2017-2018 Bauer Summary
The M.R. Bauer Foundation Colloquium Series, Distinguished Lecturer Series, Annual Scientific Retreat, and Summer Science Research Fellowship
Basic science drives modern society. Advances in technology, medicine, health care, and other areas, made possible by investments in research, are entwined with our lives. There is much to marvel at and be amazed by.
But policies made far from campus may hamper our progress. The dramatic decline of federal support for basic science is affecting emerging and veteran researchers alike. There is urgency, since so much research, which can change entire sectors, is at stake. While our peers recognize the value of our work, decision makers increasingly undervalue the contributions of scientists. We must bridge that gap. Scientists cannot remain disengaged from the public discourse. We must educate government, industry, and the community about the importance of basic research.
Why? Because groundbreaking basic science has profound implications for human health. Last year, my Volen colleagues, Michael Rosbash and Jeffrey Hall, were awarded the Nobel Prize for their pioneering work on circadian rhythms. This work was done in the fruit fly but the findings allowed us to finally begin to understand the human clock. The full role of circadian rhythms in health and disease are just starting to be revealed, but it is clear that this basic science finding is going to bring important changes to the lives of many. The recognition of their work by the Nobel Committee should renew our joy in the process of discovery and the generation of new knowledge—and animate the public conversation.
There are other ways for us to gain inspiration. We are fortunate to have the support of the M.R. Bauer Foundation, which recognizes that the Colloquium Series, Distinguished Lecturer Series, and the Annual Retreat enable us to reflect and plan ahead. The Volen National Center for Complex Systems is richer for these gatherings, and it is clear that they stimulate our students, postdocs, staff and faculty in diverse ways.
Finally, we must redouble our efforts in training the next generation. Again, the M.R. Bauer Foundation, along with other generous donors, provide resources for undergraduate summer research fellowships. You may read about their experiences in this brochure, and they join me in encouraging you to be a mentor at your institutions. Student collaborations with Brandeis faculty prepare them to assume the mantle of leadership. These undergraduates, like the postdocs and other young scientists who were fortunate to join the Rosbash and Hall Labs, are ambassadors and are the future of science.
Leslie Griffith, MD, PhD Nancy Lurie Marks Professor of Neuroscience
Director, Volen National Center for Complex Systems
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Imagine the moment a baby is born — the first bright lights, the first unmuffled sounds, the first feeling of cold rather than warm liquid. Imagine how overwhelming the onslaught of sensations must be! As we develop and learn, our senses help us to make sense of the world. Every image, sound, or smell offers information, information that is transduced to electrical signals that are then interpreted by the billions of neurons in the brain. These neurons communicate in multiple ways, electrical and chemical, to use that information to learn, form memories, and navigate the world. An understanding of the mechanics behind sensory processing and neuronal communication can lead to possible treatments for when those mechanics do not develop and function correctly.
The 2017-2018 M.R. Bauer Colloquium Series explored the many functions of sensory processing: how vision is used for navigation, how itch and pain are intensified, how neurons communicate on an individual or network level. The nine distinguished scientists included in this Series offered myriad insights into the mechanisms, development, and communication among sensory systems in the brain. Each speaker has presented a summary of their work, which is preceded by a brief introduction set in italics, explaining the presentation in a broader framework.
Paola Arlotta, PhD
Professor, Department of Stem Cell and Regenerative Biology, Harvard University
Vivian Budnik, PhD
Chair, Professor, Department of Neurobiology, University of Massachusetts Medical School
Jeff Holt, PhD
Professor, Department of Otolaryngology and Neurology, Boston Children’s Hospital
Antonio Giraldez, PhD
Fergus F. Wallace Professor of Genetics, Chair of Genetics Department, Department of Genetics, Yale School of Medicine
Shawn Xu, PhD
Bernard W. Agranoff Collegiate Professor of the Life Sciences, Department of Molecular & Integrative Physiology, University of Michigan
Sarah Ross, PhD
Associate Professor, Department of Neurobiology, University of Pittsburgh
Laura Colgin, PhD
Associate Professor, Department of Neuroscience, University of Texas at Austin
Every year the M.R. Bauer Distinguished Lecturer program brings to campus two distinguished visitors who spend a full week at Brandeis. These weeklong visitors present talks to small and large groups, visit Center laboratories, and engage students, postdoctoral fellows and faculty in informational and highly interactive conversations about shared areas of research interests. This year our distinguished lecturers were Betty Eipper from UCONN and Matteo Carandini from University College London.
Betty Eipper, PhD
Professor, Department of Molecular Biology and Biophysics, UCONN Health
Matteo Carandini, PhD
Professor, Department of Neuroscience, University College London
The Volen National Center for Complex Systems held its annual scientific retreat on October 12, 2017, at Brandeis University. This year we honored the pioneering work of Volen Center for Complex Systems faculty member John Lisman. The retreat, titled “Breakthroughs in understanding the role of CaMKII in synaptic function and memory,” brought together renowned researchers in the field of CaMKII and neural function. Volen Director Leslie Griffith started the day off and was followed by Thomas Reese of the NIH, Margaret Stratton from the University of Massachusetts, Amherst, and Roger Nicoll from UCSF. John Lisman was our keynote speaker and presented an amazing summary of the field of CaMKII and its role in memory formation, including the pivotal work the Lisman Lab has contributed to this field of knowledge over the last forty years.
Scientists from across Brandeis departments attended to hear the lectures, share lunch, and attend the poster session for this day of science. The tribute to CaMKII and John Lisman’s contributions to the field are particularly poignant as, sadly, John passed away eight days after the retreat.
October 12, 2017
Leslie Griffith, Brandeis University
“Local translation of CaMKII regulates plasticity of spontaneous release”
Thomas Reese, NIH
“A structural view of CaMKII in the molecular organization of the PSD”
Keynote Speaker
John Lisman, Brandeis University
“The critical role of CaMKII in memory storage: 6 key physiological and behavioral tests”
Margaret Stratton, University of Massachusetts, Amherst
“Activation-triggered subunit exchange in CaMKII and its role in memory”
Roger Nicoll, University of California, San Francisco
“The NMDAR/CaMKII complex is the master of the PSD universe”
The Volen Retreat offers the opportunity for all Volen-affiliated faculty, postdoctoral fellows, graduate and undergraduate students to present a poster detailing their research. This is an opportunity for other members of the community to engage with their fellow scientists and exchange ideas. The face-to-face format of a poster session allows for direct and detailed discussion of data and techniques. This year 23 postdoctoral fellows and students presented posters at the Volen Retreat. The presenters and titles are below.
Presenter |
Poster Title |
Daniel Acker |
“Memory in structurally unstable neural networks” |
Stephen Alkins |
“The long UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogaster” |
Nicole Ayasse |
“The impact of context and competition on speech comprehension in younger and older adults revealed using eye-tracking and pupillometry” |
Madelen Diaz |
“Allatostatin-C is a novel circadian neuropeptide in Drosophila melanogaster” |
Johanna Flyer-Adams |
“Pigment dispersing factor (PDF): A novel circuit for memory regulation” |
Josiah Herzog |
“TDP-43 misexpression causes defects in dendritic growth” |
Alexis Johns |
“Misrecognizing spoken words: The time course of context effects, and why older adults are more susceptible to mishearing a word” |
Katie Kimbrell |
“The role of Rem2 in conditioned taste aversion” |
Aishwarya Krishnamoorthy |
“Neuronal functions of circular RNA” |
Chelsea Groves Kuhnle |
“Temporal dynamics of acuity changes during monocular deprivation” |
Kang Liu |
“Physical principles for stable synaptic structure and long-term memory” |
Jacqueline McDermott |
“The role of Class 4 Semaphorins and PlexinB receptors in GABAergic synapse formation” |
Nate Miska |
“Brief visual deprivation shifts up excitation-inhibition ratio via selective depression at thalamocortical synapses onto PV+ interneurons” |
Daniel Powell |
“Modulation of the pyrokinin-elicited gastric mill rhythm by an endogenous peptide hormone and a mechanosensory neuron” |
Xiaodong Qu |
“A personalized reading coach using wearable EEG sensors” |
Sarah Richards |
“Regulation of dendritic branching by sensory experience and the small GTPase Rem2” |
Leandro de Oliveira Royer |
“The Ras-like GTPase Rem2 is a potent endogenous inhibitor of calcium/calmodulin-dependent kinase II activity” |
Nadya Styczynski |
“Warmth and competence with motor resonance” |
Stephen Thornquist |
“CaMKII measures the passage of time to coordinate motivational state” |
ShiYu Wang |
“Molecular mechanisms of Sorting Nexin 16 (SNX16) on endosomes” |
Timothy Wiggin |
“Mapping synapses between dorsal paired medial (DPM) and dopamine neurons in Drosophila melanogaster” |
Weijin Xu |
“Reforming the TRIBE: a more efficient approach to identify RNA-binding protein targets” |
Emmanuel Rivera-Rodriguez |
“Unraveling miR-190 and its role in sleep” |
Benjamin Franklin said “Tell me and I forget. Teach me and I remember. Involve me and I learn.” Due to the gracious gift from the M.R. Bauer Foundation ten Brandeis undergraduates were able to learn science this summer. Sophie Lis, an undergraduate in the lab of Gina Turrigiano, expressed this best saying “I would like to sincerely thank the donors who made this opportunity possible for me and allowed me to do full-time research this summer without any barriers, and to really experience life as a scientist.” The experience of full time science for a summer is formative for these students and often solidifies their passion for science, confidence in themselves as scientists, and desire to continue in research. The students present their science in poster format at the end of the summer during SciFest. Faculty, postdocs, graduate students, and research staff from the entire Division of Science attend SciFest and interact with the Bauer Fellows to learn about the science each student pursued. The following pages include the abstract from each of the M.R. Bauer Fellows’ posters and a personal statement expressing what this opportunity to do research in a Volen Center laboratory meant to them.
Alison Ma
Oprian Laboratory, Department of Biochemistry
Sophie Lis
Turrigiano Laboratory, Department of Biology
Muibat Yussuff
Rosbash Laboratory, Department of Biology
Kendrick Rubino
Sengupta Laboratory, Department of Biology
Lauren Hayashi
Van Hooser Laboratory, Department of Biology
Abigail Zeamer
Nelson Laboratory, Department of Biology
Chiquita McCoy-Crisp
Kern Laboratory, Department of Biochemistry
Alana Hodson
Wingfield Laboratory, Department of Psychology
Michael Hsiao
Griffith Laboratory, Department of Biology
Sam Lageson
Dizio Laboratory, Department of Psychology
As always, we thank the speakers who came to the Brandeis campus this past year to share their research with us and to engage us in many hours of stimulating discussion and exchanges of ideas with Volen Center faculty, students, and postdoctoral fellows. We are also grateful to our visitors for forwarding to us their lecture summaries that form the basis of this report.
We especially acknowledge Kim MacKenzie, a past neuroscience PhD graduate, for her valuable contributions and editorial assistance in the preparation of this report.
The text of this summary of the Bauer Foundation series, along with summaries from previous years, can be found at the Brandeis Bauer Foundation.