Julia Kardon

Assistant Professor of Biochemistry

kardon@brandeis.edu
781-736-2359
Kosow-Wolfson-Rosensweig Building, 303

Departments/Programs

Biochemistry

Degrees

University of California, San Francisco, Ph.D.
Yale University, B.S.

Expertise

Control of protein structure and activity by chaperones. Mitochondrial protein regulation and quality control. Regulation of heme biosynthesis.

Profile

My research addresses the molecular mechanisms that control the activity and quality of mitochondrial proteins to match the dynamic needs of eukaryotic cells. I use diverse biochemical and biophysical approaches to understand how chaperones tune mitochondrial protein activity, in combination with cell biological, genetic, and proteomic tools to discover new components of mitochondrial protein regulation and quality control.

lab website: https://sites.google.com/brandeis.edu/kardonlab/

Courses Taught

BCBP	296a	Master's Lab Rotation I
BCBP	296b	Master's Lab Rotation I
BCBP	300a	Introduction to Research in Biochemistry and Biophysics I
BCBP	300b	Introduction to Research in Biochemistry and Biophysics II
BCHM	104b	Physical Chemistry of Macromolecules II

Awards and Honors

Ruth L. Kirschstein postdoctoral fellowship (NIDDK) (2012 - 2015)

National Science Foundation predoctoral fellowship (2004 - 2007)

Scholarship

*Kardon, J. R., Moroco, J. A., Engen, J. R., *Baker, T. A. *co-corresponding author. "Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding." eLife 9 (2020): e54387.

Brown, B. L., Kardon, J. R., Sauer, R. T., Baker, T. A.. "Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme." Structure 26. 4 (2018): 580-589.

Yien, Y. Y., Ducamp, S., van der Vorm, L. N., Kardon, J. R., Manceau, H., Kannengiesser, C., Bergonia, H. A., Kafina, M. D., Karim, Z., Gouya, L., Baker, T. A., Puy, H., Phillips, J. D., Nicolas, G. & Paw, B. H.. "Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria." PNAS 114. 38 (2017): E8045-E8052.

Kardon, Julia R, Yien, Y. Y., Huston, N. C., Branco, D. S., Hildick-Smith, G. J., Rhee, K. Y., Paw, B. H., Baker, T. A.. "Mitochondrial ClpX activates a key enzyme for heme biosynthesis and erythropoiesis." Cell 161. 4 (2015): 858-67.