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RBIF 110
Macromolecular Biophysics
This course covers the basis of molecular interactions and biological experimental technologies. The course addresses topics in basic macromolecular structure and system thermodynamics of DNA, RNA, lipids, carbohydrates, and proteins with a focus on structure and energetics. The course also introduces the energetics of macromolecular interactions, such as Nucleic acid hybridization, covalent and hydrogen bonding, protein-DNA interactions, energetics of hydrophobic interactions; and the physics behind laboratory techniques such as crystallography, NMR, and column separation.
At the end of the course, students will be able to:
Recognize intermolecular interactions given a PDB structure.
Interpret enzyme kinetics data.
Read a protein structure paper.
Describe the role of thermodynamics in DNA melting, protein folding, and ligand binding.
Describe the physical basis of techniques for separating proteins and nucleic acids.
Students registered for current offerings of this course can find a list of book requirements at the Brandeis University Bookstore or online at http:// brandeis.bkstore.com.
Students must meet all course prerequisites. A list of course prerequisites per program may be found at http://www.brandeis.edu/gps/programscourses/courselist.