Department of Biology

Last updated: November 4, 2010 at 3:19 p.m.

Objectives

Undergraduate Major
The undergraduate program in biology, leading either to the BA or to the BS degree, is designed to give students an understanding of fundamental and current biological knowledge in a variety of fields. The program offers a wide array of courses to undergraduates, ranging from introductory to advanced, specialized, graduate-level courses in many of these areas. The biology department has more than twenty-five full-time faculty members with teaching and research interests in the fields of genetics, molecular biology, development, cancer, immunology, neurobiology, motility, cell biology, structural biology, animal behavior, and ecology.

Because the interests and needs of our students vary, the major is designed to provide flexibility once the core courses have been completed. Students may elect undergraduate-level courses in a variety of areas of biology and biochemistry or may choose to obtain more-advanced, in-depth training in one particular area. Students are also encouraged to take advantage of opportunities to become integral members of research laboratories in the department and to attend departmental colloquia.

A major in biology provides excellent preparation for students intent on careers in biological research; for those seeking careers in medicine, veterinary medicine, and dentistry; and for those interested in the allied health professions such as public health, genetic counseling, physical therapy, or physician assistant. For those seeking courses concerned with ecology or environmental science, the biology department offers study in those areas. See "Special Note B" below for additional programs in those areas.

Graduate Programs in the Biological Sciences
For MS and PhD degrees in the biological sciences, see the separate listings for molecular and cell biology, biophysics and structural biology, neuroscience, and genetic counseling programs in this Bulletin.

How to Become a Major

Students wishing to major in biology should enroll in general chemistry during their first year. Students may elect to take BIOL 15b, an introductory course in biology, in the first year. Exceptionally well-prepared students may enroll in BIOL 22a (Genetics) in their first year.

Most students begin the biology series in their sophomore year and take BIOL 22a (Genetics) and BIOL 22b (Cell Structure and Function), plus BIOL18a and b labs. During their sophomore year, students can also enroll in CHEM 25a and b (Organic Chemistry), with associated labs.

Other course schedules are indeed possible, but students should note that some biology electives have a prerequisite of completion of CHEM 25a. Taking CHEM 25a and b in the sophomore year allows students to begin taking electives in their junior year, as well as to begin completing the remaining requirements for the BA or BS degree in biology. Students also have the option of enrolling in BIOL 93a (Independent Research) during their junior or senior year, and BIOL 93a/BIOL 99a or BIOL 99a and b (Senior Research) during the senior year.

To learn more about the biology major, students should attend one of the special departmental programs held each fall or consult with the undergraduate advising head.

Faculty

Leslie Griffith, Chair (National Center for Behavioral Genomics; Volen National Center for Complex Systems)
Biochemistry of synaptic plasticity.

Susan Birren (National Center for Behavioral Genomics; Volen National Center for Complex Systems)
Developmental neurobiology.

Carolyn Cohen (Rosenstiel Center)
Structural molecular biology.

Paul Garrity (National Center for Behavioral Genomics; Volen National Center for Complex Systems)
Neural development and behavior.

Bruce Goode (Rosenstiel Center)
Biochemistry and genetics of yeast cytoskeleton.

James Haber (Director, Rosenstiel Center)
Genetics and molecular biology of yeast meiotic and mitotic recombination. Mating-type switching. Repair of broken chromosomes.

Kenneth Hayes (Director, Foster Animal Lab) on leave spring 2011
Comparative nutritional pathophysiology in man and animals. Lipoprotein metabolism and atherogenesis, cholelithiasis.

Lizbeth Hedstrom
Enzyme structure-function. Chemical biology. Mechanisms of retinal degeneration.

Elaine Hiller
Human genetics.

Melissa Kosinski-Collins
Protein biochemistry and biology education.

Nelson Lau (Rosenstiel Center)
Gene and genome regulation by RNAi and small RNAs. Molecular biology of germline gene and transposon regulation.

John Lisman (Volen National Center for Complex Systems; Chair, Neuroscience)
Mechanisms of phototransduction. Molecular mechanism of memory storage.

Susan Lovett ( Assistant Director, Professional Science Master’s Program in Biotechnology; Rosenstiel Center)
Genetics and molecular biology of bacteria and yeast. DNA repair. Recombination and mutagenesis.

Michael Marr (Rosenstiel Center)
Mechanisms controlling gene expression.

Eve Marder (Volen National Center for Complex Systems)
Neurotransmitter modulation of neural circuits.

Paul Miller (Volen National Center for Complex Systems)
Computational and theoretical neuroscience.

James Morris
Epigenetics and biology education.

Sacha Nelson (National Center for Behavioral Genomics; Volen National Center for Complex Systems) on leave 2010-2011
Synaptic integration in the visual cortex.

Daniela Nicastro (Rosenstiel Center)
Electron tomography of cellular and macromolecular structures.

Suzanne Paradis (National Center for Behavioral Genomics; Volen National Center for Complex Systems)
Molecular mechanisms of synapse development.

Dan L. Perlman
Ecology, conservation biology, animal behavior.

Joan Press, Undergraduate Advising Head and Senior Honors Coordinator (Rosenstiel Center) on leave fall 2010
Developmental immunology and immunogenetics.

Ruibao Ren (Rosenstiel Center)
Signal transduction.

Avital Rodal (Rosenstiel Center)
Endosomal Membrane Traffic in Neurons.

Michael Rosbash (National Center for Behavioral Genomics; Volen National Center for Complex Systems)
RNA processing and molecular neurobiology.

Piali Sengupta (National Center for Behavioral Genomics; Volen National Center for Complex Systems)
Behavioral and neuronal development in C. elegans.

Neil Simister (Director, Professional Science Master’s Program in Biotechnology; Rosenstiel Center)
Molecular immunology. Antibody transport.

Judith Tsipis (Chair, Genetic Counseling)
Genetic counseling.

Gina Turrigiano (National Center for Behavioral Genomics; Volen National Center for Complex Systems) on leave 2010-2011
Activity-dependent regulation of neuronal properties.

Stephen Van Hooser (Volen National Center for Complex Systems)
Development and function of cortical circuits.

Lawrence Wangh
Mammalian embryogenesis. Gene expression in single cells. DNA amplification and in vitro DNA diagnostics.

Satoshi Yoshida (Rosenstiel Center)
Cytoskeletal organization during cell division.

Requirements for the Major

A. Required of all candidates: BIOL 22a,b; BIOL 18a,b lab; CHEM 11a,b or CHEM 15a,b; CHEM 18a,b or CHEM 19a,b lab; CHEM 25a,b; CHEM 29a,b lab; PHYS 10a,b or PHYS 11a,b or PHYS 15a,b; PHYS 18a,b or PHYS 19a,b lab; and Option I or II below.

Option I: The BA Degree in Biology
The BA is the standard biology option that provides students with a general background in biology. In addition to the courses required of all candidates (listed above), students must complete one course from the Quantitative Course List below. Also, students must complete a total of five elective courses, three of which must come from Category 1 (below) and be taken at Brandeis.

The combination of BIOL 93 plus BIOL 99, or two semesters of BIOL 99 (or NEUR 99a,b) may count as one elective in Category 1 with permission of the biology department honors coordinator and the biology undergraduate advising head.

Additional courses may be taken as electives from the Quantitative Course List, Category 1, or Category 2 (see below).

Option II: The BS Degree in Biology
The BS is the intensive biology option that provides students with a strong background in several areas of biology. In addition to the courses required of all candidates (listed as in A above), students must complete BCHM 100a plus two courses from the Quantitative Course List. In addition, students must complete five elective courses, at least three of which must come from Category 1 and be taken at Brandeis.

The combination of BIOL 93 plus BIOL 99, or two semesters of BIOL 99 (or NEUR 99a,b) may count as one elective in Category 1 with permission of the biology department honors coordinator and the biology undergraduate advising head.

Additional courses may be taken as electives from the Quantitative Course List (beyond the two used to fulfill the BS quantitative requirement), Category 1, or Category 2 (see below).

No course offered for major requirements in either Option I or II may be taken on a pass/fail basis. Satisfactory grades (C- or above) must be earned in all biology and biochemistry courses offered for the major, in any course(s) offered for the quantitative requirement, and in all elective courses offered for the major in biology. No more than one D will be allowed in any other course offered toward the requirements in this department.

Quantitative Course List
BIOL 135b
CHEM 144a
MATH 10a, 10b, 15a, 20a, 22a, 22b
NPHY 115a
NPSY 137b
QBIO 110a
Any one of the following statistics courses: BIOL 51a, ECON 83a, HSSP 100b, MATH 36b, or PSYC 51a.

Category 1 Electives (three electives must come from this course list)
BIOL 15a (only if taken before BIOL 22a or b)
BIOL 17b
All other BIOL courses numbered higher than 22 (excluding BIOL 51a, courses numbered 90-98 and BIOL 135b.)
BCHM 100a (for BA only; BCHM100 is a requirement for the BS)
CBIO 106b
All NBIO courses (excluding courses numbered 90-98)

One semester of BIOL 93 plus one semester of BIOL 99, or two semesters of BIOL 99 (or NEUR 99a,b) may count as one elective with permission of the biology department honors coordinator and the biology undergraduate advising head.

Category 2 Electives
ANTH 116a
BCHM courses numbered higher than 100
CHEM 33a, CHEM 141a, CHEM 142a, CHEM 143b, CHEM 146a, CHEM 147b
QBIO 120b
PHYS 105a

Note: Only one course may be taken from the statistics grouping (BIOL 51a, PSYC 51a, ECON 83a, MATH 36b, or HSSP 100b), and this one course can be used either as an elective or to fulfill the quantitative requirement, but not both.  

Note:  AP calculus can not be used to satisfy the quantitative requirement or the elective requirement. 

B. Independent Research (BIOL 93)
Any junior or senior majoring in biology may enroll in BIOL 93 (Independent Research). This course on its own does not count as an elective but may be used for course credit. The internship may be done during the summer or during one academic semester. No more than one BIOL 93 course may be taken. Students must petition the department for participation in BIOL 93. Petitions and information about the research internships are available in the biology department office. See BIOL 93 course description for details.

C. Senior Research
Any senior majoring in biology may enroll in senior research. This two-semester program is taken as a combination of two courses, which can be either BIOL 93 and BIOL 99, or  BIOL 99a and BIOL 99b

In the first option, the student can do the BIOL 93 research internship in the summer of junior year followed by BIOL 99a in fall semester of senior year; or the student may do the BIOL 93 research internship in fall semester, followed by BIOL 99 in spring semester of senior year. 

In the second option, the student enrolls in BIOL 99a in fall semester and BIOL 99b (or BIOL 99e) in spring semester of the senior year. The combination of BIOL 93 and BIOL 99, or the combination of BIOL 99a and BIOL 99b, may be used as one elective in biology. No more than 3 courses (combinations of BIOL 93, BIOL 99) may be taken for course credit. Students petition the department for participation in BIOL 93 or BIOL 99. Petitions and information about the research internship and senior research are available in the biology department office. See BIOL 93 and BIOL 99 course descriptions for details.

D. Senior Honors Program
Intensive laboratory research and scholastic excellence are major components of the senior honors program. The student enrolls in senior research (as described above, in section C above). At the conclusion of their second research semester (BIOL 93 and BIOL 99a, or BIOL 99a and BIOL 99b), candidates for senior honors will give an oral defense of their senior honors thesis to a designated faculty research committee. At the conclusion of their senior year, candidates for senior honors must have either (i) a minimum 3.30 GPA in all courses offered for the biology major, or (ii) a minimum 3.00 GPA in courses offered for the biology major and also have achieved an average of B+ or higher in three biology electives, not including the BIOL 93 or BIOL 99 elective. Petitions and information about the senior honors program are available in the biology department office.

Combined BS/MS Program

Four-year Combined BS/MS Program in Biology

Candidates for departmental honors may be admitted to a special four-year BS/MS program upon recommendation of the department and approval by the Graduate School. Application to the Graduate School must be made by May 1 preceding the senior year; applications should include a proposed course of study specifying how all degree requirements will be met, a transcript, a letter of recommendation from the research sponsor, and a brief description of the proposed research project.

To qualify for the BS/MS degree in biology, students must complete a total of thirty-eight courses; these courses must include those needed to satisfy requirements A option II, and D, as indicated above, plus three additional electives in biology or biochemistry or as listed under requirement A option II, above. Of the eight electives required for the BS/MS degree, at least six must be at the graduate level (and completed with a grade of B- or higher) and they must include courses from at least three of the research areas of the biology department. Research areas include genetics, molecular biology, cell biology, structural biology, immunology, and neurobiology.

In addition, a substantial research contribution is required, and students must submit a research thesis to the biology department graduate committee for review. A thesis submitted for the master's degree may also be submitted to the biology department for departmental honors. The master’s thesis must be deposited electronically to the Robert D. Farber University Archives at Brandeis.

Five-year Combined BA /MS or BS/MS Program in Biotechnology

This combined degree program allows students to complete the full master’s program in biotechnology with one additional year of graduate study after earning a BA or BS degree at Brandeis. Requirements for the bachelor's degree, defined by the College of Arts and Sciences, remain unaffected by participation in this program. Students who successfully complete the five-year program must receive the bachelor's degree by the end of their fourth year and will matriculate in the Graduate School in the fifth year.

Applicants must demonstrate (through their transcripts and as clearly described in the application statement of purpose) that they can complete the requirements for a bachelor’s degree while pursuing the courses of the full Year 1 master's in biotechnology curriculum. Students may achieve the bachelor’s degree in any major, but must have completed one full year of introductory biology and laboratory (BIOL 22a,b, BIOL 18a,b) and introductory chemistry and laboratory (CHEM 11a,b or CHEM 15a,b and CHEM 18a,b or CHEM 19a,b) to qualify for admission into the 5-year program.

Students interested in this option should apply to the Graduate School of Arts and Sciences in their junior year. If accepted into the program, students will be expected to take the six required courses of the Biotechnology Year 1 program, plus CONT200 Ethics, in their senior years Students may elect one additional course of their choosing each semester to complete any bachelor’s degree requirements.

Brandeis 5-year degree students would then continue with the summer internship and enter the Year 2 curriculum in the fall of their 5th years.

Special Notes Relating to the Undergraduate Program

A. BIOL 18a and b (labs) and BIOL 22a and b will satisfy the general biology entrance requirements of most medical schools. 

B. Biology majors wishing to study ecology, conservation, and marine studies may wish to look into the environmental studies program described in this Bulletin, as well as the following programs:

Semester in Environmental Science at the Marine Biological Laboratory in Woods Hole: Five courses are offered each fall as part of a residential program, including the analysis of terrestrial and aquatic ecosystems, microbial and animal ecology, global issues, and ecological modeling. Every student must do an independent research project during the semester. Up to four semester course credits may be earned toward the Brandeis degree and two semester course credits may be counted toward the biology BA or BS elective requirement.

Denmark's International Studies Program: DIS offers a range of programs in marine biology and ecology, environmental biology, medical practice and policy, and molecular biology and genetics.

School for Field Studies: SFS offers programs at a number of different sites around the world, including East Africa, Costa Rica, Baja Mexico, Australia, and the West Indies.

School for International Training: SIT offers programs around the world in ecology, conservation, and sustainable development.

Students should see Mr. D.L. Perlman for further information on these programs, including information on the transferability of course credits as biology electives.

C. Biology majors who wish to enroll in PHYS 11a and b (Basic Physics), rather than PHYS 10a and b (Physics for the Life Sciences), must complete both MATH 10a and b as prerequisites.

D. AP exam credit: Students receiving AP credit as per university guidelines may use these to satisfy the general chemistry (CHEM 11) or physics (PHYS 10, 11) requirements. However, neither AP Math AB scores of 4, 5 nor AP Math BC scores of 3, 4, 5 may be used to satisfy the quantitative course requirement for the biology major.

Master of Science in Biotechnology

Program of Study
The program provides interdisciplinary, professionally-oriented training in biotechnology, stressing both science and business concepts. Mastery of the field of biotechnology will be taught both in the classroom and through hands-on laboratory work. In addition, students will build professional skills in data analysis, searching and reading the scientific literature, scientific writing, oral presentation and team project management.

The program includes a summer internship at a biotechnology or pharmaceutical company or non-profit research center or in one of many biological sciences research laboratories on the Brandeis campus. Research areas on campus include genetics, molecular biology, developmental biology, cell biology, chemical biology, biophysics, structural biology, immunology, and neurobiology. Students should enroll in BIOT 212a for credit for the internship.

A total of 12 other graduate-level courses are required for the program, which must include BIOL 101b (Molecular Biotechnology), BIOL 103a (Mechanisms of Cell Function) or BIOL 102a (Structural Molecular Biology), and two laboratory courses, BIOL 156a (Project Laboratory in Biotechnology) and BCHM 155b (Biochemistry Laboratory). Required business-focused courses include BIOT 200a (Proseminar in Biotechnology), BIOT 201b (The Business of Biotechnology), BIOT 202a (Regulatory Affairs in Bioscience), and BUS 261a (Managing Technology). The remaining courses in science or business will be elected in consultation with the Program Director.

In addition, all students are required to take CONT 300b (Ethical Practice in Health-Related Sciences), offered in the spring. The student must receive grades of B- or better in all courses and may be terminated at the end of the first semester if the student's record is unsatisfactory.

Residence Requirement
The minimum residence requirement is two years.


Courses of Instruction

(1-99) Primarily for Undergraduate Students

BIOL 15b Biology: Human Implications
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This course may not be taken for credit by students who have completed BIOL 22a or BIOL 22b. Core course for the HSSP program.
The last half-century brought an unprecedented expansion of our knowledge of the living world. The effects of these discoveries on our lives and the effects of our lives on the rest of the living world are increasing. Recent developments in biology affect our health care choices, our consumer choices, and even our choices as parents. This course is intended as an introduction to contemporary biology. It stresses the fundamentals of cell biology and genetics and explores the diversity of life, including microorganisms and plants. It emphasizes evolution, physiology, and ecology. The course is intended to prepare students to understand the biology of everyday life, and to provide a strong foundation for those who continue to study the life sciences. Usually offered every year.
Mr. Simister

BIOL 17b Conservation Biology
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First- and second-year students should contact the instructor before enrolling in this writing-intensive course.
Considers the current worldwide loss of biological diversity, causes of this loss, and methods for protecting and conserving biodiversity. Explores biological and social aspects of the problems and their solutions. Usually offered every year.
Mr. D.L. Perlman

BIOL 18a General Biology Laboratory
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This is an experiential learning course. Prerequisites: CHEM 18a or 19a, and BIOL 18b, or permission of the instructor. BIOL 22a must be taken before or concurrently with this course. Yields full-course credit. Laboratory fee: $150 per semester. This lab is time-intensive and students will be expected to come in to lab between regular scheduled lab sessions. In order to accommodate students with time conflicts it may be necessary to re-assign students without conflicts to another section of the course. Students' section
choice will be honored if possible
Provides firsthand experience with a wide array of organisms and illustrates basic approaches to experimental design and problem solving in genetics and genomics. Usually offered every year.
Ms. Kosinski-Collins

BIOL 18b General Biology Laboratory
This is an experiential learning course. Prerequisites: CHEM 18a or 19a. BIOL 22b must be taken before or concurrently with this course. Yields half-course credit. Laboratory fee: $150 per semester. This lab is time-intensive and students will be expected to come to lab between regular scheduled lab sessions. In order to accommodate students with time conflicts it may be necessary to re-assign students without conflicts to another section of the course. Students' section choice will be honored if possible.
Provides firsthand experience with modern molecular biology techniques and illustrates basic approaches to experimental design and problem solving in molecular and cellular biology including applications of biochemical techniques. Usually offered every year.
Ms. Kosinski-Collins

BIOL 22a Genetics and Molecular Biology
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Prerequisite: CHEM 10a or 11a or 15a.
An introduction to our current understanding of hereditary mechanisms and the molecular basis of gene transmission and expression. Usually offered every year.
Mr. Haber and Mr. Marr

BIOL 22b Cell Structure and Function
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Prerequisite: CHEM 10a or 11a or 15a.
An introduction to the architecture and function of cells, organelles, and their macromolecular components. Topics include fundamental processes that are common to all cells, and the functions of specialized cells. Usually offered every year.
Ms. Nicastro

BIOL 23a Ecology
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Prerequisites: BIOL 22a or 15b, or a score of 5 on the AP Biology Exam, or permission of the instructor.
Studies organisms and the environments in which they live. Focuses on the physical factors and intra- and interspecies interactions that explain the distribution and abundance of individual species from an evolutionary perspective. Usually offered every year.
Staff

BIOL 25a Molecular Motors
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Prerequisite: BIOL 22b.
A discussion of movement at the cellular level. Analyzes how molecular motors generate motion and how their activity is controlled. Topics include intracellular transport, muscle contraction, rotary motion, enzymes moving along DNA, and cell division. Usually offered every second year.
Staff

BIOL 28a Marine Biology
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Prerequisites: BIOL 22a and b.
Survey of the basic biology, behavior, and life history of marine biota. Review of physical habitats, from polar to tropical waters. Weekly laboratory consists of field trips to different habitats and examination of specimens from several marine phyla. Focus is on the evolution of adaptive responses to the physical and biological factors in marine communities. Usually offered every third year.
Staff

BIOL 30b Biology of Whales
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Prerequisites: BIOL 22a and b, plus one upper-level biology elective.
Examines the biology and conservation of whales, dolphins, and porpoises. Topics include physiology, morphology, population biology, life history, molecular genetics, distributional ecology, and social behavior. Usually offered every third year.
Staff

BIOL 31b Biology of Fishes
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Prerequisites: BIOL 22a and b, plus two upper-level biology electives.
Topics include evolution, systematics, anatomy, physiology, and behavior of freshwater, marine, and anadromous fishes from temperate and tropical environments. Studies fish interactions in communities: predator/prey, host/symbiont relationships, and fish as herbivores. Also examines the ecology of fish populations. Usually offered every third year.
Staff

BIOL 32a Field Biology
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Students must be enrolled in the Environmental Field Semester (JBS) to enroll in this course in fall 2010.
This is an experiential learning course. Introduces students to the biodiversity of southern New England, emphasizing woody plants . Course work primarily takes place on field trips to various terrestrial and aquatic habitats. Usually offered every year.
Mr. D.L. Perlman

BIOL 42a Physiology
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Prerequisites: BIOL 22a and b. CHEM 25a and b are recommended.
Introduces basic physiological principles. Topics include physiology of cardiovascular and respiratory systems, electrolyte regulation, digestion and absorption, and reproduction, with an overview of immunology. Usually offered every year.
Mr. Ren

BIOL 43b Comparative Vertebrate Anatomy
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This is an experiential learning course. Prerequisite: BIOL 22b.
This course provides a solid basis for understanding of vertebrate and, in particular, human anatomy. The gross and microscopic morphology of each organ system is considered in depth. Comparative anatomy, embryology, and relationships between structure and function are emphasized. Lectures, laboratory dissections, and clinical cases are used to illustrate the structure and function of the vertebrate body. Usually offered every year.
Mr. Morris

BIOL 50b Animal Behavior
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Prerequisites: BIOL 23a or BIOL 60b.
Examines a wide range of animal behavior, including mating and reproductive tactics, territoriality, and social behaviors. The course employs an ecological framework to understand the evolution of behavior. Usually offered every second year.
Mr. D.L. Perlman

BIOL 51a Biostatistics
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Prerequisite: MATH 10a.
A basic introduction to methods of statistics and mathematical analysis applied to problems in the life sciences. Topics include statistical analysis of experimental data, mathematical description of chemical reactions, and mathematical models in neuroscience, population biology, and epidemiology. Usually offered every year.
Staff

BIOL 55b Diet and Health
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Prerequisite: BIOL 22b must be successfully completed prior to taking BIOL 55b.
Reviews the current evidence concerning dietary impact on the chronic diseases of humans. Topics include genetics and nutrition, cardiovascular disease, obesity, diabetes, osteoporosis, and cancer. Students also examine the involvement of specific nutrients; for example, fat and cholesterol, vitamins, minerals, fiber, and alcohol in these disease processes. Usually offered every second year.
Mr. Hayes

BIOL 60b Evolution
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Prerequisite: BIOL 22a.
"Nothing in biology makes sense except in the light of evolution," Dobzhansky said famously. Evolution is a unifying theory of biology because it explains almost everything about the living worldboth the diversity of life and the similarities among organisms. This course examines processes and patterns of evolution, including the origin and fate of variation, natural and sexual selection, inbreeding and genetic drift, the evolution of sociality, the species concept and the origin of species, biodiversity, and phylogenetics, as well as the history of life on Earth, including the fossil record and human evolution. Usually offered every year.
Mr. Morris

BIOL 93a Research Internship and Analysis
Supervised biological research experience in a Brandeis University laboratory. In consultation with a Brandeis faculty member, the student will design and execute an individual research project, culminating in an oral and written presentation. Students seeking to do biology research in Brandeis laboratories outside the biology department must obtain sponsorship of a biology department faculty member as well as permission of the departmental undergraduate advising head (UAH). This course is not intended to and will not provide credit for off-campus internships. BIOL 93a is offered both semesters but is a one-semester course and may be taken only once. Students must petition the department for permission to enroll in BIOL 93a.Course requirements include laboratory research, a written report and an oral presentation, as specified in the BIOL 93a petition. Students wishing to do a summer internship for academic credit must: obtain permission from their biology department sponsor prior to commencing the internship; complete the summer internship (a minimum of 10 weeks full-time); and complete the appropriate academic work. Credit will be awarded via the student enrolling BIOL 93a in the subsequent fall term. BIOL 93a may also be used as one of the two courses needed for Senior Research (see BIOL 99). Usually offered every semester.
Staff

BIOL 98a Readings in Biology
Prerequisites: BIOL 22a and b. Does NOT meet requirements for the major in biology. May not be taken for credit by students who have satisfactorily completed BIOL 98b.
Open to exceptionally well-qualified students. This is a tutorial course with readings in a specified biological field. The student will be given a reading list, including current literature and reviews of the topic to be discussed. Course requirements include weekly discussions and the writing of several papers. Usually offered every year.
Staff

BIOL 98b Readings in Biology
Prerequisites: BIOL 22a and b. Does NOT meet the major requirement in biology. May not be taken for credit by students who have satisfactorily completed BIOL 98a.
See BIOL 98a for course description. Usually offered every year.
Staff

BIOL 99a Senior Research
The first of a two-semester course involving the student in an independent research project conducted under the supervision of a staff member and serving as an intensive introduction to specific methods of biological research. In cases where students are able to do unusually long, intensive work in the laboratory, they may request a third course credit during the petition process; if this request is approved by the senior honors coordinator, students should register for BIOL 99a (fall) followed by BIOL 99e (spring). The combined enrollments for Senior Research may not exceed three semester course credits. Two semesters of BIOL 99 may be used as one elective for the biology major. Students may also use one semester of BIOL 93 and one semester of BIOL 99 to count as senior research and one elective. To fulfill the BIOL 99 requirements, students must (1) submit to their research sponsor, at the conclusion of their first BIOL 99 semester, a paper that reviews the literature pertinent to their field of research (or, fulfill the BIOL 93 requirements), and (2) submit to their research sponsor, at the conclusion of their second BIOL 99 semester, a senior thesis that includes an abstract, an introduction, a review of materials and methods, results, discussion, and references. Students must petition the department for permission to enroll in BIOL 99. Usually offered every year.
Staff

BIOL 99b Senior Research
A continuation of BIOL 99a. See BIOL 99a for course description.
Staff

BIOL 99e Senior Research
See BIOL 99a for course description. Usually offered every semester.
Staff

BISC 2a Human Reproduction, Population Explosion, Global Consequences
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Does NOT meet requirements for the major in biology.
Appropriate for students interested in a broad range of fields, including biology, environmental studies, and the social sciences. This course progresses from a molecular and cellular biology description of basic facts in human genetics and reproduction, AND an evolutionary description of human origins in Africa and global migration, to a demographic and epidemiological view of human population growth, and a consideration of some of the very complex problems arising from the presence of more than six billion people on Earth today. Readings include scientific papers appropriate to students with high school backgrounds in biology and chemistry, essays in the social sciences, and a wide variety of other texts and media. Usually offered every second year.
Mr. Wangh

BISC 2b Genes and the Human Story
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Does NOT meet requirements for the major in biology.
Findings from the Human Genome Project are correlated with cultural,historical, and religious information about human origins, human reproduction, infectious diseases, and lineages of human populations. Usually offered every third year.
Mr. Wangh

BISC 3a Paradigms of Biological Investigation
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Does NOT meet requirements for the major in biology. May not be taken by students who have completed BIOL 22a or BIOL 22b.
Examines the concepts and principles of scientific research with examples from its Greek beginnings to modern times. Topics from evolutionary biology, biophysics, molecular biology, and physics are used to describe the nature of scientific advances. Concepts related to experimental design and critical thinking are considered. Usually offered every year.
Mr. Farber

BISC 3b Humans and the Environment
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Does NOT meet requirements for the major in biology.
Explores a range of interactions between organisms and their environments. Focuses on human interactions with and impacts on the natural world. Usually offered every third year.
Mr. D.L. Perlman

BISC 4a Heredity
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Does NOT meet requirements for the major in biology. May not be taken by students who have completed BIOL 22a.
An exploration of what genes are and their functions. Examines how genes are inherited, how they work, and how changes in certain genes cause inherited diseases. Also investigates recent biological developments such as the Human Genome Project, genomics, gene therapy, stem cells, and the new medical and ethical challenges these developments pose in the twenty-first century. Usually offered every third year.
Ms. Sengupta

BISC 4b Food, Nutrition, and Health
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Does NOT meet requirements for the major in biology.
Nutrition is the science of food and its role in health and disease. This course will introduce the biological background to provide students with tools to better understand everything from how we choose food to how our diet influences our long-term health. Usually offered every year.
Ms. Lai

BISC 5a Pathogens and Human Disease
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Prerequisite: High school chemistry and biology. Does NOT meet requirements for the major in biology. May not be taken by students who have completed BIOL 125a, 132a, or 175b.
This course discusses the life cycle, pathogenesis, transmission, and epidemiology of certain organisms (bacteria, viruses, fungi, etc.) that cause important human diseases. Other topics include emerging diseases, host defense mechanisms, vaccines, public health concerns. Usually offered every year.
Ms. Press

BISC 5b Diseases of the Mind
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Prerequisite: High school chemistry. Does NOT meet requirements for the major in biology. May not be taken by students who have completed BIOL 22b.
An exploration of biology of several protein folding diseases including Alzheimer's, Parkinson's, Huntington's, ALS, and mad cow disease and their effect on normal brain function. Examines the medical and ethical challenges of therapies, drug design, and clinical trials on patients afflicted with these disorders. Usually offered every second year.
Ms. Kosinski-Collins

BISC 6b Environmental Health
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Does NOT meet requirements for the major in biology. Yields six semester-hour credits towards rate of work and graduation.
The impact on human health of environmental contamination with toxic, carcinogenic, or pathogenic agents. Tools of toxicology, epidemiology, and risk assessment are applied to specific environmental issues such as air and water quality, petroleum, metal, and other chemical contaminations. Usually offered every second year.
Staff

BISC 6bj Environmental Health
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Does NOT meet requirements for the major in biology. Yields six semester-hour credits towards rate of work and graduation.
An introduction to the science and tools of environmental health, giving students hands-on skills to explore directly current issues experienced by local communities. Students will become familiar with the environmental health paradigm, the conceptual model of the field, including underlying principles of hazard identification, exposure assessment, toxicology, risk assessment, and characterization and interpretation of epidemiological studies. Offered as part of JBS program.
Mr. Stewart

BISC 7a The Biology and Culture of Deafness
This is an experiential learning course. Does NOT satisfy the school of science requirement. Does NOT meet requirements for the major in biology.
An exploration of the biology, sociology, and language of the deaf. Looks at mechanisms of hearing and different causes of deafness. Medical models of deafness are compared with sociological and cultural concepts of deafness. The course also introduces students to the language of the deaf community in the United States, American Sign Language (ASL). Usually offered every second year.
Mr. Morris

BISC 7b Exercise Physiology
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Does NOT meet requirements for the major in biology.
An introductory course in exercise physiology, with the focus on the muscular, neuromuscular, cardiovascular, and metabolic responses and the physiological adaptations that occur during exercise. Concepts related to physical fitness, body composition/weight control, and training principles are discussed. Usually offered every year.
Mr. Burr

BISC 8a Stem Cells and Regenerative Medicine
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Prerequisite: High school biology and chemistry. Does NOT meet the requirements for the major in biology.
Examines the science, history, policies and ethics behind this biomedical field. Although stem cells and regenerative medicine are touted as the next breakthroughs in human therapies, they have also engendered much argument and controversy. This course provides the scientific context for understanding the debate over stem cell research, and discusses the promises and pitfalls of the field. Usually offered every second year.
Mr. Lau

BISC 8b Drugs that Changed the World
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Prerequisite: High school chemistry and biology. Does NOT meet the requirements for the major in biology.
Introduces the science underlying drug discovery and development. Students learn basic principles of microbiology, chemistry, biology, pharmacology and statistics while learning how a drug progresses from bench to bedside. Students learn to decipher a drug packaging insert. Topics include landmarks in antibiotic and cancer chemotherapy, featuring recently approved drugs such as Herceptin and Gleevec. Readings are drawn from the original scientific literature, FDA rulings, patent law, and the popular press. Usually offered every third year.
Ms. Hedstrom

(100-199) For Both Undergraduate and Graduate Students

BIOL 101a Molecular Biotechnology
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Prerequisite: BIOL 22a.
A study of the molecular basis of DNA replication, RNA transcription focusing on molecular biology techniques such as PCR, DNA sequencing, genomics, cloning, microarrays, and siRNA and their relation to human disease research applications. Usually offered every year.
Ms. Kosinski-Collins

BIOL 102b Structural Molecular Biology
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Prerequisites: BIOL 22a and b, or permission of the instructor.
Cells are filled with machines that carry materials about the cell, that chemically transform molecules, that transduce energy, and much more. Our understanding of how these machines work depends on understanding their structures. This introduction to the structural basis of molecular biology examines the designs of proteins, their folding and assembly, and the means whereby we visualize these structures. Usually offered every second year.
Ms. Kosinski-Collins

BIOL 103b Mechanisms of Cell Functions
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Prerequisite: BIOL 22b or permission of the instructor.
An advanced course focusing on a mechanistic understanding of cell biological processes and the methods by which these processes are elucidated. Papers are chosen to illustrate a variety of experimental approaches, including biochemistry, genetics, and microscopy. Topics include cell cycle, signal transduction, cytoskeleton and cell movement, membrane traffic, and intercellular transport. Usually offered every year.
Mr. Goode and Mr. Yoshida

BIOL 105b Molecular Biology
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Prerequisites: BIOL 22a and b.
Examination of molecular processes in replication and expression of genetic information and techniques by which this understanding has been achieved. Topics include recombinant DNA and other molecular biological techniques, structure and organization of DNA in chromosomes, DNA replication, transcription and regulation of gene expression, RNA structure and processing, mRNA stability, and other mechanisms of post-translational control. Usually offered every year.
Mr. Marr and Mr. Rosbash

BIOL 111a Developmental Biology
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Prerequisite: BIOL 22b.
How do complex organisms build themselves starting from single cells? Examines how processes such as fertilization, embryogenesis, cell differentiation, and tissue-specific gene expression occur; what is known about the key molecules and genes that orchestrate these processes; and how genetic changes affecting these processes underlie the evolution of body form. Usually offered every second year.
Ms. Paradis and Ms. Sengupta

BIOL 122a Molecular Genetics
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Prerequisite: BIOL 22a.
A lecture- and literature-based course emphasizing strategies of genetic analysis in understanding complex processes,mostly in eukaryotes such as budding and fission yeast, fruit flies, worms and mice. Examples will focus on the control of DNA replication, the regulation of the cell cycle and cell differentiation, and on mechanisms that preserve genetic stability and ensure accurate transmission of genetic information from generation to generation in both somatic and germ cells. Classical genetic methods and recent molecular genetic and genomic approaches will be examined. Usually offered every second year.
Mr. Haber

BIOL 124b Epigenetics
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Prerequisites: BIOL 18a,b and 22a,b.
For years our concept of gene expression has been written in the language of DNA. Recently, scientists are turning their attention to alterations in chromatin structure that can stably and heritably influence gene expression. Such epigenetic changes are reversible and responsive to the environment. Drawing on readings from the primary literature, this course explores molecular mechanisms underlying diverse epigenetic phenomena. Their role in development, evolution, and human health is also considered.
Mr. Morris

BIOL 125a Immunology
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Prerequisites: BIOL 22a and b.
Topics include properties, functions of cells involved in innate and adaptive immunity; genes, structure, function of immunoglobins and T cell receptors; cell interactions; lymphocyte differentiation; genetic regulation; MHC restriction; cell interactions and signaling; tolerance and autoimmunity; vaccines; viral immunity; AIDS. Usually offered every year.
Ms. Press

BIOL 126b Protein Structure and Disease
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Prerequisites: BIOL 22a and b, or the equivalent, or permission of the instructor.
Reviews the basic principles of protein structure so that the functional aspects of different protein designs may be understood. Examines various protein mutations related to certain molecular diseases and the architecture of some key viruses and their infectivity. Consideration of drug design is an integral part of the course. Student presentations are essential to the course. Usually offered every second year.
Ms. Cohen

BIOL 128a Human Genetics
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Prerequisites: BIOL 22a and b.
Survey of topics, including: mutation and polymorphism; molecular methodology; single-gene inheritance and complexities thereof; multifactorial conditions, risk assessment, and Bayesian analysis; cytogenetics; hemoglobinopathies; population genetics; gene mapping; cancer genetics; ethical considerations in genetics; immunogenetics; pharmacogenetics; genetics of development; biochemistry of selected genetic diseases; gene therapy, genomics, proteomics, and bioinformatics. Usually offered every year.
Ms. Hiller

BIOL 132a General Microbiology
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Prerequisites: BIOL 22a and b.
A survey of the physiology and the properties of bacteria, viruses, and other microorganisms. Topics include microbial nutrition, metabolism, growth, and genetics; immunity and other means of microbial control; pathogenicity, epidemiology, concepts in infectious disease. Selected disease-causing organisms are discussed, including problems they pose for medical control and society. Usually offered every year.
Ms. Press

BIOL 134b Topics in Ecology
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Prerequisites: BIOL 23a or permission of the instructor. Topics may vary from year to year. Please consult the Course Schedule for topic and description. Course may be repeated once for credit with permission of the instructor.
Annually, a different aspect of the global biosphere is selected for analysis. In any year the focus may be on specific ecosystems (e.g., terrestrial, aquatic, tropical, arctic), populations, system modeling, restoration ecology, or other aspects of ecology. Usually offered every year.
Staff

BIOL 135b The Principles of Biological Modeling
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Prerequisite: MATH 10a or 10b.
With examples from neuroscience, cell biology, ecology, evolution, and physiology, dynamical concepts of significance throughout the biological world are discusses. Simple computational and mathematical models are used to demonstrate important roles of the exponential function, feedback, stability, oscillations, and randomness. Usually offered every second year.
Mr. Miller

BIOL 141b Molecular Pathophysiology
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Prerequisite: BIOL 42a, BCHM 100a, or NBIO 140b, or permission of the instructor.
An in-depth investigation of the molecular mechanisms by which the body's organ systems maintain health/homeostasis and succumb to genetic diseases (e.g., cystic fibrosis, Parkinson's disease, ALS), with additional emphasis on understanding how the body adapts to physical exertion and exercise. Usually offered every second year.
Staff

BIOL 149b Molecular Pharmacology
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Prerequisites: BIOL 22b and CHEM 25a and b. NBIO 140b strongly recommended.
Covers the essentials of pharmacology and the study of the actions of chemical agents (drugs, toxins, neurotransmitters, and hormones) that interact with living systems. Emphasizes molecular mechanisms of neuropharmacology. Topics include pharmacokinetics, hormone action, autonomic pharmacology, and the psychopharmacology of drugs of abuse and mental disorders. Usually offered every third year.
Ms. Marder

BIOL 155a Project Laboratory in Genetics and Genomics
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This is an experiential learning course. Prerequisites: BIOL 18a,b and 22a,b. Course fee: $150.
This small, laboratory-based course provides a unique opportunity for students to pursue a genuine research project. Each semester, we focus on a specific topic, such as bacterial genetics, epigenetic mechanisms of gene regulation, or microbial diversity, and design and carry out original experiments. Students learn basic molecular biology techniques, genetic and genomic analysis, experimental design, and the fundamentals of reading and writing research papers. Usually offered every year.
Mr. Morris

BIOL 156a Project Laboratory in Biotechnology
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This is an experiential learning course. Prerequiste: BIOL 18a,b and 22a,b or equivalents. Course fee: $150.
This laboratory course features experiments in molecular biology that are fundamental to the field of biotechnology. This includes DNA isolation, DNA sequence analysis, generation of mutations, recombinant DNA cloning, RNA isolation, polymerase chain reaction including real-time quantitative PCR, and DNA/RNA hybridization methods. As part of the course, students will contribute to real research projects of unknown outcome. Usually offered every year.
Ms. Lovett

BIOL 160b Human Reproductive and Developmental Biology
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Prerequisites: BIOL 22a and b.
Course deals with hormonal, cellular, and molecular aspects of gametogenesis, fertilization, pregnancy, and birth. Pathological and abnormal variations that occur and the available medical technologies for intervention, correction, and facilitation of these processes are discussed. Usually offered every year.
Ms. Jackson

BIOL 172b Growth Control and Cancer
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Prerequisites: BIOL 22a and b.
Covers the fundamental rules of behavior of cells in multicellular organisms. Examines cellular and molecular mechanisms that govern cell growth, and differentiation and survival in normal cells, as well as how this regulation is disrupted in cancer. Usually offered every second year.
Mr. Ren

BIOL 174b Stem Cells
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Prerequisites: BIOL 22a and b.
Stem cells are cells that can both undergo self-renewal and give rise to all cells or special cell types of the body. They have the potential for the restoration of lost organ function that cannot be achieved through traditional drug therapies. Covers stem cell biology, cell differentiation and transdifferentiation, cell lineage commitment, gene expression regulation, signal transduction, cell identity memory, and cell therapies. Provides a unique way to gain insights into developmental biology, molecular and cell biology, cancer biology, biology of aging, and regenerative medicine, as well as bioethics and health and public policies. Usually offered every second year.
Mr. Ren

BIOL 175b Advanced Immunology: Topics in Infectious Disease
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Prerequisites: BIOL 125a and permission of the instructor.
An advanced lecture- and literature-based course that focuses on a select group of microorganisms (bacteria, viruses, etc.) considered important in human disease. Topics include mechanisms/determinants of pathogenicity, immune evasion, host immune responses, vaccines, public health issues, and bioterrorism agents. Usually offered every second year.
Ms. Press

CBIO 106b Chemical Biology: Medicinal Enzymology
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Prerequisites: Satisfactory grade in BIOL 22a and BIOL 22b and CHEM 25a and CHEM 25b or the equivalent.
Introduces students to the conceptual framework and experimental methods in medicinal chemistry. Topics include mechanisms of drug-target interactions, strategies for lead optimization and issues in metabolism, pharmacokinetics and pharmacodynamics. Readings drawn from textbooks and the original scientific literature. Usually offered every third year.
Ms. Hedstrom

NBIO 123b Population Genetics/Genomics
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Prerequisite: BIOL 22a.
Overviews the causes and consequences of genetic differences between and within species. Introduces classical population genetics and modern genomics and explores their application to understanding the genetics of neurological disorders. Usually offered every second year.
Mr. Garrity

NBIO 136b Computational Neuroscience
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Prerequisite: MATH 10a or PHYS 10a or approved equivalents.
An introduction to concepts and methods in computer modeling of neural systems. Topics include single and multicompartmental models of neurons, information representation and processing by populations of neurons, synaptic plasticity and models of learning, working memory, decision making and neuroeconomics. Usually offered every second year.
Mr. Miller

NBIO 140b Principles of Neuroscience
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Prerequisite: BIOL 22b or permission of the instructor.
Examines the basic principles of neuroscience. Topics include resting potentials, action potentials, synaptic transmission, sensory systems, motor systems, learning, neural circuits underlying behavior, neurological diseases, and mental illness. Usually offered every year.
Ms. Marder

NBIO 143b Developmental Neurobiology
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Prerequisite: BIOL 22b or permission of the instructor.
Discusses the mechanisms used in the development of the nervous system. Topics include determination of neuronal cell fates, neuronal differentiation and pattern formation, neuron survival and growth, and mechanisms responsible for generation of connectivity in the nervous system. This course emphasizes reading of original scientific research papers and class discussion. Usually offered every second year.
Ms. Paradis

NBIO 145b Systems Neuroscience
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Prerequisite: NBIO 140b.
We are entering an historic period during which many systems-level mysteries of brain function will be solved. This course will attempt to give a perspective on this enterprise. We will begin by defining what it means to understand a brain region, i.e. what criteria must be satisfied. We will then read and discuss key papers that begin to meet these criteria for different brain stuctures, including the cortex, thalamus, hippocampus, basal ganglia and cerebellum. Usually offered every year.
Mr. Lisman

NBIO 146a The Neurobiology of Human Disease
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Prerequisite: NBIO 140b.
A lecture- and literature-based overview of the neurobiological underpinnings of neurological and psychiatric disorders including autism, mental retardation, schizophrenia, bipolar disorder, Alzheimer's disease, Parkinson's disease, and other developmental and degenerative disorders. Usually offered every second year.
Mr. Nelson

NBIO 147a Neurogenetics
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Prerequisites: BIOL 18a and BIOL 22a.
Topics include function of genes, neurons and neuronal circuits in the generation of behavior. The use of genetics and genetic manipulations in the study of behavior will be emphasized. Model organisms to be discussed will include Drosophila, C. elegans, zebrafish and mammals.Usually offered every third year.
Ms. Sengupta

NBIO 148b Cellular Neuroscience
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Prerequisite: NBIO 140b or permission of the instructor. Graduate students may take this course concurrently with NBIO 140b.
Focuses on cellular and molecular mechanisms of excitability and synaptic plasticity. Students examine classic experiments on action potentials and synaptic transmission and the original research literature dealing with the cellular mechanisms of developmental and learning-related plasticity. Usually offered every year.
Mr. Lisman

NBIO 150a Autism and Human Developmental Disorders
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Prerequisite: BIOL 22b.
Autism and other developmental disorders are characterized by cognitive and behavioral deficits and by subtle changes in brain development. This course takes an integrative approach to investigate the biological, behavioral, medical, and social aspects of human developmental disorders. Usually offered every second year.
Ms. Birren

(200 and above) Primarily for Graduate Students

BIOL 200a Proseminar
For first-year PhD students. Emphasizes the reading, analysis, and presentation of scientific papers. There is considerable emphasis on oral presentations and writing. Students will be guided toward preparing research papers and grant applications, presenting talks and posters at scientific meetings, and writing and defending PhD qualifying exams. Also examines how scientists frame important questions and design appropriate experiments. Papers will be chosen by the instructor for discussions and exercises. Papers focus on one specific research topic while encompassing a broad range of molecular biological, genetic, structural, and biochemical approaches. Usually offered every year.
Mr. Haber and Mr. Yoshida

BIOL 202d Introduction to Genetic Counseling
A two-semester sequence that provides the historical and theoretical foundations for the practice of genetic counseling and the role of genetic services within the health care delivery system. Introduces students to some of the practical aspects of genetic counseling, including case preparation, pedigree construction/interpretation, and medical documentation. Usually offered every year.
Ms. Schneider

BIOL 203a Proseminar: The Molecular Basis of Genetic Diseases
Covers the molecular basis of muscular dystrophy, fragile X syndrome, cystic fibrosis, Huntington's disease, and several inherited cancer syndromes. A historical perspective is used for each topic; molecular diagnostics and genetic counseling issues are addressed as well. Usually offered every year.
Ms. Tsipis

BIOL 204b Clinical Genetics I
Introduction to basic concepts of biochemical genetics, cytogenetics, and clinical molecular genetics. Makes use of clinical cases ranging from single-gene disorders to multifactorially determined conditions and includes problems in dysmorphology, inborn errors of metabolism, and cancer genetics. A problem-solving approach is emphasized. Usually offered every year.
Ms. Schneider and Ms. Stoler

BIOL 205b Counseling Theory and Technique
A comprehensive overview of counseling theory and practice. Topics include listening, observation, and interview skills and strategies; family dynamics and development; coping and adaptation processes; referral and consultation procedures; and ethical principles. Students are provided an opportunity to integrate clinical experiences with the coverage of topics. Usually offered every year.
Mr. Rintell

BIOL 206d Genetic Counseling Journal Club
Noncredit.
Informal biweekly meeting of students and faculty at which recent papers are discussed. Usually offered every year.
Staff

BIOL 207a Genetic Counseling: Case Conferences and Family Counseling
Taught by a team of health care professionals. Case studies provide the basis for discussion of a variety of genetic disorders and the application of counseling modalities. Students have an opportunity to share experiences gained during clinical internships. Discussions emphasize the interplay of medical, psychological, ethical, legal, social, and cultural factors in genetic counseling. Usually offered every year.
Mr. Rintell

BIOL 211a Genetic Counseling Fieldwork Placement: Part I
Students work one day per week in a community-based health service organization, school, clinic, or public health agency to develop awareness of disability-related issues and the variety of community-based services for individuals with special needs. Students also observe in a genetics clinic twenty to thirty hours over the course of the semester to gain exposure to concepts learned in BIOL 202d (Introduction to Genetic Counseling). Periodic course discussions supplement the fieldwork experience. Usually offered every year.
Ms. Rosen-Sheidley

BIOL 211b Genetic Counseling Fieldwork Placement: Part II
To begin preparing for clinical genetics internships, students participate in a variety of experiences that serve to foster and integrate the concepts introduced in courses and presentations. Students are exposed to procedures in clinical labs through lectures, site visits, and/or lab work. In addition, students continue observations in a genetics clinic and meet several times with a family with a child with a disability. Periodic course discussions supplement the fieldwork experience.
Ms. Rosen-Sheidley

BIOL 212a Genetic Counseling Internship I
Students complete a 25-30 contact day clinical genetic internship under the supervision of a genetic counselor or other qualified clinician. Students increase their knowledge of clinical genetics and master genetic counseling skills by offering genetic counseling services in a prenatal, pediatric, cancer, general, adult ,or specialty clinic setting. Usually offered every summer.
Ms. Schneider

BIOL 212b Genetic Counseling Internship II
Students complete a 25-30 contact day clinical genetic internship under the supervision of a genetic counselor or other qualified clinician. Students increase their knowledge of clinical genetics and master genetic counseling skills by offering genetic counseling services in a prenatal, pediatric, cancer, general, adult, or specialty clinic setting. Usually offered every fall and spring.
Ms. Schneider

BIOL 213a Genetic Counseling Research I
In the summer semester students chose a research project, do a review of the literature and summarize key findings, and write a research proposal for a thesis project (to be done in the following fall/spring semesters). Usually offered in the summer.
Ms. Rosen-Sheidley

BIOL 213b Genetic Counseling Research II
Prerequisite: BIOL 213a.
Students are introduced to the principles and basic techniques of social science research in a series of seminars while they implement their thesis research projects. Usually offered fall and spring.
Ms. Rosen-Sheidley

BIOL 214c Genetic Counseling Process Group
In this small group setting, students can share and learn from their collective experiences in their field placements, courses, and individual lives and have the opportunity to process and integrate the experience of becoming a genetic counselor. Usually offered every semester.
Mr. Cunningham

BIOL 215b Readings in Molecular Biology
A combination of readings and clinical laboratory work to provide students with an in-depth understanding of the molecular biology of several human genetic diseases and the techniques used for their diagnosis. Usually offered every year.
Ms. Tsipis

BIOL 216b Internship Seminar Series
This is a noncredit seminar required for all genetic counseling students.
Students meet once a week for a series of lectures, presentations and mock sessions that explore issues related to advanced practice in genetic counseling. Topics include advanced genetic counseling case management, Baysian analysis, and the use of the NSGC code of ethics. Usually offered every year.
Staff

BIOL 220a Clinical Genetics II
Prerequisite: BIOL 204b or permission of the instructor.
Continuation of BIOL 204b with emphasis on the genetic and developmental disorders of most major organ systems. A case-based, problem-solving approach is emphasized. Usually offered every year.
Ms. Schneider and Ms. Stoler

BIOL 224b The RNA World
Prerequisite: BCHM 100a, BIOL 105b, or permission of the instructor.
This course employs seminars and lectures to approach a wide range of topics in RNA research. Topics include RNA enzymes, RNA structure, protein-RNA interactions, pre-mRNA splicing, and RNA localization.
Staff

BIOL 236b Genetics, Law, and Social Policy
Explores advances in human genetics, the clinical and economic benefits promised by new tests, and problems generated by our new ability to manipulate our biological future. Analyzes the role of government in regulating technological development and the legal doctrines of privacy, informed consent, and professional liability. Usually offered every second year.
Ms. Roche

BIOL 298a Readings in Molecular and Cell Biology
Usually offered every year.
Staff

BIOL 299a Master's Research Project
Usually offered every year.
Staff

BIOL 300a Biological Research
Primarily for the first-year student, with the purpose of introducing him or her to biological research and to the work in progress in the laboratories of a number of faculty members. In consultation with the graduate adviser, the student plans a sequence of such tenures, each comprising nine weeks, and then carries out experimental investigations under the guidance of the faculty members involved. Usually offered every year.
Staff

BIOL 300b Biological Research
Primarily for the first-year student, with the purpose of introducing him or her to biological research and to the work in progress in the laboratories of a number of faculty members. In consultation with the graduate adviser, the student plans a sequence of such tenures, each comprising nine weeks, and then carries out experimental investigations under the guidance of the faculty members involved. Usually offered every year.
Staff

BIOL 305d Topics in Molecular Genetics and Development
Usually offered every year.
Mr. Marr

BIOL 316d Mechanisms of Recombination
Usually offered every year.
Mr. Haber and Ms. Lovett

BIOL 350d Graduate Student Research Seminar
Usually offered every year.
Staff

BIOL 401d Dissertation Research
Independent research for PhD candidates. Specific sections for individual faculty members as requested.
Staff

BIOT 200a Biotechnology Proseminar
Prepares students to work in life science industries. Skills taught include reading and evaluating print and online sources, including peer-reviewed publications. Develops skills in written and oral communication for scientific and non-scientific audiences. Usually offered every year.
Mr. Simister

BIOT 201b Business of Biotechnology
Biotechnology industries are based upon recombinant DNA methodology. Most are in areas of medicine, agriculture, and manufacturing. Business of Biotechnolgy gives an overview of these sectors and introduces their research and development models, regulation, financing, and marketing. Usually offered every year.
Mr. Simister

CONT 300b Ethical Practice in Health-Related Sciences
Required of all first-year graduate students in health-related science programs. Not for credit.
Ethics is an essential aspect of scientific research. This course, taught by university faculty from several graduate disciplines, covers major ethical issues germane to the broader scientific enterprise, including areas or applications from a number of fields of study. Usually offered every year.
Ms. Ringe

Cross-Listed in Biology

ANTH 116a Human Osteology
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This is an experiential learning course. Junior and senior majors have priority for enrollment.
Skeletal anatomy and application of forensic techniques to archaeological problems. Hands-on laboratory sessions focus on methods of estimating age, determining sex, assessing variability, distinguishing bone disorders, and identifying cultural and natural modifications to bony tissue. Case studies exemplify bioarchaeological approaches. Usually offered every second year.
Mr. Urcid

BCHM 155b Biochemistry Laboratory
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Prerequisite: BCHM 100a must be taken before or concurrently with this course. Required course for the MS in Biotechnology. Course fee: $150.
Time-intensive laboratory class provides hands-on experience in biochemical techniques, with a focus on proteins. Students engage in skill-building and inquiry-based experiments. Students present research findings in written and oral formats. Usually offered every year.
Ms. Westover

COSI 230a Topics in Computational Biology
Prerequisite: COSI 178a.
This course aims to transcend traditional departmental boundaries and facilitate communications between experimental biologists and computational scientists. Through reading literature and small research projects, students will be introduced to problems in computational biology and learn the methods for studying them.
Mr. Hong

PHYS 105a Biological Physics
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Physical forces in living matter are studied from the perspective offered by statistical mechanics, elasticity theory, and fluid dynamics. Quantitative models for biological structure and function are developed and used to discuss recent experiments in single-molecule biology. Usually offered every second year.
Mr. Hagan

QBIO 110a Numerical Modeling of Biological Systems
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Prerequisite: MATH 10a and b or equivalent.
Modern scientific computation applied to problems in molecular and cell biology. Covers techniques such as numerical integration of differential equations, molecular dynamics and Monte Carlo simulations. Applications range from enzymes and molecular motors to cells. Usually offered every second year.
Staff

QBIO 120b Quantitative Biology Instrumentation Laboratory
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Focuses on optical and other instruments commonly used in biomedical laboratories to make quantitative measurements in vivo and in vitro. Students disassemble and reconfigure modular instruments in laboratory exercises that critically evaluate instrument reliability and usability and investigate the origins of noise and systematic error in measurements. Usually offered every year.
Gelles