The Brandeis OTL is interested in working with all kinds of companies, from large to small to start-ups. We welcome you to contact us to learn more about our available technologies, and for introductions to faculty members.

Take a closer look at the Brandeis patent portfolio here.

Technologies Available for Licensing

•Carrot Fiber as an Antidiabetic Agent in Foods: Currently, the market for dietary fibers is large, with applications for weight loss, gut health, and blood glucose control.  With the rapid rise in multibillion dollar global demand for fiber, a growing drive exists to identify new, better functioning sources of fiber.  Carrot pomace has the potential to be at the top of this list. Although carrot pomace is currently considered a “waste product” of carrot juice production, it is rich in soluble and insoluble fibers. The Nile rat is a novel model for Type 2 Diabetes and  Metabolic Syndrome that, like humans, responds favorably to increased fiber consumption and low glycemic load diets.  Using the Nile rat model, this invention is used as a fiber substitute for other commercial fibers (nonfermentable cellulose and soluble inulin, the current gold standard of healthful fibers), showing that our proprietary carrot pomace powder is the only fiber that completely prevents diabetes.   Read More

Optimized Coffee Particle Grind Sizes for Single-Serve Pods: Our invention provides a simple solution for increasing components extracted from a given amount of coffee placed into a single serving filter cartridge.  We have found the optimal weighted average particle size for large scale grinds of coffee beans packaged into single serving pods falls around 450 microns.  The single serve brewing efficiency can be further improved by “truncating” the Gaussian particle size distribution to remove those particles larger than 500-600 microns from the mix using air classifying or commercial high-throughput sieve-shakers (e.g. US Standard No. 30 or 35 sieving opening). Read more

•Versatile Coffee Flour Preserves Antioxidants and Caffeine:  In recent years, green coffee bean extract from unroasted coffee beans has attracted worldwide attention as a dietary supplement.  The green coffee beans provide chlorogenic acid (CGA) antioxidants that have been clinically proven to beneficially modulate sugar metabolism and the insulin response. CGA may also assist in, controlling blood pressure and heart disease. However, green coffee beans have an unfavorable flavor profile. Roasting of green coffee beans to improve its flavor for consumption, aroma, and color (as in drinking coffee) degrades CGA, necessitating the packaging of unroasted coffee extract as capsules. The current invention relates to a new method for partially baking (“par-baking”) the green coffee beans to produce coffee flour that not only preserves the CGA levels, but retains the caffeine. Read More

•Multifunctional Hydrogels of Basic Building Blocks with Advanced Nanobiomedicinal Applications:  Every year, millions who suffer from tissue loss or failure as a result of accidents or disease rely on alternative biomedical materials to regenerate living, healthy, and functional tissues. Engineered tissue scaffolds have been developed for cellular regeneration, wound healing, and diseased tissue treatment. Unfortunately, natural and synthetic polymers currently serving as these scaffolds are limited by separation and purification roadblocks, cytotoxicity, and demonstrate poor responsiveness to biological cues.  The solution to these problems lies in this invention. Facile conjugation of small peptides with nucleobases and/or glycosides generates a new kind of supramolecular hydrogelator that mimics extracellular matrices for tissue engineering with high biocompatibility. Read More

•Taurine Boosts Intracellular Delivery of Functional Molecules:  Internalization of functional molecules is the basis for intracellular delivery of therapeutic agents for the treatment and diagnosis of diseases. Unfortunately, the delivery of biologically active molecules into cells is prevented by the non-permeable plasma cell membrane. Cell penetrating proteins (CPPs) are traditionally used to facilitate the cellular uptake of various cargo, but CPPs are limited by their susceptibility to metabolic degradation, dependency on cell lines, and poor cellular compatibility. The present invention relies on the covalent conjugation of taurine to a D-peptidic hydrogel precursor to overcome the limitations of non-permeable cell membranes and CPPs. Read More

•New MALDI MS Imaging Revolutionizes Disease Diagnosis: Matrix-Assisted Laser Desorption Ionization (MALDI) is an ionization technique often used for mass spectrometric (MS) analysis of large biomolecules, such as proteins. Direct MS analysis imaging of a tissue sample provides spatial and chemical information on hundreds of molecules at a time, correlating molecular composition and disease pathology, and ultimately leading to a diagnosis. However, without sample preparation technology, the resolution of MALDI MS imaging is in the range of 1 mm, which is inadequate for comprehensive protein profiling of small tissue or cellular samples. Moreover, sample preparation takes hours and expensive instrumentation is required, leading to irreproducible results and unreliable images. The current invention overcomes these limitations with a novel MALDI sample preparation method that enables high-resolution protein profiling up to 1 μm. This technology increases spatial resolution by fifty times, while reducing sample preparation time and costs by a hundred times compared to existing processes. Read More

•  A Novel Therapy for Epilepsy - Rebuilding Inhibition in the Epileptic Brain: Currently, millions of Americans suffer from epilepsy and fully 1/3 of these patients do not respond to available treatments. Researchers at Brandeis University have discovered that the Sema4D-PlexinB1 interaction may be harnessed as a novel strategy for the treatment of seizure disorders. A key aspect of neuronal circuit formation is achieving the proper balance of excitation and inhibition (E/I) within the circuit. A given neuron, through its synaptic connections, either excites or inhibits other neurons in the circuit, thus establishing this balance. Disruptions to the E/I balance can have pathological consequences for circuit function as demonstrated by the manifestation of devastating neurological disorders, including epilepsy and Autism Spectrum Disorders (ASD). The current invention is a novel approach to treating disorders such as epilepsy that would restore the normal E/I balance in network activity by permanently increasing the number of inhibitory synapses. Read More

A New Strategy for Selective and Specific mTOR Inhibition: As the average life expectancy increases, so does the need to address chronic diseases associated with aging.  The mammalian target of rapamycin (mTOR) is dysregulated in many diseases including cancers, immunosuppression and neurodegeneration, and is a clinically validated therapy target. The currently available mTOR-targeted drugs (rapamycin derivatives and Torin) act by inhibiting all functions of mTOR, including both mTOR complex 1 (mTORC1) and complex 2 (mTORC2).  mTORC1 is the primary regulator of protein biosynthesis, cell growth, cell proliferation, and cell survival, while mTORC2 is the primary regulator of metabolism.  Blocking mTORC1 signaling pathways can increase lifespan and displays efficacy in the treatment of diseases, however, inhibiting the metabolic pathways regulated by mTORC2 leads to new-onset type 2 diabetes.  Thus, there is a significant unmet need for new and selective mTOR-targeted therapies.   The current invention addresses the need for therapeutically advantageous mTOR-based treatments without the detrimental side effects.  This invention utilizes small molecules which inhibit mTORC1 signaling while leaving mTORC2 function unaffected, resulting in comparatively lower risk of developing new-onset type 2 diabetes.  Utilizing a distinctively different mechanism for inhibiting mTOR signaling, this invention has the potential to augment currently approved cancer and neurodegeneration therapies without the additional metabolic side effects. Read More