Barry B Snider
Degrees
Harvard University, Ph.D.University of Michigan, B.S.
Expertise
Development of new synthetic methods. Mechanisms of synthetically important reactions. Total synthesis of natural products.Profile
I work on the development of new methods for the contruction of highly functionalized organic molecules and the synthesis of natural products, which often have useful drug-like activity but are often not available in sufficient quantity from the plants and animals that produce them. A large number of the drugs currently in use, including the statins, most antibiotics and many cancer drugs are either natural products or derived from them. Thus this chemistyr is closely related to work that is done in the pharmaceutical industry.Courses Taught
| BCBP | 297b | Master's Lab Research II |
| CHEM | 49a | Advanced Laboratory: Organic Chemistry |
| CHEM | 132b | Advanced Organic Chemistry: Spectroscopy |
| CHEM | 134b | Advanced Organic Chemistry: Synthesis |
| CHEM | 137b | The Chemistry of Organic Natural Products |
| CHEM | 220b | Inorganic Chemistry Seminar |
| CHEM | 230b | Organic Chemistry Seminar |
Awards and Honors
Treasurer, Division of Organic Chemistry of the American Chemical Society (2017)
Member of the Editorial Advisory Board of the The Journal of Organic Chemistry (2014 - 2017)
Secretary-Treasurer, Division of Organic Chemistry of the American Chemical Society (2014 - 2016)
Fellow the American Chemical Society (2011)
Past Chair of the Division of Organic Chemistry of the American Chemical Society (2008)
Chair of the Divison of Organic Chemistry of the American Chemical Society (2007)
Honorary Profess East China University of Science and Technology (2006)
Chair-Elect of the Division of Organic Chemistry, American Chemical Society (2005)
Boehringer Ingelheim Distinguished Lecturer at the Universite de Sherbrooke (2004)
Fellowship, Japan Society for the Promotion of Science (1999)
Arthur C. Cope Scholar Award, American Chemical Society (1995)
Chair, National Institutes of Health Medicinal Chemistry Study Section (1995 - 1997)
Medicinal Chemistry Study Section, Division of Research Grants (1992 - 1995)
Dreyfus Teacher-Scholar Grant (1982 - 1987)
Sloan Fellow (1979 - 1983)
Dupont Young Faculty Grant (1977)
Upjohn Young Faculty Grant (1976 - 1977)
National Institutes of Health Postdoctoral Fellow (1975)
National Science Foundation Predoctoral Fellow (1970 - 1973)
Scholarship
Snider, Barry B. and Grabowski, J. F.. "Synthesis of (+/-)-cartorimine." Tetrahedron Letters (2005): 823-825.
Snider, Barry B. and Zhou, J.. "Synthesis of Lanopylin B1." Journal of Organic Chemistry (2005).
Snider, Barry B.. "Synthesis of (±)-cartorimine." Tetrahedron Letters (2005).
Snider, Barry B.. "Synthesis of 2,3-Dihydro-hydroxy-2-hydroxylalkybenzofurans from Epoxy Aldehdes. One -step Syntheses of Brosimacutin G, Vaginidiol, Vaginol, Smyrindiol, Xanthoarnol, and Aviencol A. Biommimetic Syntheses of Angelicin and Psoralen." Journal of Organic Chemistry (2005).
Snider,Barry B., Zou, Y. and Lobera, M.. "Synthesis of 2,3-Dihydro-3-hydroxy-2-hydroxylalkylbenzofurans from Epoxy Aldehydes. One-step Syntheses of Brosimacutin G, Vaginidiol, Vaginol, Smyrindiol, Xanthoarnol, and Avicenol A. Biomimetic Syntheses of Angelicin and Psoralen." Journal of Organic Chemistry (2005): in press.
Snider, Barry B. and Che, Q.. "Synthesis of cladobotryal, CJ16,169 and CJ16,170." Organic Letters 6. (2004): 2877-2880.
Snider, Barry B. and Duvall, J. R.. "Termination of Mn(III)-Based Oxidative Cyclizations by Trapping with Azide." Organic Letters 6. (2004): 1265-1268.
Snider, Barry B. and Gao, X.. "Syntheses of (-)-TAN-2483A, (-)-Massarilactone B, and the Fusidilactone B Ring System. Revision of the Structures of and Syntheses of (±)-Waol A (FD-211) and (±)-Waol B (FD-212)." Journal of Organic Chemistry 69. (2004): 5517-5527.
Snider, Barry B. and Lobera, M.. "Synthesis of the tetracyclic core of the bisabosquals." Tetrahedron Lett 45. (2004): 5015-5018.
Snider, Barry B. and Neubert, B. J.. "A Novel Biomimetic Route to the 3-Acyl-5-hydroxy-3-pyrrolin-2-one and 3-Acyl-3,4-epoxy-5-hydroxy-pyrrolidin-2-one Ring Systems." Journal of Organic Chemistry 69. (2004): 8952-8955.
Snider, Barry B., Duvall, J. R., Sattler, I., Huang, X. "Synthesis of a piperidone model compound and revision of the structures of jenamidines A to C." Tetrahedron Letters 45. (2004): 6725-2727.
Snider, Barry B.. "Manganese(III)-Based Oxidative Free-Radical Cyclizations." Transition Metals for Organic Synthesis. Second Edition M. Beller, C. Bolm, Eds: Wiley-VCH; Weinheim: Volume 1. (2004): 483-490.
Snider, Barry B.. "Oxidative Addition of Chloro-and Dichloroacetic Acid to Alkenes to Give alpha-Chloro anbd alpha, alpha-Dichlorobutyrolactones with Manganese (III,") Acetate." Heterocycles (2004).
Snider, Barry B.. "Termination of Mn(III,""");; Based Oxidative Cyclizations by Trapping with Azide." Organic Letters (2004).
Snider, Barry B.. "Total Synthesis of Cylindrospermopsin." Strategies and Tactics In Organic Synthesis, vol. 4 M. Harmata, Ed: Elsevier, NY:. (2004): 19-40.
Snider,Barry B and Che, Q. "Oxidative Addition of Chloro- and Dichloroacetic Acid to Alkenes to Give alpha-Chloro- and alpha,alpha-Dichlorobutyrolactones with Manganese(III) Acetate." Heterocycles 64. (2004): 325-332.
Snider,Barry B. "Syntheses of (-,");;-TAN-2483A (-,");;-Massarilactone B, and the Fusidilactone B Ring System. Revision of the Sturctures of and Syntheses of (=/-,");;-Waol A (FD-211,");; and (=/-,');;-Waol B (FD-212-,'''),,." (2004).
Snider,Barry B. "Synthesis of a piperidone model compound and revision to the structure of jenamidines A to C." (2004).
Snider,Barry B. "Synthesis of cladobotryal, CJI16, 169 and CJ16." (2004): 170.
Snider,Barry B. Analogs of 1-phosphonooxy-2,2-dihydroxy-3-0xo-5 (methylthio,"");;;-pentane, acyclic intermdiate in the methioneine salvage pathway: a new preparation and charcterizaton of activity with E1 enolase/phosphatase from Klebsiella oxytoca. Bioorganic and Medicinal Chemistyr, 2004.
Zhang, Y.; Heinsen, M. H.; Kostic, M.; Pagani, G. M.; Riera, T. V.; Perovic, I.; Hedrstom, L.; Snider, Barry. B.; Pochapsky, T. C.. "Analogs of 1-phosphonooxy-2,2-dihydroxy-3-oxo-5-(methylthio)-pentane, an acyclic intermediate in the methionine salvage pathway: a new preparation and charcterization of activity with E1 enolase/phosphatase from Klebsiella oxytoca." Bioorganic and Medicinal Chemistry 12. (2004): 3847-3855.
Snider, Barry B. and Zeng, H.. "Amine-Induced Rearrangement Of 4-Imino-4H-3,1-Benzoxazines To 4-Quinazolinones Via Amidine Carboxamides." Heterocycles 61. (2003): 173-182.
Snider, Barry B. and Duvall, J. R.. "Synthesis of the 4-Methyl-1,2-oxazetidine-4-carboxylic Acid Moiety of the Originally Proposed Halipeptin A and B Structures." Tetrahedron Letters 44. (2003): 3067-3070.
Snider, Barry B. and Gu, Y.. "Synthesis of ent-Haterumalide NA (ent-Oocydin A) Methyl Ester." Organic Letters 5. (2003): 4385-4388.
Snider, Barry B. and Neubert, B. J.. "Synthesis of (±)-Phloeodictine A1." Organic Letters 5. (2003): 765-768.
Snider, Barry B. and Zeng, H.. "Total Syntheses of (-)-Fumiquinazolines A, B, C, E, H, and I. Approaches to the Synthesis of Fiscalin A." Journal of Organic Chemistry 68. (2003): 545-563.
Snider, Barry B., Gao, X. and Nakadai, M.. "Synthesis of (-)-TAN-2483A. Revision of the Structures of and Syntheses of (±)-FD-211 (Waol A) and (±)-FD-212 (Waol B)." Organic Letters 5. (2003): 451-454.
Snider,Barry B., Ghavami, A., Sadalapure, K. S., Johnston, B. D.. "Improved Syntheses of the Naturally Occurring Glycosidase Inhibitor Salacinol." Synlett (2003): 1259-12662.
Snider,Barry B., Lobera, M. and Marien, T. P. "Stereocontrol in the EtAlCl2-Induced Cyclization of Chiral gamma,delta-Unsaturated Methyl Ketones to Form Cyclopentanones." Journal of Organic Chemistry 68. (2003): 6451-6454.
Snider,Barry B., Shi, B. and Hawryluk, N. A.. "Formal Synthesis of (±)-Guanacastepene." Journal of Organic Chemistry 68. (2003): 1030-1042.