Michael Hagan
Assistant Professor of Physics
Ph.D., University of California, Berkeley, 2003
Michael Hagan's lab endeavors to understand how fundamental physical principles lead to the forces that control assembly and dynamic pattern formation in biological and biomimetic systems. Because assembling structures can be orders of magnitude larger than the individual components, his lab develops and applies computational and theoretical methods that bridge disparate length and time scales. Applications of these methods include understanding assembly mechanisms for viral capsids and other large protein complexes, and learning to direct the rational design of novel materials with biomimetic function.
CV and list of publications
Sample of Recent Publications
Hagan, M.F. “Understanding the Concentration Dependence of Viral Capsid Assembly Kinetics - the Origin of the Lag Time and Identifying the Critical Nucleus Size”, submitted to Biophys. J, arxiv: 0905.0375v1 [q-bio.BM]> PDF
Hagan, M.F. “A theory for viral capsid assembly around electrostatic cores”, J. Chem. Phys., 2009, 130, 114902 PDF
Elrad, O.M.; Hagan, M.F. “Mechanisms of size control and polymorphism in viral capsid assembly”, Nano Letters, 2008, 8, 3850-3857 PDF
Huang, F.; Addas, K.; Ward, A ; Flynn, N.T.; Hagan, M.F.; Dogic, Z.; Fraden, S. “The pair potential of colloidal stars”, Phys. Rev. Lett., 2009, 102, 108302 PDF
Whitelam, S.; Feng, E.H.; Hagan, M.F.; Geissler, P.G. “The role of collective motion in examples of coarsening and self-assembly”, Soft Matter, 2009, 6, 1251-1262 PDF
Hagan, M. F. "Controlling viral capsid assembly with templating," Phys. Rev. E, 2008, 77, 051904. PDF
Jack, R.L., M.F. Hagan, and D. Chandler, "Fluctuation-dissipation ratios in the dynamics of self-assembly." Physical Review E, 2007. *76*: in press. PDF
Hagan, M. F.; Chandler, D. "Dynamic Pathways for Viral Capsid Assembly," Biophysical Journal, 2006. *91*(1): p. 42-54. PDF
Hagan, M. F.; Chakraborty, A. K. "Hybridization Dynamics of Surface Immobilized DNA," J. Chem. Phys. (2004), 120, 4958. PDF
Hagan, M. F.; Dinner, A. R.; Chander, D.; Chakraborty, A. K. "Atomistic Understanding of Kinetic Pathways for Single Base-Pair Binding and Unbinding in DN," PNAS (USA) (2003), 100, 13922. PDF
Hagan, M. F.; Majumdar, A.; Chakraborty, A. K. "Nanomechanical Forces Generated by Surface Grafted DNA," J. Phys. Chem. B (2002), 106, 10163. PDF
Wu, G.; Haifeng, J.; Hansen, K.; Thundat, T.; Datar, R.; Cote, R.; Hagan, M. F.; Chakraborty, A. K.; Majumdar, A. "Origin of Nanomechanical Cantilever Motion Generated from Biomolecular Interactions," PNAS (USA) (2001), 98, 1560. PDF