Gabbay Award Winners

25th Annual Jacob and Louise Gabbay Award Lectures in Biotechnology and Medicine Cullin-RING lipases: An Adaptable Platform for Inducing Protein Degradation by Award Recipient Raymond Deshaies and PROTACs and Targeted Protein Degradation: A New Therapeutic Modality by Award Recipient Craig Crews Wednesday, October 25, 2023, 4:00 p.m. Gerstenzang 123
25th (2023)

in recognition of their contributions in the field of targeted protein degradation, spearheading the development of PROTACs

Craig Crews
John C. Malone Professor of Molecular, Cellular, and Developmental Biology

Department of Chemistry

Department of Pharmacology

Executive Director, Yale Center for Molecular Discovery

Yale University

New Haven, CT USA

Raymond Deshaies
Senior Vice President, Global Research

Amgen, Inc.

Visiting Associate, Division of Biology & Biological Engineering

California Institute of Technology

Thousand Oaks, CA USA

VIDEO: 25TH AWARD LECTURES

24th Annual Jacob and Louise Gabbay Award Lecture in Biotechnology and Medicine Engineered Nanobodies for Structural Biology and Drug Discovery Jan Steyaert Thursday, October 27, 2022, 4:00 p.m. Gerstenzang 123
24th (2022)

in recognition of his contributions to structural biology through the development of Camelid single-domain antibodies or nanobodies

Jan Steyaert
Full Professor & Francqui Research Professor
Scientific Co-Director, VIB-VUB Center for Structural Biology
Vlaams Instituut voor Biotechnologie
Vrije Universiteit Brussel
Brussels, Belgium

VIDEO: 24TH AWARD LECTURE

23nd Annual Jacob and Louise Gabbay Award Lectures in Biotechnology and Medicine Antisense Drugs for Neurological Diseases C. Frank Bennett Antisense Modulation of RNA Splicing for Rare-Disease Therapy Adrian R. Krainer Thursday, October 21, 2021, 12:00 p.m. Zoom
23rd (2021)

in recognition of their development of a therapy for the neuromuscular disease spinal muscular atrophy

C. Frank Bennett
Executive Vice President
Chief Scientific Officer
Ionis Pharmaceuticals, Inc.
Carlsbad, CA USA

Adrian R. Krainer
St. Giles Foundation Professor
Cancer Center Deputy Director of Research
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY USA

Video: VIRTUAL 23rd Award CEREMONY

22nd Annual Jacob and Louise Gabbay Award Lectures in Biotechnology and Medicine Engineering Immune Cells to Treat Cancer Dario Campana Michel Sadelain Wednesday, October 2, 2019, 4:00 p.m. Shapiro Campus Center Theater
22nd (2019)

in recognition of their pioneering work in the development of CAR T-cell therapy for cancer

Dario Campana
Mrs. Lee Kong Chian Chair in Advanced Cellular Therapy

Professor, Department of Paediatrics

Centre for Translational Medicine

Yong Loo Lin School of Medicine

National University of Singapore

Republic of Singapore

Michel Sadelain
Stephen and Barbara Friedman Chair

Director, Center for Cell Engineering

Member, Immunology Program, Sloan Kettering Institute

Member, Department of Medicine, Memorial Hospital

Memorial Sloan Kettering Cancer Center

Professor, Weill Medical College of Cornell University

New York, NY USA

Video: 22ND Award Lectures

21st Annual Jacob and Louise Gabbay Award Lecture in Biotechnology and Medicine Building and Repairing the Human Brain: From Pluripotency to Cell Therapy Lorenz Studer Tuesday, October 9, 2018, 4:00 p.m. Shapiro Campus Center Theater
21st (2018)

in recognition of his innovative and transformative contributions to the fields of stem cell biology and patient-specific, cell-based therapy

Lorenz Studer
Director, Center for Stem Cell Biology

Member, Developmental Biology Program

Memorial Sloan Kettering Cancer Center

New York, NY USA

Video: 21st Award Lecture

20th Annual Jacob and Louise Gabbay Award Lecture in Biotechnology and Medicine Synthetic Biology Life Redesigned James J. Collins October 18, 2017, 4:00 p.m. Gerstenzang 121
20th (2017)

for his inventive work in synthetic biology that created a new area of research, enabling multiple biomedical applications and launching a new sector of the biotechnology industry

James J. Collins
Termeer Professor of Medical Engineering and Science

Professor of Biological Engineering

Massachusetts Institute of Technology

Core Founding Faculty, Wyss Institute

Harvard University

Institute Member, Broad Institute

Cambridge, MA USA

Video: 20th Award Lecture

19th Annual Jacob and Louise Gabbay Award Lecture in Biotechnology and Medicine The Chemistry and Biology of Adapting Proteostasis for Disease Intervention Jeffery W. Kelly September 29, 2016, 4:00 p.m. Shapiro Campus Center Theater
19th (2016)

in recognition of his profound and paradigm-shifting contributions to our understanding of protein folding mechanisms and protein misfolding diseases

Jeffery W. Kelly
Lita Annenberg Hazen Professor of Chemistry

Chairman, Department of Molecular and Experimental Medicine

The Scripps Research Institute

La Jolla, CA USA

Video: 19th Award Lecture

18th Annual Jacob Heskel Gabbay Award Lecture in Biotechnology and Medicine Precision Measurement of Biology Stephen Quake October 20, 2015, 4:00 p.m. Gerstenzang 123
18th (2015)

in recognition of his contributions to both the basic science of microfluidics and its applications to biomedical research

Stephen Quake
Lee Otterson Professor of Engineering

Professor of Bioengineering and Applied Physics

Member, Bio-X

Member, Stanford Cancer Institute

Faculty Fellow, Stanford ChEM-H

Member, Stanford Neurosciences Institute

Stanford University School of Medicine

Stanford, CA USA

Video: 18th Award Lecture

17th Annual Jacob Heskel Gabbay Award Lectures in Biotechnology and Medicine Genome Editing with CRISPR-cas9 Feng Zhang, Jennifer Doudna and Emmanuelle Charpentier October 27, 2014, 3:30 p.m. Rapaporte Treasure Hall Goldfarb Library
17th (2014)

in recognition of their work on the CRISPR/cas system

Feng Zhang
Core Member, Broad Institute

W.M. Keck Career Development Professor in Biomedical Engineering

Assistant Professor of Neuroscience, Department of Brain and Cognitive Sciences

Investigator, McGovern Institute for Brain Research

Massachusetts Institute of Technology

Cambridge, MA USA

Jennifer Doudna
(2020 Nobel Prize)

Investigator, Howard Hughes Medical Institute

Professor of Biochemistry, Biophysics and Structural Biology

The University of California, Berkeley

Berkeley, CA USA

Emmanuelle Charpentier
(2020 Nobel Prize)
Professor, Department of Molecular Biology

Laboratory for Molecular Infection Medicine Sweden

Umeå University

Umeå, Sweden

Head, Department of Regulation in Infection Biology

Helmholtz Centre for Infection Research

Braunschweig, Germany

16th Annual Jacob Heskel Gabbay Award Lectures in Biotechnology and Medicine Imaging The Brain Karl Deisseroth, Gero Miesenböck and Edward Boyden October 10, 2013, 3:30 p.m. Shapiro Campus Center Theater
16th (2013)

in recognition of their contributions to the discovery and applications of optogentics

Karl Deisseroth
D. H. Chen Professor of Bioengineering and Psychiatry & Behavioral Sciences
HHMI Early Career Scientist
Stanford University

Stanford, CA USA

Gero Miesenböck
Waynflete Professor of Physiology
Department of Physiology, Anatomy and Genetics
University of Oxford
Oxford, England

Edward Boyden
Leader, Synthetic Neurobiology Group
Associate Professor, Media Lab and McGovern Institute, Depts. of Biological Engineering and Brain and Cognitive Sciences
Massachusetts Institute of Technology
Cambridge, MA USA

Video: 16th Award Lectures

15th (2012)

for identifying the cellular effects of bisphenol in plastics

Patricia Hunt
Professor, School of Molecular Biosciences
Washington State University
Pullman, WA USA

Ana M. Soto
Professor of Anatomy & Cellular Biology
Sackler School of Graduate Biomedical Sciences
Tufts University School of Medicine
Boston, MA USA

Carlos Sonnenschein
Professor of Anatomy & Cellular Biology
Sackler School of Graduate Biomedical Sciences
Tufts University School of Medicine
Boston, MA USA

14th Annual Jacob Heskel Gabbay Award Lecture in Biotechnology and Medicine Mobilizing the Immune System to Treat Cancer: Immune Checkpoint Blockade James P. Allison November 14, 2011, 3:30 p.m. Gerstenzang 121
14th (2011)

for the development of strategies for the treatment of autoimmune diseases and for immunotherapy of cancer

James P. Allison
(2018 Nobel Prize)

Director, Ludwig Center for Cancer Immunotherapy
Chairman, Immunology Program
David H. Koch Chair in Immunologic Studies
Investigator, Howard Hughes Medical Institute
Attending Immunologist, Department of Medicine
Memorial Sloan Kettering Cancer Center
New York, NY USA

13th Annual Jacob Heskel Gabbay Award Lecture in Biotechnology and Medicine Aromatase Inhibitors and Breast Cancer: Concept to Clinic Angela Hartley Brodie October 12, 2010, 4:00 p.m. Gerstenzang 121
13th (2010)

for her discovery and development of aromatase inhibitors as a treatment for breast cancer

Angela Hartley Brodie
Professor of Pharmacology
Marlene and Stewart Greenebaum Cancer Center
University of Maryland School of Medicine
Baltimore, MD USA

12th Annual Jacob Heskel Gabbay Award Lectures in Biotechnology and Medicine Breakthrough Technologies in In-Vitro Alan H. Handyside, Ann A. Kiessling and Gianpiero D. Palermo November 16, 2009, 3:45 p.m. Gerstenzang  123
12th (2009)

for their significant contributions in the field of assisted human reproduction

Alan H. Handyside
Visiting Professor
Institute of Integrative and Comparative Biology
University of Leeds
Consultant in Pre-implantation Genetics
The London Bridge Fertility, Gynaecology and Genetics Centre
Co-director
Bridge Genoma
London, England

Ann A. Kiessling
Associate Professor of Surgery
Harvard Medical School
Director
Bedford Stem Cell Research Foundation
Boston, MA USA

Gianpiero D. Palermo
Associate Professor of Reproductive Medicine
Weill Medical College of Cornell University
Director, Assisted Fertilization and Andrology
The Center for Reproductive Medicine and Infertility
New York, NY USA

11th Annual Jacob Heskel Gabbay Award Lecture in Biotechnology and Medicine Functions of the Proteasome: From Protein Degradation and Immune Surveillance to Cancer Therapy Alfred Goldberg November 10, 2008, 4:00 p.m., Gerstenzang 121
11th (2008)

for his discovery of regulated protein turnover in bacteria and mitochondria and development of proteasome inhibitors as a treatment for cancer

Alfred Goldberg
Professor of Cell Biology
Department of Cell Biology
Harvard Medical School
Boston, MA USA

10th (2007)

for pioneering the technology of gene targeting in mouse embryo-derived stem (ES) cells

Mario R. Capecchi
(2007 Nobel Prize)
Investigator, Howard Hughes Medical Institute
Distinguished Professor of Human Genetics
The University of Utah School of Medicine
Salt Lake City, UT USA

9th (2006)

for their role in the development of contrast agents used in cardio-diagnostic procedures

Alan Davison
Professor emeritus of Chemistry
Massachusetts Institute of Technology
Cambridge, MA USA

Alun Gareth Jones
Professor of Radiology
Brigham and Women's Hospital
Harvard Medical School
Boston, MA USA

8th Annual Jacob Heskel Gabbay Award Lectures in Biotechnology and Medicine Molecular Beacons: Probes that Fluoresce upon Hybridization Fred R. Kramer and Sanjay Tyagi November 10, 2005, 3:15 p.m., Gerstenzang 123
8th (2005)

for their role in the development and use of molecular beacons as a diagnostic tool in vitro, and in the detection of RNA in living cells

Fred R. Kramer
Professor of Microbiology and Molecular Genetics
New Jersey Medical School
Member, Public Health Research Institute
Newark, NJ USA

Sanjay Tyagi
A
associate Professor
Department of Medicine
University of Medicine & Dentistry of New Jersey
Member, Public Health Research Institute
Newark, NJ USA

7th (2004)

for his many contributions to the biotechnology industry

George M. Whitesides
Woodford L. and Ann A. Flowers University Professor
Harvard University
Cambridge, MA USA

6th (2003)

for their development of yeast two-hybrid and yeast mating interaction traps

Roger Brent
President and Research Director
The Molecular Sciences Institute
Berkeley, CA USA

Stanley Fields
Professor of Genome Sciences and Medicine
Investigator, Howard Hughes Medical Institute
University of Washington
Seattle, WA USA

5th (2002)

for their pioneering achievements in developing antibodies as pharmaceutical proteins for the treatment of human diseases

William H. Rastetter
Chairman and Chief Executive Officer
IDEC Pharmaceuticals Corporation
San Diego, CA USA

Dennis J. Slamon
Executive Vice Chair for Research and
Professor of Medicine
UCLA School of Medicine
Los Angeles, CA USA

Gregory P. Winter
(2018 Nobel Prize)

Head of Division of Protein and Nucleic Acid Chemistry
MRC Laboratory of Molecular Biology
Cambridge, England

4th (2001)

for his pioneering achievements in miniaturization of fundamental biochemical experiments

J. Michael Ramsey
Group Leader, Chemical and Analytical Sciences Division
Oak Ridge National Laboratory
Oak Ridge, TN USA

3rd (2000)

for his leadership in genome sequencing

J. Craig Venter
President and Chief Scientific Officer
Celera Genomics
Rockville, MD USA

2nd (1999)

for their entrepreneurial roles in the creation of some of the most successful biotechnology firms

David V. Goeddel
Founder and Chief Executive Officer
Tularik, Inc.
South San Francisco, CA USA

Thomas P. Maniatis
Thomas H. Lee Professor of Molecular and Cellular Biology
Harvard University
Cambridge, MA USA

William J. Rutter
Chairman emeritus
Chiron Corporation
Emeryville, CA USA

1st (1998)

for their development of microarray methods for the analysis of gene expression on a genome-wide scale

Patrick O. Brown
Associate Professor of Biochemistry
Stanford University
Stanford, CA USA

Stephen P. A. Fodor
Research Scientist
Affymetrix, Inc.
Santa Clara, CA USA