Piali Sengupta

Piali Sengupta, Biology faculty member, Brandeis UniversityProfessor of Biology

Research Description

Neurogenetics of sensory behaviors

How do animals sense their environment? How do these external cues elicit specific behaviors and developmental programs? How are these responses modified by the animal’s experience and internal state? The lab aims to answer these questions by identifying the genetic, molecular, and neuronal mechanisms that allow us to robustly, yet flexibly, sense and respond to our complex and constantly changing environment. Understanding the regulation of sensory signaling and signal processing is of significant biomedical importance since disruption of these pathways leads to a range of neurological and behavioral disorders.

To address the above issues, we use a multifaceted approach combining genetic, genomic, and molecular tools, high-resolution quantitative behavioral assays, live imaging, and in vivo analyses of neuronal activity. Our experimental organism is C. elegans, but we also work with mammalian primary neurons and cultured cells. We greatly value collaborations and open communication, and seek out collaborative opportunities that allow us to learn from others, and build new scientific connections within and across disciplines.

Sensory neuron cilia in C. elegansSensory neuron cilia in C. elegans. From Doroquez et al., eLife 2014.

Ongoing work in the lab can be broadly grouped into two areas.

Please see the lab website and our publications for additional details.

Selected Publications

  • Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans. O'Donnell MP, Chao PH, Kammenga JE, Sengupta P. PLoS Genet. 2018 Feb 7;14(2):e1007213. doi: 10.1371/journal.pgen.1007213. eCollection 2018 Feb.
  • Centriolar remodeling underlies basal body maturation during ciliogenesis in Caenorhabditis elegans. Nechipurenko IV, Berciu C, Sengupta P, Nicastro D. Elife. 2017 Apr 15;6. pii: e25686. doi: 10.7554/eLife.25686.
  • Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging. Cornils A, Maurya AK, Tereshko L, Kennedy J, Brear AG, Prahlad V, Blacque OE, Sengupta P. PLoS Genet. 2016 Dec 1;12(12):e1006325. doi: 10.1371/journal.pgen.1006325. eCollection 2016 Dec.
  • A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis. Nechipurenko IV, Olivier-Mason A, Kazatskaya A, Kennedy J, McLachlan IG, Heiman MG, Blacque OE, Sengupta P. Dev Cell. 2016 Sep 12;38(5):493-506. doi: 10.1016/j.devcel.2016.07.013.
  • Receptor-type Guanylyl Cyclases Confer Thermosensory Responses in C. elegans. Takeishi A, Yu YV, Hapiak VM, Bell HW, O'Leary T, Sengupta P. Neuron. 2016 Apr 20;90(2):235-44. doi: 10.1016/j.neuron.2016.03.002. 
  • Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling. Neal SJ, Takeishi A, O'Donnell MP, Park J, Hong M, Butcher RA, Kim K, Sengupta P. Elife. 2015 Sep 3;4. pii: e10110. doi: 10.7554/eLife.10110. Erratum in: Elife. 2015;4:e11547. PMID: 26335407
  • CaMKI-dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron. Yu YV, Bell HW, Glauser D, Van Hooser SD, Goodman MB, Sengupta P. Neuron. 2014 Dec 3;84(5):919-926. doi: 0.1016/j.neuron.2014.10.046.  PMID: 25467978
  • A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans. Doroquez DB*, Berciu C*, Anderson JR, Sengupta P*, Nicastro D.* Elife. 2014 Mar 25;3:e01948. doi: 10.7554/eLife.01948. PMID: 24668170
  • Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans. Jang H*, Kim K*, Neal SJ, Macosko E, Kim D, Butcher RA, Zeiger DM, Bargmann CI*, Sengupta P.* Neuron. 2012 Aug 23;75(4):585-92. doi: 10.1016/j.neuron.2012.06.034.PMID: 22920251 

* - co-corresponding authors