Contact Information

Seth Fraden
Abelson 214
(781) 736-2888

Group webpage

Seth Fraden

seth fradenProfessor of Physics
Ph.D., Brandeis University, 1987

Our group studies a broad range of topics in Soft Matter. We utilize a variety of methods and approaches covering experiment, theory, and simulation. Our research interests lie squarely in the intersection of physics, chemistry, biology and materials science. Our lab is interdisciplinary, but we are also involved in several multi-investigator projects. Current areas of interest are active matter, coupled non-linear chemical oscillators, protein crystallization, microfluidics, colloidal liquid crystals, DNA - colloid self-assembly and DNA origami.

Recent Ph.D. Students

Camille Girabawe (2017). "Synchronization In Pairs of Chemical Oscillators" Present position: Analyst, Data Analytics. Boston, MA

Achini Opathalage (2016) "X-ray Transparent Microfluidics for Protein Crystallization and Biomeneralization" Present Position: Postdoctoral Fellow, Brandeis University, Waltham, MA

Nate Tompkins (2015) "Synchronization Dynamics of Coupled Chemical Oscillators" Present Position: Assistant Director of Education, Outreach and Diversity, MRSEC

Ning Li (2015 )"Nonlinear Chemical Dynamics and Synchronization" Present Position: Research Scientist, GNS Healthcare, Cambridge, MA

"Microfluidic Tools to Investigate Protein Crystallization"
Michael Heymann (2014). Present position: Postdoc, Max Planck Institut for Biochemistry, Germany

Rafael A. Cabanas (2014) Present Position: Assistant Professor, Bunker Hill Community College

Sathish Akella (2014) "Characterizing Protein Crystal Nucleation"  Present Position: Postdoctoral Fellow, Okinawa Inste of Technology, Japan

Šeila Selimović (2010) "Microfluidics for Protein Crystallization and Mapping Phase Diagrams of Aqueous Solutions"  Present Position: AAAS Science and Technology Policy Fellow in Washington, DC, working on science diplomacy issues relating to energy security and sustainability.

Sample of Recent Publications

Transition from turbulent to coherent flows in confined three-dimensional active fluids  Kun-Ta Wu, Jean Bernard Hishamunda, Daniel T. N. Chen, Stephen J. DeCamp, Ya-Wen Chang, Alberto Fernández-Nieves, Seth Fraden, Zvonimir Dogic  Science, eaal1979 (2017);  DOI: 10.1126/science.aal1979  Perspective, Supplemental Materials: SupplementVideo 1Video 2Video 3Video 4Video 5Video 6Video 7Video 8.

Rapid prototyping of cyclic olefin copolymer (COC) microfluidic devices  S. Ali Aghvami, Achini Opathalage, Z.K. Zhang, Markus Ludwig, Michael Heymann, Michael Norton, Niya Wilkins, Seth Fraden  Sensors and Actuators B: Chemical, 247 (2017) 940-949;  DOI: 10.1016/j.snb.2017.03.023  Supplemental Materials: SupplementVideo 1Video 2Video 3Video 4Video 5Video 6Video 7Store then create AutocadAl Mold Layer 1 SolidworksAl Mold Layer 2 SolidworksCover SolidworksMold for Ferrule Solidworks. 

An image-driven drop-on-demand system C. Girabawe, S. Fraden  Sensors and Actuators B: Chemical, 238 (2017) 532-539;  DOI: 10.1016/j.snb.2016.07.065  Supplemental Materials: SupplementVideo 1Video 2Video 3Video 4

Configurable NOR gate arrays from Belousov-Zhabotinsky micro-droplets A.L. Wang, J.M. Gold, N. Tompkins, M. Heymann, K.I. Harrington, S. Fraden  The European Physical Journal Special Topics 225 (1),211-227 (2016); DOI: 10.1140/epjst/e2016-02622-y  Supplemental Materials: Video 1Video 2Video 3Video 4Video 5Matlab Code

An inexpensive programmable illumination microscope with active feedback Nathan Tompkins and Seth Fraden American Journal of Physics 84, 150 (2016); DOI: 10.1119/1.4935806  

ATP Consumption of Eukaryotic Flagella Measured at a Single-Cell Level
Daniel T. N. Chen, Michael Heymann, Seth Fraden, Daniela Nicastro, and Zvonimir Dogic
Biophysical Journal 109, 2562-2573 (2015)
DOI: 10.1016/j.bpj.2015.11.003

Low-Z polymer sample supports for fixed-target serial femtosecond X-ray crystallography G. K. Feld, M. Heymann, W. H. Benner, T. Pardini, C.-J. Tsai, S. Boutet, M. A. Coleman, M. S. Hunter, X. Li, M. Messerschmidt, A. Opthalage, B. Pedrini, G. J. Williams, B. A. Krantz, S. Fraden, S. Hau-Riege, J. E. Evans, B. W. Segelke and M. FrankJ. Appl. Cryst.48, 1-8 (2015); DOI 10.1107/S16005767150104933

Creation and perturbation of planar networks of chemical oscillators Nathan Tompkins, Matthew Carl Cambria, Adam L. Wang, Michael Heymann, and Seth FradenChaos25, 064611 (2015); DOI: 10.1063/1.4922056Supplement and Video Captions Supplemental Videos: SV1aSV1dSV1gSV1jSV3aSV3cSV4aSV4bSV4cSV4dSV6aSV6bSV6dSVS1a (PDMS Mold Fabrication)SVS1b (Plastic Master Fabrication)SVS1c (Thin PDMS Device Fabrication)SVS2 (Clamping Procedure)

Tunable diffusive lateral inhibition in chemical cells Ning Li, Nathan Tompkins, Hector Gonzalez-Ochoa and Seth FradenEur. Phys. J. E38, 18 (2015); DOI 10.1140/epje/i2015-15018-3

A simple and inexpensive device to remove edge beads, Markus Ludwig and Seth Fraden, Chips and Tips, 2015

DNA driven self-assembly of micron-sized rods using DNA-grafted bacteriophage fd virions R. R. Unwin, R. A. Cabanas, T. Yanagishima, T. R. Blower, H. Takahashi, G. P. C. Salmond, J. M. Edwardson, S. Fraden and E. EiserPhys. Chem. Chem. Phys.17, 8194-8202 (2015); SupplementMovieDOI: 10.1039/c4cp05405a

Emulsion-Based Technique To Measure Protein Crystal Nucleation Rates of Lysozyme Sathish V. Akella, Aaron Mowitz, Michael Heymann, and Seth FradenCrystal Growth & Design 14, 4487-4509 (2014); Movies:DOI: 10.1021/cg500562r

Cross polarization compatible dialysis chip, Micha Kornreich, Michael Heymann, Seth Fraden and Roy BeckLab on a Chip 14, 3700-3704 (2014); DOI: 10.1039/c4lc00600c 

Room-temperature serial crystallography using a kinetically optimized microfluidic device for protein crystallization and on-chip X-ray diffraction Michael Heymann, Achini Opthalage, Jennifer L. Wierman, Sathish Akella, Doletha M. E. Szebenyi, Sol M. Gruner and Seth Fraden IUCrJ (2014). 1, 349–360;  doi:10.1107/S2052252514016960

Giant Volume Change of Active Gels under Continuous Flow, Ye Zhang, Ning Zhou, Ning Li, Megan Sun, Dongshin Kim, Seth Fraden, Irving R. Epstein, and Bing XuJACS (2014);; movie S1, oscillating gel annulus; movie S2, oscillating gel array

Combined excitatory and inhibitory coupling in a 1D array of Belousov- Zhabotinsky droplets N. Li, J. Delgado, H. O. González-Ochoa, I. R. Epstein and S. FradenPhys. Chem. Chem. Phys. 16, 10965-10978 (2014); DOI:10.1039/C4CP00957F

Testing Turing's Theory of Morphogenesis in Chemical Cells Nathan Tompkins, Ning Li, Camille Girabawe, Michael Heymann, G. Bard Ermentrout, Irving R. Epstein, and Seth FradenProceedings of the National Academy of Sciences 111, 4397–4402 (2014); DOI: 10.1073/pnas.1322005111. Supporting information:,,

Controlling uniformity of photopolymerized microscopic hydrogels Sukho Park, Dongshin Kim, Seong Young Ko, Jong-Oh Park, Sathish Akella, Bing Xu, Ye Zhang and Seth FradenLab on a Chip14 (9), 1551 - 1563 (2014); DOI: 10.1039/c4lc00158c

Supporting information; Movie 1; Movie 2