Stephen Van Hooser
Degrees
Brandeis University, Ph.D.California Institute of Technology, B.S.
Expertise
Single and multichannel extracellular recording (neurophysiology)In vivo whole cell recording
In vivo 2-photon imaging
In vivo optical stimulation with optogenetic channels
Data analysis and statistics
Profile
A fundamental mystery of brain science is to understand how networks of neurons assemble during development and function in circuits to enable perception and behavior. Unraveling this mystery requires an understanding of the relationships between the cellular-level properties of circuits – the anatomical “wiring diagram” of connectivity on the one hand, and the functional properties of single neurons and synapses on the other – and the systems-level properties such as sensory responses or motor outputs.In the Neural Circuits Lab, we are applying a new generation of optical and optogenetic tools to observe both fine-scale circuit features and systems-level responses at the same time, in the living brain. We combine these optical approaches with advanced physiological and anatomical techniques to address previously inaccessible questions about neural circuitry and its development in mammalian visual cortex. Webpage
Courses Taught
| BIOL | 91g | Introduction to Research Practice |
| BIOL | 107a | Data Analysis and Statistics Workshop |
| NBIO | 140b | Principles of Neuroscience |
| NEUR | 91g | Introduction to Research Practice |
Awards and Honors
Beverly Petterson Bishop Award for Excellent in Neuroscience (2015)
Scholarship
Tatavarty V, Torrado Pacheco A, Groves Kuhnle C, Lin H, Koundinya P, Miska NJ, Hengen KB, Wagner FF, Van Hooser SD, Turrigiano GG. "Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent V1.." Neuron (2020). (forthcoming)
Zaltsman JB, Heimel JA, Van Hooser SD.. "Weak orientation and direction selectivity in lateral geniculate nucleus representing central vision in the gray squirrel Sciurus carolinensis.." Journal of Neurophysiology (2015). (forthcoming)
Van Hooser SD, Escobar GM, Maffei A, Miller P.. "Emerging feed-forward inhibition allows the robust formation of direction selectivity in the developing ferret visual cortex." J Neurophysiol 111. 11 (2014): 2355-73. (forthcoming)
Richards SEV, Moore AR, Nam AY, Saxena S, Paradis S, Van Hooser SD. "Experience-dependent development of dendritic arbors in mouse visual cortex." Journal of Neuroscience 40. (2020): 6536-6556.
Roy A, Osik JJ, Meschede-Krasa B, Alford WT, Leman DP, Van Hooser SD. "Synaptic and intrinsic mechanisms underlying development of cortical direction selectivity." eLife 9. (2020): 58509.
Roy A, Wang S, Meschede-Krasa B, Breffle J, Van Hooser SD. "An early phase of instructive plasticity before the typical onset of sensory experience.." Nature Communications 11. (2020): 11.
Stacy, Andrea K; Nelson, Sacha B; Van Hooser, Stephen D. "Visual System." Encyclopedia of Life Sciences., 2020
Popović M, Stacy AK, Kang M, Nanu R, Oettgen CE, Wise DL, Fiser J, Van Hooser SD. "Development of cross-orientation suppression and size tuning and the role of experience." Journal of Neuroscience 38. 11 (2018): 2656-2670.
Roy, Arani; Christie, Ian K.; Escobar, Gina M; Osik, Jason J.; Popovic, Marjena; Ritter, Neil J.; Stacy, Andrea K.; Wang, Shen; Fiser, Jozsef; Miller, Paul; Van Hooser, Stephen D.. "Does experience provide a permissive or instructive influence on the development of direction selectivity in visual cortex?." Neural Development 13. 1 (2018): 16.
Christie IK, Miller P, Van Hooser SD. "Cortical amplification models of experience-dependent development of selective columns and response sparsification." Journal of Neurophysiology 118. 2 (2017): 874-893.
Ritter NJ, Anderson NM, Van Hooser SD. "Visual Stimulus Speed Does Not Influence the Rapid Emergence of Direction Selectivity in Ferret Visual Cortex." Journal of Neuroscience 37. 6 (2017): 1557-1567.
Hengen KB, Torrado Pacheco A, McGregor JN, Van Hooser SD, Turrigiano GG. "Neuronal Firing Rate Homeostasis Is Inhibited by Sleep and Promoted by Wake." Cell 165. 1 (2016): 180-91.
O'Hare JK*, Ade KK*, Sukharnikova T, Van Hooser SD, Parlmeri ML, Yin HH, Calakos N,. "Pathway-Specific Striatal Substrates for Habitual Behavior." Neuron 89. (2016): 472-9.
Roy A*, Osik JJ*, Ritter JR*, Wang S, Shaw JT, Fiser J, Van Hooser SD. "Optogenetic spatial and temporal control of cortical circuits on a columnar scale." Journal of Neurophysiology 115. 2 (2016): 1043-62.
Rubin DB, Van Hooser SD, Miller KD.. "The stabilized supralinear network: a unifying circuit motif underlying multi-input integration in sensory cortex.." Neuron 85. 2 (2015): 402-17.
Smith GB, Sederberg A, Elyada YM, Van Hooser SD, Kaschube M, Fitzpatrick D. "The development of cortical circuits for motion discrimination.." Nature Neuroscience 18. 2 (2015): 252-61.
Ghiretti AE, Moore AR, Brenner RG, Chen LF, West AE, Lau NC, Van Hooser SD, Paradis S. "Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo." J Neurosci 34. 2 (2014): 392-407.
Mazurek, M., Kager, M., and Van Hooser, Stephen D.. "Robust quantification of orientation selectivity and direction selectivity.." Frontiers in Neural Circuits 8. 92 (2014).
Yu YV, Bell HW, Glauser DA, Van Hooser SD, Goodman MB, Sengupta P. "CaMKI-dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron.." Neuron 84. 5 (2014): 919-26.
Hengen KB, Lambo ME, Van Hooser SD, Katz DB, Turrigiano GG. "Firing rate homeostasis in visual cortex of freely behaving rodents.." Neuron 80. 2 (2013): 335-42.
Van Hooser SD, Roy A, Rhodes HJ, Culp JH, Fitzpatrick D. "Transformation of receptive field properties from lateral geniculate nucleus to superficial V1 in the tree shrew." J Neurosci 33. 28 (2013): 11494-505.
Clemens JM, Ritter NJ, Roy A, Miller JM, Van Hooser SD. "The laminar development of direction selectivity in ferret visual cortex." Journal of Neuroscience 32. 50 (2012): 18177-85.
Felch DL, Van Hooser SD. "Molecular compartmentalization of lateral geniculate nucleus in the gray squirrel (Sciurus carolinensis).." Frontiers in Neuroanatomy 6. (2012): 12.
Van Hooser SD, Li Y, Christensson M, Smith GB, White LE, Fitzpatrick D. "Initial neighborhood biases and the quality of motion stimulation jointly influence the rapid emergence of direction preference in visual cortex." Journal of Neuroscience 32. 21 (2012): 7258-66.
Johnson, Elizabeth N., Van Hooser, Stephen D., Fitzpatrick, David. "The representation of S-cone signals in primary visual cortex.." Journal of Neuroscience 30. 31 (2010): 10337-50.