Professor of Physics
Ph.D., Brandeis University, 1987
The focus of Seth Fraden and his group is to understand the relation between interparticle interactions and phase transitions in colloidal suspensions such as genetically engineered viruses, latex, proteins, and polymers. Combining experiment, computer simulation, and theory, Fraden examines the role of entropy in driving disorder-to-order transitions. Other major objectives are to understand the physics of protein crystallization and the development of microfluidic based high throughput crystallization devices.
Recent Ph.D. Students
Šeila Selimović (2010) "Microfluidics for Protein Crystallization and Mapping Phase Diagrams of Aqueous Solutions." Present Position: AAAS Science and Technology Policy Fellow in Washington, DC, working on science diplomacy issues relating to energy security and sustainability.
Fei Huang (2008) "Interactions and Collective Behavior of Attractive Colloidal Rods and Microspheres Grafted with Filamentous Bacteriophage." Present Position: Deutsche Bank, Florida
Jung-uk Shim (2007) "Novel Approach to Protein Crystallization; Control of the Phase Behavior of Aqueous Solutions Using Microfluidics." Present Position: Research Fellow, Cambridge University
Joshua Blouwolff (2006) "Experimental Investigations of Interactions and Collective Behavior in Protein/Polymer Mixtures and Granular Rods" Present Position: Staff Scientist, US Genomics
Kirstin R. Purdey (2004) "Liquid Crystal Phase Transitions of Mono- disperse and Bidisperse Suspensions of Rodlike Colloidal Virus" Present Position: Physics Lecturer, Penn State University
Sample of Recent Publications
Zhang Y, Zhou N, Akella S, Kuang Y, Kim D, Schwartz A, Bezpalko M, Foxman BM, Fraden S, Epstein IR, Xu B. Active Cross-Linkers that Lead to Active Gels. Angew Chem Int Ed Engl. 2013;52(44):11494-8. doi: 10.1002/anie.201304437. [abstract].
Zhang Y, Li N, Delgado J, Zhou N, Yoshida R, Fraden S, Epstein IR, Xu B. Structural modulation of self-oscillating gels: changing the proximity of the catalyst to the polymer backbone to tailor chemomechanical oscillation. Soft Matter. 2012;8(26):7056-61.
Zhang Y, Li N, Delgado J, Gao Y, Kuang Y, Fraden S, Epstein IR, Xu B. Post-self-assembly cross-linking of molecular nanofibers for oscillatory hydrogels. Langmuir. 2012;28(6):3063-6. Epub 2012/01/27. doi: 10.1021/la203923d. [abstract].
Di Michele, L., Yanagishima, T., Brewer, A., Kotar, J., Eiser, E. and Fraden, S. "Interactions between Colloids Induced by a Soft Cross-Linked Polymer Substrate." Physical Review Letters 136101 (2011).
Delgado, J., Li, N., Leda, M., Gonzalez-Ochoa, H., Fraden, S. and Epstein, I. "Coupled oscillations in a 1D emulsion of Belousov–Zhabotinsky droplets."Soft Matter, 2011 ; DOI: 10.1039/c0sm01240h.