Ruibao Ren

Professor of Biology

Departments/Programs

Biology
Rosenstiel Basic Medical Sciences Research Center

Degrees

Columbia University, Ph.D.
Beijing Medical University, M.D.
Beijing Medical University, M.M.

Expertise

Signal transduction and transcription regulation in the development of blood cells and leukemia.

Profile

Ruibao Ren received his M.D. in 1983 from Beijing Medical University and Ph.D. in 1992 from the Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, USA. As a student, he studied transgenic mice that expressed the human poliovirus receptor ¿ a model for human poliomyelitis. He did his postdoctoral training in the laboratory of David Baltimore at The Rockefeller University, where he discovered that SH3 domains mediate protein¿protein interactions by binding to small, linear, proline-rich motifs. He joined the faculty of the Department of Biology, Brandeis University in 1994 and is currently an associate professor. There, he has generated mouse models for human chronic myelogenous leukemia, chronic myelomonocytic leukemia and acute myelogenous leukemia. Using these models he has dissected the molecular mechanism of myelogenous leukemia and develop/test therapies. He has received Junior Faculty Awards from American Cancer Society and March of Dimes, Basil O¿Connor as well as The Leukemia and Lymphoma Society Scholar Award. He is currently a member of Hematopoiesis Study Section, NIH, The Leukemia and Lymphoma Society Career Development Program Subcommittee, and Integration Panel of Chronic Myelogenous Leukemia Research Program, of the Department of Defense Congressionally Directed Medical Research Programs.

Over the years Ruibao Ren has developed and teaches in alternating years of "Growth Control and Cancer" and "Stem Cell" courses.

Awards and Honors

American Cancer Society Research Scholar (2003)

Leukemia and Lymphoma Society Scholar Award (2001)

Leukemia Society of America Scholar Award (1998 - 2003)

Cancer Research Institute Postdoctoral Fellowship (1992 - 1993)

Dean's Award for excellence in research, Columbia University (1992)

Irvinton Institute Postdoctoral Fellowship (declined) (1992)

Scholarship

Wang, Y.Y., L.J. Zhao, C.F. Wu, P. Liu, L. Shi, Y. Liang, S.M. Xiong, J.Q. Mi, Z. Chen, R. Ren (co-corresponding author), S.J. Chen.. "C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice.." Proc. Natl. Acad. Sci. USA. 108. (2011): 2450-5.

Cuiffo, B., Ren, R.. "Palmitoylation of oncogenic NRAS is essential for leukemogenesis." Blood 115. (2010): 3598-605.

Cuiffo, B., Ren, R.. "Palmitoylation of oncogenic NRAS is essential for leukemogenesis." Blood Epub. (2010).

Jo, S., J. Schatz, J. Acquaviva, H. Singh and R. Ren.. "Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis.." Blood. 116. (2010): 2759-67..

Jagani, Z., Song, K., Kutok, J. L., Dewar, M. R., Melet, A., Santos, T., Grassian, A., Ghaffari, S., Wu, C., Yeckes-Rodin, H., Ren, R., Miller, K., Khosravi-Far, R.. "Proteasome inhibition causes regression of leukemia and abrogates BCR-ABL-induced evasion of apoptosis in part through regulation of forkhead tumor suppressors." Cancer Res 69. 16 (2009): 6546-55.

Acquaviva, J., Chen, X., Ren, R.. "IRF-4 functions as a tumor suppressor in early B-cell development." Blood 112. 9 (2008): 3798-806.

Baum, K. J., Ren, R.. "Effect of Ras Inhibition in Hematopoiesis and BCR/ABL Leukemogenesis." J Hematol Oncol 1. (2008): 5.

Parikh, C., Ren, R.. "Mouse model for NRAS-induced leukemogenesis." Methods Enzymol 439. (2008): 15-24.

Zhang, S. J., Ma, L. Y., Huang, Q. H., Li, G., Gu, B. W., Gao, X. D., Shi, J. Y., Wang, Y. Y., Gao, L., Cai, X., Ren, R. B., Zhu, J., Chen, Z., Chen, S. J.. "Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia." Proc Natl Acad Sci U S A 105. 6 (2008): 2076-81.

Zhang, S. J., Ma, L. Y., Huang, Q. H., Li, G., Gu, B. W., Gao, X. D., Shi, J. Y., Wang, Y. Y., Gao, L., Cai, X., Ren, R. B., Zhu, J., Chen, Z., Chen, S. J.. "Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia." Proc Natl Acad Sci U S A 105. 6 (2008): 2076-81.

Parikh, C., Subrahmanyam, R., Ren, R.. "Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice." Cancer Res 67. 15 (2007): 7139-46.

Yan, M., Luo, J.K., Ritchie, K.J., Sakai, I., Takeuchi, K., Ren, R., Zhang, D.E.. "Ubp43 regulates BCR-ABL leukemogenesis via the Type I interferon receptor signaling.." Blood 110. (2007): 305-312.

Cuiffo, B., Ren, R.. "Models of hematopoietic malignancies: chronic myeloid leukemia.." Drug Discovery Today 3. (2006): 183-189.

Parikh, C., Subrahmanyam, R., Ren, R.. "Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice." Blood 108. 7 (2006): 2349-57.

Shackelford, D., Kenific, C., Blusztajn, A., Waxman, S., Ren, R.. "Targeted degradation of the AML1/MDS1/EVI1 oncoprotein by arsenic trioxide." Cancer Res 66. 23 (2006): 11360-9.

Ren, Ruibao and Perera, S.A lY. Ji, A.W.Gross. "TEL/ABL induces CML-Like myeloproliferative disorder versus a small bowel disease in mice in a dose-dependent manner." Blood (2005).

Ren, Ruibao and Subrahmanyam, R., C. Parikh. "Oncogenic N-Ras rapidly and efficiently induces CMML-and AML-like diseases in mice." Blood (2005).

Ren, Ruibao. "Mechanisms of BCR? ll-{ABL in the pathogenesis of chronic myelogenous leukemia." Nature Reviews Cancer (2005).

Ren,Ruibao. "Molecular mechanism of chronic myelogenous leukemia." Nature Reviews Cancer (2004).

Ren,Ruibao. "R. Ren Restraing CML by adhesives.." Blood (2004).

Ren, Ruibao and Cuenco, G. M.. "Both AML1 and EVI1 oncogenic components are required to the cooperation of AML1/MDS1/EVI1 with BCR/ABL in induction of acute myelogenous leukemia in mice." Oncogene 23. (2003): 569-79.

Ren, Ruibao, Dinulescu, D. M., L. J. Wood, L. Shen, M. Loriaux, C. L. Corless, A. W. Gross, M. W..N. Deininger & B. J. Druker. "c-CBL is not required for leukemia induction by Bcr-Abl in mice." Oncogene 22. (2003): 8852-60.

Ren, Ruibao. "Modeling the dosage effect of oncogenes in leukemogenesis." Current Opinion in Hematology 11. (2003): 25-34.

Ren,Ruibao. "Overriding BCR/ABL mitotic signal by ICSBP-induced differentiation." Blood 102. (2003): 4251-52.