Publications

2024

Henshaw, R. J., Moon, J., Stehnach, M. R., Bowen, B. P., Kosina, S. M., Northen, T. R., Guasto, J. S., & Floge, S. A. (2024). Metabolites from intact phage-infected Synechococcus chemotactically attract heterotrophic marine bacteria. Nat Microbiol.
Tordoff, E., Allen, J., Elgart, K., Elsherbini, A., Kalia, V., Wu, H., Eren, E., Kapogiannis, D., Gololobova, O., Witwer, K., Volpert, O., & Eitan, E. (2024). A novel multiplexed immunoassay for surface-exposed proteins in plasma extracellular vesicles. J Extracell Vesicles, 13(11), e70007.
Wise, D. L., Escobedo-Lozoya, Y., Valakh, V., Isaac, B., Gao, E. Y., Bhonsle, A., Lei, Q. L., Cheng, X., Greene, S. B., Van Hooser, S. D., & Nelson, S. B. (2024). Prolonged Activity Deprivation Causes Pre- and Postsynaptic Compensatory Plasticity at Neocortical Excitatory Synapses. eNeuro, 11(6).
Curtis, Z., Escudeiro, P., Mallon, J., Leland, O., Rados, T., Dodge, A., Andre, K., Kwak, J., Yun, K., Isaac, B., Martinez Pastor, M., Schmid, A. K., Pohlschroder, M., Alva, V., & Bisson, A. (2024). Halofilins as emerging bactofilin families of archaeal cell shape plasticity orchestrators. Proc Natl Acad Sci U S A, 121(40), e2401583121.
Videbaek, T. E., Hayakawa, D., Grason, G. M., Hagan, M. F., Fraden, S., & Rogers, W. B. (2024). Economical routes to size-specific assembly of self-closing structures. Sci Adv, 10(27), eado5979.
Wei, W. S., Trubiano, A., Sigl, C., Paquay, S., Dietz, H., Hagan, M. F., & Fraden, S. (2024). Hierarchical assembly is more robust than egalitarian assembly in synthetic capsids. Proc Natl Acad Sci U S A, 121(7), e2312775121.
Dresselhaus, E. C., Harris, K. P., Blanchette, C. R., Koles, K., Del Signore, S. J., Pescosolido, M. F., Ermanoska, B., Rozencwaig, M., Soslowsky, R. C., Parisi, M. J., Stewart, B. A., Mosca, T. J., & Rodal, A. A. (2024). ESCRT disruption provides evidence against trans-synaptic signaling via extracellular vesicles. J Cell Biol, 223(9).
Draganova, E. B., Wang, H., Wu, M., Liao, S., Vu, A., Gonzalez-Del Pino, G. L., Zhou, Z. H., Roller, R. J., & Heldwein, E. E. (2024). The universal suppressor mutation restores membrane budding defects in the HSV-1 nuclear egress complex by stabilizing the oligomeric lattice. PLoS Pathog, 20(1), e1011936.
Qiao, Y., Wu, G., Liu, Z., He, H., Tan, W., & Xu, B. (2024). Assessment of the Enzymatic Dephosphorylation Kinetics in the Assemblies of a Phosphopentapeptide that Forms Intranuclear Nanoribbons. Biomacromolecules.

2023

Vasquez, S., Marquez, M. D., Brignole, E. J., Vo, A., Kong, S., Park, C., Perlstein, D. L., & Drennan, C. L. (2023). Structural and biochemical investigations of a HEAT-repeat protein involved in the cytosolic iron-sulfur cluster assembly pathway. Commun Biol, 6(1), 1276.
Pitsawong, W., Pádua, R. A., Grant, T., Hoemberger, M., Otten, R., Bradshaw, N., Grigorieff, N., & Kern, D. (2023). From primordial clocks to circadian oscillators. Nature, 616(7955), 183-189.
Stehnach MR, H. R., Floge SA, Guasto JS. (2023). Multiplexed microfluidic screening of bacterial chemotaxis. Elife, 12

2022

Mukherjee, K., Gu, C., Collins, A., Mettlen, M., Samelko, B., Altintas, M.M., Sudhini, Y.R., Wang, X., Bouley, R., Brown, D., Pedro, B.P., Bane, S.L., Gupta, V., Brinkkoetter, P.T., Hagmann, H., Reiser, J., Sever, S. Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury. Nature Communications (2022) 13, 2422.
Thorsen, M.K., Draganova, E.B., Heldwein, E.E. The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven mechanism. PLoS Pathogens(2022) 18 (7): e1010623.
Hayakawa, D., Videbaek, T.E., Hall, D.M., Fang, H., Sigl, C., Feigl, E., Dietz, H., Fraden, S., Hagan M.F., Grason, G.M., Rogers, W.B. Geometrically programmed self-limited assembly of tubules using DNA origami colloids. PNAS (2022) 119 (43) e2207902119.
Liu, S., Zhang, Q., He, H., Yi, M., Tan, W., Guo, J., Xu, B. Intranuclear Nanoribbons for Selective Killing of Osteosarcoma Cells. Angewandte Chemie International Edition (2022) 61 (44) e202210568.
Yi, M., Wang, F., Tan, W. Hsieh, J.-T., Egelman,H., Xu, B. Enzyme Responsive Rigid-Rod Aromatics Target “Undruggable” Phosphatases to Kill Cancer Cells in Mimetic Bone Microenvironment. Journal of the American Chemical Society (2022) 144 (29) 13055-13059.
Tan, W., Zhang, Q., Quiñones-Frías, M.C., Hsu, A., Zhang, Y., Rodal, A.A., Hong, P., Luo, H., Xu, B. Enzyme Responsive Peptide Thioesters for Targeting Golgi Apparatus. Journal of the American Chemical Society (2022) 144 (15) 6709-6713.

2021

Herrmann, T., Torres, R., Salgado, E.N., Berciu, C., Stoddard, D., Nicastro, D., Jenni, S., Harrison, S.C. Functional refolding of the penetration protein on a non-enveloped virus. Nature (2021) 590, 666–670.
Walsh, R.B., Becalska, A.N., Zunitch, M.J., Lemos, T., Dresselhaus, E.C., Lee, S.M., Apiki, J., Wang, S., Isaac, B., Yeh, A., Koles, K., Rodal, A.A. Opposing functions for retromer and Rab11 in extracellular vesicle cargo traffic at presynaptic terminals. Journal of Cell Biology (2021) 220 (8): e202012034.
Liu, S.,Zhang, Q.,Shy, A. N.,Yi, M.,He, H.,Lu, S.,Xu, B. Enzymatically Forming Intranuclear Peptide Assemblies for Selectively Killing Human Induced Pluripotent Stem Cells (iPSCs). Journal of the American Chemical Society (2021) 143 (38), 15852-15862.
Yang, D., Kim, B.J., He, H., Xu, B. Enzymatically Forming Cell Compatible Supramolecular Assemblies of Tryptophan-Rich Short Peptides. Peptide Science (2021) 113 (2), e24173.
Shy, A.N., Wang, H., Feng, Z., Xu, B. Heterotypic Supramolecular Hydrogels Formed by Noncovalent Interactions in Inflammasomes. Molecules (2021) 26 (1), 77.
Yang, D., He, H., Kim, B.J., Xu, B. Peptide Assemblies Mimicking Chaperones for Protein Trafficking. Bioconjugate Chemistry (2021) 32 (3), 502-506.
He, H., Guo, J., Xu, J., Wang, J., Liu, S., Xu, B. The Dynamic Continuum of Nanoscale Peptide Assemblies Facilitates Endocytosis and Endosomal Escape. Nano Letters (2021) 21 (9), 4878-4085.
Tan, W., Zhang, Q., Wang, J., Yi, M., He, H., Xu, B. Enzymatic Assemblies of Thiophosphopeptides Instantly Target Golgi Apparatus and Selectively Kill Cancer Cells. Angewandte Chemie International Edition (2021) 60 (23), 12796-12801.
He, H., Guo, J., Xu, B. Enzymatic Delivery of Magnetic Nanoparticles into Mitochondria of Live Cells. ChemNanoMat (2021) 7 (10), 1104-1107.
Yi, M., Guo, J., He, H., Tan, W., Harmon, N., Ghebreyessus, K., Xu, B. Phosphobisaromatic motifs enable rapid enzymatic self-assembly and hydrogelation of short peptides. Soft Matter (2021) 17, 8590 - 8594.
Kim, B. J., Fang, Y., He, H., Xu, B. Trypsin-Instructed Self-Assembly on Endoplasmic Reticulum for Selectively Inhibiting Cancer Cells. Advanced Healthcare Materials (2021) 10 (4), 2000416.

2020

Draganova, E.B., Zhang, J., Zhou, Z.H., Heldwein, E.E. Structural basis for capsid recruitment and coat formation during HSV-1 nuclear egress. Elife (2020) 9, e56627 .
Yang, D., He, H., Xu, B. Enzyme-Instructed Morphological Transition of the Supramolecular Assemblies of Branched Peptides. Beilstein Journal of Organic Chemistry (2020) 16, 2700-2718.
He, H., Lin, X., Wu, D., Wang, J., Guo, J., Green, D.R., Zhang, H., Xu, B. Enzymatic Noncovalent Synthesis for Mitochondrial Genetic Engineering of Cancer Cells. Cell Reports Physical Science (2020) 1 (12), 100270.
He, H., Liu, S., Wu, D., Xu, B.Enzymatically-Formed Peptide Assemblies Sequestrate Proteins and Relocate Inhibitors for Selectively Killing Cancer Cells. Angewandte Chemie International Edition (2020) 59 (38), 16445-16450.
Guo, J., He, H., Kim, B.J., Wang, J., Yi, M., Lin, C., Xu, B. The Ratio of Hydrogelator and Precursor Controls Enzymatic Hydrogelation of a Branched Peptide. Soft Matter (2020) 16 (44), 10101-10105.
Shy, A.N., Li, J., Shi, J., Zhou, N., Xu, B. Enzyme-Instructed Self-assembly of the Stereoisomers of Pentapeptides to Form Biocompatible Supramolecular Hydrogels. Journal of Drug Targeting (2020) 28 (7-8), 760-765.
He, H., Guo, J., Lin, X., Xu, B. Enzyme-Instructed Assemblies Enable Mitochondria Localization of H2B in Cancer Cells. Angewandte Chemie International Edition (2020) 59 (24), 9330-9334.
He, H., Xingyi Lin, X., Guo, J., Wang, J., Xu, B. Perimitochondrial Enzymatic Self-Assembly for Selective Targeting the Mitochondria of Cancer Cells. ACS Nano (2020) 14 (6), 6947-6955.
Feng, Z., Wang, H., Yi, M., Lo, C.-Y., Sallee, A., Hsieh, J.-T., Xu, B. Instructed-Assembly of Small Peptides Inhibits Drug-Resistant Prostate Cancer Cells. Peptide Science (2020) 112 (1), e24123.

2019

Wang, S., Zhao, Z., Rodal, A.A., Higher-order assembly of Sorting Nexin 16 controls tubulation and distribution of neuronal endosomes. Journal of Cellular Biology (2019) 218 (8), 2600-2618 .
Wang, H., Feng, Z., Tan, W., Bing Xu, B. Assemblies of D-peptides for Targeting Cell Nucleolus. Bioconjugate Chemistry (2019) 30 (10), 2528-2532.
Wang, H., Feng, Z., Xu, B. Intercellular Instructed-Assembly Mimics Protein Dynamics to Induce Cell Spheroids. Journal of the American Chemical Society (2019) 141 (18), 7271-7274.
Wang, H., Feng, Z., Xu, B. Instructed-Assembly as Context-Dependent Signals for Death and Morphogenesis of Cells. Angewandte Chemie International Edition (2019) 58 (17), 5567-5571.
Feng, Z., Han, X., Wang, H., Tang, T., Xu, B. Enzyme- Instructed Peptide Assemblies Selectively Inhibit Bone Tumors. Chem (2019) 5 (9), 2442-2449.
Wang, J., Zhou, J., He, H., Wu, D., Du, X., Xu B. Cell-compatible Nanoprobes for Imaging Intracellular Phosphatase Activities ChemBioChem (2019) 20 (4), 526- 531.

2018

Zhou, J., Du, X., Chen, X., Xu, B. Adaptive Multifunctional Supramolecular Assemblies of Glycopeptides Rapidly Enable Morphogenesis. Biochemistry (2018) 57 (32), 4867- 4879.
Zhou, J., Du, X., Berciu, C., Del Signore, S.J., Chen, X., Yamagata, N., Rodal, A.A., Nicastro, D., Xu, B. Cellular Uptake of a Taurine-Modified, Ester Bond-Decorated D-Peptide Derivative Via Dynamin-Based Endocytosis and Macropinocytosis. Molecular Therapy (2018) 26 (2), 648-658.
Wang, J., Xiong, T., Zhou, J., He, H., Wu, D., Du, X., Li, X., Xu, B. Enzymatic Formation of Curcumin in Vitro and in Vivo. Nano Research (2018) 11, 3453-3461.
Feng, Z., Wang, H., Xu, B. Instructed-Assembly of Peptides for Intracellular Enzyme Sequestration. Journal of the American Chemical Society (2018) 140 (48), 16433-16437.
Wang, H., Feng, Z., Qin, Y., Wang, J., Xu, B. Nucleopeptide Assemblies Selectively Sequester ATP in Cancer Cells to Increase the Efficacy of Doxorubicin. Angewandte Chemie International Edition (2018) 57 (18), 4931-4935.
Feng, Z., Wang, H., Wang, S., Zhang, Q., Zhang, X., Rodal, A.A., Xu, B. Enzymatic Assemblies Disrupt the Membrane and Target Endoplasmic Reticulum for Selective Cancer Cell Death. Journal of the American Chemical Society (2018) 140 (30), 9566-9573.
Li, J., Zhan, Z., Du, X., Wang, J., Hong, B., Xu, B. Selection of Secondary Structures of Heterotypic Supramolecular Peptide Assemblies by an Enzymatic Reaction. Angewandte Chemie International Edition (2018) 57 (36), 11716-11721.
Zhou, J., Du, X., Chen, X., Wang, J., Zhou, N., Wu, D., Xu, B. Enzymatic Self-Assembly Confers Exceptionally Strong Synergism with NF-κB Targeting for Selective Necroptosis of Cancer Cells. Journal of the American Chemical Society (2018) 140 (6), 2301-2308.
He, H., Wang, J., Wang, H., Zhou, N., Yang, D., Green, D.R., Xu, B. Enzymatic Cleavage of Branched Peptides for Targeting Mitochondria. Journal of the American Chemical Society (2018) 140 (4), 1215-1218.
Li, J., Du, X., Powell, D.J., Zhou, R., Shi, J. He, H., Feng, Z., Xu, B. Down-Regulating Proteolysis to Enhance Anticancer Activity of Peptide Nanofibers. Chemistry-An Asian Journal (2018) 13 (22), 3464-3468.
Li, J., Bullara, D., Du, X., He, H., Sofou, S., Kevrekidis, I.G., Epstein, I.R., Xu, B. Kinetic Analysis of Nano-Structures Formed by Enzyme- Instructed Intracellular Assemblies against Cancer Cells. ACS Nano (2018) 12 (4), 3804-3815.
He, H., Wang, H., Zhou N., Yang, D., Xu, B. Branched Peptides for Enzymatic Supramolecular Hydrogelation. Chemical Communications (2018) 54, 86-89.

2017

Zhou, N., Cao, X., Du, X., Wang, H., Wang, M., Liu, S., Khang, N., Schmidt-Rohr, K., Xu, Q., Liang, G., Xu, B. Hyper-Crosslinkers Lead to Temperature- and Ph-Responsive Polymeric Nanogels with Unusual Volume Change. Angewandte Chemie International Edition (2017) 56 (10), 2623-2627.
Wang, H., Shi, J., Feng, Z., Zhou, R., Wang, S., Rodal, A.A., Xu, B. An in Situ Dynamic Continuum of Supramolecular Phosphoglycopeptides Enables Formation of 3d Cell Spheroids. Angewandte Chemie International Edition (2017) 56 (51), 16297- 16301.
Li, J., Du, X., Hashim, S., Shy, A., Xu, B. Aromatic-Aromatic Interactions Enable Alpha-Helix to Beta-Sheet Transition of Peptides to Form Supramolecular Hydrogels. Journal of the American Chemical Society (2017) 139 (1), 71-74.
Feng, Z., Wang, H., Chen, X., Xu, B. Self-Assembling Ability Determines the Activity of Enzyme-Instructed Self-Assembly for Inhibiting Cancer Cells. Journal of the American Chemical Society (2017) 139 (43), 15377-15384.
Feng, Z., Wang, H., Zhou, R., Li, J., Xu, B. Enzyme-Instructed Assembly and Disassembly Processes for Targeting Downregulation in Cancer Cells. Journal of the American Chemical Society (2017) 139 (11), 3950-3953.
Zhou, J., Du, X., Wang, J., Yamagata, N., Xu, B. Enzyme-Instructed Self- Assembly of Peptides Containing Phosphoserine to Form Supramolecular Hydrogels as Potential Soft Biomaterials. Frontiers of Chemical Science and Engineering (2017) 11, 509-515.
Yamagata, N., Chen, X., Zhou, J., Li, J., Du, X., Xu, B. Enzymatic Self- Assembly of an Immunoreceptor Tyrosine-Based Inhibitory Motif (ITIM). Organic & Biomolecular Chemistry (2017) 15, 5689-5692.
Du, X., Zhou, J., Wang, J., Zhou, R., Xu, B. Chirality Controls Reaction-Diffusion of Nanoparticles for Inhibiting Cancer Cells. ChemNanoMat 2017, 3, 17-21.
Du, X., Zhou, J., Wang, H., Shi, J., Kuang, Y., Zeng, W., Yang, Z., Xu, B. In Situ Generated D-Peptidic Nanofibrils as Multifaceted Apoptotic Inducers to Target Cancer Cells. Cell Death & Disease (2017) 8, e2614.
Du, X., Zhou, J., Li, X., Xu, B. Self-Assembly of Nucleopeptides to Interact with DNAs. Interface Focus (2017) 7 (6), 20160116.

Older Publications

Huaimin Wang, Zhaoqianqi Feng, Dongdong Wu, Keith J. Fritzsching, Mike Rigney, Jie Zhou, Yujie Jiang, Klaus Schmidt-Rohr, and Bing Xu, Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells. Journal of the American Chemical Society 2016 138 (34), 10758-10761, DOI: 10.1021/jacs.6b06075
Jie Zhou, Michael O'Keeffe, Gongxian Liao, Fan Zhao, Cox Terhorst, Bing Xu* “Design and Synthesis of Nanofibers of Self-Assembled De Novo Glycoconjugates Towards Mucosal Lining Restoration and Anti-Inflammatory Drug Delivery". Tetrahedron 2016, 72, 6078-6083.
Jie Zhou, Xuewen Du, Bing Xu* “Regulating the Rate of Molecular Self-Assembly for Targeting Cancer Cells". Angewandte Chemie International Edition 2016, 55, 5770-5775.
Jie Zhou, Xuewen Du, Cristina Berciu, Hongjian He, Junfeng Shi, Daniela Nicastro, Bing Xu* “Enzyme-Instructed Self-Assembly for Spatiotemporal Profiling of the Activities of Alkaline Phosphatases on Live Cells". Chem 2016, 1, 246-263.
Huaimin Wang, Zhaoqianqi Feng, Dongdong Wu, Keith J. Fritzsching, Mike Rigney, Jie Zhou, Yujie Jiang, Klaus Schmidt-Rohr, Bing Xu* “Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells". Journal of the American Chemical Society 2016, 138, 10758-10761.
Józef R. Lewandowski, Patrick C. A. van der Wel, Mike Rigney, Nikolaus Grigorieff, and Robert G. Griffin, Structural Complexity of a Composite Amyloid Fibril. Journal of the American Chemical Society 2011 133 (37), 14686-14698, DOI: 10.1021/ja203736z
Sokolova, Olga, et al. "Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvβ2-subunit." Proceedings of the National Academy of Sciences 100.22 (2003): 12607-12612.
Kern, David M., et al. "The outer kinetochore protein KNL-1 contains a defined oligomerization domain in nematodes." Molecular Biology of the Cell 26.2 (2015): 229-237.
Fu, Yuan, et al. "Uncoupling of allosteric and oligomeric regulation in a functional hybrid enzyme constructed from Escherichia coli and human ribonucleotide reductase." Biochemistry 52.40 (2013): 7050-7059.
Jurica, M., Sousa, D., Moore, M. et al. Three-dimensional structure of C complex spliceosomes by electron microscopy. Nat Struct Mol Biol 11, 265–269 (2004).
David B Doroquez, Cristina Berciu, James R Anderson, Piali Sengupta, Daniela Nicastro (2014) A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans. eLife 3:e01948.