Department of Chemistry

Bing Xu

Bing XuProfessor of Chemistry

Group website
Curriculum Vitae (PDF)

Degrees

University of Pennsylvania, PhD
Nanjing University, MS
Nanjing University, BS

Profile

Our research focuses on the interdisciplinary frontier of materials chemistry. We integrate the knowledge and techniques in organic chemistry, materials science, surface chemistry, biochemistry, and nanotechnology to design new biofunctional materials, including nanomaterials, for the exploration in biomedicine (e.g., molecular drug delivery, cancer therapy, biomedical diagnostics, and biomimetics), and other fundamental problems in nanoscience and biological science.

Selected Publications

  • Tan, W. Y.; Zhang,Q. X.; Wang, J. Q.; Yi, M. H.; He, H. J.; Xu, B.* “Enzymatic Assemblies of Thiophosphopeptides Instantly Target Golgi Apparatus and Selectively Kill Cancer Cells” Angew. Chem. Int. Ed., 2021, 60, 12796-12801.
  • He, H. J.; Lin, X. Y.; Wu, D. F.; Wang, J. Q.; Guo, J. Q.; Green, D. R.; Zhang, H. W.; Xu, B.* “Enzymatic Noncovalent Synthesis for Mitochondrial Genetic Engineering of Cancer Cells”  Cell Reports Physical Science, 2020, 1, 100270.
  • He, H. J.; Tan, W. Y.; Guo, J. Q.; Yi, M. H.; Shy, A. N.; Xu, B.*“Enzymatic Noncovalent Synthesis” Chemical Reviews, 2020, 18, 9994-10078.
  • He, H. J.; Liu, S.; Wu, D. F.; and Xu, B.* " Enzymatically-Formed Peptide Assemblies Sequestrate Proteins and Relocate Inhibitors for Selectively Killing Cancer Cells " Angew. Chem. Int. Ed. 2020,59, 16445-16450.
  • Feng, Z. Q. Q.; Wang, H. M.; Wang, F. B.; Oh, Y. H; Berciu, C.; Cui, Q.;* Egelman, E. H.;* and Xu, B.* "Artificial Intracellular Filaments " Cell Reports Physical Science. 2020,1,10085.
  • He, H. J.; Guo, J. Q.; Lin X. Y.; Xu, B.* "Enzyme‐Instructed Assemblies Enable Mitochondria Localization of Histone H2B in Cancer Cells" Angew. Chem. Int. Ed. 2020, 59, 9330-9334.
  • Feng, Z. Q. Q.; Han, X. G.; Wang, H. M.; Tang, T. T.*; Xu B.* “Enzyme-Instructed Peptide Assemblies Selectively Inhibit Bone Tumors” Chem 2019, 5, 2442-2449.
  • Wang, J. Q.; Cooper, D. L.;  Zhan, W. J.; Wu, D. F.; He,H. J.; Sun, S. H.; Lovett, S. T.*, Xu, B.* “Diglycine Enables Rapid Intrabacterial Hydrolysis for Activating Anbiotics against Gram-negative Bacteria” Angew. Chem. Int. Ed. 2019, 58, 10631-10634.
  • Wang, H. M.; Feng, Z. Q. Q.;Xu, B.* “Intercellular Instructed-Assembly Mimics Protein Dynamics to Induce Cell Spheroids”J. Am. Chem. Soc. 2019, 141, 7271-7274.
  • Wang, H. M.; Feng, Z. Q. Q.; Xu, B.* “Assemblies of Peptides in Complex Environment and Their Applications”Angew. Chem. Int. Ed.2019, 58,10423-10432.
  • Wang, H. M.; Feng, Z. Q. Q.; Xu, B.* “Instructed-Assembly as Context-Dependent Signals for Death and Morphogenesis of Cells” Angew. Chem. Int. Ed. 2019, 58, 5567-5571.
  • Feng, Z. Q. Q.; Wang, H. M.; Xu, B.* “Instructed-Assembly of Peptides for Intracellular Enzyme Sequestration.” J. Am. Chem. Soc. 2018, 140, 16433-16437.
  • Li, J.; Zhan, Z. Q.; Du, X. W.; Wang, J. Q.; Hong, B.; Xu, B.* “Enzymatic Reaction Selects Secondary Structures of Heterotypic Supramolecular Assemblies of Peptides” Angew. Chem. Int. Ed. 2018, 57, 11716-11721.
  • Feng, Z. Q. Q.; Wang, H. M.; Wang, S. Y.; Zhang, Q.; Zhang, X. X.; Rodal, A.; Xu, B.* “Enzymatic Assemblies Disrupt Membrane and Target Endoplasmic Reticulum (ER) for Selective Cancer Cell Death” J. Am. Chem. Soc. 2018, 140, 9566-9573.
  • Wang,H. M.; Feng, Z. Q. Q.; Qin, Y. N.; Wang, J. Q.; Xu, B* “Nucleopeptide Assemblies Selectively Sequester ATP in Cellsto Increase the Efficcay of Doxorubicin” Angew. Chem. Int. Ed. 2018, 57, 4931-4935.
  • Wang, H. M.; Feng, Z. Q. Q.;DelSignore, S. J. ; Rodal, A. A.; Xu, B.* “Active Probes for Imaging Membrane Dynamics of Live Cells with High Spatial and Temporal Resolution over Extended Timescales and Areas” J. Am. Chem. Soc. 2018, 140, 3505-3509.
  • Zhou, J.; Du, X. W.; Chen, X. Y.; Wang, J. Q.; Zhou, N.; Wu, D. F.; Xu, B.* “Enzymatic Self-Assembly Confers Exceptionally Strong Synergism with NF-kB Targeting for Selective Necroptosis of Cancer Cells” J. Am. Chem. Soc., 2018, 140, 2301-2308.
  • He, H. J.; Wang, J. Q.; Wang, H. M.; Zhou, N.; Green, D.; Xu, B.* “Enzymatic Cleavage of Branched Peptides for Targeting Mitochondria” J. Am. Chem. Soc. 2018, 140, 1215-1218.
  • Wang, H. M.; Shi, J. F.; Feng, Z. Q. Q; Zhou, R.; Wnag, S. Y.; Rodal, A. A.; Xu, B.* “An in-situ Dynamic Continuum of Supramolecular Phosphoglycopeptides Enables Formation of 3D Cell Spheroids” Angew. Chem. Int. Ed. 2017, 56, 7579-7583.
  • Feng, Z. Q. Q.; Wang, H. M.; Chen, X. Y.; Xu, B.* "Self-Assembling Ability Determines the Activity of Enzyme-Instructed Self-Assembly for Inhibiting Cancer Cells"J. Am. Chem. Soc. 2017, 139, 15377-15384.
  • Wang, H. M.; Feng, Z. Q. Q.; Lu, A.; Jiang, Y. J.; Wu, H.; Xu, B.* “Instant Hydrogelation Inspired by Inflammasomes” Angew. Chem. Int. Ed. 2017, 56, 7579-7583.
  • Zhou, N.; Cao, X. Y.; Du, X. W.; Wang, H. M.; Wang, M.; Liu, S.; Nguyen, K.; Schmidt-Rohr, K.; Xu, Q. B.; Liang, G. L.; Xu, B.* ”Hyper-Crosslinkers Impart Dual Responsive Polymeric Nanogels with Unusual Volume Change” Angew. Chem. Int. Ed. 2017, 56, 2623-2627.
  • Li, J.; Du, X. W.; Hashim, S.; Shy, A.; Xu, B.* "Aromatic-Aromatic Interactions Enable α-Helix to β-Sheet Transition of Peptides to Form Supramolecular Hydrogels" J. Am. Chem. Soc., 2017, 139, 71-74.
  • Wang, H. M.; Feng, Z. Q. Q.; Wang, Y. Z.; Zhou, R.; Yang, Z. M.; Xu, B.* “Integrating Enzymatic Self-Assembly and Mitochondria Targeting for Selectively Killing Cancer Cells without Acquired Drug Resistance” J. Am. Chem. Soc., 2016, 138, 16046−16055.
  • Haburcak, R.; Shi, J. F.; Du, X. W.; Yuan, D.; Xu, B.* “Ligand-Receptor Interaction Modulates the Energy Landscape of Enzyme-Instructed Self-Assembly of Small Molecules” J. Am. Chem. Soc., 2016, 138, 15397–15404.
  • Wang, H. M.; Feng, Z. Q.Q.; Wu, D. D.; Fritzsching, K.; Rigney, M.; Zhou, J.; Jiang, Y. J.; Schmidt-Rohr, K.; Xu, B.* “Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells” J. Am. Chem. Soc., 2016, 138, 10758-10761.
  • Zhou, J.; Du, X. W.; Berciu, C.; He, H. J.; Shi, J. F.; Nicastro, D.; Xu, B.* ”Enzyme-Instructed Self-Assembly for Spatiotemporal Profiling of the Activities of Alkaline Phosphatases of Live Cells” Chem, 2016, 1, 246-263.
  • Zhou, J.; Du, X. W.; Xu, B.* “Regulating the Rate of Molecular Self-Assembly for Targeting Cancer Cells” Angew. Chem. Int. Ed., 2016, 55, 5770-5775.
  • Jie Zhou, Xuewen Du, Natsuko Yamagata and Bing Xu* “Enzyme-Instructed Self-Assembly of Small D-Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells” J. Am. Chem. Soc. 2016, 138, 3813-3823.
For a complete list of publications, see the complete Curriculum Vitae (PDF).