.; Rodal, A. A.; Montefiori, D. C.; Wilson, I. A.; Krauss, I. J.. "The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans." ACS Chemical Biology 15. (2020): 789-798.

Morehouse, B. R.; Kumar, R. P.; Matos, J. O.; Yu, Q.; Bannister, A.; Malik, K.; Temme, J. S.; Krauss, I. J.; Oprian, D. D.. "Direct evidence for an enzyme generated LPP intermediate in (+)-limonene synthase using a fluorinated GPP substrate analog.." ACS Chemical Biology 14. (2019): 2035-2043.

Nguyen, D. N.; Xu, B.; Stanfield, R. L.; Bailey, J. K.; Horiya, S.; Temme, S. J.; Leon, D. R.; LaBranche, C. C.; Montefiori, D. C.; Costello, C. E.; Wilson, I. A.; Krauss, I. J. "Oligomannose glycopeptide conjugates elicit antibodies targeting the glycan core rather than its extremeties." ACS Central Science 5. (2019): 237-249.

Kumar, R. P.; Morehouse, B. R.; Matos, J. O.; Malik, K.; Lin, H.; Krauss, I. J.; Oprian, D. D.. "Structural Characterization of Early Michaelis Complexes in the Reaction Catalyzed by (+)-Limonene Synthase from Citrus sinensis using Fluorinated Substrate Analogs." Biochemistry (2018).

Tian, L.; Krauss I. J.. "Stereoselective Homocrotylation of Aldehydes: Enantioselective Synthesis of Allylic-Substituted Z/E-Alkenes." Organic Letters 20. (2018): 6730-6735.

MacPherson, I. S.; Temme, J. S.; Krauss, I. J.. "DNA Display of Folded RNA Libraries: Removing the Reverse Transcription Step from RNA Selection." Chemical Communications 53. (2017): 2878-2881.

Bailey, J.; Nguyen, D. N.; Horiya, S; Krauss, I. J.. "Synthesis of Multivalent Glycopeptide Conjugates that Mimic an HIV Epitope." Tetrahedron 72. 40 (2016): 6091-6098.

Krauss, Isaac J.. "Antibody Recognition of HIV and Dengue Glycoproteins." Glycobiology (2016): doi: 10.1093/glycob/cww031.

Krauss, Isaac J.. "SELMA: Selection with Modified Aptamers." Curr. Protoc. Chem. Biol. 7. (2015): 73-92.

Lin, H. K.; Tian, L.; Krauss, I. J.. "Enantioselective syn and anti Homocrotylation of Aldehydes: Application to the Formal Synthesis of Spongidepsin." Journal of the American Chemical Society 137. 40 (2015): 13176-13182.

Horiya, S.; Bailey, J. K.; Temme, S. J.; Guillen-Schlippe, Y. V.; Krauss, I. J.. "Directed Evolution of Multivalent Glycopeptides Tightly Recognized by HIV Antibody 2G12." J. Am. Chem. Soc. 136. 14 (2014): 5407-5415.

Krauss, Isaac J.. "Dugas, G. J.; Lam, Y.-H.; Houk, K. N.; Krauss, I. J.." J. Org. Chem. 79. 10 (2014): 4277-4284.

Krauss, Isaac J.. "Recent Strategies Targeting HIV Glycans in Vaccine Design." Nature Chemical Biology 10. (2014): 990-999.

Temme, S. J.; MacPherson, I. S.; DeCourcey, J. F.; Krauss, I. J.. "High Temperature SELMA: Evolution of DNA-Supported Oligomannose Clusters Which Are Tightly Recognized by HIV bnAb 2G12." J. Am. Chem. Soc 136. 5 (2014): 1726-1729.

Lin, Hongkun; Pei, Wenbo; Wang, Hao; Houk, Kendall N.; Krauss, Isaac J.. "Enantioselective Homocrotylation of Aliphatic Aldehydes." Journal of the American Chemical Society 135. (2013): 82-85.

Temme, J. S.; Drzyzga, M.; MacPherson, I. S.; Krauss, I. J.. "Directed Evolution of 2G12-Targeted Nanamannose Glycoclusters by SELMA." Chem. - Eur. J. 19. 51 (2013): 17291-17295.

Lin, Hongkun; Pochapsky, Susan S.; Krauss, Isaac J.. "A Short Asymmetric Route to the Bromophycolide A and D Skeleton." Organic Letters 13. 5 (2011): 1222-1225.

MacPherson, I. S.; Temme, J. S.; Habeshian, S.; Felczak, K.; Pankiewicz, K.; Hedstrom, L.; Krauss, I. J.. "Multivalent Glycocluster Design Through Directed Evolution." Angew. Chem. Int. Ed. 50. 47 (2011): 11238–11242.

Wenbo Pei and Isaac J. Krauss. "Homoallylboration and Homocrotylboration of Aldehydes." J. Am. Chem. Soc. 133. 46 (2011): 18514–18517.

Lin, Hongkun and Krauss, Isaac J.. Studies Toward the Synthesis of Bromophycolides. Proc. of 240th ACS National Meeting. Boston: 2010.

Liu, Guixia and Krauss, Isaac J.. Insertion Reactions of Titanacyclobutanes. Proc. of 240th National ACS Meeting. Boston: 2010.

Nagorny, Pavel; Krauss, Isaac; Njardarson, Jon T.; Perez, L.; Gaul, Christoph; Yang, Guangli; Ouerfelli, Ouathek; Danishefsky, Samuel J.. "Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims." Tetrahedron Letters 51. 30 (2010): 3873-3875.

Thordur Oskarsson, Pavel Nagorny, Isaac J. Krauss, Lucy Perez, Mihirbaran Mandal, Guangli Yang, Ouathek Ouerfelli, Danhua Xiao, Malcolm A. S. Moore, Joan Massagu and Samuel J. Danishefsky. "Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog." J. Am. Chem. Soc. 132. 9 (2010): 3224-8.

Jeon, I.; Lee, D.; Krauss, I. J.; Danishefsky, S. J.. "A New Model for the Presentation of Tumor–Associated Antigens and the Quest for an Anticancer Vaccine: A Solution to the Synthesis Challenge via RCM." J. Am. Chem. Soc. 131. 40 (2009): 14337-44.

Yuan Gao, Yi Kuang, Zu-Feng Guo, Zhihong Guo, Isaac J. Krauss and Bing Xu. "Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative." J. Am. Chem. Soc. 131. 38 (2009): 13576-7.

Gao, Y.; Kuang, Y.; Guo, Z-F.; Guo, Z.; Krauss, I. J.; Xu, Bing. "Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative." J. Am. Chem. Soc. 131. 38 (2008): 13576-13577.