Bing Xu

Bing XuProfessor of Chemistry

Group Lab Site

Curriculum Vitae (PDF)


University of Pennsylvania, PhD
Nanjing University, MS
Nanjing University, BS


Our research focuses on the interdisciplinary frontier of materials chemistry. We integrate the knowledge and techniques in organic chemistry, materials science, surface chemistry, biochemistry, and nanotechnology to design new biofunctional materials, including nanomaterials, for the exploration in biomedicine (e.g., molecular drug delivery, cancer therapy, biomedical diagnostics, and biomimetics), and other fundamental problems in nanoscience and biological science.

Selected Publications

Wang H, Feng Z, Wu D, Fritzsching KJ, Rigney M, Zhou J, Jiang Y, Schmidt-Rohr K, Xu B. "Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells." J Am Chem Soc. 138:10758-61 (2016).

Zhou J, Du XW, Berciu C, He HJ, Shi JF, Nicastro D, Xu B. ”Enzyme-Instructed Self-Assembly for Spatiotemporal Profiling of the Activities of Alkaline Phosphatases of Live Cells” Chem. 1, 246-263 (2016).

Wang H, Feng Z, Xu B. "D-amino acid-containing supramolecular nanofibers for potential cancer therapeutics." Adv Drug Deliv Rev. (2016).

Feng Z, Wang H, Du X, Shi J, Li J, Xu B. "Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells." Chem Commun (Camb). 52:6332-5 (2016).

Zhou J, Du X, Xu B. "Regulating the Rate of Molecular Self-Assembly for Targeting Cancer Cells." Angew Chem Int Ed Engl. 55:5770-5 (2016).

Zhou J, Du X, Yamagata N, Xu B. "Enzyme-Instructed Self-Assembly of Small D-Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells." J Am Chem Soc. 138:3813-23 (2016).

Shi J, Xu B"Nanoscale Assemblies of Small Molecules Control the Fate of Cells." Nano Today. 10:615-630 (2015).

Du X, Zhou J, Shi J, Xu B. "Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials." Chem Rev. 115:13165-307 (2015).

Shi J, Yuan D, Haburcak R, Zhang Q, Zhao C, Zhang X, Xu B. "Enzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels." Chemistry. 21:18047-51

Li J, Kuang Y, Shi JF, Zhou J, Medina JE, Zhou R, Yuan D, Yang CH, Wang HM, Yang ZM, Liu JF, Dinulescu DM, and Xu B.“Enzyme-Instructed Intracellular Molecular Self-assembly to Boost Activity of Cisplatin against Drug-Resistant Ovarian Cancer Cells” Angew. Chem. Intl. Ed., 54:13307-11 (2015).

Yuan D, Shi JF, Du XW, Zhou N, Xu B. “Supramolecular Glycosylation Accelerates Proteolytic Degradation of Peptide Nanofibrils” J. Am. Chem. Soc., 137, 10092-10095 (2015).

Zhou J, Du XW, Li J, Yamagata N, Xu B. “Taurine Boosts Cellular Uptake of Small D-peptides for Enzyme-Instructed Intracellular Molecular Self-assembly”, J. Am. Chem. Soc. 137, 10040-10043 (2015).

Zhou J, Xu B. “Enzyme-Instructed Self-Assembly (EISA): A Multi-Step Process for Potential Cancer Therapy” Bioconjugate Chem., 26, 987-999 (2015).

Yuan D, Du XW, Shi JF, Zhou N, Zhou J, Xu B. “Mixing Biomimetic Heterodimers of Nucleopeptides to Generate Biocompatible and Biostable Supramolecular Hydrogels” Angew. Chem. Intl. Ed., 54, 5705-5708 (2015).

Zhang Y,  Zhou N, Shi JF, Pochapsky SS, Pochapsky SS, Zhang B, Zhang XX, Xu B. “Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures” Nat. Commun. 6, 6165 (2015).

Shi JF, Du XW, Huang YB, Zhou J, Yuan D, Wu DD, Zhang Y, Haburcak R, Epstein IR, Xu B. “Ligand-Receptor Interaction Catalyzes the Aggregation of Small Molecules to Induce Cell Necroptosis” J. Am. Chem. Soc. 137, 26-29 (2015).

Kuang Y, Long MJC, Zhou J, Shi JF, Gao Y, Xu C, Hedstrom L, Xu B. “Prion-like Nanofibrils of Small Molecules (PriSM) Selectively Inhibit Cancer Cells by Impeding Cytoskeleton Dynamics” J. Biol. Chem. 289, 29208 (2014).

Kuang Y, Shi JF, Li J, Yuan D, Alberti KA, Xu QB, Xu B. “Pericellular Hydrogel/Nanonets Inhibit Cancer Cells” Angew. Chem. Intl. Ed., 53, 8104-8107 (2014).

Zhou J, Du XW, Gao Y, Shi JF, Xu B. “Aromatic-Aromatic Interactions Enhance Interfiber Contacts for Enzymatic Formation of A Spontaneously Aligned Supramolecular Hydrogel” J. Am. Chem. Soc., 136, 2970-2973 (2014).

For a complete list of publications, see the complete Curriculum Vitae (PDF).