Michael Lostica
The Enzyme Instructed Self-Assembly of a Phosphorylated
Hexapeptide
Michael Lostica, Jie Li, Bing Xu
University of California, Berkeley / Chemistry
Hosted by Xu's Lab
Abstract
Small peptides and their derivatives have been shown to self-assemble in solution, forming supramolecular structures, like nanotubes and nanofibrils, and resulting in hydrogels. These molecules may not initially form such structures in solution, but do so after removal of moieties by enzymatic cleavage. Here, a hexapeptide containing phosphorylated tyrosine residues (LREYpFYp), and a derivative containing Fmoc (fluorenylmethyloxycarbonyl), were shown to undergo enzyme instructed self-assembly (EISA).
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