Chemistry Faculty

Bing Xu

Bing Xu

Professor of Chemistry


Group Lab Site
Curriculum Vitae (PDF)


Contact Information

781-736-5201
781-736-2516 FAX
bxu@brandeis.edu


Office

Edison-Lecks 320


Mailing Address

Bing Xu
Brandeis University
MS 015
415 South Street
Waltham, MA 02454-9110


Degrees

Ph.D., University of Pennsylvania
M.S., Nanjing University
B.S., Nanjing University


Profile

Our research focuses on the interdisciplinary frontier of materials chemistry. We integrate the knowledge and techniques in organic chemistry, materials science, surface chemistry, biochemistry, and nanotechnology to design new biofunctional materials, including nanomaterials, for the exploration in biomedicine (e.g., molecular drug delivery, cancer therapy, biomedical diagnostics, and biomimetics), and other fundamental problems in nanoscience and biological science.


Selected Publications

Li, J.; Kuang, Y.; Shi, J. F.; Zhou, J.; Medina, J. E.; Zhou, R.; Yuan, D.; Yang, C. H.; Wang, H. M.; Yang, Z. M.; Liu, J. F.; Dinulescu, D. M.* and Xu, B.* “Enzyme-Instructed Intracellular Molecular Self-assembly to Boost Activity of Cisplatin against Drug-Resistant Ovarian Cancer Cells” Angew. Chem. Intl. Ed., 2015, in press.

Yuan, D.; Shi, J. F.; Du, X. W.; Zhou, N.; Xu, B.* “Supramolecular Glycosylation Accelerates Proteolytic Degradation of Peptide Nanofibrils” J. Am. Chem. Soc., 2015, 137, 10092-10095.

Zhou, J.; Du, X. W.; Li, J.; Yamagata, N.; Xu, B.* “Taurine Boosts Cellular Uptake of Small D-peptides for Enzyme-Instructed Intracellular Molecular Self-assembly”, J. Am. Chem. Soc. 2015, 137, 10040-10043.

Zhou, J.; Xu, B.* “Enzyme-Instructed Self-Assembly (EISA): A Multi-Step Process for Potential Cancer Therapy” Bioconjugate Chem., 2015, 26, 987-999.

Yuan, D.; Du, X. W.; Shi, J. F.; Zhou, N.; Zhou, J.; Xu, B.* “Mixing Biomimetic Heterodimers of Nucleopeptides to Generate Biocompatible and Biostable Supramolecular Hydrogels” Angew. Chem. Intl. Ed., 2015, 54, 5705-5708.

Zhang, Y.;  Zhou, N.; Shi, J. F.; Pochapsky, S. S.; Pochapsky, S. S.; Zhang, B.; Zhang, X. X.;  Xu, B.*  “Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures” Nat. Commun. 2015, 6, 6165.

Shi, J. F.; Du, X. W.; Huang, Y. B.; Zhou, J.; Yuan, D.; Wu, D. D.; Zhang, Y.; Haburcak, R.; Epstein, I. R.*; Xu, B.* “Ligand-Receptor Interaction Catalyzes the Aggregation of Small Molecules to Induce Cell Necroptosis” J. Am. Chem. Soc. 2015, 137, 26-29.

Kuang,Y.; Long, M. J. C.; Zhou, J.; Shi, J. F.; Gao, Y.; Xu, C.; Hedstrom, L.; Xu, B.* “Prion-like Nanofibrils of Small Molecules (PriSM) Selectively Inhibit Cancer Cells by Impeding Cytoskeleton Dynamics” J. Biol. Chem. 2014, 289, 29208.

Kuang, Y.; Shi, J. F.; Li, J.; Yuan, D.; Alberti, K. A.; Xu, Q. B.; Xu, B.* “Pericellular Hydrogel/Nanonets Inhibit Cancer Cells” Angew. Chem. Intl. Ed., 2014, 53, 8104-8107.

Zhou, J.; Du, X. W.; Gao, Y.; Shi, J. F.; Xu, B.* “Aromatic-Aromatic Interactions Enhance Interfiber Contacts for Enzymatic Formation of A Spontaneously Aligned Supramolecular Hydrogel” J. Am. Chem. Soc., 2014, 136, 2970-2973.

For a complete list of publications, see the complete Curriculum Vitae (PDF).