Christopher Miller
Degrees
University of Pennsylvania, Ph.D.Swarthmore College, B.A.
Expertise
Structure and function of ion channel proteins. Membrane transport and mechanisms of electrical excitation.Profile
Please visit my new faculty profile page.
I work on ion channels- the proteins that make electricity in all types of cells. I try to figure out how they work through a combination of high-resolution electrical recording methods and x-ray crystallography to determine their molecular structures Webpage
Awards and Honors
Member, National Academy of Sciences (2007)
National Institutes of Health grant renewed, "Ion Channel Mechanisms" (2006 - 2010)
President, Biophysical Society (2000 - 2001)
Pew Scholars Program National Advisory Committee (1999)
"Decade of the Brain" lecture, Society for Neuroscience (1998)
MERIT (Method to Extend Research in Time) Award, National Institutes of Health (1996 - 2001)
Alden W. Spencer Neurobiology Award, Columbia University College of Physicians and Surgeons (1994 - 1995)
Howard Hughes Medical Institute Investigator (1989)
K.S. Cole Award in Membrane Physics (1985 - 1986)
Muscular Dystrophy Association Postdoctoral Fellowship (1974 - 1976)
National Institutes of Health Molecular Biology Training Grant (1972 - 1974)
National Institutes of Health University Fellowship (1970 - 1972)
National Science Foundation Traineeship (1969 - 1970)
Scholarship
Turman, D.L., Nathanson, J.T., Stockbridge, R.B., Street, T.O., and Miller, C.. "Two-sided block of a dual-topology F– channel." PNAS 112. (2015): 5697-5701. (forthcoming)
Last, N.B., Sun, S., Pham, M., Miller, C. "Molecular determinants of permeation in a fluoride-specific ion channel." eLife (2018).
Turman, D.L., Cheloff, A.Z., Corrado, A.D., Nathanson, J.T., Miller, C. "Molecular interactions between a fluoride ion channel and synthetic protein blockers." Biochemistry (2018).
Tsai, C-W., Wu, Y., Williams, C., Phillips, C.B., Pao, P-C., Miller, C, and Tsai, M-F.. "Proteolytic control of the mitochondrial calcium uniporter complex.." PNAS 114. (2017): 4388-4393.
Last, N., Kolmakova, L., Shane, T, Miller, C. "Mechanistic signs of double-barreled structure in a fluoride ion channel." eLife 5. (2016): doi: 10.7554/eLife.18767.
Last, N.B. and Miller, C. "Functional monomerization of a ClC-type fluoride transporter." J. Mol. Biol. 327. (2016): 3607-3612.
Miller, C. "In the beginning: A personal reminiscence on the origin and legacy of CLC-0, the 'Torpedo Cl- channel." J. Physiol. 593. (2016): 4085-4090.
Miller, C. "Singin’ in the rain: My Oxford sabbatical." The Oxford Magazine.
Stockbridge, R.B., Kolmakova-Partensky, L., Koide, A., Koide, S., Miller, C., and Newstead, S.. "Crystal structures of a double-barreled fluoride ion channel.." Nature 525. (2016): 548-551.
Tsai, M-F., Phillips, C.B., Ranaghan, M., Tsai, C-W, Wu, Y., Williams, C.,Miller, C. "Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex." eLife 5. doi:10.7554/eLife.15545 (2016).
Brammer, A., Stockbridge, R.B., and Miller, C. "F-/Cl- selectivity in CLCF-type F-/H+ antiporters." J. Gen. Physiol 144. (2014): 129-136.
Ji, C., Stockbridge, R.B., and Miller, C.. "Bacterial fluoride resistance, Fluc channels, and the weak acid accumulation effect." J. gen. Physiol. 144. (2014): 257-261.
Stockbridge, R.B., Koide, A., Miller, C., and Koide, S.. "Proof of dual-topology architecture of Fluc F- channels by monobody blockers.." Nature Commun. 5. (2014): 1-5.
Tsai, M.-F., Jiang, D., Zhao, L., Clapham, D.E., and Miller, C.. "Functional reconstitution of the mitochondrial Ca2+-H+ antiporter Letm1." J. Gen. Physiol. 143. (2014): 67-73.
Lim, H.-H., Stockbridge, R.B., and Miller, C.. "Fluoride-dependent interruption of the transport cycle of a CLC Cl-/H+ exchanger." Nature Chem Biol 9. (2013): 721-725.
Stockbridge, R.B., Robertson, J.L., Kolmakova-Partensky, L., and Miller, C.. "A family of fluoride-specific ion channels with dual-topology architecture." eLife 2. (2013): e01084.
Lim, H.H., Shane, T., and Miller, C. "Intracellular proton access in a Cl-/H+ antiporter." PLoS Biol 10. * (2012): 1-8.
Lim, HH and Miller, C. "News & Views: It takes two to transport - or is it one?." Nature Struct. Mol. Biol. 19. (2012): 129-130.
Miller, C. and Piasta, K.. "Feel the force: Bio-electricity and the sensing of electric fields." The Biochemist 33. (2012): 26-29.
Piasta, K., Theobald, D.L., Miller, C.. "Potassium-selective block of barium permeation through single KcsA channels.." J. Gen Physiol. 138. (2012): 421-426.
Stockbridge, R., Lim, H.H, Otten, R., Williams, C., Shane, T., Weinberg, Z., and Miller, C. "Fluoride resistance and transport by riboswitch-controlled CLC antiporters.." PNAS 109. * (2012): 15289-15294.
Tsai, M-F., Fang, Y., and Miller, CMiller. "Sided functions of an arginine-agmatine exchange-transporter oriented in liposomes." Biochemistry 51. ** (2012): 1577-1585.
Clapham, D., and Miller, C.. "A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels." PNAS 108. (2011): 19492-19497.
Jayaram, H, Robertson, J.L. Wu, F., Williams, C., and Miller, C.. "Structure of a slow CLC Cl-/H+ antiporter from a cyanobacterium. Biochemistry 50:788-794.." Biochemistry 50. 0000 (2011): 788-794.
Miller, C. "Model-free free energy for voltage-gated channels.." J. Gen Physiol 139. (2011): 1-2.
Fang, Y, Jayaram, H, Shane, T., Kolmakova-Partensky, L., Wu, F., Williams, C., Xiong, Y., Miller, C. "Structure of a prokaryotic virtual proton pump at 3.2 Å resolution." Nature 460. (2010): 1040-1043.
Miller, Christopher. "A provisional mechanism for Cl-/H+ exchange in CLC transport proteins." Phil Trans Roy Soc B 364. (2009): 175-180.
Miller, Christopher. "Intracellular proton-transfer mutants in a bacterial CLC Cl-/H+ exchanger." J Gen Physiol 133. (2009): 131-138.
Miller, Christopher. "Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger." PNAS 105. (2009): 11194-99.
Miller, Christopher. "News and Views: Coughing up flu¿s proton channels." Nature 451. (2008): 532-533.
Miller, Christopher. "A bacterial arginine-agmatine exchange transporter involved in extreme acid resistance.." J. Biol. Chem. 282. (2007): 176-182.
Miller, Christopher. "Uncoupling and turnover in a CLC Cl-/H+ exchanger." J. Gen. Physiol. 129. (2007): 317-329.
Nguitragool, W. and Miller, C.. "CLC Cl-/H+ exchangers constrained by covalent cross-linking." Proc. Nat. Acad. Sci. USA 104. (2007): 20659-20665.
Miller,Christopher with Accardi, A., Kolmakova-Partensky, L., Williams, C., and Miller. "Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels." J. Gen. Physiol. 123. (2004): 109-119.
Miller,Christopher with Accardi, A., Kolmakova-Partensky, L., Williams, C., and Miller. "Secondary active transport mediated by prokaryotic homologue of CLC CI channels.." Nature 427. (2004): 803-807.
Miller,Christopher with Blaustein, R.O. and Miller C.. "News and Views: Ion channels: Shake, rattle or roll?." Nature (2004): 499-500.
Miller,Christopher with Nimigean, CM., Shane, T., and Miller, C.. "A cyclic nuceleotide modulated prokaryotic K+ channel." J. Gen Physiol. 124. (2004): 203-210.
Miller,Christopher, ed.. Ion Channel Reconstitution. New York: Plenum Press, 1986.