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RBIF 101

Structural Bioinformatics

In this intensive course students will investigate the interrelationships existing amongst protein sequence, structure, and function through the lens of a structural bioinformaticist. Topics covered range from analysis of protein structure to domain classification, phylogeny, structural modeling, interaction site prediction, and structure-based drug design. Throughout the course students will be exposed to software tools utilized by structural bioinformaticists in their daily work.

At the end of the course, students will be able to:
• Recognize the structural elements of a protein
• Classify proteins based on sequence and structure
• Perform homology searches and build phylogenetic trees
• Characterize and predict interaction sites
• Build structural models
• Perform structural comparisons
• Predict function based on sequence and structure
• Assess druggability based on structure

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