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RBIF 115

Statistical Genetics

This course covers methods in statistical genetics used to detect disease or quantitative trait loci in experimental and human populations. Basic concepts in Genetics, Genomics and Genetic Epidemiology are reviewed, with an emphasis on the statistical and practical issues involved in genetic analysis. Both linkage and association approaches will be covered, with a focus on applications in the human genome wide association (GWAS) setting for both SNPs and CNVs. Approaches to extracting and enriching GWAS through genotype imputation, GSEA, meta-analysis and genetics of gene expression analysis will also be covered, along with topics relevant to pharmacogenetics and techniques to analyze next generation sequencing data in a population setting.

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