Shantanu Jadhav
Degrees
University of California, San Diego, Ph.D.Indian Institute of Technology, Bombay, B.Sc.
Expertise
Neural basis of learning, memory and decision making in the mammalian brain.Profile
Our research aims to understand the neural basis of memory and cognition. My lab employs a systems neuroscience approach in rodent models, in both health and disease, to investigate distributed brain networks necessary for the ability to learn, remember and make decisions. We use a combination of techniques, including behavior, simultaneous high-density electrophysiological recordings in multiple brain regions, and novel methods for real-time detection and perturbation of neural activity during behavior. We have used these experimental and computational tools to make several seminal contributions, and discovered novel coordination mechanisms in limbic – cortical networks with a role in learning and memory-guided behavior.http://www.bio.brandeis.edu/jadhavlab/index.html
Courses Taught
| BIOL | 91g | Introduction to Research Practice |
| NBIO | 145b | Systems Neuroscience |
| NBIO | 207a | Advanced Topics in Data Analysis |
| NEUR | 91g | Introduction to Research Practice |
| NPSY | 139a | Memory and the Brain |
Awards and Honors
RO1 Grant, National Institute of Health (2019 - 2024)
Smith Family Foundation Odyssey Award (2019 - 2021)
RO1 grant, National Institute of Mental Health (2017 - 2022)
Whitehall Foundation Award (2016 - 2020)
2015 Alfred P. Sloan Research Fellowship in Neuroscience (2015 - 2017)
2015 NARSAD Young Investigator Award, Brain and Behavior Foundation (2015 - 2018)
K99/R00 Career Transition Grant, National Institute of Mental Health, NIH (2013 - 2017)
Peter and Patricia Gruber International Research Award (2013)
Scholarship
Symanski CA, Bladon JH, Kullberg ET, Jadhav SP. "Rhythmic coordination of hippocampal-prefrontal ensembles for odor-place associative memory and decision making." bioRxiv (Preprint) https://doi.org/10.1101/2020.06.08.140939. 1 (2021)
Tang W, Shin JD, Jadhav, SP. "Multiple time-scales of decision-making in the hippocampus and prefrontal cortex." eLife 10. 1 (2021): e66227.
Herzog LE, Katz DB, Jadhav SP. "Refinement and reactivation of a taste-responsive hippocampal network." Current Biology 30. 1 (2020): 1-6.
Jadhav, Shantanu. "Hippocampal-prefrontal replay supports spatial learning and memory-guided behavior." Winter Conference on Neurobiology of Learning and Memory. Park City, Utah. 11 Jan 2020.
Zielinski MC, Tang W, Jadhav SP. "The role of replay and theta sequences in mediating hippocampal-prefrontal interactions for memory and cognition." Hippocampus 30. 1 (2020): 60-72.
Herzog LE, Pascual LM, Scott SJ, Mathieson ER, Katz DB, Jadhav SP. "Interaction of taste and place coding in the hippocampus." Journal of Neuroscience 39. 16 (2019): 3057-3069.
Jadhav, Shantanu. "Hippocampal-prefrontal ensemble mechanisms for memory-guided behavior." Yale University School of Medicine. Yale University, New Haven, CT. May 12, 2019.
Jadhav, Shantanu. "Hippocampal-prefrontal interactions underlying memory-guided behavior." Winter Conference on the Neurobiology of Learning and Memory. Park City, Utah. 06 Jan 2019.
Jadhav, Shantanu. "Hippocampal-prefrontal replay supports retrospective and prospective evaluation for spatial learning and planning." Spring Hippocampal Research Conference. Taormina, Italy. 05 June 2019.
Jadhav, Shantanu. "Navigation and Place." Bridging the Two Cultures. Brandeis University. 21 November 2019.
Jadhav, Shantanu. "Neural ensemble mechanisms for learning and memory-guided behavior." Wellesley College Neuroscience Program. Wellesley MA. 03 December 2019.
Shin JD, Tang W, Jadhav SP. "Dynamics of awake hippocampal-prefrontal replay for spatial learning and memory-guided decision making." Neuron 104. 6 (2019): 1110-1125.
Shin JD, Tang W, Jadhav SP. Development of coordinated representations in the hippocampal-prefrontal network during spatial learning. Proc. of Society for Neuroscience 2019. Chicago, USA: SFN, 2019.
Shin JD, Tang W, Jadhav SP. Ontogeny of representations in hippocampal-prefrontal networks for spatial learning (Best Poster Award). Proc. of Conference on Learning and Memory. University of Texas at Austin, Austin, TX: UT Austin, 2019.
Symanski CA, Kullberg E, Jadhav SP. Odor-place associative memory in the hippocampal-prefrontal network. Proc. of Society for Neuroscience 2019. Chicago, USA: SFN, 2019.
Tang W, Shin JD, Jadhav SP. Dynamics of awake hippocampal-prefrontal replay for spatial learning and memory-guided decision making. Proc. of Society for Neuroscience 2019. Chicago, USA: SFN, 2019.
Tang W, Shin, JD, Jadhav SP. Hippocampal-prefrontal replay mediates retrospection and prospection for spatial choice learning. Proc. of Conference on Learning and Memory. University of Texas at Austin, Austin, TX: UT Austin, 2019.
Zielinski MC, Shin JD, Jadhav SP. "Coherent coding of spatial position mediated by theta oscillations in hippocampus and prefrontal cortex." Journal of Neuroscience 39. 23 (2019): 4550-4565.
Herzog LE, Pascual L, Katz DB and Jadhav SP. Interaction of taste and place coding in the hippocampus. Proc. of Society for Neuroscience. San Diego, CA: SFN, 2018.
Jadhav, Shantanu. "Hippocampal-prefrontal ensemble mechanisms for memory-guided behavior." Rice University/ Baylor College of Medicine. Rice University, Houston, TX. 08 Jan 2018.
Jadhav, Shantanu. "Hippocampal-prefrontal interactions underlying memory-guided behavior." International Conference on Learning & Memory. UC Irvine, CA. 18 April 2018.
Jadhav, Shantanu. "Neural ensemble mechanisms for memory-guided behavior." Indian Institute of Science Education and Research. IISER, Pune, India. 13 Feb 2018.
Maharjan DM, Glantz EH, Dai Y, Jadhav SP. "Disruption of dorsal hippocampal-prefrontal interactions using chemogenetic inactivation impairs spatial learning." Neurobiology of Learning and Memory 155. 1 (2018): 351-360.
Nanu R, Lin C, Katz DB, Jadhav SP, Pi H and Lisman J. Investigating thalamic contributions to abnormal hippocampal oscillatory activity in a mouse model of schizophrenia. Proc. of Society for Neuroscience (SFN). San Diego, CA: SFN, 2018.
Shin JD, Tang W and Jadhav SP. Development of hippocampal-prefrontal representations in parallel with behavioral learning. Proc. of Society for Neuroscience. San Diego, CA: SFN, 2018.
Symanski CA, Kulberg E and Jadhav SP. Odor-place associative memory in the hippocampal-prefrontal network. Proc. of Society for Neuroscience. San Diego, CA: SFN, 2018.
Tang W, Jadhav SP. "Conducting the neural symphony of memory replay." Neuron 100. 5 (2018): 1016-1019.
Tang W, Jadhav SP. "Sharp-wave ripples as a signature of hippocampal-prefrontal reactivation for memory during sleep and waking states." Neurobiology of Learning and Memory doi: https://doi.org/10.1016/j.nlm.2018.01.002. 1 (2018): 1:10.
Tang W, Shin JD and Jadhav SP. Learning-associated changes in awake replay content in the hippocampal-prefrontal network. Proc. of Society for Neuroscience. San Diego, CA: SFN, 2018.
Young RY, Shin JD and Jadhav SP. Dual phase-locking in the hippocampal-prefrontal network. Proc. of Society for Neuroscience. San Diego, CA: SFN, 2018.
Zielinski MC, Shin JD and Jadhav SP. Hippocampal theta supports distinct prefrontal representations on a behavioral timescale. Proc. of Society for Neuroscience. San Diego, CA: SFN, 2018.
Jadhav, Shantanu. "Hippocampal-prefrontal ensemble mechanisms for memory-guided behavior." Heidelberg Neuronal Ensemble Meeting. University of Heidelberg, Germany. 15 Sep 2017.
Jadhav, Shantanu. "Hippocampal-prefrontal ensemble mechanisms for memory-guided behavior." Max Planck Institute for Brain Research. MPI, Frankfurt, Germany. 18 Sep 2017.
Jadhav, Shantanu. "Hippocampal-prefrontal reactivation during behavior and sleep." Spring Hippocampal Research Conference. Sicily, Italy. 16 June 2017.
Tang W, Shin JD, Frank LM and Jadhav SP. Coordination in the hippocampal-prefrontal network during awake and sleep sharp wave ripple events. Proc. of Computational and Systems Neuroscience (Cosyne) Meeting. Salt Lake City, UT: COSYNE, 2017.
Tang W, Shin JD, Frank LM, Jadhav SP. "Hippocampal-prefrontal reactivation during learning is stronger in awake compared with sleep states." Journal of Neuroscience 37. 49 (2017): 11789-11805.
Tang W, Shin JD, Frank LM, Jadhav SP. Hippocampal-prefrontal reactivation during awake and sleep sharp-wave ripple events. Proc. of Society for Neuroscience. Washington DC: SFN, 2017.
Jadhav, Shantanu, Rothschild G, Roumis DK, Frank LM. "Coordinated Excitation and Inhibition of Prefrontal Ensembles during Awake Hippocampal Sharp-Wave Ripple Events." Neuron 90. (2016): 1-15.
Maharjan DM, Glantz EH, Dai Y, Jadhav SP. Contralateral inactivation of the dorsal hippocampus and prefrontal cortex using Dreadds impairs spatial learning. Proc. of Society for Neuroscience. San Diego, CA: Society for Neuroscience, 2016.
Papale AE, Zielinski MC, Frank, LM, Jadhav SP, Redish AD. "Interplay between hippocampal sharp-wave ripple events and vicarious trial and error behaviors in decision making." Neuron 92. 5 (2016): 975-982.
Shin JD and Jadhav SP. "Multiple modes of hippocampal-prefrontal interactions in memory-guided behavior." Current Opinion in Neurobiology 40. 1 (2016): 161-169.
Zielinski MC, Papale AE, Redish AD, Frank LM, Jadhav SP. Disrupting awake sharp-wave ripples increases vicarious trial and error behavior. Proc. of Society for Neuroscience. Chicago: SFN, 2015.
Jadhav SP, Frank LM. "Memory replay in the hippocampus." Time, Space and Memory in the Hippocamal Formation. Ed. D. Derdikman; J. Knierim. Springer, 2014
Felix SH, Shah KG, Tolosa VM, Sheth HJ, Tooker AC, Delima TL, Jadhav SP, Frank LM, Pannu SS. "Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive." Journal of Visualized Experiments 79. 1 (2013): e50609.
Jadhav SP; Kemere C; German PW, Frank LM. "Awake hippocampal sharp-wave ripples support spatial memory." Science 336. 6087 (2012): 1454-1458.
Carr MF*, Jadhav SP*, Frank LM. "Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval." Nature Neuroscience 14. 2 (2011): 147-153.
Morita T, Kang H, Wolfe J, Jadhav SP, Feldman DE. "Psychometric curve and behavioral strategies for whisker-based texture discrimination in rats." PLoS One 6. 6 (2011): e20437.
Jadhav SP, Feldman DE. "Texture coding in the whisker system." Current Opinion in Neurobiology 20. 1 (2010): 1-6.
Jadhav SP, Wolfe J, Feldman DE. "Sparse temporal coding of elementary tactile features during active whisker sensation." Nature Neuroscience 12. 6 (2009): 792-800.
Li L, Bender KJ, Drew PJ, Jadhav SP, Sylwestrak E, Feldman DE. "Endocannabinoid signaling is required for development and critical period plasticity of the whisker map in somatosensory cortex." Neuron 64. 4 (2009): 537-549.
Vyas A*, Jadhav S*, Chattarji S. "Prolonged chronic stress induces amygdaloid neuronal hypertrophy and enhanced anxiety-like behavior." Neuroscience 143. 2 (2006): 387-393.
Gabernet L, Jadhav SP, Feldman DE, Carandini M, Scanziani M. "Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition." Neuron 48. 2 (2005): 315-327.
Mitra R, Jadhav S, McEwen BS, Vyas A, Chattarji S. "Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala." PNAS 102. 26 (2005): 9371-9376.