CHEM 11a General Chemistry I
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This course may not be taken for credit by students who have passed CHEM 15a in previous years. Four class hours and one sixty-minute structured study group session per week. The corresponding lab is CHEM 18a.

Covers a wide array of topics, embracing aspects of descriptive, as well as quantitative, chemistry. No prior study of chemistry is assumed, as the course begins by looking at the atomic foundation of matter, the elements, and the organization of the periodic table, working its way up to studying how atoms are bonded together to form larger units of matter. Students who complete this course will have an understanding of the three major phases of matter--solids, liquids, and gasses--and how they behave, as well as a knowledge of the major types of chemical reactions and how to represent them. A strong focus is put on learning methods of creative problem-solving, using the material as a way to develop creative approaches to solving unfamiliar problems--a skill that carries students far beyond the confines of the classroom. Usually offered every year.

CHEM 11b General Chemistry II
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Prerequisite: A satisfactory grade (C- or better) in CHEM 11a or an approved equivalent. This course may not be taken for credit by students who have passed CHEM 15b in previous years. Four class hours and one sixty-minute structured study group session per week. The corresponding lab is CHEM 18b.

Picks up where Chemistry 11a left off, advancing students' understanding of bonding models and molecular structure and exploring the basics of coordination chemistry. Three major quantitative topics are covered in the second half of General Chemistry'chemical equilibrium (including acid-base chemistry, solubility, and complex-ion formation), chemical kinetics, and thermodynamics. Other topics explored are electrochemistry and nuclear chemistry. Usually offered every year.

CHEM 15a Honors General Chemistry I
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This course may not be taken for credit by students who have passed CHEM 11a in previous years. Three class hours and one recitation per week. The corresponding laboratory is CHEM 19a.

An advanced version of general chemistry for students with good preparation in math and chemistry in high school. Topics include chemical stoichiometry, chemical bonding from a classical and quantum mechanical perspective, gasses, thermochemistry, solutions, states of matter, atomic structure and periodic properties. Real world examples are used to demonstrate the concepts. Usually offered every year.

CHEM 15b Honors General Chemistry II
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Prerequisite: A satisfactory grade (C- or better) in CHEM 15a or the equivalent. This course may not be taken for credit by students who have passed CHEM 11b in previous years. Three class hours and one recitation per week. The corresponding laboratory is CHEM 19b.

A continuation of CHEM 15a. Topics include an introduction to thermodynamics, chemical equilibria, including acid-base and solubility equilibria, electrochemistry, chemical kinetics, nuclear chemistry, and special topics. Usually offered every year.

CHEM 18a General Chemistry Laboratory I
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Corequisite: CHEM 11a. Dropping CHEM 11a necessitates written permission from the lab instructor to continue with this course. Two semester-hour credits; yields half-course credit. This course may not be taken for credit by students who have passed CHEM 19a in previous years.

Introduction to basic laboratory methods and methods of qualitative and quantitative analyses. Included in the analytical methods are gas chromatography and infrared measurements. A synthesis project that includes analyzing the product by titration. Calorimetric experiment using probes interfaced with computers. Identification of unknowns based on physical and chemical properties. Analysis of the metal content of substances by atomic absorption. One laboratory lecture per week. One afternoon of laboratory per week. Usually offered every year.

CHEM 18b General Chemistry Laboratory II
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Prerequisites: A satisfactory grade (C- or better) in CHEM 18a and CHEM 11a. Corequisite: CHEM 11b. Dropping CHEM 11b necessitates written permission from the lab instructor to continue with this course. May yield half-course credit toward rate of work and graduation. Two semester-hour credits. This course may not be taken for credit by students who have passed CHEM 19b in previous years.

The second semester of the general chemistry laboratory program. Continued use of probes interfaced with computers to monitor pH and electrical conductivity changes in titrating weak monoprotic and polyprotic amino acids, to monitor pressure changes as part of a kinetics study, and to monitor voltage changes of electrochemical cells with temperature so as to establish thermodynamic parameters for redox reactions. Also included is identification of unknowns based on selective precipitation. Usually offered every year.

CHEM 19a Honors General Chemistry Laboratory I
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Corequisite: CHEM 15a. Dropping CHEM 15a necessitates written permission from the lab instructor to continue with this course. May yield half-course credit toward rate of work and graduation. Two semester-hour credits. This course may not be taken for credit by students who have taken CHEM 18a in previous years.

An advanced version of CHEM 18a. One afternoon of laboratory per week. One laboratory lecture per week. Usually offered every year.

CHEM 19b Honors General Chemistry Laboratory II
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Prerequisite: A satisfactory grade (C- or better) in CHEM 15a and CHEM 19a. Corequisite: CHEM 15b. Dropping CHEM 15b necessitates written permission from the lab instructor to continue with this course. May yield half-course credit toward rate of work and graduation. Two semester-hour credits. This course may not be taken for credit by students who have taken CHEM 18b in previous years.

Continuation of CHEM 19a. An advanced version of CHEM 18b. Usually offered every year.

CHEM 25a Organic Chemistry I
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Prerequisite: A satisfactory grade (C- or better) in CHEM 11b or 15b or the equivalent. CHEM 25a honors option involves a separate recitation and permission of the instructor to enroll. Students in the honors section will receive a note on their transcript designating the class "Honors Organic Chemistry." Three class hours and one ninety-minute recitation per week.

Structure, reactions, preparations, and uses of the compounds of carbon. Usually offered every year.

CHEM 25b Organic Chemistry II
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Prerequisite: A satisfactory grade (C- or better) in CHEM 25a or its equivalent. CHEM 25b honors option involves a separate recitation and permission of the instructor to enroll. Students in the honors section will receive a note on their transcript designating the class "Honors Organic Chemistry." Three class hours and one ninety-minute recitation per week.

A continuation of CHEM 25a. Usually offered every year.

CHEM 29a Organic Chemistry Laboratory I
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Prerequisite: A satisfactory grade (C- or better) in CHEM 18b or 19b or the equivalent. Corequisite: CHEM 25a. Dropping CHEM 25a necessitates written permission from the lab instructor to continue with this course. May yield half-course credit toward rate of work and graduation. Two semester-hour credits.

Gives experience in the important techniques of organic chemical laboratory practice of isolation and purification of organic compounds by crystallization, distillation, and chromatography, and their characterization using analytical and instrumental methods. One afternoon of laboratory per week. One ninety-minute laboratory lecture per week. Usually offered every year.

CHEM 29b Organic Chemistry Laboratory II

Prerequisite: A satisfactory grade (C- or better) in CHEM 25a and CHEM 29a or the equivalent. Corequisite: CHEM 25b. Dropping CHEM 25b necessitates written permission from the lab instructor to continue with this course. May yield half-course credit toward rate of work and graduation. Two semester-hour credits.

A continuation of CHEM 29a with an emphasis on the synthesis of typical organic compounds. One afternoon of laboratory per week. One ninety-minute laboratory lecture per week. Usually offered every year.

CHEM 33a Environmental Chemistry
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Prerequisite: A satisfactory grade (C- or higher) in CHEM 11b or 15b or the equivalent.

The course surveys the important chemical principles and reactions that determine the balance of the molecular species in the environment and how human activity affects this balance. The class evaluates current issues of environmental concern such as ozone depletion, global warming, sustainable energy, toxic chemicals, water pollution, and green chemistry. Usually offered every year.

CHEM 49a Advanced Laboratory: Organic Chemistry
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Prerequisites: C- or higher in CHEM 25a and b, and CHEM 29a and b, or the equivalent. Four semester-hour credits.

Compounds will be synthesized, purified and then characterized by NMR, IR and mass spectroscopy. Multi-week projects will be completed with a lab report in the style of a journal article with full experimental supporting information. The lectures cover the necessary background and experimental techniques for each project. Usually offered every second year.

CHEM 59b Advanced Laboratory: Physical Chemistry
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Prerequisites: A satisfactory grade (C- or higher in CHEM 18b or equivalent; CHEM 141a or 142a (may be taken concurrently) or equivalent. One one-hour lecture and one afternoon of lab per week.

This course introduces the student to a number of topics of current interest in physical and analytical chemistry and provides experimental verification of physico-chemical principles in thermodynamics, kinetics, macromolecules, organic chemistry, semiconductors, nanochemistry, photochemistry, magnetic resonance imaging and electrochemistry. The properties, reactions, and structure of compounds are understood by evaluating their physicochemical responses to changes in experimental conditions. The experiments use synthesis, spectroscopy, chromatography, electrochemical and other instrumental methods employed in the modern chemical laboratory. The program includes the methodology of quantitative measurement, statistical data analysis, and report writing. One one-hour lecture and one afternoon of laboratory per week. Usually offered every second year.

CHEM 69a Advanced Laboratory: Materials Chemistry
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Prerequisites: C- or higher in CHEM 25a and b, and CHEM 29a and b, or the equivalent. Four semester-hour credits.

Introduces the student to selected topics in materials chemistry and provides hands-on experience for making materials that find applications in the real world or are being intensively explored for a wide range of applications. By focusing on the design, control, and characterization of the atomic and molecular structures, macroscopic properties, and applications of materials, we will introduce materials chemistry as a frontier of science that aims to address important societal problems, such as energy and health. Usually offered every second year.

CHEM 88a Communication and Career Skills in Chemistry
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Prerequisites: A satisfactory grade (C- or better) in CHEM 25b and 29b, or the equivalent. Does not count as one of the lecture or lab courses for the chemistry major.

A course focused on honing skills for effective scientific communication and career development in chemistry. Students will practice presenting chemical information, learn about various career paths in chemistry, and gain insight into standard safety and ethical protocols in science. Usually offered every second year.

CHEM 91g Introduction to Research Practice

Prerequisite: Students must complete online safety training relevant to their research group. Offered exclusively on a credit/no-credit basis. Yields quarter-course credit. May be repeated for credit.

Students engage in Chemistry research by working in the laboratory of a faculty member for a minimum of 3 hours per week for one semester. Students who have declared a Chemistry major must receive permission from the Chemistry Undergraduate Advising Head as well as the faculty sponsor to enroll in CHEM 91g. Students who have not yet declared a major must receive permission from their academic advisor as well as the faculty sponsor. Usually offered every year.

CHEM 94a Peer Assistantship in Chemistry

Offered exclusively on a credit/no-credit basis.

Usually offered every year.

CHEM 95a Directed Studies in Chemistry

Prerequisites: CHEM 25a and 29a or equivalent or permission of the Undergraduate Advising Head. Does not meet the major requirements in chemistry. May not be repeated for credit. A designated library training component must be completed as soon as it is offered.

Readings and/or independent laboratory work. Periodic conferences with advisor and a final written report. CHEM 95a and 95b may be taken individually as one-semester courses or together as a year-long sequence. Usually offered every year.

CHEM 95b Directed Studies in Chemistry

See CHEM 95a for course description. Usually offered every year.

CHEM 99d Senior Research

Prerequisites: Permission of instructor and Undergraduate Advising Head; open only to senior honors candidates. Does not meet the major requirements in chemistry. A designated library training component must be completed as soon as it is offered. At the end of the first semester, the introduction to the research thesis with extensive bibliography is due.

A year-long course focused on a research project with a member of the department. Successful completion of the course involves writing a detailed report on the project. Usually offered every year.

CHSC 2a From Molecules to Million Dollar Medicines: The Science and Business of the Pharmaceutical Industry
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Does not meet the requirements for the major in chemistry.

Provides a basic understanding of how drugs and medicines are developed from the laboratory to the commercialization. Students will gain an appreciation for basic chemical principles, the value of clinical studies, and the considerations made when a drug is brought to market. Usually offered every second year.

CHSC 6a Introduction to Forensic Science
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Open only to students who have not taken CHEM 11a/b or CHEM 15a/b. Designed to fulfill the core science requirement for non-science majors. This course does not meet the requirements for the major or minor in Chemistry.

Covers the fundamentals of crime scene investigation. Students will begin by learning the scientific method applied to evidence collection, followed by the examination and analysis of the evidence as performed within a modern crime lab, and the use of scientific reasoning to interpret data. Usually offered every year.

CHSC 7b Culinary Chemistry
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Does not meet the requirements for the major or minor in Chemistry. Open to students who have not taken CHEM 11a or b.

Provides a basic understanding of chemical principles as they relate to food, cooking, baking, and other culinary transformations. Students will gain an appreciation for basic chemical principles, experimental design, data analysis, and science communication through hands-on experimentation. Usually offered every second year.

CBIO 101a Chemical Biology
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Prerequisites: A satisfactory grade (C- or better) in BIOL 14a, BIOL 15b, and CHEM 25a and b, or the equivalent.

Explores how scientific work in chemistry led to fundamental understanding of and ability to manipulate biological processes. Emphasis is placed on chemical design and synthesis as well as biological evaluation and utility. Content based on scientific literature readings. Usually offered every second year.

CBIO 102a Chemical Innovation Feeding Biological Discovery
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Prerequisite: A satisfactory grade (C- or better) in BIOL 14a, BIOL 15b, and CHEM 25a and b, or the equivalents.

Cover exciting instances in which chemical innovation has been used to fuel biological discovery that is not possible with standard biological techniques. Topics will vary but include a basic introduction to carbohydrate, peptide and bioorthogonal (i.e., 'click') reactions, incorporation of unnatural amino acids into proteins, chemically defined vaccines, and the use of directed evolution to produce biological macromolecules with desired recognition or catalytic functions. Readings drawn from textbooks and the original scientific literature. Usually offered every second year.

CBIO 103b Synthetic Molecules and Human Medicine
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Prerequisites: A satisfactory grade (C- or better) in BIOL 14a, BIOL 15b, and CHEM 25a and b, or equivalent.

This course will discuss the remarkable achievements in human medicine facilitated by synthetic molecules (small molecules as well as biologics). It will introduce key concepts and practices in drug discovery, including drug targets, drug design, pharmacokinetics, and pharmacodynamics. It will also analyze recent discoveries of therapeutic molecules for a variety of diseases as case studies, including diabetes, cardiovascular and metabolic diseases, osteoporosis, glaucoma, autoimmune diseases, infectious diseases (including COVID-19), cancers, as well as neurodegenerative and psychiatric diseases. There is a strong organic chemistry component in this course and selected examples of industrial manufacture processes of medicines will be discussed. Readings drawn from textbooks and the original scientific literature. Usually offered every second year.

CBIO 106b Chemical Biology: Medicinal Enzymology
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Prerequisites: Satisfactory grade in BIOL 14a, BIOL 15b, CHEM 25a and 25b, and BCHM 100a or the equivalent.

Introduces students to the conceptual framework and experimental methods in medicinal chemistry. Topics include mechanisms of drug-target interactions, strategies for lead optimization and issues in metabolism, pharmacokinetics and pharmacodynamics. Readings drawn from textbooks and the original scientific literature. Usually offered every second year.

CHEM 121a Inorganic Chemistry I, Lectures
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Prerequisite: A satisfactory grade in CHEM 25a and b and CHEM 29a and b.

Simple bonding theory. Symmetry, structure, and bonding in inorganic compounds. Solid-state chemistry; ionic and electronic conductors. Applications of group theory and bonding theory to main group compounds and transition metal complexes. Coordination chemistry: isomerism, structure, and reactions. Usually offered every year.

CHEM 130a Advanced Organic Chemistry: Structure
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Prerequisite: A satisfactory grade in CHEM 25a and b, or the equivalent.

Chemical bonding and structure, stereochemical principles and conformational analysis, organic reaction mechanisms, structures and activities of reactive intermediates, and pericyclic reactions. Usually offered every year.

CHEM 132b Advanced Organic Chemistry: Spectroscopy
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Prerequisite: A satisfactory grade in CHEM 25a and b, or the equivalent.

Application of spectroscopy to the elucidation of structure and stereochemistry of organic compounds, with emphasis on modern NMR and MS methods. Usually offered every year.

CHEM 134b Advanced Organic Chemistry: Synthesis
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Prerequisite: A satisfactory grade in CHEM 25a and b, or the equivalent.

Modern synthetic methods are covered, with an emphasis on mechanism and stereochemical control. Discusses the formation of carbon-carbon single and double bonds and carbocycles and procedures for oxidation, reduction, and functional group interchange. Examines selected total syntheses. Usually offered every year.

CHEM 135a Advanced Organic Chemistry: Modern Catalytic Reactions in Organic Synthesis
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Prerequisite: A satisfactory grade in CHEM 25a and b, or the equivalent.

Examines the application of modern catalytic and asymmetric methods in organic synthesis is illustrated. Hydrogenation, hydride addition, epoxidation, dihydroxylation, olefin metathesis, C-H activation, and C-C bond forming reactions are discussed, together with recent applications of these reactions to natural product synthesis. Catalysis by metal complexes and organic molecules is discussed with emphasis on the interplay between mechanistic insight and catalyst design. Usually offered every second year.

CHEM 137b The Chemistry of Organic Natural Products
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Prerequisite: A satisfactory grade in CHEM 25a and b, or the equivalent.

Natural products chemistry is surveyed within a biosynthetic framework. Occurrence, isolation, structure elucidation, biosynthesis, and biomimetic synthesis are covered with an emphasis on modern methods of establishing biosynthesis and biomimetic syntheses. Usually offered every second year.

CHEM 141a Chemical Thermodynamics
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Prerequisites: Satisfactory grade in CHEM 11a, 15a and CHEM 11b, 15b or the equivalent; MATH 10b or the equivalent; PHYS 10a,b, 11a,b or 15a,b or the equivalent. Organic chemistry is also recommended.

Thermodynamic principles, tools, and applications in chemistry and biology. Usually offered every year.

CHEM 142a Quantum Mechanics and Spectroscopy
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Prerequisites: A satisfactory grade in CHEM 11b or 15b or the equivalent; MATH 10b or the equivalent; PHYS 10b, 11b, or 15b or the equivalent. Organic chemistry is also recommended.

Solutions to the Schrodinger equation of relevance to molecular structure, reactivity and spectroscopy; introduction to quantum mechanical calculations and computational methods. Usually offered every year.

CHEM 146b Advanced Spectroscopy
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Prerequisites: A satisfactory grade in PHYS 10a,b, 11a,b, or 15a,b or the equivalent; MATH 10a,10b.

A detailed discussion of modern NMR methods will be presented. The course is designed so as to be accessible to non-specialists, but still provide a strong background in the theory and practice of modern NMR techniques. Topics include the theory of pulse and multidimensional NMR experiments, chemical shift, scalar and dipolar coupling, NOE, spin-operator formalism, heteronuclear and inverse-detection methods, Hartmann-Hahn and spin-locking experiments. Experimental considerations such as pulse sequence design, phase cycling, and gradient methods will be discussed. Guest lecturers will provide insight into particular topics such as solid-state NMR and NMR instrumental design. Usually offered every second year.

CHEM 160a Materials Chemistry: Molecular Foundation for Nanobiotechnology
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Prerequisites: A satisfactory grade in CHEM 11B, 15B or the equivalent or permission of instructor.

Focuses on the elucidation and design of nanomaterials at the molecular scale, with emphasis on nanomaterials to be used in biotechnology and biomedicine. It aims to provide students with multidisciplinary knowledge at the intersection of physical, biological, and materials science. Usually offered every second year.

CHEM 161a Polymer and Inorganic Materials Chemistry
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Prerequisite: CHEM 25b or the equivalent.

Covers molecular, structural, and chemical origins of the electronic, thermal, and optical and other physical properties of materials; synthetic methods for the preparation of polymers with diverse structures and properties; principles of emerging technologies and devices that incorporate novel materials. Usually offered every second year.

CHEM 199d BA/MA Research
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Prerequisites: Permission of instructor and Undergraduate Advising Head; open only to BA/MA candidates. Does not meet the major requirements in chemistry. A designated library training component must be completed as soon as it is offered. At the end of the first semester, the introduction to the research thesis with extensive bibliography is due.

A year-long course focused on a research project with a member of the department. Successful completion of the course involves writing a detailed report on the project. Usually offered every year.

CHEM 200a Advanced Chemistry Laboratory I

Usually offered every year.

CHEM 200b Advanced Chemistry Laboratory II

Usually offered every year.

CHEM 230b Organic Chemistry and Chemical Biology Seminar

Yields half-course credit.

Required of graduate students in organic chemistry whenever offered. Usually offered every year.

CHEM 240b Physical Chemistry and Materials Seminar

Yields half-course credit.

Required of graduate students in physical chemistry whenever offered. Usually offered every year.

CHEM 298a Independent Study

Usually offered every year.

CHEM 300c Chemistry Colloquium

Yields half-course credit per semester.

Required of graduate students in Chemistry. Usually offered every semester.

CHEM 401d Dissertation Research

Independent research for graduate dissertation. Specific sections for individual faculty members as requested.

BCHM 100a Advanced Introductory Biochemistry
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Prerequisite: One year of organic chemistry with laboratory.

Topics include protein and nucleic acid structure; chemical basis of enzyme-catalyzed reaction mechanisms and enzyme kinetics; the chemical logic of metabolic pathways, including glycolysis and oxidative phosphorylation; and regulation of enzymatic pathways through allosteric control. Usually offered every year in multiple sections.

BCHM 101a Advanced Biochemistry: Enzyme Mechanisms
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Prerequisites: One year of organic chemistry with laboratory and BCHM 100a or equivalents.

Describes the principles of biological catalysts and the chemical logic of metabolic pathways. Discusses representative enzymes from each reaction class, with an emphasis on understanding how mechanisms are derived from experimental evidence. Topics include serine proteases, phosphatases, isomerases, carboxylases, and dehydrogenases. Usually offered every year.

BCHM 102a Quantitative Approaches to Biochemical Systems
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Prerequisite: BCHM 100a or equivalent and Math 10a and b or equivalent.

Introduces quantitative approaches to analyzing macromolecular structure and function. Emphasizes the use of basic thermodynamics and single-molecule and ensemble kinetics to elucidate biochemical reaction mechanisms. Also discusses the physical bases of spectroscopic and diffraction methods commonly used in the study of proteins and nucleic acids. Usually offered every year.

BCHM 103b Advanced Biochemistry: Cellular Information Transfer Mechanisms
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Prerequisites: One year of organic chemistry with laboratory and BCHM 100a or equivalents. BIOL 14a or the equivalent is recommended.

Molecular mechanisms of information transfer in biological systems. Topics include nucleic acid biochemistry, processing of genetic information, and signal transduction. Each section will focus on the chemistry and regulation of a selected example from these fundamental processes. Lectures will be complemented by reading assignments and student presentations on articles from the original research literature. Usually offered every year.

BCHM 104b Physical Chemistry of Macromolecules II
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Prerequisites: BCHM 100a, and one of the following: BCHM 104a, CHEM 141a, or Phys 40a, and Math 10a and b or equivalent.

Illustrates the basic principles on which biological macromolecules are constructed and by which they function. Describes overall structures of proteins, nucleic acids, and membranes in terms of the underlying molecular forces: electrostatics, hydrophobic interactions, and H-bonding. The energetics of macromolecular folding and of the linkage between ligand binding and conformational changes will also be discussed. Recitation optional. Usually offered every year.

NBIO 136b Computational Neuroscience
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Prerequisites: MATH 10a or higher and one of the following: NBIO 140b/240b, PHYS 10b/11b/15b, BIOL 107a, or any COSI course.

An introduction to concepts and methods in computer modeling and analysis of neural systems. Topics include single and multicompartmental models of neurons, information representation and processing by populations of neurons, synaptic plasticity and models of learning, working memory, decision making and neural oscillations. The course will be based on in-class computer tutorials, assuming limited prior coding experience, with reading assignments and preparation as homework. Usually offered every second year.

QBIO 110a Numerical Modeling of Biological Systems
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Prerequisite: MATH 10a and b or equivalent.

Modern scientific computation applied to problems in molecular and cell biology. Covers techniques such as numerical integration of differential equations, molecular dynamics and Monte Carlo simulations. Applications range from enzymes and molecular motors to cells. Usually offered every second year.

QBIO 120b Quantitative Biology Instrumentation Laboratory
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Focuses on optical and other instruments commonly used in biomedical laboratories to make quantitative measurements in vivo and in vitro. Students disassemble and reconfigure modular instruments in laboratory exercises that critically evaluate instrument reliability and usability and investigate the origins of noise and systematic error in measurements. Usually offered every year.