Julia R Kardon
Degrees
University of California, San Francisco, Ph.D.Yale University, B.S.
Expertise
Control of protein structure and activity by chaperones. Mitochondrial protein regulation and quality control. Regulation of heme biosynthesis.Profile
My research addresses the molecular mechanisms that control the activity and quality of mitochondrial proteins to match the dynamic needs of eukaryotic cells. I use diverse biochemical and biophysical approaches to understand how chaperones tune mitochondrial protein activity, in combination with cell biological, genetic, and proteomic tools to discover new components of mitochondrial protein regulation and quality control.lab website: https://sites.google.com/brandeis.edu/kardonlab/
Courses Taught
| BCBP | 296a | Master's Lab Rotation I |
| BCBP | 296b | Master's Lab Rotation I |
| BCBP | 300a | Introduction to Research in Biochemistry and Biophysics I |
| BCBP | 300b | Introduction to Research in Biochemistry and Biophysics II |
| BCHM | 104b | Physical Chemistry of Macromolecules II |
Awards and Honors
Ruth L. Kirschstein postdoctoral fellowship (NIDDK) (2012 - 2015)
National Science Foundation predoctoral fellowship (2004 - 2007)
Scholarship
*Kardon, J. R., Moroco, J. A., Engen, J. R., *Baker, T. A. *co-corresponding author. "Mitochondrial ClpX activates an essential metabolic enzyme through partial unfolding." bioRxiv (2018).
Brown, B. L., Kardon, J. R., Sauer, R. T., Baker, T. A.. "Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme." Structure 26. 4 (2018): 580-589.
Yien, Y. Y., Ducamp, S., van der Vorm, L. N., Kardon, J. R., Manceau, H., Kannengiesser, C., Bergonia, H. A., Kafina, M. D., Karim, Z., Gouya, L., Baker, T. A., Puy, H., Phillips, J. D., Nicolas, G. & Paw, B. H.. "Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria." PNAS 114. 38 (2017): E8045-E8052.
Kardon, Julia R, Yien, Y. Y., Huston, N. C., Branco, D. S., Hildick-Smith, G. J., Rhee, K. Y., Paw, B. H., Baker, T. A.. "Mitochondrial ClpX activates a key enzyme for heme biosynthesis and erythropoiesis." Cell 161. 4 (2015): 858-67.