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RBIF 109

Biological Sequence Analysis

This course provides a foundation in biological sequence analysis, including methods for handling next-generation sequencing data. Topics include genomic assembly and variant detection using short reads, methods for homology detection, functional annotation of sequences, and use of databases and visualization tools.
At the end of the course, students will be able to:
·Align short reads to a reference genome
·Call variants using NGS data
·Evaluate the quality of a genomic assembly
·Perform de novo gene prediction
·Search large databases for homologous sequences
·Annotate genomic sequences using profile-based tools such as HMMer
·Discovery small regulatory motifs in enriched sequences

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