Department of Chemistry

Hao Xu

Hao Xu, Professor of ChemistryProfessor of Chemistry

Degrees

Harvard University, Postdoc
Scripps Research Institute, PhD
Peking University, Bsc Chemistry

Profile

Non-precious metal catalysis directed towards organic synthesis.  Translational synthetic chemistry.  Discovery of new disease targets and therapeutic probes in human biology. 

Selected Publications

  • Li, H.; Shen, S.-J.; Zhu, C.-L.; Xu, H.* “Direct Intermolecular Anti–Markovnikov Hydroazidation of Unactivated Olefins” J. Am. Chem. Soc. 2019, 141, 9415.
  • Li, H.; Shen, S.-J.; Zhu, C.-L.; Xu, H.* “Enantioselective Synthesis of Oseltamivir Phosphate (Tamiflu) via the Iron-Catalyzed Stereoselective Olefin Diazidation.” J. Am. Chem. Soc. 2018, 140, 10619.
  • Shen, S.-J.; Zhu, C.-L.; Lu, D.-F.; Xu, H.* “Iron-Catalyzed Direct Olefin Diazidation via Peroxyester Activation Promoted by Nitrogen-Based Ligands” ACS Catal. 2018, 8, 4473.
  • Lu, D.-F.; Zhu, C.-L.; Sears, J. D.; Xu, H.* “Iron(II)-Catalyzed Intermolecular Aminofluorination of Unfunctionalized Olefins Using Fluoride Ion”  J. Am. Chem. Soc. 2016, 138, 11360.
  • Yuan, Y.-A.; Lu, D.-F.; Chen, Y.-R.; Xu, H.* “Iron-Catalyzed Direct Diazidation for a Broad Range of Olefins” Angew. Chem. Int. Ed. 2016, 55, 534.
  • Lu, D. F.; Zhu, C. L.; Jia, Z. X.; Xu, H.* “Iron(II)-Catalyzed Intermolecular Amino-Oxygenation of Olefins through the N-O Bond Cleavage of Functionalized Hydroxylamines” J. Am. Chem. Soc. 2014, 136, 13186.
  • Lu, D. F.; Liu, G. S.; Zhu, C. L.; Yuan, B.; Xu, H.* “Iron(II)-Catalyzed Intramolecular Olefin Aminofluorination.” Org. Lett. 2014, 16, 2912.
  •  Liu, G. S.; Zhang, Y. Q.; Yuan, Y. A.; Xu, H.* “Iron(II)-Catalyzed Intramolecular Aminohydroxylation of Olefin with Functionalized Hydroxylamines.” J. Am. Chem. Soc. 2013, 135, 3343.